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Q8K449 (ABCA9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family A member 9
Gene names
Name:Abca9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1623 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in monocyte differentiation and lipid homeostasis By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Highly expressed in heart and to lower extent in kidney, brain and spleen. Ref.1

Induction

Down-regulated by digoxin. Ref.5

Sequence similarities

Belongs to the ABC transporter superfamily. ABCA family.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16231623ATP-binding cassette sub-family A member 9
PRO_0000250681

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane295 – 31521Helical; Potential
Transmembrane329 – 34921Helical; Potential
Transmembrane354 – 37421Helical; Potential
Transmembrane398 – 41821Helical; Potential
Transmembrane863 – 88321Helical; Potential
Transmembrane1025 – 104521Helical; Potential
Transmembrane1071 – 109121Helical; Potential
Transmembrane1107 – 112721Helical; Potential
Transmembrane1135 – 115521Helical; Potential
Transmembrane1163 – 118321Helical; Potential
Transmembrane1199 – 121921Helical; Potential
Domain481 – 716236ABC transporter 1
Domain1287 – 1520234ABC transporter 2
Nucleotide binding517 – 5248ATP 1 Potential
Nucleotide binding1325 – 13328ATP 2 Potential

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict571A → T in AAM90894. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K449 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 666E67039EDB2627

FASTA1,623183,114
        10         20         30         40         50         60 
MRKRHLRLGQ QMWALLCKNW LRKFRMRRET LLEWLFSLLL ILFVYQLSSN LHQVHDAPEM 

        70         80         90        100        110        120 
SVVDLGRVDN FNDSNYMMVF APESEATHEI MNKVASAPFM KGRTIVACPD EKSMNELDLN 

       130        140        150        160        170        180 
YSIDAVRVIF KDTFSYHLKF SWGQRIPKTK EHKDHSAPCE PLNNKMICEN SAFWEKGFVA 

       190        200        210        220        230        240 
FQAAINAGII EMITNHSVME ELMSVIGSNM KMPPFIAQGG VATDFFIFFC VISFSSLIYY 

       250        260        270        280        290        300 
LSVNITQERQ YMTTLMAMMG LRESAFWLSW SLMYAGFILV VAVLMSLIVK SAQVVVLTGF 

       310        320        330        340        350        360 
MVVFLLFLFY GLSLITLSFL MSVLIKKPFL TGLAIFILTV FWGSLGFTAL YKHLPAFVEW 

       370        380        390        400        410        420 
TLCFLSPFAF TTGMAQLIHL DYDVNSNVNL NSPNNSYLIM ATLFMLVLDA LLYLVLALYF 

       430        440        450        460        470        480 
DKITLSKYGH QRSPLFFLKS SYWFKRRGAS HVVLENEIDS DPSLNDSLEP VSPEFQGKEA 

       490        500        510        520        530        540 
IRIKNLKKEY SGKHGKVEAL RGLGFDIYEG QITALLGHSG AGKTTLINTL SGLSPPTTGS 

       550        560        570        580        590        600 
VTIYNQTVSE MDDSDAVLTI TGVCPQSNVQ FGFLTVRENL RLFAKIKGIL PHEVEQEVQQ 

       610        620        630        640        650        660 
VLQDLEMENI QDILAQNLSG GQKRKLTLGI AILGDPQVLL LDEPTAGLDP LSRHRIWNLL 

       670        680        690        700        710        720 
KERRAGRVIV FSTQFMDEAD ILADRKVFIS NGRLKCAGSS LFLKKKWGIG YHLSLHLNEA 

       730        740        750        760        770        780 
CDPEGITSLV KKHISDARLT TQSEERLVYI LPLERTNKFP DLYRDLDRCS NQGIEDYGVS 

       790        800        810        820        830        840 
MTTLNEVFLK LEGKSMADES DVGICGRLQS DGARDMESLV ELEQVLSLDS SGSSVSGMAL 

       850        860        870        880        890        900 
WRQQLCAVAK VRFFKLKNER KSLMTVLLLF GISFVPQLLE HLVYKVYHKS YSWGLSPSMY 

