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Q8K4B0

- MTA1_MOUSE

UniProt

Q8K4B0 - MTA1_MOUSE

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Protein
Metastasis-associated protein MTA1
Gene
Mta1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression by covalent modification of histone proteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri393 – 42028GATA-type; atypical
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis-associated protein MTA1
    Gene namesi
    Name:Mta1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2150037. Mta1.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. NuRD complex Source: MGI
    2. cytoplasm Source: MGI
    3. nucleus Source: MGI
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi322 – 3221S → A: Reduction in the ability of MTA1S to repress ER transactivation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Metastasis-associated protein MTA1
    PRO_0000083494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei386 – 3861Phosphoserine By similarity
    Modified residuei449 – 4491Phosphoserine By similarity
    Modified residuei522 – 5221Phosphoserine By similarity
    Modified residuei564 – 5641Phosphothreonine1 Publication
    Modified residuei576 – 5761Phosphoserine By similarity
    Modified residuei578 – 5781Phosphothreonine By similarity
    Modified residuei639 – 6391Phosphoserine By similarity

    Post-translational modificationi

    Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8K4B0.
    PaxDbiQ8K4B0.
    PRIDEiQ8K4B0.

    PTM databases

    PhosphoSiteiQ8K4B0.

    Expressioni

    Tissue specificityi

    Widely expressed but not in skeletal muscle.

    Gene expression databases

    ArrayExpressiQ8K4B0.
    BgeeiQ8K4B0.
    CleanExiMM_MTA1.
    GenevestigatoriQ8K4B0.

    Interactioni

    Subunit structurei

    Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR By similarity. Binds to CSNK1G2 in the cytoplasm. Interacts with NACC2 By similarity.1 Publication

    Protein-protein interaction databases

    DIPiDIP-38226N.
    IntActiQ8K4B0. 9 interactions.
    MINTiMINT-1350646.
    STRINGi10090.ENSMUSP00000105349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4B0.
    SMRiQ8K4B0. Positions 165-341.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 164164BAH
    Add
    BLAST
    Domaini165 – 276112ELM2
    Add
    BLAST
    Domaini283 – 33553SANT
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi545 – 5528SH3-binding Reviewed prediction
    Motifi696 – 70510SH3-binding Reviewed prediction

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi700 – 7056Poly-Pro

    Sequence similaritiesi

    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 SANT domain.

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252834.
    GeneTreeiENSGT00580000081398.
    HOGENOMiHOG000045387.
    HOVERGENiHBG002598.
    InParanoidiQ8K4B0.
    KOiK11660.
    OMAiDKHATLS.
    OrthoDBiEOG780RM1.
    PhylomeDBiQ8K4B0.
    TreeFamiTF106444.

    Family and domain databases

    InterProiIPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view]
    SMARTiSM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4B0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD    50
    ISSSLIALAD KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK 100
    HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS 150
    LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSKLETKVWE 200
    AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT 250
    LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 300
    EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK 350
    LKQVYIPNYN KPNPNQISAS SVKATVVNGT GTPGQSPGAG RACESCYTTQ 400
    SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRNNMSP 450
    HGIPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY 500
    MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY LETHPRPPKP 550
    DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL 600
    MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW 650
    IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPLRP 700
    PPPAPVNDEP IVIED 715
    Length:715
    Mass (Da):80,798
    Last modified:October 1, 2002 - v1
    Checksum:i135152CD3554278D
    GO

    Sequence cautioni

    The sequence BAC57413.1 differs from that shown. Reason: Erroneous initiation.

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641T → R in AAK83044. 1 Publication
    Sequence conflicti65 – 8117Missing in AAK83044. 1 Publication
    Add
    BLAST
    Sequence conflicti420 – 4201C → W in AAK83044. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF463504 mRNA. Translation: AAM97588.1.
    AF450245 Genomic DNA. Translation: AAM97587.1.
    AF288137 mRNA. Translation: AAK83044.1.
    AB039744 Genomic DNA. Translation: BAC57413.1. Different initiation.
    RefSeqiXP_006515485.1. XM_006515422.1.
    XP_006536382.1. XM_006536319.1.
    UniGeneiMm.212577.

    Genome annotation databases

    EnsembliENSMUST00000009099; ENSMUSP00000009099; ENSMUSG00000021144.
    GeneIDi116870.
    KEGGimmu:116870.
    UCSCiuc007pfw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF463504 mRNA. Translation: AAM97588.1 .
    AF450245 Genomic DNA. Translation: AAM97587.1 .
    AF288137 mRNA. Translation: AAK83044.1 .
    AB039744 Genomic DNA. Translation: BAC57413.1 . Different initiation.
    RefSeqi XP_006515485.1. XM_006515422.1.
    XP_006536382.1. XM_006536319.1.
    UniGenei Mm.212577.

    3D structure databases

    ProteinModelPortali Q8K4B0.
    SMRi Q8K4B0. Positions 165-341.
    ModBasei Search...

    Protein-protein interaction databases

    DIPi DIP-38226N.
    IntActi Q8K4B0. 9 interactions.
    MINTi MINT-1350646.
    STRINGi 10090.ENSMUSP00000105349.

    PTM databases

    PhosphoSitei Q8K4B0.

    Proteomic databases

    MaxQBi Q8K4B0.
    PaxDbi Q8K4B0.
    PRIDEi Q8K4B0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009099 ; ENSMUSP00000009099 ; ENSMUSG00000021144 .
    GeneIDi 116870.
    KEGGi mmu:116870.
    UCSCi uc007pfw.1. mouse.

    Organism-specific databases

    CTDi 9112.
    MGIi MGI:2150037. Mta1.

    Phylogenomic databases

    eggNOGi NOG252834.
    GeneTreei ENSGT00580000081398.
    HOGENOMi HOG000045387.
    HOVERGENi HBG002598.
    InParanoidi Q8K4B0.
    KOi K11660.
    OMAi DKHATLS.
    OrthoDBi EOG780RM1.
    PhylomeDBi Q8K4B0.
    TreeFami TF106444.

    Miscellaneous databases

    ChiTaRSi MTA1. mouse.
    PROi Q8K4B0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K4B0.
    Bgeei Q8K4B0.
    CleanExi MM_MTA1.
    Genevestigatori Q8K4B0.

    Family and domain databases

    InterProi IPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view ]
    SMARTi SM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression."
      Zhou J., Ashouian N., Delepine M., Matsuda F., Chevillard C., Riblet R., Schildkraut C.L., Birshtein B.K.
      Proc. Natl. Acad. Sci. U.S.A. 99:13693-13698(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: BALB/c.
    2. "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
      Simpson A., Uitto J., Rodeck U., Mahoney M.G.
      Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Strain: 129/Sv.
    3. Takiguchi S.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Liver.
    4. "Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase."
      Mishra S.K., Yang Z., Mazumdar A., Talukder A.H., Larose L., Kumar R.
      Oncogene 23:4422-4429(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CSNK1G2/CK1, MUTAGENESIS OF SER-322, INTERACTION WITH CSNK1G2, SUBCELLULAR LOCATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMTA1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4B0
    Secondary accession number(s): Q80UI1, Q8K4D4, Q924K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi