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Protein

Transmembrane inner ear expressed protein

Gene

Tmie

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Protein family/group databases

TCDBi9.A.30.1.1. the putative tmie gentamiein uptake mechanosensitive channel (tmie) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane inner ear expressed protein
Gene namesi
Name:Tmie
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2159400. Tmie.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 58ExtracellularSequence analysisAdd BLAST30
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 153CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tmie are the cause of the spinner mutant strain phenotype (sr). This disorder results in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. It is recognized by behavioral dysfunction, including bidirectional circling and head shaking. Auditory function in spinner mice is found to be reduced, based upon the lack of a startle reflex to sound at any age. Breeding experiments indicated that these defects are inherited in an autosomal recessive fashion. The postnatal defects present in the cochleae of sr/sr mice suggest a requirement for Tmie during maturation of sensory cells, including the normal development or maintenance of stereocilia bundles.

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002255629 – 153Transmembrane inner ear expressed proteinAdd BLAST125

Proteomic databases

PaxDbiQ8K467.
PRIDEiQ8K467.

PTM databases

iPTMnetiQ8K467.
PhosphoSitePlusiQ8K467.

Expressioni

Tissue specificityi

Expressed in brain, kidney, liver, lung and cochlea.1 Publication

Developmental stagei

Required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles.

Gene expression databases

BgeeiENSMUSG00000049555.
CleanExiMM_TMIE.
ExpressionAtlasiQ8K467. baseline and differential.
GenevisibleiQ8K467. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060148.

Structurei

3D structure databases

ProteinModelPortaliQ8K467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 153Lys-richAdd BLAST30

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYQZ. Eukaryota.
ENOG4111RFP. LUCA.
GeneTreeiENSGT00390000005082.
HOGENOMiHOG000060175.
HOVERGENiHBG079268.
InParanoidiQ8K467.
OMAiCCIFNCR.
OrthoDBiEOG091G188E.
PhylomeDBiQ8K467.
TreeFamiTF332314.

Family and domain databases

InterProiIPR032006. TMIE.
[Graphical view]
PfamiPF16038. TMIE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRQHGSGR LWALGGAALG ACLAGVATQL VEPSTAPPKP KPPPLTKETV
60 70 80 90 100
VFWDMRLWHV VGIFSLFVLS IIITLCCVFN CRVPRTRKEI EARYLQRKAA
110 120 130 140 150
KMYTDKLETV PPLNELTEIP GEDKKKKKKD SVDTVAIKVE EDEKNEAKKK

GEK
Length:153
Mass (Da):17,027
Last modified:October 1, 2002 - v1
Checksum:i2B22474B275CBBD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481143 mRNA. Translation: AAM89222.1.
CCDSiCCDS23578.1.
RefSeqiNP_666372.1. NM_146260.2.
XP_006512070.1. XM_006512007.3.
XP_006512071.1. XM_006512008.3.
XP_006512072.1. XM_006512009.3.
XP_006512073.1. XM_006512010.3.
XP_006512076.1. XM_006512013.3.
XP_011241246.1. XM_011242944.2.
XP_011241247.1. XM_011242945.2.
UniGeneiMm.390229.

Genome annotation databases

EnsembliENSMUST00000050958; ENSMUSP00000060148; ENSMUSG00000049555.
GeneIDi20776.
KEGGimmu:20776.
UCSCiuc009rvb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481143 mRNA. Translation: AAM89222.1.
CCDSiCCDS23578.1.
RefSeqiNP_666372.1. NM_146260.2.
XP_006512070.1. XM_006512007.3.
XP_006512071.1. XM_006512008.3.
XP_006512072.1. XM_006512009.3.
XP_006512073.1. XM_006512010.3.
XP_006512076.1. XM_006512013.3.
XP_011241246.1. XM_011242944.2.
XP_011241247.1. XM_011242945.2.
UniGeneiMm.390229.

3D structure databases

ProteinModelPortaliQ8K467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060148.

Protein family/group databases

TCDBi9.A.30.1.1. the putative tmie gentamiein uptake mechanosensitive channel (tmie) family.

PTM databases

iPTMnetiQ8K467.
PhosphoSitePlusiQ8K467.

Proteomic databases

PaxDbiQ8K467.
PRIDEiQ8K467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050958; ENSMUSP00000060148; ENSMUSG00000049555.
GeneIDi20776.
KEGGimmu:20776.
UCSCiuc009rvb.1. mouse.

Organism-specific databases

CTDi259236.
MGIiMGI:2159400. Tmie.

Phylogenomic databases

eggNOGiENOG410IYQZ. Eukaryota.
ENOG4111RFP. LUCA.
GeneTreeiENSGT00390000005082.
HOGENOMiHOG000060175.
HOVERGENiHBG079268.
InParanoidiQ8K467.
OMAiCCIFNCR.
OrthoDBiEOG091G188E.
PhylomeDBiQ8K467.
TreeFamiTF332314.

Miscellaneous databases

PROiQ8K467.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049555.
CleanExiMM_TMIE.
ExpressionAtlasiQ8K467. baseline and differential.
GenevisibleiQ8K467. MM.

Family and domain databases

InterProiIPR032006. TMIE.
[Graphical view]
PfamiPF16038. TMIE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMIE_MOUSE
AccessioniPrimary (citable) accession number: Q8K467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.