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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADSequence analysis6
Nucleotide bindingi191 – 196NADPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8. 5301.
SABIO-RKQ8K4B7.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi628601. Fmo4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei516 – 530HelicalSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476631 – 560Dimethylaniline monooxygenase [N-oxide-forming] 4Add BLAST560

Proteomic databases

PaxDbiQ8K4B7.
PRIDEiQ8K4B7.

PTM databases

iPTMnetiQ8K4B7.
PhosphoSitePlusiQ8K4B7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003400.
ExpressionAtlasiQ8K4B7. baseline and differential.
GenevisibleiQ8K4B7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004599.

Structurei

3D structure databases

ProteinModelPortaliQ8K4B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8K4B7.
KOiK00485.
OMAiMGHISIK.
OrthoDBiEOG091G0465.
PhylomeDBiQ8K4B7.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8K4B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERSSDFGGL WKFAEASEDG
60 70 80 90 100
MTRVYRSLVT NVCKEMSCYS DFPFHEDYPN FMSHEKFWDY LREFAEHFGL
110 120 130 140 150
LKYIRFKTTV RSVTKRPDFS ETGQWEVVTE TEGKQDRAVF DAVMVCTGQF
160 170 180 190 200
LSPRLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDVA
210 220 230 240 250
VELSGIAAQV FLSTRTGAWV RSRSSVGGYP LNMMQTRWRN FLAQVLPSRF
260 270 280 290 300
VSWNQERQMN KIFNHENYGL SIAKGKKPKF IVNDELPTCI LCGKITMKTS
310 320 330 340 350
VKDFTESSIV FEDGTIEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKVIL
360 370 380 390 400
YKRVFPPNLE RSTLAIIGLI SLTGSILVGT EFQARWATRV FKGLCNIPPS
410 420 430 440 450
QKLMAEAIKK EELIKRGVIK DTSQDKLDFI SYMDELTQCI GAKPNIPLLF
460 470 480 490 500
LKDPRLAWEV FFGPCTPYQY RLMGPGRWDG ARNAILTQWD RTVKPLKTRT
510 520 530 540 550
VPKSQEPASL SRYLKTWGAP VLIVSLLLIY KSSLFLELVQ SKLQGRFSPS
560
RILWYIPQNS
Length:560
Mass (Da):63,660
Last modified:January 23, 2007 - v3
Checksum:i9A7A77C41A328EFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244Q → R in AAM46764 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458416 mRNA. Translation: AAM46764.1.
BC081721 mRNA. Translation: AAH81721.1.
RefSeqiNP_653147.1. NM_144561.2.
XP_006250206.1. XM_006250144.3.
UniGeneiRn.216582.

Genome annotation databases

EnsembliENSRNOT00000004599; ENSRNOP00000004599; ENSRNOG00000003400.
GeneIDi246247.
KEGGirno:246247.
UCSCiRGD:628601. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458416 mRNA. Translation: AAM46764.1.
BC081721 mRNA. Translation: AAH81721.1.
RefSeqiNP_653147.1. NM_144561.2.
XP_006250206.1. XM_006250144.3.
UniGeneiRn.216582.

3D structure databases

ProteinModelPortaliQ8K4B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004599.

PTM databases

iPTMnetiQ8K4B7.
PhosphoSitePlusiQ8K4B7.

Proteomic databases

PaxDbiQ8K4B7.
PRIDEiQ8K4B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004599; ENSRNOP00000004599; ENSRNOG00000003400.
GeneIDi246247.
KEGGirno:246247.
UCSCiRGD:628601. rat.

Organism-specific databases

CTDi2329.
RGDi628601. Fmo4.

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8K4B7.
KOiK00485.
OMAiMGHISIK.
OrthoDBiEOG091G0465.
PhylomeDBiQ8K4B7.
TreeFamiTF105285.

Enzyme and pathway databases

BRENDAi1.14.13.8. 5301.
SABIO-RKQ8K4B7.

Miscellaneous databases

PROiQ8K4B7.

Gene expression databases

BgeeiENSRNOG00000003400.
ExpressionAtlasiQ8K4B7. baseline and differential.
GenevisibleiQ8K4B7. RN.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFMO4_RAT
AccessioniPrimary (citable) accession number: Q8K4B7
Secondary accession number(s): Q66HR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.