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Q8K4B0 (MTA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metastasis-associated protein MTA1
Gene names
Name:Mta1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the regulation of gene expression by covalent modification of histone proteins.

Subunit structure

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR By similarity. Binds to CSNK1G2 in the cytoplasm. Ref.4

Subcellular location

Nucleus Ref.2 Ref.4.

Tissue specificity

Widely expressed but not in skeletal muscle.

Post-translational modification

Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).

Sequence similarities

Contains 1 BAH domain.

Contains 1 ELM2 domain.

Contains 1 GATA-type zinc finger.

Contains 1 SANT domain.

Sequence caution

The sequence BAC57413.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715Metastasis-associated protein MTA1
PRO_0000083494

Regions

Domain1 – 164164BAH
Domain165 – 276112ELM2
Domain283 – 33553SANT
Zinc finger393 – 42028GATA-type; atypical
Motif545 – 5528SH3-binding Potential
Motif696 – 70510SH3-binding Potential
Compositional bias700 – 7056Poly-Pro

Amino acid modifications

Modified residue3861Phosphoserine By similarity
Modified residue4491Phosphoserine By similarity
Modified residue5221Phosphoserine By similarity
Modified residue5641Phosphothreonine Ref.5
Modified residue5761Phosphoserine By similarity
Modified residue5781Phosphothreonine By similarity
Modified residue6391Phosphoserine By similarity

Experimental info

Mutagenesis3221S → A: Reduction in the ability of MTA1S to repress ER transactivation. Ref.4
Sequence conflict641T → R in AAK83044. Ref.2
Sequence conflict65 – 8117Missing in AAK83044. Ref.2
Sequence conflict4201C → W in AAK83044. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8K4B0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 135152CD3554278D

FASTA71580,798
        10         20         30         40         50         60 
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSSLIALAD 

        70         80         90        100        110        120 
KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT 

       130        140        150        160        170        180 
HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL 

       190        200        210        220        230        240 
LKEGEEDGRD QSKLETKVWE AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM 

       250        260        270        280        290        300 
SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 

       310        320        330        340        350        360 
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN 

       370        380        390        400        410        420 
KPNPNQISAS SVKATVVNGT GTPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC 

       430        440        450        460        470        480 
WTYWKKYGGL KMPTRLDGER PGPNRNNMSP HGIPARSSGS PKFAMKTRQA FYLHTTKLTR 

       490        500        510        520        530        540 
IARRLCREIL RPWHAARHPY MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY 

       550        560        570        580        590        600 
LETHPRPPKP DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL 

       610        620        630        640        650        660 
MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM 

       670        680        690        700        710 
ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPLRP PPPAPVNDEP IVIED 

« Hide

References

« Hide 'large scale' references
[1]"The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression."
Zhou J., Ashouian N., Delepine M., Matsuda F., Chevillard C., Riblet R., Schildkraut C.L., Birshtein B.K.
Proc. Natl. Acad. Sci. U.S.A. 99:13693-13698(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: BALB/c.
[2]"Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3."
Simpson A., Uitto J., Rodeck U., Mahoney M.G.
Gene 273:29-39(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
Strain: 129/Sv.
[3]Takiguchi S.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Liver.
[4]"Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase."
Mishra S.K., Yang Z., Mazumdar A., Talukder A.H., Larose L., Kumar R.
Oncogene 23:4422-4429(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY CSNK1G2/CK1, MUTAGENESIS OF SER-322, INTERACTION WITH CSNK1G2, SUBCELLULAR LOCATION.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF463504 mRNA. Translation: AAM97588.1.
AF450245 Genomic DNA. Translation: AAM97587.1.
AF288137 mRNA. Translation: AAK83044.1.
AB039744 Genomic DNA. Translation: BAC57413.1. Different initiation.
RefSeqXP_006515485.1. XM_006515422.1.
XP_006536382.1. XM_006536319.1.
UniGeneMm.212577.

3D structure databases

ProteinModelPortalQ8K4B0.
SMRQ8K4B0. Positions 165-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-38226N.
IntActQ8K4B0. 9 interactions.
MINTMINT-1350646.
STRING10090.ENSMUSP00000105349.

PTM databases

PhosphoSiteQ8K4B0.

Proteomic databases

MaxQBQ8K4B0.
PaxDbQ8K4B0.
PRIDEQ8K4B0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009099; ENSMUSP00000009099; ENSMUSG00000021144.
GeneID116870.
KEGGmmu:116870.
UCSCuc007pfw.1. mouse.

Organism-specific databases

CTD9112.
MGIMGI:2150037. Mta1.

Phylogenomic databases

eggNOGNOG252834.
GeneTreeENSGT00580000081398.
HOGENOMHOG000045387.
HOVERGENHBG002598.
InParanoidQ8K4B0.
KOK11660.
OMADKHATLS.
OrthoDBEOG780RM1.
PhylomeDBQ8K4B0.
TreeFamTF106444.

Gene expression databases

ArrayExpressQ8K4B0.
BgeeQ8K4B0.
CleanExMM_MTA1.
GenevestigatorQ8K4B0.

Family and domain databases

InterProIPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTA1. mouse.
PROQ8K4B0.
SOURCESearch...

Entry information

Entry nameMTA1_MOUSE
AccessionPrimary (citable) accession number: Q8K4B0
Secondary accession number(s): Q80UI1, Q8K4D4, Q924K9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot