Q8K449 (ABCA9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family A member 9

Gene names

Name:

Abca9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in monocyte differentiation and lipid homeostasis By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Highly expressed in heart and to lower extent in kidney, brain and spleen. Ref.1
Induction	Down-regulated by digoxin. Ref.5
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1623	1623	ATP-binding cassette sub-family A member 9		PRO_0000250681
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Transmembrane	295 – 315	21	Helical; Potential
	Transmembrane	329 – 349	21	Helical; Potential
	Transmembrane	354 – 374	21	Helical; Potential
	Transmembrane	398 – 418	21	Helical; Potential
	Transmembrane	863 – 883	21	Helical; Potential
	Transmembrane	1025 – 1045	21	Helical; Potential
	Transmembrane	1071 – 1091	21	Helical; Potential
	Transmembrane	1107 – 1127	21	Helical; Potential
	Transmembrane	1135 – 1155	21	Helical; Potential
	Transmembrane	1163 – 1183	21	Helical; Potential
	Transmembrane	1199 – 1219	21	Helical; Potential
	Domain	481 – 716	236	ABC transporter 1
	Domain	1287 – 1520	234	ABC transporter 2
	Nucleotide binding	517 – 524	8	ATP 1 Potential
	Nucleotide binding	1325 – 1332	8	ATP 2 Potential
Amino acid modifications
	Modified residue	113	1	Phosphoserine Ref.6
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	57	1	A → T in AAM90894. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8K449 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: 666E67039EDB2627	FASTA	1,623	183,114
	10 20 30 40 50 60 MRKRHLRLGQ QMWALLCKNW LRKFRMRRET LLEWLFSLLL ILFVYQLSSN LHQVHDAPEM 70 80 90 100 110 120 SVVDLGRVDN FNDSNYMMVF APESEATHEI MNKVASAPFM KGRTIVACPD EKSMNELDLN 130 140 150 160 170 180 YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK EHKDHSAPCE PLNNKMICEN SAFWEKGFVA 190 200 210 220 230 240 FQAAINAGII EMITNHSVME ELMSVIGSNM KMPPFIAQGG VATDFFIFFC VISFSSLIYY 250 260 270 280 290 300 LSVNITQERQ YMTTLMAMMG LRESAFWLSW SLMYAGFILV VAVLMSLIVK SAQVVVLTGF 310 320 330 340 350 360 MVVFLLFLFY GLSLITLSFL MSVLIKKPFL TGLAIFILTV FWGSLGFTAL YKHLPAFVEW 370 380 390 400 410 420 TLCFLSPFAF TTGMAQLIHL DYDVNSNVNL NSPNNSYLIM ATLFMLVLDA LLYLVLALYF 430 440 450 460 470 480 DKITLSKYGH QRSPLFFLKS SYWFKRRGAS HVVLENEIDS DPSLNDSLEP VSPEFQGKEA 490 500 510 520 530 540 IRIKNLKKEY SGKHGKVEAL RGLGFDIYEG QITALLGHSG AGKTTLINTL SGLSPPTTGS 550 560 570 580 590 600 VTIYNQTVSE MDDSDAVLTI TGVCPQSNVQ FGFLTVRENL RLFAKIKGIL PHEVEQEVQQ 610 620 630 640 650 660 VLQDLEMENI QDILAQNLSG GQKRKLTLGI AILGDPQVLL LDEPTAGLDP LSRHRIWNLL 670 680 690 700 710 720 KERRAGRVIV FSTQFMDEAD ILADRKVFIS NGRLKCAGSS LFLKKKWGIG YHLSLHLNEA 730 740 750 760 770 780 CDPEGITSLV KKHISDARLT TQSEERLVYI LPLERTNKFP DLYRDLDRCS NQGIEDYGVS 790 800 810 820 830 840 MTTLNEVFLK LEGKSMADES DVGICGRLQS DGARDMESLV ELEQVLSLDS SGSSVSGMAL 850 860 870 880 890 900 WRQQLCAVAK VRFFKLKNER KSLMTVLLLF GISFVPQLLE HLVYKVYHKS YSWGLSPSMY 910 920 930 940 950 960 FLSPGQPPQD PLTHLLVINR TGSSIDNFVH ALRQQGIALD LDALGTRNGT EEALYNGAIT 970 980 990 1000 1010 1020 VLGEEKALRF SVACNAKRLN CFPVLMDIIS NGLLGIFNSS ERIQTDRSTV FEEHMLYEYG 1030 1040 1050 1060 1070 1080 FMSNAFFWIP VAASLTPYIA MGSISDHKKK VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI 1090 1100 1110 1120 1130 1140 LFLMQIMDSV FSSEEFISVM ESLLIQIPCS IGYASSLIFM TYVISFIFRN GRKNSGIWSF 1150 1160 1170 1180 1190 1200 FFLIVTIFFI IATDINEYGF LELLICTFLV PPFTLIGSLL IFSEVSYDSV DYLGTSESQL 1210 1220 1230 1240 1250 1260 VFLALLIPYL HFLLFFFILR CLERYLRKKS LRVDPVFRIS PRSCPAVPNP EEPGEEDEDV 1270 1280 1290 1300 1310 1320 QMERVRTTGA MATLQTDEKP VIIASCLRKE YIGRTKRCFS KMKKKIATRN ISFCVKKGEV 1330 1340 1350 1360 1370 1380 LGLLGHNGAG KSTTISMITG DTIPTAGQVF LKGSGGGAAL GFLGYCPQEN VLWPNLTVKE 1390 1400 1410 1420 1430 1440 HLELYAAVKG LKKKDAVVTI TRLVNALKLQ DHLKALVRTL SEGVKRKLCF VLSILGNPPV 1450 1460 1470 1480 1490 1500 VLLDEPSTGM DPEGQQQMWQ AIRATFTNTE RGALLTTHYM AEAEAVCDRV AIMVSGRLRC 1510 1520 1530 1540 1550 1560 IGSIQHLKSK FGKDYLLEMK VKTPSQVEPL NTEIMRLFPQ AARQERYSSL MVYKLPVEDV 1570 1580 1590 1600 1610 1620 RPLSEAFFKL ERLKENFDLE EYSLSQSTLE QVFLELSKEQ ELDDFGEEAN SSVKWKLLPQ EEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes." Annilo T., Chen Z.-Q., Shulenin S., Dean M. Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1623. Strain: C57BL/6J. Tissue: Head.
[5]	"Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver." Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S. Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF491299 mRNA. Translation: AAM90894.1. AL603792 Genomic DNA. Translation: CAM20975.1. CH466558 Genomic DNA. Translation: EDL34378.1. AK029256 mRNA. Translation: BAC26358.1.
IPI	IPI00170152.
RefSeq	NP_671753.2. NM_147220.2.
UniGene	Mm.291459.
3D structure databases
ProteinModelPortal	Q8K449.
ModBase	Search...
PTM databases
PhosphoSite	Q8K449.
Proteomic databases
PaxDb	Q8K449.
PRIDE	Q8K449.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
GeneID	217262.
KEGG	mmu:217262.
Organism-specific databases
CTD	10350.
MGI	MGI:2386796. Abca9.
Phylogenomic databases
eggNOG	COG1131.
GeneTree	ENSGT00690000101975.
HOGENOM	HOG000231057.
HOVERGEN	HBG079884.
InParanoid	A2A6R5.
KO	K05651.
OMA	IQILCSI.
OrthoDB	EOG40P45W.
Gene expression databases
Bgee	Q8K449.
Genevestigator	Q8K449.
GermOnline	ENSMUSG00000041797. Mus musculus.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026082. ABC_A. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
PANTHER	PTHR19229. PTHR19229. 1 hit.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	375711.
SOURCE	Search...

Entry information

Entry name

ABCA9_MOUSE

Accession

Primary (citable) accession number: Q8K449
Secondary accession number(s): A2A6R5, Q8C114

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program