       910        920        930        940        950        960 
FLSPGQPPQD PLTHLLVINR TGSSIDNFVH ALRQQGIALD LDALGTRNGT EEALYNGAIT 

       970        980        990       1000       1010       1020 
VLGEEKALRF SVACNAKRLN CFPVLMDIIS NGLLGIFNSS ERIQTDRSTV FEEHMLYEYG 

      1030       1040       1050       1060       1070       1080 
FMSNAFFWIP VAASLTPYIA MGSISDHKKK VLSQLWTSGL YPSAYWCGQA LVDIPIYFLI 

      1090       1100       1110       1120       1130       1140 
LFLMQIMDSV FSSEEFISVM ESLLIQIPCS IGYASSLIFM TYVISFIFRN GRKNSGIWSF 

      1150       1160       1170       1180       1190       1200 
FFLIVTIFFI IATDINEYGF LELLICTFLV PPFTLIGSLL IFSEVSYDSV DYLGTSESQL 

      1210       1220       1230       1240       1250       1260 
VFLALLIPYL HFLLFFFILR CLERYLRKKS LRVDPVFRIS PRSCPAVPNP EEPGEEDEDV 

      1270       1280       1290       1300       1310       1320 
QMERVRTTGA MATLQTDEKP VIIASCLRKE YIGRTKRCFS KMKKKIATRN ISFCVKKGEV 

      1330       1340       1350       1360       1370       1380 
LGLLGHNGAG KSTTISMITG DTIPTAGQVF LKGSGGGAAL GFLGYCPQEN VLWPNLTVKE 

      1390       1400       1410       1420       1430       1440 
HLELYAAVKG LKKKDAVVTI TRLVNALKLQ DHLKALVRTL SEGVKRKLCF VLSILGNPPV 

      1450       1460       1470       1480       1490       1500 
VLLDEPSTGM DPEGQQQMWQ AIRATFTNTE RGALLTTHYM AEAEAVCDRV AIMVSGRLRC 

      1510       1520       1530       1540       1550       1560 
IGSIQHLKSK FGKDYLLEMK VKTPSQVEPL NTEIMRLFPQ AARQERYSSL MVYKLPVEDV 

      1570       1580       1590       1600       1610       1620 
RPLSEAFFKL ERLKENFDLE EYSLSQSTLE QVFLELSKEQ ELDDFGEEAN SSVKWKLLPQ 


EEL 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
Annilo T., Chen Z.-Q., Shulenin S., Dean M.
Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1623.
Strain: C57BL/6J.
Tissue: Head.
[5]"Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF491299 mRNA. Translation: AAM90894.1.
AL603792 Genomic DNA. Translation: CAM20975.1.
CH466558 Genomic DNA. Translation: EDL34378.1.
AK029256 mRNA. Translation: BAC26358.1.
CCDSCCDS25589.1.
RefSeqNP_671753.2. NM_147220.2.
XP_006533127.1. XM_006533064.1.
UniGeneMm.291459.

3D structure databases

ProteinModelPortalQ8K449.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K449.

Proteomic databases

PaxDbQ8K449.
PRIDEQ8K449.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044850; ENSMUSP00000036338; ENSMUSG00000041797.
GeneID217262.
KEGGmmu:217262.
UCSCuc007mdh.1. mouse.

Organism-specific databases

CTD10350.
MGIMGI:2386796. Abca9.

Phylogenomic databases

eggNOGCOG1131.
GeneTreeENSGT00740000115040.
HOGENOMHOG000231057.
HOVERGENHBG079884.
InParanoidA2A6R5.
KOK05651.
OMAESDIGIW.
OrthoDBEOG73Z2SB.
TreeFamTF105192.

Gene expression databases

BgeeQ8K449.
GenevestigatorQ8K449.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR19229. PTHR19229. 1 hit.
PfamPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio375711.
PROQ8K449.
SOURCESearch...

Entry information

Entry nameABCA9_MOUSE
AccessionPrimary (citable) accession number: Q8K449
Secondary accession number(s): A2A6R5, Q8C114
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot