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Protein

C-X-C motif chemokine

Gene

Cxcl9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR3 chemokine receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:Cxcl9Imported
Synonyms:MigImported
ORF Names:rCG_60435Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi628798. Cxcl9.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_500845241922 – 125C-X-C motif chemokineUniRule annotationAdd BLAST104

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000022242.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR3 chemokine receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 88SCYInterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 105Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG091G0YSL.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVALFLMG IIFLDHCGVR GTLVIRNQRC SCISTSQGTF HYKSLKDLKQ
60 70 80 90 100
FAPSPNCNKT EIIATLKNGD QTCLDPDSAR VKKLMKEWEK KISQKKKQKR
110 120
GKNHQRSKKT RKAKTPHHPE SKKTA
Length:125
Mass (Da):14,266
Last modified:October 1, 2002 - v1
Checksum:i1D99E61243C5BFDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113621 Genomic DNA. No translation available.
BC087594 mRNA. Translation: AAH87594.1.
AF462610 mRNA. Translation: AAM73881.1.
AF537208 mRNA. Translation: AAQ10775.1.
CH474060 Genomic DNA. Translation: EDL88617.1.
RefSeqiNP_663705.1. NM_145672.4.
UniGeneiRn.7391.

Genome annotation databases

EnsembliENSRNOT00000003082; ENSRNOP00000003627; ENSRNOG00000022242.
GeneIDi246759.
KEGGirno:246759.
UCSCiRGD:628798. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113621 Genomic DNA. No translation available.
BC087594 mRNA. Translation: AAH87594.1.
AF462610 mRNA. Translation: AAM73881.1.
AF537208 mRNA. Translation: AAQ10775.1.
CH474060 Genomic DNA. Translation: EDL88617.1.
RefSeqiNP_663705.1. NM_145672.4.
UniGeneiRn.7391.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003082; ENSRNOP00000003627; ENSRNOG00000022242.
GeneIDi246759.
KEGGirno:246759.
UCSCiRGD:628798. rat.

Organism-specific databases

CTDi4283.
RGDi628798. Cxcl9.

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG091G0YSL.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSRNOG00000022242.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8K4B1_RAT
AccessioniPrimary (citable) accession number: Q8K4B1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.