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Q8K4D3

- S36A1_MOUSE

UniProt

Q8K4D3 - S36A1_MOUSE

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Protein

Proton-coupled amino acid transporter 1

Gene

Slc36a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid.1 Publication

GO - Molecular functioni

  1. glycine transmembrane transporter activity Source: MGI
  2. hydrogen:amino acid symporter activity Source: MGI
  3. hydrogen ion transmembrane transporter activity Source: Ensembl
  4. L-alanine transmembrane transporter activity Source: MGI
  5. L-proline transmembrane transporter activity Source: MGI

GO - Biological processi

  1. glycine transport Source: MGI
  2. L-alanine transport Source: MGI
  3. proline transmembrane transport Source: GOC
  4. proline transport Source: MGI
  5. proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_229738. Proton-coupled neutral amino acid transporters.
REACT_230460. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.8.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 1
Short name:
Proton/amino acid transporter 1
Alternative name(s):
Solute carrier family 36 member 1
Gene namesi
Name:Slc36a1
Synonyms:Pat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2445299. Slc36a1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Lysosome membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Topological domaini72 – 776ExtracellularSequence Analysis
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 14042CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 18928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 2144CytoplasmicSequence Analysis
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Topological domaini236 – 25621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 28811CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 34132ExtracellularSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 3719CytoplasmicSequence Analysis
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Topological domaini393 – 3964ExtracellularSequence Analysis
Transmembranei397 – 41721HelicalSequence AnalysisAdd
BLAST
Topological domaini418 – 43821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST
Topological domaini460 – 47516ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: Ensembl
  4. lysosome Source: MGI
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Proton-coupled amino acid transporter 1PRO_0000093826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi179 ↔ 328By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8K4D3.
PaxDbiQ8K4D3.
PRIDEiQ8K4D3.

PTM databases

PhosphoSiteiQ8K4D3.

Expressioni

Tissue specificityi

Highly expressed in small intestine, colon, kidney and brain.1 Publication

Gene expression databases

BgeeiQ8K4D3.
ExpressionAtlasiQ8K4D3. baseline and differential.
GenevestigatoriQ8K4D3.

Interactioni

Protein-protein interaction databases

IntActiQ8K4D3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8K4D3.
KOiK14209.
OMAiDCHNNET.
OrthoDBiEOG73V6KC.
PhylomeDBiQ8K4D3.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTQRLRNED YHDYSSTDVS PEESPSEGLG SFSPGSYQRL GENSSMTWFQ
60 70 80 90 100
TLIHLLKGNI GTGLLGLPLA VKNAGLLLGP LSLLVIGIVA VHCMGILVKC
110 120 130 140 150
AHHLCRRLNK PFLDYGDTVM YGLECSPSTW VRNHSHWGRR IVDFFLIVTQ
160 170 180 190 200
LGFCCVYFVF LADNFKQVIE AANGTTTNCN NNVTVIPTPT MDSRLYMLSF
210 220 230 240 250
LPFLVLLSFI RNLRVLSIFS LLANISMFVS LIMIYQFIVQ RIPDPSHLPL
260 270 280 290 300
VAPWKTYPLF FGTAIFAFEG IGVVLPLENK MKDSQKFPLI LYLGMAIITV
310 320 330 340 350
LYISLGSLGY LQFGANIKGS ITLNLPNCWL YQSVKLLYSI GIFFTYALQF
360 370 380 390 400
YVAAEIIIPA IVSRVPEHFE LMVDLCVRTA MVCVTCVLAI LIPRLDLVIS
410 420 430 440 450
LVGSVSSSAL ALIIPPLLEV VTYYGEGISP LTVTKDALIS ILGFVGFVVG
460 470
TYESLCELIQ PSHSDSSTNS TSAFI
Length:475
Mass (Da):52,466
Last modified:October 1, 2002 - v1
Checksum:i113C23309F2B51F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431N → S in AAO37090. (PubMed:15058382)Curated
Sequence conflicti198 – 1981L → P in AAO37090. (PubMed:15058382)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453743 mRNA. Translation: AAM80480.1.
AY211262 mRNA. Translation: AAO37090.1.
CCDSiCCDS36156.1.
RefSeqiNP_694779.3. NM_153139.4.
UniGeneiMm.35732.

Genome annotation databases

EnsembliENSMUST00000020499; ENSMUSP00000020499; ENSMUSG00000020261.
ENSMUST00000108867; ENSMUSP00000104495; ENSMUSG00000020261.
ENSMUST00000108872; ENSMUSP00000104500; ENSMUSG00000020261.
GeneIDi215335.
KEGGimmu:215335.
UCSCiuc007izd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453743 mRNA. Translation: AAM80480.1 .
AY211262 mRNA. Translation: AAO37090.1 .
CCDSi CCDS36156.1.
RefSeqi NP_694779.3. NM_153139.4.
UniGenei Mm.35732.

3D structure databases

ProteinModelPortali Q8K4D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K4D3. 1 interaction.

Protein family/group databases

TCDBi 2.A.18.8.1. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q8K4D3.

Proteomic databases

MaxQBi Q8K4D3.
PaxDbi Q8K4D3.
PRIDEi Q8K4D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020499 ; ENSMUSP00000020499 ; ENSMUSG00000020261 .
ENSMUST00000108867 ; ENSMUSP00000104495 ; ENSMUSG00000020261 .
ENSMUST00000108872 ; ENSMUSP00000104500 ; ENSMUSG00000020261 .
GeneIDi 215335.
KEGGi mmu:215335.
UCSCi uc007izd.1. mouse.

Organism-specific databases

CTDi 206358.
MGIi MGI:2445299. Slc36a1.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00390000011245.
HOGENOMi HOG000006823.
HOVERGENi HBG057183.
InParanoidi Q8K4D3.
KOi K14209.
OMAi DCHNNET.
OrthoDBi EOG73V6KC.
PhylomeDBi Q8K4D3.
TreeFami TF314873.

Enzyme and pathway databases

Reactomei REACT_229738. Proton-coupled neutral amino acid transporters.
REACT_230460. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi Slc36a1. mouse.
NextBioi 374674.
PROi Q8K4D3.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4D3.
ExpressionAtlasi Q8K4D3. baseline and differential.
Genevestigatori Q8K4D3.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters."
    Boll M., Foltz M., Rubio-Aliaga I., Kottra G., Daniel H.
    J. Biol. Chem. 277:22966-22973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "Organization and expression of the SLC36 cluster of amino acid transporter genes."
    Bermingham J.R. Jr., Pennington J.
    Mamm. Genome 15:114-125(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS36A1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4D3
Secondary accession number(s): Q811N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3