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Protein

Proton-coupled amino acid transporter 1

Gene

Slc36a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid.1 Publication

GO - Molecular functioni

  • glycine transmembrane transporter activity Source: MGI
  • hydrogen:amino acid symporter activity Source: MGI
  • hydrogen ion transmembrane transporter activity Source: GO_Central
  • L-alanine transmembrane transporter activity Source: MGI
  • L-proline transmembrane transporter activity Source: MGI

GO - Biological processi

  • glycine transport Source: MGI
  • L-alanine transport Source: MGI
  • proline transport Source: MGI
  • proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-428559. Proton-coupled neutral amino acid transporters.

Protein family/group databases

TCDBi2.A.18.8.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 1
Short name:
Proton/amino acid transporter 1
Alternative name(s):
Solute carrier family 36 member 1
Gene namesi
Name:Slc36a1
Synonyms:Pat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2445299. Slc36a1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Lysosome membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: In neurons, colocalizes with the exocyst complex in the axonal processes.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 77ExtracellularSequence analysis6
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 140CytoplasmicSequence analysisAdd BLAST42
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 189ExtracellularSequence analysisAdd BLAST28
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 214CytoplasmicSequence analysis4
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 256ExtracellularSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 288CytoplasmicSequence analysisAdd BLAST11
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 341ExtracellularSequence analysisAdd BLAST32
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 371CytoplasmicSequence analysis9
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 396ExtracellularSequence analysis4
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 438CytoplasmicSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 475ExtracellularSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938261 – 475Proton-coupled amino acid transporter 1Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi179 ↔ 328By similarity
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8K4D3.
PaxDbiQ8K4D3.
PRIDEiQ8K4D3.

PTM databases

PhosphoSitePlusiQ8K4D3.

Expressioni

Tissue specificityi

Highly expressed in small intestine, colon, kidney and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000020261.
ExpressionAtlasiQ8K4D3. baseline and differential.
GenevisibleiQ8K4D3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8K4D3. 1 interactor.
STRINGi10090.ENSMUSP00000020499.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8K4D3.
KOiK14209.
OMAiSHWGRRI.
OrthoDBiEOG091G079T.
PhylomeDBiQ8K4D3.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQRLRNED YHDYSSTDVS PEESPSEGLG SFSPGSYQRL GENSSMTWFQ
60 70 80 90 100
TLIHLLKGNI GTGLLGLPLA VKNAGLLLGP LSLLVIGIVA VHCMGILVKC
110 120 130 140 150
AHHLCRRLNK PFLDYGDTVM YGLECSPSTW VRNHSHWGRR IVDFFLIVTQ
160 170 180 190 200
LGFCCVYFVF LADNFKQVIE AANGTTTNCN NNVTVIPTPT MDSRLYMLSF
210 220 230 240 250
LPFLVLLSFI RNLRVLSIFS LLANISMFVS LIMIYQFIVQ RIPDPSHLPL
260 270 280 290 300
VAPWKTYPLF FGTAIFAFEG IGVVLPLENK MKDSQKFPLI LYLGMAIITV
310 320 330 340 350
LYISLGSLGY LQFGANIKGS ITLNLPNCWL YQSVKLLYSI GIFFTYALQF
360 370 380 390 400
YVAAEIIIPA IVSRVPEHFE LMVDLCVRTA MVCVTCVLAI LIPRLDLVIS
410 420 430 440 450
LVGSVSSSAL ALIIPPLLEV VTYYGEGISP LTVTKDALIS ILGFVGFVVG
460 470
TYESLCELIQ PSHSDSSTNS TSAFI
Length:475
Mass (Da):52,466
Last modified:October 1, 2002 - v1
Checksum:i113C23309F2B51F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → S in AAO37090 (PubMed:15058382).Curated1
Sequence conflicti198L → P in AAO37090 (PubMed:15058382).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453743 mRNA. Translation: AAM80480.1.
AY211262 mRNA. Translation: AAO37090.1.
CCDSiCCDS36156.1.
RefSeqiNP_694779.3. NM_153139.4.
UniGeneiMm.35732.

Genome annotation databases

EnsembliENSMUST00000020499; ENSMUSP00000020499; ENSMUSG00000020261.
ENSMUST00000108867; ENSMUSP00000104495; ENSMUSG00000020261.
ENSMUST00000108872; ENSMUSP00000104500; ENSMUSG00000020261.
GeneIDi215335.
KEGGimmu:215335.
UCSCiuc007izd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453743 mRNA. Translation: AAM80480.1.
AY211262 mRNA. Translation: AAO37090.1.
CCDSiCCDS36156.1.
RefSeqiNP_694779.3. NM_153139.4.
UniGeneiMm.35732.

3D structure databases

ProteinModelPortaliQ8K4D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K4D3. 1 interactor.
STRINGi10090.ENSMUSP00000020499.

Protein family/group databases

TCDBi2.A.18.8.1. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitePlusiQ8K4D3.

Proteomic databases

MaxQBiQ8K4D3.
PaxDbiQ8K4D3.
PRIDEiQ8K4D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020499; ENSMUSP00000020499; ENSMUSG00000020261.
ENSMUST00000108867; ENSMUSP00000104495; ENSMUSG00000020261.
ENSMUST00000108872; ENSMUSP00000104500; ENSMUSG00000020261.
GeneIDi215335.
KEGGimmu:215335.
UCSCiuc007izd.1. mouse.

Organism-specific databases

CTDi206358.
MGIiMGI:2445299. Slc36a1.

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8K4D3.
KOiK14209.
OMAiSHWGRRI.
OrthoDBiEOG091G079T.
PhylomeDBiQ8K4D3.
TreeFamiTF314873.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-428559. Proton-coupled neutral amino acid transporters.

Miscellaneous databases

ChiTaRSiSlc36a1. mouse.
PROiQ8K4D3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020261.
ExpressionAtlasiQ8K4D3. baseline and differential.
GenevisibleiQ8K4D3. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS36A1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4D3
Secondary accession number(s): Q811N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.