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Q8K449

- ABCA9_MOUSE

UniProt

Q8K449 - ABCA9_MOUSE

Protein

ATP-binding cassette sub-family A member 9

Gene

Abca9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    May play a role in monocyte differentiation and lipid homeostasis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi517 – 5248ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1325 – 13328ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family A member 9
    Gene namesi
    Name:Abca9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2386796. Abca9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16231623ATP-binding cassette sub-family A member 9PRO_0000250681Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8K449.
    PRIDEiQ8K449.

    PTM databases

    PhosphoSiteiQ8K449.

    Expressioni

    Tissue specificityi

    Highly expressed in heart and to lower extent in kidney, brain and spleen.1 Publication

    Inductioni

    Down-regulated by digoxin.1 Publication

    Gene expression databases

    BgeeiQ8K449.
    GenevestigatoriQ8K449.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K449.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei863 – 88321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1025 – 104521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1071 – 109121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1107 – 112721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1135 – 115521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1163 – 118321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1199 – 121921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini481 – 716236ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1287 – 1520234ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00740000115040.
    HOGENOMiHOG000231057.
    HOVERGENiHBG079884.
    InParanoidiA2A6R5.
    KOiK05651.
    OMAiESDIGIW.
    OrthoDBiEOG73Z2SB.
    TreeFamiTF105192.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKRHLRLGQ QMWALLCKNW LRKFRMRRET LLEWLFSLLL ILFVYQLSSN     50
    LHQVHDAPEM SVVDLGRVDN FNDSNYMMVF APESEATHEI MNKVASAPFM 100
    KGRTIVACPD EKSMNELDLN YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK 150
    EHKDHSAPCE PLNNKMICEN SAFWEKGFVA FQAAINAGII EMITNHSVME 200
    ELMSVIGSNM KMPPFIAQGG VATDFFIFFC VISFSSLIYY LSVNITQERQ 250
    YMTTLMAMMG LRESAFWLSW SLMYAGFILV VAVLMSLIVK SAQVVVLTGF 300
    MVVFLLFLFY GLSLITLSFL MSVLIKKPFL TGLAIFILTV FWGSLGFTAL 350
    YKHLPAFVEW TLCFLSPFAF TTGMAQLIHL DYDVNSNVNL NSPNNSYLIM 400
    ATLFMLVLDA LLYLVLALYF DKITLSKYGH QRSPLFFLKS SYWFKRRGAS 450
    HVVLENEIDS DPSLNDSLEP VSPEFQGKEA IRIKNLKKEY SGKHGKVEAL 500
    RGLGFDIYEG QITALLGHSG AGKTTLINTL SGLSPPTTGS VTIYNQTVSE 550
    MDDSDAVLTI TGVCPQSNVQ FGFLTVRENL RLFAKIKGIL PHEVEQEVQQ 600
    VLQDLEMENI QDILAQNLSG GQKRKLTLGI AILGDPQVLL LDEPTAGLDP 650
    LSRHRIWNLL KERRAGRVIV FSTQFMDEAD ILADRKVFIS NGRLKCAGSS 700
    LFLKKKWGIG YHLSLHLNEA CDPEGITSLV KKHISDARLT TQSEERLVYI 750
    LPLERTNKFP DLYRDLDRCS NQGIEDYGVS MTTLNEVFLK LEGKSMADES 800
    DVGICGRLQS DGARDMESLV ELEQVLSLDS SGSSVSGMAL WRQQLCAVAK 850
    VRFFKLKNER KSLMTVLLLF GISFVPQLLE HLVYKVYHKS YSWGLSPSMY 900
    FLSPGQPPQD PLTHLLVINR TGSSIDNFVH ALRQQGIALD LDALGTRNGT 950
    EEALYNGAIT VLGEEKALRF SVACNAKRLN CFPVLMDIIS NGLLGIFNSS 1000
    ERIQTDRSTV FEEHMLYEYG FMSNAFFWIP VAASLTPYIA MGSISDHKKK 1050
    VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI LFLMQIMDSV FSSEEFISVM 1100
    ESLLIQIPCS IGYASSLIFM TYVISFIFRN GRKNSGIWSF FFLIVTIFFI 1150
    IATDINEYGF LELLICTFLV PPFTLIGSLL IFSEVSYDSV DYLGTSESQL 1200
    VFLALLIPYL HFLLFFFILR CLERYLRKKS LRVDPVFRIS PRSCPAVPNP 1250
    EEPGEEDEDV QMERVRTTGA MATLQTDEKP VIIASCLRKE YIGRTKRCFS 1300
    KMKKKIATRN ISFCVKKGEV LGLLGHNGAG KSTTISMITG DTIPTAGQVF 1350
    LKGSGGGAAL GFLGYCPQEN VLWPNLTVKE HLELYAAVKG LKKKDAVVTI 1400
    TRLVNALKLQ DHLKALVRTL SEGVKRKLCF VLSILGNPPV VLLDEPSTGM 1450
    DPEGQQQMWQ AIRATFTNTE RGALLTTHYM AEAEAVCDRV AIMVSGRLRC 1500
    IGSIQHLKSK FGKDYLLEMK VKTPSQVEPL NTEIMRLFPQ AARQERYSSL 1550
    MVYKLPVEDV RPLSEAFFKL ERLKENFDLE EYSLSQSTLE QVFLELSKEQ 1600
    ELDDFGEEAN SSVKWKLLPQ EEL 1623
    Length:1,623
    Mass (Da):183,114
    Last modified:June 28, 2011 - v2
    Checksum:i666E67039EDB2627
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571A → T in AAM90894. (PubMed:12532264)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF491299 mRNA. Translation: AAM90894.1.
    AL603792 Genomic DNA. Translation: CAM20975.1.
    CH466558 Genomic DNA. Translation: EDL34378.1.
    AK029256 mRNA. Translation: BAC26358.1.
    CCDSiCCDS25589.1.
    RefSeqiNP_671753.2. NM_147220.2.
    XP_006533127.1. XM_006533064.1.
    UniGeneiMm.291459.

