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Q8K449

- ABCA9_MOUSE

UniProt

Q8K449 - ABCA9_MOUSE

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Protein

ATP-binding cassette sub-family A member 9

Gene
Abca9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in monocyte differentiation and lipid homeostasis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi517 – 5248ATP 1 Reviewed prediction
Nucleotide bindingi1325 – 13328ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 9
Gene namesi
Name:Abca9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2386796. Abca9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Transmembranei265 – 28521Helical; Reviewed predictionAdd
BLAST
Transmembranei295 – 31521Helical; Reviewed predictionAdd
BLAST
Transmembranei329 – 34921Helical; Reviewed predictionAdd
BLAST
Transmembranei354 – 37421Helical; Reviewed predictionAdd
BLAST
Transmembranei398 – 41821Helical; Reviewed predictionAdd
BLAST
Transmembranei863 – 88321Helical; Reviewed predictionAdd
BLAST
Transmembranei1025 – 104521Helical; Reviewed predictionAdd
BLAST
Transmembranei1071 – 109121Helical; Reviewed predictionAdd
BLAST
Transmembranei1107 – 112721Helical; Reviewed predictionAdd
BLAST
Transmembranei1135 – 115521Helical; Reviewed predictionAdd
BLAST
Transmembranei1163 – 118321Helical; Reviewed predictionAdd
BLAST
Transmembranei1199 – 121921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16231623ATP-binding cassette sub-family A member 9PRO_0000250681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K449.
PRIDEiQ8K449.

PTM databases

PhosphoSiteiQ8K449.

Expressioni

Tissue specificityi

Highly expressed in heart and to lower extent in kidney, brain and spleen.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiQ8K449.
GenevestigatoriQ8K449.

Structurei

3D structure databases

ProteinModelPortaliQ8K449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini481 – 716236ABC transporter 1Add
BLAST
Domaini1287 – 1520234ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000115040.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiA2A6R5.
KOiK05651.
OMAiESDIGIW.
OrthoDBiEOG73Z2SB.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K449-1 [UniParc]FASTAAdd to Basket

« Hide

MRKRHLRLGQ QMWALLCKNW LRKFRMRRET LLEWLFSLLL ILFVYQLSSN     50
LHQVHDAPEM SVVDLGRVDN FNDSNYMMVF APESEATHEI MNKVASAPFM 100
KGRTIVACPD EKSMNELDLN YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK 150
EHKDHSAPCE PLNNKMICEN SAFWEKGFVA FQAAINAGII EMITNHSVME 200
ELMSVIGSNM KMPPFIAQGG VATDFFIFFC VISFSSLIYY LSVNITQERQ 250
YMTTLMAMMG LRESAFWLSW SLMYAGFILV VAVLMSLIVK SAQVVVLTGF 300
MVVFLLFLFY GLSLITLSFL MSVLIKKPFL TGLAIFILTV FWGSLGFTAL 350
YKHLPAFVEW TLCFLSPFAF TTGMAQLIHL DYDVNSNVNL NSPNNSYLIM 400
ATLFMLVLDA LLYLVLALYF DKITLSKYGH QRSPLFFLKS SYWFKRRGAS 450
HVVLENEIDS DPSLNDSLEP VSPEFQGKEA IRIKNLKKEY SGKHGKVEAL 500
RGLGFDIYEG QITALLGHSG AGKTTLINTL SGLSPPTTGS VTIYNQTVSE 550
MDDSDAVLTI TGVCPQSNVQ FGFLTVRENL RLFAKIKGIL PHEVEQEVQQ 600
VLQDLEMENI QDILAQNLSG GQKRKLTLGI AILGDPQVLL LDEPTAGLDP 650
LSRHRIWNLL KERRAGRVIV FSTQFMDEAD ILADRKVFIS NGRLKCAGSS 700
LFLKKKWGIG YHLSLHLNEA CDPEGITSLV KKHISDARLT TQSEERLVYI 750
LPLERTNKFP DLYRDLDRCS NQGIEDYGVS MTTLNEVFLK LEGKSMADES 800
DVGICGRLQS DGARDMESLV ELEQVLSLDS SGSSVSGMAL WRQQLCAVAK 850
VRFFKLKNER KSLMTVLLLF GISFVPQLLE HLVYKVYHKS YSWGLSPSMY 900
FLSPGQPPQD PLTHLLVINR TGSSIDNFVH ALRQQGIALD LDALGTRNGT 950
EEALYNGAIT VLGEEKALRF SVACNAKRLN CFPVLMDIIS NGLLGIFNSS 1000
ERIQTDRSTV FEEHMLYEYG FMSNAFFWIP VAASLTPYIA MGSISDHKKK 1050
VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI LFLMQIMDSV FSSEEFISVM 1100
ESLLIQIPCS IGYASSLIFM TYVISFIFRN GRKNSGIWSF FFLIVTIFFI 1150
IATDINEYGF LELLICTFLV PPFTLIGSLL IFSEVSYDSV DYLGTSESQL 1200
VFLALLIPYL HFLLFFFILR CLERYLRKKS LRVDPVFRIS PRSCPAVPNP 1250
EEPGEEDEDV QMERVRTTGA MATLQTDEKP VIIASCLRKE YIGRTKRCFS 1300
KMKKKIATRN ISFCVKKGEV LGLLGHNGAG KSTTISMITG DTIPTAGQVF 1350
LKGSGGGAAL GFLGYCPQEN VLWPNLTVKE HLELYAAVKG LKKKDAVVTI 1400
TRLVNALKLQ DHLKALVRTL SEGVKRKLCF VLSILGNPPV VLLDEPSTGM 1450
DPEGQQQMWQ AIRATFTNTE RGALLTTHYM AEAEAVCDRV AIMVSGRLRC 1500
IGSIQHLKSK FGKDYLLEMK VKTPSQVEPL NTEIMRLFPQ AARQERYSSL 1550
MVYKLPVEDV RPLSEAFFKL ERLKENFDLE EYSLSQSTLE QVFLELSKEQ 1600
ELDDFGEEAN SSVKWKLLPQ EEL 1623
Length:1,623
Mass (Da):183,114
Last modified:June 28, 2011 - v2
Checksum:i666E67039EDB2627
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571A → T in AAM90894. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491299 mRNA. Translation: AAM90894.1.
AL603792 Genomic DNA. Translation: CAM20975.1.
CH466558 Genomic DNA. Translation: EDL34378.1.
AK029256 mRNA. Translation: BAC26358.1.
CCDSiCCDS25589.1.
RefSeqiNP_671753.2. NM_147220.2.
XP_006533127.1. XM_006533064.1.
UniGeneiMm.291459.

Genome annotation databases

EnsembliENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
GeneIDi217262.
KEGGimmu:217262.
UCSCiuc007mdh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491299 mRNA. Translation: AAM90894.1 .
AL603792 Genomic DNA. Translation: CAM20975.1 .
CH466558 Genomic DNA. Translation: EDL34378.1 .
AK029256 mRNA. Translation: BAC26358.1 .
CCDSi CCDS25589.1.
RefSeqi NP_671753.2. NM_147220.2.
XP_006533127.1. XM_006533064.1.
UniGenei Mm.291459.

3D structure databases

ProteinModelPortali Q8K449.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K449.

Proteomic databases

PaxDbi Q8K449.
PRIDEi Q8K449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044850 ; ENSMUSP00000036338 ; ENSMUSG00000041797 .
GeneIDi 217262.
KEGGi mmu:217262.
UCSCi uc007mdh.1. mouse.

Organism-specific databases

CTDi 10350.
MGIi MGI:2386796. Abca9.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000115040.
HOGENOMi HOG000231057.
HOVERGENi HBG079884.
InParanoidi A2A6R5.
KOi K05651.
OMAi ESDIGIW.
OrthoDBi EOG73Z2SB.
TreeFami TF105192.

Miscellaneous databases

NextBioi 375711.
PROi Q8K449.
SOURCEi Search...

Gene expression databases

Bgeei Q8K449.
Genevestigatori Q8K449.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
    Annilo T., Chen Z.-Q., Shulenin S., Dean M.
    Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1623.
    Strain: C57BL/6J.
    Tissue: Head.
  5. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
    Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
    Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiABCA9_MOUSE
AccessioniPrimary (citable) accession number: Q8K449
Secondary accession number(s): A2A6R5, Q8C114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi