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Protein

Interleukin-23 receptor

Gene

Il23r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 receptor
Short name:
IL-23 receptor
Short name:
IL-23R
Gene namesi
Name:Il23r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2181693. Il23r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 374ExtracellularSequence analysisAdd BLAST351
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 644CytoplasmicSequence analysisAdd BLAST249

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000026866324 – 644Interleukin-23 receptorAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated in response to IL23.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K4B4.
PRIDEiQ8K4B4.

PTM databases

iPTMnetiQ8K4B4.
PhosphoSitePlusiQ8K4B4.

Expressioni

Tissue specificityi

Expressed by Th1, Th2 and dendritic cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000049093.
CleanExiMM_IL23R.

Interactioni

Subunit structurei

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113342.

Structurei

3D structure databases

ProteinModelPortaliQ8K4B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 217Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini219 – 318Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHH9. Eukaryota.
ENOG410YRR7. LUCA.
HOGENOMiHOG000113040.
HOVERGENiHBG081787.
InParanoidiQ8K4B4.
KOiK05065.
PhylomeDBiQ8K4B4.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLTLQLHV VIALYVLFRW CHGGITSINC SGDMWVEPGE IFQMGMNVSI
60 70 80 90 100
YCQEALKHCR PRNLYFYKNG FKEEFDITRI NRTTARIWYK GFSEPHAYMH
110 120 130 140 150
CTAECPGHFQ ETLICGKDIS SGHPPDAPSN LTCVIYEYSG NMTCTWNTGK
160 170 180 190 200
PTYIDTKYIV HVKSLETEEE QQYLASSYVK ISTDSLQGSR KYLVWVQAVN
210 220 230 240 250
SLGMENSQQL HVHLDDIVIP SASIISRAET TNDTVPKTIV YWKSKTMIEK
260 270 280 290 300
VFCEMRYKTT TNQTWSVKEF DANFTYVQQS EFYLEPDSKY VFQVRCQETG
310 320 330 340 350
KRNWQPWSSP FVHQTSQETG KRNWQPWSSP FVHQTSQTVS QVTAKSSHEP
360 370 380 390 400
QKMEMLSATI FRGHPASGNH QDIGLLSGMV FLAIMLPIFS LIGIFNRSLR
410 420 430 440 450
IGIKRKVLLM IPKWLYEDIP NMENSNVAKL LQEKSVFEND NASEQALYVD
460 470 480 490 500
PVLTEISEIS PLEHKPTDYK EERLTGLLET RDCPLGMLST SSSVVYIPDL
510 520 530 540 550
NTGYKPQVSN VPPGGNLFIN RDERDPTSLE TTDDHFARLK TYPNFQFSAS
560 570 580 590 600
SMALLNKTLI LDELCLVLNQ GEFNSLDIKN SRQEETSIVL QSDSPSETIP
610 620 630 640
AQTLLSDEFV SCLAIGNEDL PSINSYFPQN VLESHFSRIS LFQK
Length:644
Mass (Da):73,453
Last modified:October 1, 2002 - v1
Checksum:iAA461FD270E599D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461423 mRNA. Translation: AAM44230.1.
BC112425 mRNA. Translation: AAI12426.1.
RefSeqiNP_653131.2. NM_144548.1.
UniGeneiMm.221227.

Genome annotation databases

GeneIDi209590.
KEGGimmu:209590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461423 mRNA. Translation: AAM44230.1.
BC112425 mRNA. Translation: AAI12426.1.
RefSeqiNP_653131.2. NM_144548.1.
UniGeneiMm.221227.

3D structure databases

ProteinModelPortaliQ8K4B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113342.

PTM databases

iPTMnetiQ8K4B4.
PhosphoSitePlusiQ8K4B4.

Proteomic databases

PaxDbiQ8K4B4.
PRIDEiQ8K4B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi209590.
KEGGimmu:209590.

Organism-specific databases

CTDi149233.
MGIiMGI:2181693. Il23r.

Phylogenomic databases

eggNOGiENOG410IHH9. Eukaryota.
ENOG410YRR7. LUCA.
HOGENOMiHOG000113040.
HOVERGENiHBG081787.
InParanoidiQ8K4B4.
KOiK05065.
PhylomeDBiQ8K4B4.

Miscellaneous databases

PROiQ8K4B4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049093.
CleanExiMM_IL23R.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL23R_MOUSE
AccessioniPrimary (citable) accession number: Q8K4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.