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Q8K4D3

- S36A1_MOUSE

UniProt

Q8K4D3 - S36A1_MOUSE

Protein

Proton-coupled amino acid transporter 1

Gene

Slc36a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid.1 Publication

    GO - Molecular functioni

    1. glycine transmembrane transporter activity Source: MGI
    2. hydrogen ion transmembrane transporter activity Source: Ensembl
    3. L-alanine transmembrane transporter activity Source: MGI
    4. L-proline transmembrane transporter activity Source: MGI
    5. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycine transport Source: MGI
    2. L-alanine transport Source: MGI
    3. proline transmembrane transport Source: GOC
    4. proline transport Source: MGI
    5. proton transport Source: MGI

    Keywords - Biological processi

    Amino-acid transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.18.8.1. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proton-coupled amino acid transporter 1
    Short name:
    Proton/amino acid transporter 1
    Alternative name(s):
    Solute carrier family 36 member 1
    Gene namesi
    Name:Slc36a1
    Synonyms:Pat1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2445299. Slc36a1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Lysosome membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: UniProtKB-SubCell
    4. lysosome Source: MGI
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Proton-coupled amino acid transporter 1PRO_0000093826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi179 ↔ 328By similarity
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8K4D3.
    PRIDEiQ8K4D3.

    PTM databases

    PhosphoSiteiQ8K4D3.

    Expressioni

    Tissue specificityi

    Highly expressed in small intestine, colon, kidney and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8K4D3.
    BgeeiQ8K4D3.
    GenevestigatoriQ8K4D3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K4D3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 776ExtracellularSequence Analysis
    Topological domaini99 – 14042CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini211 – 2144CytoplasmicSequence Analysis
    Topological domaini236 – 25621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 28811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 34132ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini363 – 3719CytoplasmicSequence Analysis
    Topological domaini393 – 3964ExtracellularSequence Analysis
    Topological domaini418 – 43821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini460 – 47516ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00390000011245.
    HOGENOMiHOG000006823.
    HOVERGENiHBG057183.
    InParanoidiQ8K4D3.
    KOiK14209.
    OMAiDCHNNET.
    OrthoDBiEOG73V6KC.
    PhylomeDBiQ8K4D3.
    TreeFamiTF314873.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTQRLRNED YHDYSSTDVS PEESPSEGLG SFSPGSYQRL GENSSMTWFQ    50
    TLIHLLKGNI GTGLLGLPLA VKNAGLLLGP LSLLVIGIVA VHCMGILVKC 100
    AHHLCRRLNK PFLDYGDTVM YGLECSPSTW VRNHSHWGRR IVDFFLIVTQ 150
    LGFCCVYFVF LADNFKQVIE AANGTTTNCN NNVTVIPTPT MDSRLYMLSF 200
    LPFLVLLSFI RNLRVLSIFS LLANISMFVS LIMIYQFIVQ RIPDPSHLPL 250
    VAPWKTYPLF FGTAIFAFEG IGVVLPLENK MKDSQKFPLI LYLGMAIITV 300
    LYISLGSLGY LQFGANIKGS ITLNLPNCWL YQSVKLLYSI GIFFTYALQF 350
    YVAAEIIIPA IVSRVPEHFE LMVDLCVRTA MVCVTCVLAI LIPRLDLVIS 400
    LVGSVSSSAL ALIIPPLLEV VTYYGEGISP LTVTKDALIS ILGFVGFVVG 450
    TYESLCELIQ PSHSDSSTNS TSAFI 475
    Length:475
    Mass (Da):52,466
    Last modified:October 1, 2002 - v1
    Checksum:i113C23309F2B51F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431N → S in AAO37090. (PubMed:15058382)Curated
    Sequence conflicti198 – 1981L → P in AAO37090. (PubMed:15058382)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453743 mRNA. Translation: AAM80480.1.
    AY211262 mRNA. Translation: AAO37090.1.
    CCDSiCCDS36156.1.
    RefSeqiNP_694779.3. NM_153139.4.
    UniGeneiMm.35732.

    Genome annotation databases

    EnsembliENSMUST00000020499; ENSMUSP00000020499; ENSMUSG00000020261.
    ENSMUST00000108867; ENSMUSP00000104495; ENSMUSG00000020261.
    ENSMUST00000108872; ENSMUSP00000104500; ENSMUSG00000020261.
    GeneIDi215335.
    KEGGimmu:215335.
    UCSCiuc007izd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453743 mRNA. Translation: AAM80480.1 .
    AY211262 mRNA. Translation: AAO37090.1 .
    CCDSi CCDS36156.1.
    RefSeqi NP_694779.3. NM_153139.4.
    UniGenei Mm.35732.

    3D structure databases

    ProteinModelPortali Q8K4D3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K4D3. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.18.8.1. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q8K4D3.

    Proteomic databases

    PaxDbi Q8K4D3.
    PRIDEi Q8K4D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020499 ; ENSMUSP00000020499 ; ENSMUSG00000020261 .
    ENSMUST00000108867 ; ENSMUSP00000104495 ; ENSMUSG00000020261 .
    ENSMUST00000108872 ; ENSMUSP00000104500 ; ENSMUSG00000020261 .
    GeneIDi 215335.
    KEGGi mmu:215335.
    UCSCi uc007izd.1. mouse.

    Organism-specific databases

    CTDi 206358.
    MGIi MGI:2445299. Slc36a1.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00390000011245.
    HOGENOMi HOG000006823.
    HOVERGENi HBG057183.
    InParanoidi Q8K4D3.
    KOi K14209.
    OMAi DCHNNET.
    OrthoDBi EOG73V6KC.
    PhylomeDBi Q8K4D3.
    TreeFami TF314873.

    Miscellaneous databases

    ChiTaRSi SLC36A1. mouse.
    NextBioi 374674.
    PROi Q8K4D3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K4D3.
    Bgeei Q8K4D3.
    Genevestigatori Q8K4D3.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters."
      Boll M., Foltz M., Rubio-Aliaga I., Kottra G., Daniel H.
      J. Biol. Chem. 277:22966-22973(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "Organization and expression of the SLC36 cluster of amino acid transporter genes."
      Bermingham J.R. Jr., Pennington J.
      Mamm. Genome 15:114-125(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiS36A1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4D3
    Secondary accession number(s): Q811N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3