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Protein

Probable G-protein coupled receptor 156

Gene

Gpr156

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
GABAB-related G-protein coupled receptor
Gene namesi
Name:Gpr156
Synonyms:Gababl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708438. Gpr156.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 86CytoplasmicSequence analysisAdd BLAST16
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 118ExtracellularSequence analysisAdd BLAST11
Transmembranei119 – 139Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini140 – 164CytoplasmicSequence analysisAdd BLAST25
Transmembranei165 – 185Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini186 – 222ExtracellularSequence analysisAdd BLAST37
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 257CytoplasmicSequence analysisAdd BLAST14
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 287ExtracellularSequence analysis9
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 792CytoplasmicSequence analysisAdd BLAST484

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002069011 – 792Probable G-protein coupled receptor 156Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K451.
PRIDEiQ8K451.

PTM databases

iPTMnetiQ8K451.
PhosphoSitePlusiQ8K451.

Expressioni

Tissue specificityi

Widely expressed throughout the brain and is particularly dense in the olfactory tubercles, islands of Calleja, nucleus accumbens, piriform cortex and all fields of the hippocampus.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003773.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili354 – 390Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 269Poly-Leu4
Compositional biasi579 – 582Poly-Arg4
Compositional biasi724 – 729Poly-Ser6

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ8K451.
KOiK04617.
PhylomeDBiQ8K451.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITDSQHGSA DISPLSPALL
60 70 80 90 100
GVIWTFLSCG LLLVLFFLAF TIRCRKNRIV KMSSPNLNIV TLLGSCLTYS
110 120 130 140 150
SAYLFGIQDA LVGSSVEALI QTRLSLLCIG TTLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALVVADVILL VTWVLTDPIQ CLQILGVSMK
210 220 230 240 250
VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA YLAGLTNHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTVNCCVFLP QLRQRKAFEG ENQTIRHMAK YFSTPSKTFR SKFDEDQSCH
360 370 380 390 400
LRDEXSCMER LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CALDSPEWAV
410 420 430 440 450
PAAASAGGPA ECXATSEKES GAAAEDSLPA SAASQHMQGP GASRRDXSPS
460 470 480 490 500
PDQKYDMPLK QFCDHLDMGC SQKPKAEQSE GPERGNQEPM APGQSLMTDG
510 520 530 540 550
VACEPHRPRQ NSEVLPERLP RVSSVVREKL QEVLQELDLG TEAPLSPLPC
560 570 580 590 600
PQQPWKSNTS GSPQKLSPSK LGFSPYVVRR RRAAQRARSR IPGSVGLKMG
610 620 630 640 650
HQANNTVSGS QNGLIVQNRD SPRLDHHNAR SKEPRSSSVK PSPISAPHQR
660 670 680 690 700
RGSLEGSKQC ETEPQEARGY SVAFPRQPSA SAPAQSSTAP CLSSXPALPR
710 720 730 740 750
QRQPLPLLSP GCPSLSSGCY NLDSESSSSD EFFCRCHRPY CEICFQSSLD
760 770 780 790
SNDSDTSDSD LEQTSGLASW EKLLARSKPV VNFKDDLKPT LV
Length:792
Mass (Da):86,426
Last modified:October 1, 2002 - v1
Checksum:i17E252E8AC8F8FFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488741 mRNA. Translation: AAN03797.1.
RefSeqiNP_695207.1. NM_153295.1.
UniGeneiRn.213724.

Genome annotation databases

GeneIDi260430.
KEGGirno:260430.
UCSCiRGD:708438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488741 mRNA. Translation: AAN03797.1.
RefSeqiNP_695207.1. NM_153295.1.
UniGeneiRn.213724.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003773.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8K451.
PhosphoSitePlusiQ8K451.

Proteomic databases

PaxDbiQ8K451.
PRIDEiQ8K451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi260430.
KEGGirno:260430.
UCSCiRGD:708438. rat.

Organism-specific databases

CTDi165829.
RGDi708438. Gpr156.

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ8K451.
KOiK04617.
PhylomeDBiQ8K451.

Miscellaneous databases

PROiQ8K451.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP156_RAT
AccessioniPrimary (citable) accession number: Q8K451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.