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Reviewed, UniProtKB/Swiss-Prot Q8K4B7 (FMO4_RAT)

Last modified January 19, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4
    EC=1.14.13.8
Alternative name(s):
    Hepatic flavin-containing monooxygenase 4
      Short name=FMO 4
    Dimethylaniline oxidase 4
Gene names
Name: Fmo4
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides By similarity.

Catalytic activity

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactor

FAD By similarity.

Subcellular location

Microsome membrane By similarity. Endoplasmic reticulum membrane By similarity.

Sequence similarities

Belongs to the FMO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 560559Dimethylaniline monooxygenase [N-oxide-forming] 4
PRO_0000147663

Regions

Transmembrane516 – 53015 Potential
Nucleotide binding9 – 146FAD Potential
Nucleotide binding191 – 1966NADP Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict2441Q → R in AAM46764. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K4B7-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 9A7A77C41A328EFB

FASTA56063,660
        10         20         30         40         50         60 
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERSSDFGGL WKFAEASEDG MTRVYRSLVT 

        70         80         90        100        110        120 
NVCKEMSCYS DFPFHEDYPN FMSHEKFWDY LREFAEHFGL LKYIRFKTTV RSVTKRPDFS 

       130        140        150        160        170        180 
ETGQWEVVTE TEGKQDRAVF DAVMVCTGQF LSPRLPLESF PGIHKFKGQI LHSQEYRIPD 

       190        200        210        220        230        240 
AFRGKRILVV GLGNTGGDVA VELSGIAAQV FLSTRTGAWV RSRSSVGGYP LNMMQTRWRN 

       250        260        270        280        290        300 
FLAQVLPSRF VSWNQERQMN KIFNHENYGL SIAKGKKPKF IVNDELPTCI LCGKITMKTS 

       310        320        330        340        350        360 
VKDFTESSIV FEDGTIEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKVIL YKRVFPPNLE 

       370        380        390        400        410        420 
RSTLAIIGLI SLTGSILVGT EFQARWATRV FKGLCNIPPS QKLMAEAIKK EELIKRGVIK 

       430        440        450        460        470        480 
DTSQDKLDFI SYMDELTQCI GAKPNIPLLF LKDPRLAWEV FFGPCTPYQY RLMGPGRWDG 

       490        500        510        520        530        540 
ARNAILTQWD RTVKPLKTRT VPKSQEPASL SRYLKTWGAP VLIVSLLLIY KSSLFLELVQ 

       550        560 
SKLQGRFSPS RILWYIPQNS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4. Two different FMO4 are produced by tissue specific alternative splicing."
Lattard V., Longin-Sauvageon C., Benoit E.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF458416 mRNA. Translation: AAM46764.1.
BC081721 mRNA. Translation: AAH81721.1.
IPIIPI00325823.
RefSeqNP_653147.1.
UniGeneRn.216582

3D structure databases

SMRQ8K4B7. Positions 3-447.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8K4B7.

Genome annotation databases

EnsemblENSRNOT00000004599; ENSRNOP00000004599; ENSRNOG00000003400; Rattus norvegicus. [Genome view]
GeneID246247.
KEGGrno:246247.
UCSCNM_144561. rat.

Organism-specific databases

CTD246247.
RGD628601. Fmo4.

Phylogenomic databases

eggNOGmaNOG04376.
HOVERGENQ8K4B7.
InParanoidQ8K4B7.
OMAPLKSLCT.
OrthoDBEOG9GMXG7.
PhylomeDBQ8K4B7.

Enzyme and pathway databases

BRENDA1.14.13.8. 248.

Gene expression databases

ArrayExpressQ8K4B7.
GenevestigatorQ8K4B7.
GermOnlineENSRNOG00000003400. Rattus norvegicus.

Family and domain databases

InterProIPR012143. dManiline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFPIRSF000332. FMO. 1 hit.
PRINTSPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
ProtoNetSearch...

Other Resources

NextBio623572.

Entry information

Entry nameFMO4_RAT
AccessionPrimary (citable) accession number: Q8K4B7
Secondary accession number(s): Q66HR6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents