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Protein

ATP-binding cassette sub-family A member 9

Gene

Abca9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in monocyte differentiation and lipid homeostasis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi517 – 524ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1325 – 1332ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 9
Gene namesi
Name:Abca9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2386796. Abca9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei863 – 883HelicalSequence analysisAdd BLAST21
Transmembranei1025 – 1045HelicalSequence analysisAdd BLAST21
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Transmembranei1107 – 1127HelicalSequence analysisAdd BLAST21
Transmembranei1135 – 1155HelicalSequence analysisAdd BLAST21
Transmembranei1163 – 1183HelicalSequence analysisAdd BLAST21
Transmembranei1199 – 1219HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506811 – 1623ATP-binding cassette sub-family A member 9Add BLAST1623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K449.
PaxDbiQ8K449.
PeptideAtlasiQ8K449.
PRIDEiQ8K449.

PTM databases

iPTMnetiQ8K449.
PhosphoSitePlusiQ8K449.

Expressioni

Tissue specificityi

Highly expressed in heart and to lower extent in kidney, brain and spleen.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiENSMUSG00000041797.
GenevisibleiQ8K449. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036338.

Structurei

3D structure databases

ProteinModelPortaliQ8K449.
SMRiQ8K449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini481 – 716ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1287 – 1520ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8K449.
KOiK05651.
OMAiCLEMKFR.
OrthoDBiEOG091G00AG.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKRHLRLGQ QMWALLCKNW LRKFRMRRET LLEWLFSLLL ILFVYQLSSN
60 70 80 90 100
LHQVHDAPEM SVVDLGRVDN FNDSNYMMVF APESEATHEI MNKVASAPFM
110 120 130 140 150
KGRTIVACPD EKSMNELDLN YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK
160 170 180 190 200
EHKDHSAPCE PLNNKMICEN SAFWEKGFVA FQAAINAGII EMITNHSVME
210 220 230 240 250
ELMSVIGSNM KMPPFIAQGG VATDFFIFFC VISFSSLIYY LSVNITQERQ
260 270 280 290 300
YMTTLMAMMG LRESAFWLSW SLMYAGFILV VAVLMSLIVK SAQVVVLTGF
310 320 330 340 350
MVVFLLFLFY GLSLITLSFL MSVLIKKPFL TGLAIFILTV FWGSLGFTAL
360 370 380 390 400
YKHLPAFVEW TLCFLSPFAF TTGMAQLIHL DYDVNSNVNL NSPNNSYLIM
410 420 430 440 450
ATLFMLVLDA LLYLVLALYF DKITLSKYGH QRSPLFFLKS SYWFKRRGAS
460 470 480 490 500
HVVLENEIDS DPSLNDSLEP VSPEFQGKEA IRIKNLKKEY SGKHGKVEAL
510 520 530 540 550
RGLGFDIYEG QITALLGHSG AGKTTLINTL SGLSPPTTGS VTIYNQTVSE
560 570 580 590 600
MDDSDAVLTI TGVCPQSNVQ FGFLTVRENL RLFAKIKGIL PHEVEQEVQQ
610 620 630 640 650
VLQDLEMENI QDILAQNLSG GQKRKLTLGI AILGDPQVLL LDEPTAGLDP
660 670 680 690 700
LSRHRIWNLL KERRAGRVIV FSTQFMDEAD ILADRKVFIS NGRLKCAGSS
710 720 730 740 750
LFLKKKWGIG YHLSLHLNEA CDPEGITSLV KKHISDARLT TQSEERLVYI
760 770 780 790 800
LPLERTNKFP DLYRDLDRCS NQGIEDYGVS MTTLNEVFLK LEGKSMADES
810 820 830 840 850
DVGICGRLQS DGARDMESLV ELEQVLSLDS SGSSVSGMAL WRQQLCAVAK
860 870 880 890 900
VRFFKLKNER KSLMTVLLLF GISFVPQLLE HLVYKVYHKS YSWGLSPSMY
910 920 930 940 950
FLSPGQPPQD PLTHLLVINR TGSSIDNFVH ALRQQGIALD LDALGTRNGT
960 970 980 990 1000
EEALYNGAIT VLGEEKALRF SVACNAKRLN CFPVLMDIIS NGLLGIFNSS
1010 1020 1030 1040 1050
ERIQTDRSTV FEEHMLYEYG FMSNAFFWIP VAASLTPYIA MGSISDHKKK
1060 1070 1080 1090 1100
VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI LFLMQIMDSV FSSEEFISVM
1110 1120 1130 1140 1150
ESLLIQIPCS IGYASSLIFM TYVISFIFRN GRKNSGIWSF FFLIVTIFFI
1160 1170 1180 1190 1200
IATDINEYGF LELLICTFLV PPFTLIGSLL IFSEVSYDSV DYLGTSESQL
1210 1220 1230 1240 1250
VFLALLIPYL HFLLFFFILR CLERYLRKKS LRVDPVFRIS PRSCPAVPNP
1260 1270 1280 1290 1300
EEPGEEDEDV QMERVRTTGA MATLQTDEKP VIIASCLRKE YIGRTKRCFS
1310 1320 1330 1340 1350
KMKKKIATRN ISFCVKKGEV LGLLGHNGAG KSTTISMITG DTIPTAGQVF
1360 1370 1380 1390 1400
LKGSGGGAAL GFLGYCPQEN VLWPNLTVKE HLELYAAVKG LKKKDAVVTI
1410 1420 1430 1440 1450
TRLVNALKLQ DHLKALVRTL SEGVKRKLCF VLSILGNPPV VLLDEPSTGM
1460 1470 1480 1490 1500
DPEGQQQMWQ AIRATFTNTE RGALLTTHYM AEAEAVCDRV AIMVSGRLRC
1510 1520 1530 1540 1550
IGSIQHLKSK FGKDYLLEMK VKTPSQVEPL NTEIMRLFPQ AARQERYSSL
1560 1570 1580 1590 1600
MVYKLPVEDV RPLSEAFFKL ERLKENFDLE EYSLSQSTLE QVFLELSKEQ
1610 1620
ELDDFGEEAN SSVKWKLLPQ EEL
Length:1,623
Mass (Da):183,114
Last modified:June 28, 2011 - v2
Checksum:i666E67039EDB2627
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → T in AAM90894 (PubMed:12532264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491299 mRNA. Translation: AAM90894.1.
AL603792 Genomic DNA. Translation: CAM20975.1.
CH466558 Genomic DNA. Translation: EDL34378.1.
AK029256 mRNA. Translation: BAC26358.1.
CCDSiCCDS25589.1.
RefSeqiNP_671753.2. NM_147220.2.
XP_017169975.1. XM_017314486.1.
UniGeneiMm.291459.

Genome annotation databases

EnsembliENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
GeneIDi217262.
KEGGimmu:217262.
UCSCiuc007mdh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491299 mRNA. Translation: AAM90894.1.
AL603792 Genomic DNA. Translation: CAM20975.1.
CH466558 Genomic DNA. Translation: EDL34378.1.
AK029256 mRNA. Translation: BAC26358.1.
CCDSiCCDS25589.1.
RefSeqiNP_671753.2. NM_147220.2.
XP_017169975.1. XM_017314486.1.
UniGeneiMm.291459.

3D structure databases

ProteinModelPortaliQ8K449.
SMRiQ8K449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036338.

PTM databases

iPTMnetiQ8K449.
PhosphoSitePlusiQ8K449.

Proteomic databases

MaxQBiQ8K449.
PaxDbiQ8K449.
PeptideAtlasiQ8K449.
PRIDEiQ8K449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
GeneIDi217262.
KEGGimmu:217262.
UCSCiuc007mdh.1. mouse.

Organism-specific databases

CTDi10350.
MGIiMGI:2386796. Abca9.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8K449.
KOiK05651.
OMAiCLEMKFR.
OrthoDBiEOG091G00AG.
TreeFamiTF105192.

Miscellaneous databases

PROiQ8K449.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041797.
GenevisibleiQ8K449. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCA9_MOUSE
AccessioniPrimary (citable) accession number: Q8K449
Secondary accession number(s): A2A6R5, Q8C114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.