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Protein
Submitted name:

Chemokine (C-X-C motif) ligand 9

Gene

Cxcl9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chemokine activity Source: RGD
  2. CXCR3 chemokine receptor binding Source: RGD

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: GO_Central
  2. defense response to virus Source: Ensembl
  3. G-protein coupled receptor signaling pathway Source: GO_Central
  4. immune response Source: GO_Central
  5. induction of positive chemotaxis Source: RGD
  6. inflammatory response Source: GO_Central
  7. positive regulation of cAMP-mediated signaling Source: Ensembl
  8. positive regulation of cAMP metabolic process Source: Ensembl
  9. positive regulation of leukocyte chemotaxis Source: GO_Central
  10. positive regulation of myoblast differentiation Source: Ensembl
  11. positive regulation of myoblast fusion Source: Ensembl
  12. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  13. regulation of cell proliferation Source: GO_Central
  14. response to lipopolysaccharide Source: GO_Central
  15. T cell chemotaxis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-X-C motif) ligand 9Imported
Submitted name:
Monokine induced by gamma interferonImported
Submitted name:
Monokine-like proteinImported
Submitted name:
Protein Cxcl9Imported
Gene namesi
Name:Cxcl9Imported
Synonyms:MigImported
ORF Names:rCG_60435Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi628798. Cxcl9.

Subcellular locationi

Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 125104C-X-C motif chemokineUniRule annotationPRO_5001373729Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8K4B1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003627.

Structurei

3D structure databases

ProteinModelPortaliQ8K4B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiNOG38935.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ8K4B1.
KOiK05416.
OMAiNGDQTCL.
OrthoDBiEOG7HHWVH.
PhylomeDBiQ8K4B1.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVALFLMG IIFLDHCGVR GTLVIRNQRC SCISTSQGTF HYKSLKDLKQ
60 70 80 90 100
FAPSPNCNKT EIIATLKNGD QTCLDPDSAR VKKLMKEWEK KISQKKKQKR
110 120
GKNHQRSKKT RKAKTPHHPE SKKTA
Length:125
Mass (Da):14,266
Last modified:September 30, 2002 - v1
Checksum:i1D99E61243C5BFDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06077780 Genomic DNA. No translation available.
BC087594 mRNA. Translation: AAH87594.1.
AF462610 mRNA. Translation: AAM73881.1.
AF537208 mRNA. Translation: AAQ10775.1.
CH474060 Genomic DNA. Translation: EDL88617.1.
RefSeqiNP_663705.1. NM_145672.4.
UniGeneiRn.7391.

Genome annotation databases

EnsembliENSRNOT00000003082; ENSRNOP00000003627; ENSRNOG00000022242.
GeneIDi246759.
KEGGirno:246759.
UCSCiRGD:628798. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06077780 Genomic DNA. No translation available.
BC087594 mRNA. Translation: AAH87594.1.
AF462610 mRNA. Translation: AAM73881.1.
AF537208 mRNA. Translation: AAQ10775.1.
CH474060 Genomic DNA. Translation: EDL88617.1.
RefSeqiNP_663705.1. NM_145672.4.
UniGeneiRn.7391.

3D structure databases

ProteinModelPortaliQ8K4B1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003082; ENSRNOP00000003627; ENSRNOG00000022242.
GeneIDi246759.
KEGGirno:246759.
UCSCiRGD:628798. rat.

Organism-specific databases

CTDi4283.
RGDi628798. Cxcl9.

Phylogenomic databases

eggNOGiNOG38935.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ8K4B1.
KOiK05416.
OMAiNGDQTCL.
OrthoDBiEOG7HHWVH.
PhylomeDBiQ8K4B1.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi623820.
PROiQ8K4B1.

Gene expression databases

GenevestigatoriQ8K4B1.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat homolog of monokine induced by interferon gamma."
    Han G.D., Koike H., Shimizu F., Kawachi H.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.
  3. "Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat."
    Mitsuhashi N., Kearns-Jonker M., Wu G.D., Bowdish M.E., Jin Y.S., Mencel R., Zahorsky-Reeves J., Fischer-Lougheed J., Weinberg K.I., Starnes V.A., Cramer D.V.
    Immunology 112:87-93(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LEWImported.
  4. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  7. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ8K4B1_RAT
AccessioniPrimary (citable) accession number: Q8K4B1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2002
Last sequence update: September 30, 2002
Last modified: March 31, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.