    Genome annotation databases

    EnsembliENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
    GeneIDi217262.
    KEGGimmu:217262.
    UCSCiuc007mdh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF491299 mRNA. Translation: AAM90894.1 .
    AL603792 Genomic DNA. Translation: CAM20975.1 .
    CH466558 Genomic DNA. Translation: EDL34378.1 .
    AK029256 mRNA. Translation: BAC26358.1 .
    CCDSi CCDS25589.1.
    RefSeqi NP_671753.2. NM_147220.2.
    XP_006533127.1. XM_006533064.1.
    UniGenei Mm.291459.

    3D structure databases

    ProteinModelPortali Q8K449.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K449.

    Proteomic databases

    PaxDbi Q8K449.
    PRIDEi Q8K449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044850 ; ENSMUSP00000036338 ; ENSMUSG00000041797 .
    GeneIDi 217262.
    KEGGi mmu:217262.
    UCSCi uc007mdh.1. mouse.

    Organism-specific databases

    CTDi 10350.
    MGIi MGI:2386796. Abca9.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00740000115040.
    HOGENOMi HOG000231057.
    HOVERGENi HBG079884.
    InParanoidi A2A6R5.
    KOi K05651.
    OMAi ESDIGIW.
    OrthoDBi EOG73Z2SB.
    TreeFami TF105192.

    Miscellaneous databases

    NextBioi 375711.
    PROi Q8K449.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K449.
    Genevestigatori Q8K449.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
      Annilo T., Chen Z.-Q., Shulenin S., Dean M.
      Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1623.
      Strain: C57BL/6J.
      Tissue: Head.
    5. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
      Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
      Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiABCA9_MOUSE
    AccessioniPrimary (citable) accession number: Q8K449
    Secondary accession number(s): A2A6R5, Q8C114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3