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Protein

Interleukin-17 receptor C

Gene

Il17rc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity).By similarity2 Publications

GO - Molecular functioni

  • interleukin-17 receptor activity Source: MGI
  • receptor binding Source: UniProtKB

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • defense response to fungus Source: UniProtKB
  • granulocyte chemotaxis Source: UniProtKB
  • positive regulation of cytokine production involved in inflammatory response Source: MGI
  • positive regulation of interleukin-6 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor C
Short name:
IL-17 receptor C
Short name:
IL-17RC
Alternative name(s):
Interleukin-17 receptor-like protein
Short name:
IL-17RL
ZcytoR14
Gene namesi
Name:Il17rc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2159336. Il17rc.

Subcellular locationi

Isoform 1 :
Isoform 2 :
Isoform 3 :
Isoform 4 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 464443ExtracellularSequence analysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence analysisAdd
BLAST
Topological domaini486 – 698213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 698677Interleukin-17 receptor CPRO_0000011035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K4C2.
PRIDEiQ8K4C2.

PTM databases

PhosphoSiteiQ8K4C2.

Expressioni

Gene expression databases

CleanExiMM_IL17RC.
ExpressionAtlasiQ8K4C2. baseline and differential.
GenevisibleiQ8K4C2. MM.

Interactioni

Subunit structurei

Heterodimer with IL17RA. Heterodimerization with IL17RA is independent of the cytoplasmic tail. Associates with non-glycosylated IL17RA constitutively. Binding of IL17A and IL17F induces association with glycosylated IL17RA. Interacts (via SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated).1 Publication

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi228481. 2 interactions.
IntActiQ8K4C2. 2 interactions.
STRINGi10090.ENSMUSP00000055343.

Structurei

3D structure databases

ProteinModelPortaliQ8K4C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini496 – 645150SEFIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IES9. Eukaryota.
ENOG4111MUJ. LUCA.
GeneTreeiENSGT00730000111286.
HOGENOMiHOG000112986.
HOVERGENiHBG081776.
InParanoidiQ8K4C2.
KOiK05166.
OMAiLQLWDDD.
OrthoDBiEOG7J4466.
TreeFamiTF335852.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K4C2-3) [UniParc]FASTAAdd to basket

Also known as: IL17RC1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVSWFLLSL ALGRNPVVVS LERLMEPQDT ARCSLGLSCH LWDGDVLCLP
60 70 80 90 100
GSLQSAPGPV LVPTRLQTEL VLRCPQKTDC ALCVRVVVHL AVHGHWAEPE
110 120 130 140 150
EAGKSDSELQ ESRNASLQAQ VVLSFQAYPI ARCALLEVQV PADLVQPGQS
160 170 180 190 200
VGSAVFDCFE ASLGAEVQIW SYTKPRYQKE LNLTQQLPDC RGLEVRDSIQ
210 220 230 240 250
SCWVLPWLNV STDGDNVLLT LDVSEEQDFS FLLYLRPVPD ALKSLWYKNL
260 270 280 290 300
TGPQNITLNH TDLVPCLCIQ VWSLEPDSER VEFCPFREDP GAHRNLWHIA
310 320 330 340 350
RLRVLSPGVW QLDAPCCLPG KVTLCWQAPD QSPCQPLVPP VPQKNATVNE
360 370 380 390 400
PQDFQLVAGH PNLCVQVSTW EKVQLQACLW ADSLGPFKDD MLLVEMKTGL
410 420 430 440 450
NNTSVCALEP SGCTPLPSMA STRAARLGEE LLQDFRSHQC MQLWNDDNMG
460 470 480 490 500
SLWACPMDKY IHRRWVLVWL ACLLLAAALF FFLLLKKDRR KAARGSRTAL
510 520 530 540 550
LLHSADGAGY ERLVGALASA LSQMPLRVAV DLWSRRELSA HGALAWFHHQ
560 570 580 590 600
RRRILQEGGV VILLFSPAAV AQCQQWLQLQ TVEPGPHDAL AAWLSCVLPD
610 620 630 640 650
FLQGRATGRY VGVYFDGLLH PDSVPSPFRV APLFSLPSQL PAFLDALQGG
660 670 680 690
CSTSAGRPAD RVERVTQALR SALDSCTSSS EAPGCCEEWD LGPCTTLE
Length:698
Mass (Da):77,148
Last modified:March 16, 2016 - v3
Checksum:i24EC9DA8B3A144E7
GO
Isoform 2 (identifier: Q8K4C2-4) [UniParc]FASTAAdd to basket

Also known as: IL17RC-delta71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     189-203: Missing.

Show »
Length:683
Mass (Da):75,399
Checksum:i495E0785DAEACFFA
GO
Isoform 3 (identifier: Q8K4C2-1) [UniParc]FASTAAdd to basket

Also known as: IL17RC-delta7,81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     189-212: Missing.

Show »
Length:674
Mass (Da):74,389
Checksum:i131EF5CE5C8E09E6
GO
Isoform 4 (identifier: Q8K4C2-5) [UniParc]FASTAAdd to basket

Also known as: IL17RC-delta81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     204-212: Missing.

