Frizzled-9 - Rattus norvegicus (Rat)

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Unreviewed, UniProtKB/TrEMBL Q8K4C8 (Q8K4C8_RAT)

Last modified November 3, 2009. Version 42. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
    Frizzled-9 EMBL AAN03014.1
Submitted name:
    Frizzled homolog 9 (Drosophila) EMBL EDM13380.1
    Frizzled-like protein 9 EMBL ABB20594.1

Gene names

Name:	Fzd9 RGD 628817
ORF Names:	rCG_21444 EMBL EDM13380.1

Organism

Rattus norvegicus (Rat) EMBL AAN03014.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. Spearmint SPM015526

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Ontologies

Keywords
Biological process	Wnt signaling pathway Spearmint SPM017981
Cellular component	Membrane
Domain	Transmembrane Spearmint SPM015526
Molecular function	Developmental protein Spearmint SPM015526 G-protein coupled receptor Spearmint SPM015526 Receptor Transducer
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor signaling pathway Ref.1 Inferred from direct assay. Source: RGD learning or memory Inferred from electronic annotation. Source: Compara neuroblast proliferation Inferred from electronic annotation. Source: Compara
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor activity Ref.1 Inferred from direct assay. Source: RGD non-G-protein coupled 7TM receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8K4C8-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 71B2D4F8DF3234CE
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FASTA

592

64,965

        10         20         30         40         50         60 
MAVPPLLRGA LLLWQLLATG GAALEIGRFD PERGRGPAPC QAMEIPMCRG IGYNLTRMPN 

        70         80         90        100        110        120 
LLGHTSQGEA AAQLAEFSPL VQYGCHSHLR FFLCSLYAPM CTDQVSTPIP ACRPMCEQAR 

       130        140        150        160        170        180 
LRCAPIMEQF NFGWPDSLDC ARLPTRNDPH ALCMEAPENA TAGPTEPHKG LGMLPVAPRP 

       190        200        210        220        230        240 
ARPPGDSAPG PGSGGTCDNP EKFQYVEKSR SCAPRCGPGV EVFWSRRDKD FALVWMAVWS 

       250        260        270        280        290        300 
ALCFFSTAFT VFTFLLEPHR FQYPERPIIF LSMCYNVYSL AFLIRAVAGA QSVACDQEAG 

       310        320        330        340        350        360 
ALYVIQEGLE NTGCTLVFLL LYYFGMASSL WWVVLTLTWF LAAGKKWGHE AIEAHGSYFH 

       370        380        390        400        410        420 
MAAWGLPALK TIVVLTLRKV AGDELTGLCY VASMDPAALT GFVLVPLSCY LVLGTSFLLT 

       430        440        450        460        470        480 
GFVALFHIRK IMKTGGTNTE KLEKLMVKIG VFSILYTVPA TCVIVCYVYE RLNMDFWRLR 

       490        500        510        520        530        540 
ATEQPCTAAA VPGGRRDCSL PGGSVPTVAV FMLKIFMSLV VGITSGVWVW SSKTFQTWQS 

       550        560        570        580        590 
LCYRKMAAGR ARAKACRTPG GYGRGTHCHY KAPTVVLHMT KTDPSLENPT HL

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References

[1]	"Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling." Karasawa T., Yokokura H., Kitajewski J., Lombroso P.J. J. Biol. Chem. 277:37479-37486(2002) [PubMed: 12138115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAN03014.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM13380.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM13380.1.
[4]	"Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis." Becanovic K., Jagodic M., Sheng J.R., Dahlman I., Enein F.A., Olofsson P., Holmdahl R., Lassman H., Olsson T. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: DA EMBL ABB20594.1 and Hannover EMBL ABB20593.1. Tissue: Brain EMBL ABB20594.1.

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Cross-references

Sequence databases
	AF455054 mRNA. Translation: AAN03014.1. DQ211688 mRNA. Translation: ABB20593.1. DQ211689 mRNA. Translation: ABB20594.1. CH473973 Genomic DNA. Translation: EDM13380.1.
IPI	IPI00203116.
RefSeq	NP_695217.1.
UniGene	Rn.96335
3D structure databases
HSSP	HSSP built from PDB template 1IJY based on UniProtKB Q61091.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K4C8.
Genome annotation databases
Ensembl	ENSRNOT00000001973; ENSRNOP00000001973; ENSRNOG00000001452; Rattus norvegicus. [Genome view]
GeneID	266608.
KEGG	rno:266608.
UCSC	NM_153305. rat.
Organism-specific databases
CTD	266608.
RGD	628817. Fzd9.
Phylogenomic databases
HOVERGEN	Q8K4C8.
OMA	CYVYERL.
Gene expression databases
Genevestigator	Q8K4C8.
Family and domain databases
InterPro	IPR000539. Frizzled. IPR020067. Frizzled-like_dom. IPR000024. Frizzled_Cys-rich. IPR020068. Frizzled_dom_subgr. IPR015526. Frizzled_related. IPR017981. GPCR_2-like. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	624436.

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Entry information

Entry name

Q8K4C8_RAT

Accession

Primary (citable) accession number: Q8K4C8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information