Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dimethylaniline monooxygenase [N-oxide-forming] 4

Gene

Fmo4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 5301
SABIO-RKiQ8K4B7

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name:
FMO 4
Gene namesi
Name:Fmo4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi628601 Fmo4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476631 – 560Dimethylaniline monooxygenase [N-oxide-forming] 4Add BLAST560

Proteomic databases

PaxDbiQ8K4B7
PRIDEiQ8K4B7

PTM databases

iPTMnetiQ8K4B7
PhosphoSitePlusiQ8K4B7

Expressioni

Tissue specificityi

Detected in liver and kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000003400
ExpressionAtlasiQ8K4B7 baseline and differential
GenevisibleiQ8K4B7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004599

Structurei

3D structure databases

ProteinModelPortaliQ8K4B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiQ8K4B7
KOiK00485
OMAiPLKSLCT
OrthoDBiEOG091G0465
PhylomeDBiQ8K4B7
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002256 Flavin_mOase_4
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01124 FMOXYGENASE4
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q8K4B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERSSDFGGL WKFAEASEDG
60 70 80 90 100
MTRVYRSLVT NVCKEMSCYS DFPFHEDYPN FMSHEKFWDY LREFAEHFGL
110 120 130 140 150
LKYIRFKTTV RSVTKRPDFS ETGQWEVVTE TEGKQDRAVF DAVMVCTGQF
160 170 180 190 200
LSPRLPLESF PGIHKFKGQI LHSQEYRIPD AFRGKRILVV GLGNTGGDVA
210 220 230 240 250
VELSGIAAQV FLSTRTGAWV RSRSSVGGYP LNMMQTRWRN FLAQVLPSRF
260 270 280 290 300
VSWNQERQMN KIFNHENYGL SIAKGKKPKF IVNDELPTCI LCGKITMKTS
310 320 330 340 350
VKDFTESSIV FEDGTIEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKVIL
360 370 380 390 400
YKRVFPPNLE RSTLAIIGLI SLTGSILVGT EFQARWATRV FKGLCNIPPS
410 420 430 440 450
QKLMAEAIKK EELIKRGVIK DTSQDKLDFI SYMDELTQCI GAKPNIPLLF
460 470 480 490 500
LKDPRLAWEV FFGPCTPYQY RLMGPGRWDG ARNAILTQWD RTVKPLKTRT
510 520 530 540 550
VPKSQEPASL SRYLKTWGAP VLIVSLLLIY KSSLFLELVQ SKLQGRFSPS
560
RILWYIPQNS
Length:560
Mass (Da):63,660
Last modified:January 23, 2007 - v3
Checksum:i9A7A77C41A328EFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244Q → R in AAM46764 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458416 mRNA Translation: AAM46764.1
BC081721 mRNA Translation: AAH81721.1
RefSeqiNP_653147.1, NM_144561.2
XP_006250206.1, XM_006250144.3
UniGeneiRn.216582

Genome annotation databases

EnsembliENSRNOT00000004599; ENSRNOP00000004599; ENSRNOG00000003400
GeneIDi246247
KEGGirno:246247
UCSCiRGD:628601 rat

Similar proteinsi

Entry informationi

Entry nameiFMO4_RAT
AccessioniPrimary (citable) accession number: Q8K4B7
Secondary accession number(s): Q66HR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health