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Q8K4B0

- MTA1_MOUSE

UniProt

Q8K4B0 - MTA1_MOUSE

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Protein

Metastasis-associated protein MTA1

Gene
Mta1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression by covalent modification of histone proteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri393 – 42028GATA-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA1
Gene namesi
Name:Mta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2150037. Mta1.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. NuRD complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi322 – 3221S → A: Reduction in the ability of MTA1S to repress ER transactivation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Metastasis-associated protein MTA1PRO_0000083494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861Phosphoserine By similarity
Modified residuei449 – 4491Phosphoserine By similarity
Modified residuei522 – 5221Phosphoserine By similarity
Modified residuei564 – 5641Phosphothreonine1 Publication
Modified residuei576 – 5761Phosphoserine By similarity
Modified residuei578 – 5781Phosphothreonine By similarity
Modified residuei639 – 6391Phosphoserine By similarity

Post-translational modificationi

Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K4B0.
PaxDbiQ8K4B0.
PRIDEiQ8K4B0.

PTM databases

PhosphoSiteiQ8K4B0.

Expressioni

Tissue specificityi

Widely expressed but not in skeletal muscle.

Gene expression databases

ArrayExpressiQ8K4B0.
BgeeiQ8K4B0.
CleanExiMM_MTA1.
GenevestigatoriQ8K4B0.

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR By similarity. Binds to CSNK1G2 in the cytoplasm. Interacts with NACC2 By similarity.1 Publication

Protein-protein interaction databases

DIPiDIP-38226N.
IntActiQ8K4B0. 9 interactions.
MINTiMINT-1350646.
STRINGi10090.ENSMUSP00000105349.

Structurei

3D structure databases

ProteinModelPortaliQ8K4B0.
SMRiQ8K4B0. Positions 165-341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 164164BAHAdd
BLAST
Domaini165 – 276112ELM2Add
BLAST
Domaini283 – 33553SANTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi545 – 5528SH3-binding Reviewed prediction
Motifi696 – 70510SH3-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi700 – 7056Poly-Pro

Sequence similaritiesi

Contains 1 BAH domain.
Contains 1 ELM2 domain.
Contains 1 SANT domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri393 – 42028GATA-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG252834.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000045387.
HOVERGENiHBG002598.
InParanoidiQ8K4B0.
KOiK11660.
OMAiDKHATLS.
OrthoDBiEOG780RM1.
PhylomeDBiQ8K4B0.
TreeFamiTF106444.

Family and domain databases

InterProiIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4B0-1 [UniParc]FASTAAdd to Basket

« Hide

MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD    50
ISSSLIALAD KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK 100
HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS 150
LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSKLETKVWE 200
AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT 250
LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 300
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK 350
LKQVYIPNYN KPNPNQISAS SVKATVVNGT GTPGQSPGAG RACESCYTTQ 400
SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRNNMSP 450
HGIPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY 500
MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY LETHPRPPKP 550
DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL 600
MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW 650
IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPLRP 700
PPPAPVNDEP IVIED 715
Length:715
Mass (Da):80,798
Last modified:October 1, 2002 - v1
Checksum:i135152CD3554278D
GO

Sequence cautioni

The sequence BAC57413.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641T → R in AAK83044. 1 Publication
Sequence conflicti65 – 8117Missing in AAK83044. 1 PublicationAdd
BLAST
Sequence conflicti420 – 4201C → W in AAK83044. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF463504 mRNA. Translation: AAM97588.1.
AF450245 Genomic DNA. Translation: AAM97587.1.
AF288137 mRNA. Translation: AAK83044.1.
AB039744 Genomic DNA. Translation: BAC57413.1. Different initiation.
RefSeqiXP_006515485.1. XM_006515422.1.
XP_006536382.1. XM_006536319.1.
UniGeneiMm.212577.

Genome annotation databases

EnsembliENSMUST00000009099; ENSMUSP00000009099; ENSMUSG00000021144.
GeneIDi116870.
KEGGimmu:116870.
UCSCiuc007pfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF463504 mRNA. Translation: AAM97588.1 .
AF450245 Genomic DNA. Translation: AAM97587.1 .
AF288137 mRNA. Translation: AAK83044.1 .
AB039744 Genomic DNA. Translation: BAC57413.1 . Different initiation.
RefSeqi XP_006515485.1. XM_006515422.1.
XP_006536382.1. XM_006536319.1.
UniGenei Mm.212577.

3D structure databases

ProteinModelPortali Q8K4B0.
SMRi Q8K4B0. Positions 165-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38226N.
IntActi Q8K4B0. 9 interactions.
MINTi MINT-1350646.
STRINGi 10090.ENSMUSP00000105349.

PTM databases

PhosphoSitei Q8K4B0.

Proteomic databases

MaxQBi Q8K4B0.
PaxDbi Q8K4B0.
PRIDEi Q8K4B0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009099 ; ENSMUSP00000009099 ; ENSMUSG00000021144 .
GeneIDi 116870.
KEGGi mmu:116870.
UCSCi uc007pfw.1. mouse.

Organism-specific databases

CTDi 9112.
MGIi MGI:2150037. Mta1.

Phylogenomic databases

eggNOGi NOG252834.
GeneTreei ENSGT00580000081398.
HOGENOMi HOG000045387.
HOVERGENi HBG002598.
InParanoidi Q8K4B0.
KOi K11660.
OMAi DKHATLS.
OrthoDBi EOG780RM1.
PhylomeDBi Q8K4B0.
TreeFami TF106444.

Miscellaneous databases

ChiTaRSi MTA1. mouse.
PROi Q8K4B0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K4B0.
Bgeei Q8K4B0.
CleanExi MM_MTA1.
Genevestigatori Q8K4B0.

Family and domain databases

InterProi IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view ]
SMARTi SM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression."
    Zhou J., Ashouian N., Delepine M., Matsuda F., Chevillard C., Riblet R., Schildkraut C.L., Birshtein B.K.
    Proc. Natl. Acad. Sci. U.S.A. 99:13693-13698(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
  2. "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
    Simpson A., Uitto J., Rodeck U., Mahoney M.G.
    Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: 129/Sv.
  3. Takiguchi S.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  4. "Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase."
    Mishra S.K., Yang Z., Mazumdar A., Talukder A.H., Larose L., Kumar R.
    Oncogene 23:4422-4429(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CSNK1G2/CK1, MUTAGENESIS OF SER-322, INTERACTION WITH CSNK1G2, SUBCELLULAR LOCATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMTA1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4B0
Secondary accession number(s): Q80UI1, Q8K4D4, Q924K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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