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Q8K4B1

- Q8K4B1_RAT

UniProt

Q8K4B1 - Q8K4B1_RAT

Protein

C-X-C motif chemokine

Gene

Cxcl9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chemokine activity Source: RGD
    2. CXCR3 chemokine receptor binding Source: RGD

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. defense response to virus Source: Ensembl
    3. immune response Source: InterPro
    4. induction of positive chemotaxis Source: RGD
    5. inflammatory response Source: InterPro
    6. positive regulation of cAMP-mediated signaling Source: Ensembl
    7. positive regulation of cAMP metabolic process Source: Ensembl
    8. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    9. regulation of cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    CytokineUniRule annotationSAAS annotation

    Keywords - Biological processi

    ChemotaxisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokineUniRule annotation
    Gene namesi
    Name:Cxcl9Imported
    Synonyms:MigImported
    ORF Names:rCG_60435Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi628798. Cxcl9.

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedUniRule annotationSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K4B1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003627.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotation

    Keywords - Domaini

    SignalUniRule annotation

    Phylogenomic databases

    eggNOGiNOG38935.
    GeneTreeiENSGT00530000063958.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiQ8K4B1.
    KOiK05416.
    OMAiPHHPESK.
    OrthoDBiEOG7HHWVH.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027225. CXCL9.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF28. PTHR10179:SF28. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4B1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSVALFLMG IIFLDHCGVR GTLVIRNQRC SCISTSQGTF HYKSLKDLKQ    50
    FAPSPNCNKT EIIATLKNGD QTCLDPDSAR VKKLMKEWEK KISQKKKQKR 100
    GKNHQRSKKT RKAKTPHHPE SKKTA 125
    Length:125
    Mass (Da):14,266
    Last modified:October 1, 2002 - v1
    Checksum:i1D99E61243C5BFDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06077780 Genomic DNA. No translation available.
    BC087594 mRNA. Translation: AAH87594.1.
    AF462610 mRNA. Translation: AAM73881.1.
    AF537208 mRNA. Translation: AAQ10775.1.
    CH474060 Genomic DNA. Translation: EDL88617.1.
    RefSeqiNP_663705.1. NM_145672.4.
    UniGeneiRn.7391.

    Genome annotation databases

    EnsembliENSRNOT00000003082; ENSRNOP00000003627; ENSRNOG00000022242.
    GeneIDi246759.
    KEGGirno:246759.
    UCSCiRGD:628798. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06077780 Genomic DNA. No translation available.
    BC087594 mRNA. Translation: AAH87594.1 .
    AF462610 mRNA. Translation: AAM73881.1 .
    AF537208 mRNA. Translation: AAQ10775.1 .
    CH474060 Genomic DNA. Translation: EDL88617.1 .
    RefSeqi NP_663705.1. NM_145672.4.
    UniGenei Rn.7391.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003082 ; ENSRNOP00000003627 ; ENSRNOG00000022242 .
    GeneIDi 246759.
    KEGGi rno:246759.
    UCSCi RGD:628798. rat.

    Organism-specific databases

    CTDi 4283.
    RGDi 628798. Cxcl9.

    Phylogenomic databases

    eggNOGi NOG38935.
    GeneTreei ENSGT00530000063958.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi Q8K4B1.
    KOi K05416.
    OMAi PHHPESK.
    OrthoDBi EOG7HHWVH.
    TreeFami TF333433.

    Miscellaneous databases

    NextBioi 623820.
    PROi Q8K4B1.

    Gene expression databases

    Genevestigatori Q8K4B1.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027225. CXCL9.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF28. PTHR10179:SF28. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat homolog of monokine induced by interferon gamma."
      Han G.D., Koike H., Shimizu F., Kawachi H.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: OvaryImported.
    3. "Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat."
      Mitsuhashi N., Kearns-Jonker M., Wu G.D., Bowdish M.E., Jin Y.S., Mencel R., Zahorsky-Reeves J., Fischer-Lougheed J., Weinberg K.I., Starnes V.A., Cramer D.V.
      Immunology 112:87-93(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LEWImported.
    4. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ8K4B1_RAT
    AccessioniPrimary (citable) accession number: Q8K4B1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3