Show »
Length:689
Mass (Da):76,138
Checksum:i0062B44FE6CB4851
GO
Isoform 5 (identifier: Q8K4C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-698: RKAARGSRTA...WDLGPCTTLE → MTPSPPGSAA...RGDPRTGWNE

Note: No experimental confirmation available.
Show »
Length:567
Mass (Da):62,798
Checksum:iC1AAAB79E2006B1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831C → R in AAM77570 (Ref. 1) Curated
Sequence conflicti83 – 831C → R in CAD23359 (Ref. 3) Curated
Sequence conflicti83 – 831C → R in CAD23360 (Ref. 3) Curated
Sequence conflicti379 – 3791L → S in AAM77570 (Ref. 1) Curated
Sequence conflicti379 – 3791L → S in CAD23359 (Ref. 3) Curated
Sequence conflicti379 – 3791L → S in CAD23360 (Ref. 3) Curated
Sequence conflicti638 – 6381S → T in AAM77570 (Ref. 1) Curated
Sequence conflicti638 – 6381S → T in CAD23359 (Ref. 3) Curated
Sequence conflicti638 – 6381S → T in CAD23360 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei189 – 21224Missing in isoform 3. VSP_058140Add
BLAST
Alternative sequencei189 – 20315Missing in isoform 2. VSP_058139Add
BLAST
Alternative sequencei204 – 2129Missing in isoform 4. VSP_058141
Alternative sequencei490 – 698209RKAAR…CTTLE → MTPSPPGSAACYPISCKAGR PAATSGSTSTGCCTQTLCPP RSASPRSSPCPRSCRLSWMH CREAAPLPRGDPRTGWNE in isoform 5. 1 PublicationVSP_058142Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458066 mRNA. Translation: AAM77570.1.
CS251263 Unassigned DNA. No translation available.
CS251267 Unassigned DNA. No translation available.
AX360307 Unassigned DNA. Translation: CAD23359.1.
AX360310 Unassigned DNA. Translation: CAD23360.1.
AC153910 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99478.1.
BC004759 mRNA. Translation: AAH04759.1.
CCDSiCCDS20422.1. [Q8K4C2-1]
RefSeqiNP_598920.3. NM_134159.4. [Q8K4C2-1]
NP_849273.1. NM_178942.1. [Q8K4C2-3]
XP_006505728.1. XM_006505665.1. [Q8K4C2-5]
XP_006505729.1. XM_006505666.1. [Q8K4C2-4]
UniGeneiMm.213397.

Genome annotation databases

EnsembliENSMUST00000058300; ENSMUSP00000055343; ENSMUSG00000030281. [Q8K4C2-1]
GeneIDi171095.
KEGGimmu:171095.
UCSCiuc009dgl.3. mouse. [Q8K4C2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458066 mRNA. Translation: AAM77570.1.
CS251263 Unassigned DNA. No translation available.
CS251267 Unassigned DNA. No translation available.
AX360307 Unassigned DNA. Translation: CAD23359.1.
AX360310 Unassigned DNA. Translation: CAD23360.1.
AC153910 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99478.1.
BC004759 mRNA. Translation: AAH04759.1.
CCDSiCCDS20422.1. [Q8K4C2-1]
RefSeqiNP_598920.3. NM_134159.4. [Q8K4C2-1]
NP_849273.1. NM_178942.1. [Q8K4C2-3]
XP_006505728.1. XM_006505665.1. [Q8K4C2-5]
XP_006505729.1. XM_006505666.1. [Q8K4C2-4]
UniGeneiMm.213397.

3D structure databases

ProteinModelPortaliQ8K4C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228481. 2 interactions.
IntActiQ8K4C2. 2 interactions.
STRINGi10090.ENSMUSP00000055343.

PTM databases

PhosphoSiteiQ8K4C2.

Proteomic databases

PaxDbiQ8K4C2.
PRIDEiQ8K4C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058300; ENSMUSP00000055343; ENSMUSG00000030281. [Q8K4C2-1]
GeneIDi171095.
KEGGimmu:171095.
UCSCiuc009dgl.3. mouse. [Q8K4C2-3]

Organism-specific databases

CTDi84818.
MGIiMGI:2159336. Il17rc.

Phylogenomic databases

eggNOGiENOG410IES9. Eukaryota.
ENOG4111MUJ. LUCA.
GeneTreeiENSGT00730000111286.
HOGENOMiHOG000112986.
HOVERGENiHBG081776.
InParanoidiQ8K4C2.
KOiK05166.
OMAiLQLWDDD.
OrthoDBiEOG7J4466.
TreeFamiTF335852.

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Miscellaneous databases

PROiQ8K4C2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IL17RC.
ExpressionAtlasiQ8K4C2. baseline and differential.
GenevisibleiQ8K4C2. MM.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel IL-17 related receptors."
    Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Strain: 129.
    Tissue: Mammary tumor.
  7. Cited for: FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3 AND 4).
  8. "IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail."
    Ho A.W., Shen F., Conti H.R., Patel N., Childs E.E., Peterson A.C., Hernandez-Santos N., Kolls J.K., Kane L.P., Ouyang W., Gaffen S.L.
    J. Immunol. 185:1063-1070(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH TRAF3IP2.

Entry informationi

Entry nameiI17RC_MOUSE
AccessioniPrimary (citable) accession number: Q8K4C2
Secondary accession number(s): G3X9C0, Q99J43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 16, 2016
Last modified: July 6, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.