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Q8K4D3

- S36A1_MOUSE

UniProt

Q8K4D3 - S36A1_MOUSE

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Protein
Proton-coupled amino acid transporter 1
Gene
Slc36a1, Pat1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid.1 Publication

GO - Molecular functioni

  1. L-alanine transmembrane transporter activity Source: MGI
  2. L-proline transmembrane transporter activity Source: MGI
  3. glycine transmembrane transporter activity Source: MGI
  4. hydrogen ion transmembrane transporter activity Source: Ensembl
  5. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. L-alanine transport Source: MGI
  2. glycine transport Source: MGI
  3. proline transmembrane transport Source: GOC
  4. proline transport Source: MGI
  5. proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Protein family/group databases

TCDBi2.A.18.8.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 1
Short name:
Proton/amino acid transporter 1
Alternative name(s):
Solute carrier family 36 member 1
Gene namesi
Name:Slc36a1
Synonyms:Pat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2445299. Slc36a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 776Extracellular Reviewed prediction
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Topological domaini99 – 14042Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Topological domaini162 – 18928Extracellular Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Topological domaini211 – 2144Cytoplasmic Reviewed prediction
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Topological domaini236 – 25621Extracellular Reviewed prediction
Add
BLAST
Transmembranei257 – 27721Helical; Reviewed prediction
Add
BLAST
Topological domaini278 – 28811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Reviewed prediction
Add
BLAST
Topological domaini310 – 34132Extracellular Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 3719Cytoplasmic Reviewed prediction
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 3964Extracellular Reviewed prediction
Transmembranei397 – 41721Helical; Reviewed prediction
Add
BLAST
Topological domaini418 – 43821Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei439 – 45921Helical; Reviewed prediction
Add
BLAST
Topological domaini460 – 47516Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. lysosome Source: MGI
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Proton-coupled amino acid transporter 1
PRO_0000093826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi179 ↔ 328 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K4D3.
PRIDEiQ8K4D3.

PTM databases

PhosphoSiteiQ8K4D3.

Expressioni

Tissue specificityi

Highly expressed in small intestine, colon, kidney and brain.1 Publication

Gene expression databases

ArrayExpressiQ8K4D3.
BgeeiQ8K4D3.
GenevestigatoriQ8K4D3.

Interactioni

Protein-protein interaction databases

IntActiQ8K4D3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8K4D3.
KOiK14209.
OMAiDCHNNET.
OrthoDBiEOG73V6KC.
PhylomeDBiQ8K4D3.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D3-1 [UniParc]FASTAAdd to Basket

« Hide

MSTQRLRNED YHDYSSTDVS PEESPSEGLG SFSPGSYQRL GENSSMTWFQ    50
TLIHLLKGNI GTGLLGLPLA VKNAGLLLGP LSLLVIGIVA VHCMGILVKC 100
AHHLCRRLNK PFLDYGDTVM YGLECSPSTW VRNHSHWGRR IVDFFLIVTQ 150
LGFCCVYFVF LADNFKQVIE AANGTTTNCN NNVTVIPTPT MDSRLYMLSF 200
LPFLVLLSFI RNLRVLSIFS LLANISMFVS LIMIYQFIVQ RIPDPSHLPL 250
VAPWKTYPLF FGTAIFAFEG IGVVLPLENK MKDSQKFPLI LYLGMAIITV 300
LYISLGSLGY LQFGANIKGS ITLNLPNCWL YQSVKLLYSI GIFFTYALQF 350
YVAAEIIIPA IVSRVPEHFE LMVDLCVRTA MVCVTCVLAI LIPRLDLVIS 400
LVGSVSSSAL ALIIPPLLEV VTYYGEGISP LTVTKDALIS ILGFVGFVVG 450
TYESLCELIQ PSHSDSSTNS TSAFI 475
Length:475
Mass (Da):52,466
Last modified:October 1, 2002 - v1
Checksum:i113C23309F2B51F1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431N → S in AAO37090. 1 Publication
Sequence conflicti198 – 1981L → P in AAO37090. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453743 mRNA. Translation: AAM80480.1.
AY211262 mRNA. Translation: AAO37090.1.
CCDSiCCDS36156.1.
RefSeqiNP_694779.3. NM_153139.4.
UniGeneiMm.35732.

Genome annotation databases

EnsembliENSMUST00000020499; ENSMUSP00000020499; ENSMUSG00000020261.
ENSMUST00000108867; ENSMUSP00000104495; ENSMUSG00000020261.
ENSMUST00000108872; ENSMUSP00000104500; ENSMUSG00000020261.
GeneIDi215335.
KEGGimmu:215335.
UCSCiuc007izd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453743 mRNA. Translation: AAM80480.1 .
AY211262 mRNA. Translation: AAO37090.1 .
CCDSi CCDS36156.1.
RefSeqi NP_694779.3. NM_153139.4.
UniGenei Mm.35732.

3D structure databases

ProteinModelPortali Q8K4D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K4D3. 1 interaction.

Protein family/group databases

TCDBi 2.A.18.8.1. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q8K4D3.

Proteomic databases

PaxDbi Q8K4D3.
PRIDEi Q8K4D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020499 ; ENSMUSP00000020499 ; ENSMUSG00000020261 .
ENSMUST00000108867 ; ENSMUSP00000104495 ; ENSMUSG00000020261 .
ENSMUST00000108872 ; ENSMUSP00000104500 ; ENSMUSG00000020261 .
GeneIDi 215335.
KEGGi mmu:215335.
UCSCi uc007izd.1. mouse.

Organism-specific databases

CTDi 206358.
MGIi MGI:2445299. Slc36a1.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00390000011245.
HOGENOMi HOG000006823.
HOVERGENi HBG057183.
InParanoidi Q8K4D3.
KOi K14209.
OMAi DCHNNET.
OrthoDBi EOG73V6KC.
PhylomeDBi Q8K4D3.
TreeFami TF314873.

Miscellaneous databases

ChiTaRSi SLC36A1. mouse.
NextBioi 374674.
PROi Q8K4D3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K4D3.
Bgeei Q8K4D3.
Genevestigatori Q8K4D3.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters."
    Boll M., Foltz M., Rubio-Aliaga I., Kottra G., Daniel H.
    J. Biol. Chem. 277:22966-22973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "Organization and expression of the SLC36 cluster of amino acid transporter genes."
    Bermingham J.R. Jr., Pennington J.
    Mamm. Genome 15:114-125(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS36A1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4D3
Secondary accession number(s): Q811N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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