Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD11

Gene

Kctd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell differentiation Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • nervous system development Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • protein homooligomerization Source: InterPro
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of cell proliferation Source: MGI
  • regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD11
Gene namesi
Name:Kctd11
Synonyms:Ren
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2448712. Kctd11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232BTB/POZ domain-containing protein KCTD11PRO_0000248592Add
BLAST

Proteomic databases

PaxDbiQ8K485.
PRIDEiQ8K485.

Expressioni

Tissue specificityi

Weakly expressed in lung. In the cerebellum, higher expression in non proliferating external granule cells layer than in highly proliferating ones.2 Publications

Developmental stagei

Detected at E7.5 in neuroectodermal cells, and later in neural crest, in ventral region of the spinal cord and in ventricular epithelium of the neural tube.1 Publication

Gene expression databases

BgeeiENSMUSG00000046731.
GenevisibleiQ8K485. MM.

Interactioni

Subunit structurei

Homotetramer. Component of the BCR(KCTD11) E3 ubiquitin ligase complex, at least composed of CUL3 and KCTD11 and RBX1. Interacts with CUL3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059107.

Structurei

3D structure databases

ProteinModelPortaliQ8K485.
SMRiQ8K485. Positions 1-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4949BTBAdd
BLAST

Domaini

The BTB domain is required for growth-suppressing properties.

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ8K485.
OMAiEWAPRPA.
OrthoDBiEOG091G039H.
PhylomeDBiQ8K485.
TreeFamiTF315332.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAMFRADT LMPANLNPQG DGHYFIDRDG KAFRHILNFL RLGRLDLPRG
60 70 80 90 100
YGETALLKAE ADFYQIRPLL DALRELEASR GTPASTAALL HADVDVSPRQ
110 120 130 140 150
VHFSARRGPH HYELSSVQVD TFRANLFCTD PECLAAMRNR FGVAIGDRAE
160 170 180 190 200
GGPHFRLEWA SRPQELPEVE YQRLGLQPLW TGGPEDRREV ANTPTFLEEV
210 220 230
LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH
Length:232
Mass (Da):26,300
Last modified:October 1, 2002 - v1
Checksum:i993C1FFDE8D52943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465352 mRNA. Translation: AAM95915.1.
AK039558 mRNA. Translation: BAC30382.1.
AK161602 mRNA. Translation: BAE36486.1.
AK170258 mRNA. Translation: BAE41666.1.
BC052502 mRNA. Translation: AAH52502.1.
BC052734 mRNA. Translation: AAH52734.1.
CCDSiCCDS24918.1.
RefSeqiNP_694783.1. NM_153143.4.
UniGeneiMm.239498.

Genome annotation databases

EnsembliENSMUST00000050555; ENSMUSP00000059107; ENSMUSG00000046731.
GeneIDi216858.
KEGGimmu:216858.
UCSCiuc007jsd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465352 mRNA. Translation: AAM95915.1.
AK039558 mRNA. Translation: BAC30382.1.
AK161602 mRNA. Translation: BAE36486.1.
AK170258 mRNA. Translation: BAE41666.1.
BC052502 mRNA. Translation: AAH52502.1.
BC052734 mRNA. Translation: AAH52734.1.
CCDSiCCDS24918.1.
RefSeqiNP_694783.1. NM_153143.4.
UniGeneiMm.239498.

3D structure databases

ProteinModelPortaliQ8K485.
SMRiQ8K485. Positions 1-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059107.

Proteomic databases

PaxDbiQ8K485.
PRIDEiQ8K485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050555; ENSMUSP00000059107; ENSMUSG00000046731.
GeneIDi216858.
KEGGimmu:216858.
UCSCiuc007jsd.2. mouse.

Organism-specific databases

CTDi147040.
MGIiMGI:2448712. Kctd11.

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ8K485.
OMAiEWAPRPA.
OrthoDBiEOG091G039H.
PhylomeDBiQ8K485.
TreeFamiTF315332.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiKctd11. mouse.
PROiQ8K485.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046731.
GenevisibleiQ8K485. MM.

Family and domain databases

InterProiIPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD11_MOUSE
AccessioniPrimary (citable) accession number: Q8K485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of Kctd11 by lentiviral vector injection inhibits xenograft tumor growth in athymic nude mice.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.