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Q8K448

- ABCA5_MOUSE

UniProt

Q8K448 - ABCA5_MOUSE

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Protein

ATP-binding cassette sub-family A member 5

Gene
Abca5, Kiaa1888
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the processing of autolysosomes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1 Reviewed prediction
Nucleotide bindingi1333 – 13408ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. high-density lipoprotein particle remodeling Source: BHF-UCL
  3. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  4. reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 5
Gene namesi
Name:Abca5
Synonyms:Kiaa1888
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2386607. Abca5.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein By similarity. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Reviewed predictionAdd
BLAST
Transmembranei220 – 24021Helical; Reviewed predictionAdd
BLAST
Transmembranei264 – 28421Helical; Reviewed predictionAdd
BLAST
Transmembranei297 – 31721Helical; Reviewed predictionAdd
BLAST
Transmembranei328 – 34821Helical; Reviewed predictionAdd
BLAST
Transmembranei355 – 37521Helical; Reviewed predictionAdd
BLAST
Transmembranei396 – 41621Helical; Reviewed predictionAdd
BLAST
Transmembranei864 – 88421Helical; Reviewed predictionAdd
BLAST
Transmembranei967 – 98721Helical; Reviewed predictionAdd
BLAST
Transmembranei1021 – 104121Helical; Reviewed predictionAdd
BLAST
Transmembranei1071 – 109121Helical; Reviewed predictionAdd
BLAST
Transmembranei1102 – 112221Helical; Reviewed predictionAdd
BLAST
Transmembranei1138 – 115821Helical; Reviewed predictionAdd
BLAST
Transmembranei1164 – 118421Helical; Reviewed predictionAdd
BLAST
Transmembranei1207 – 122721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: BHF-UCL
  4. late endosome membrane Source: UniProtKB-SubCell
  5. lysosomal membrane Source: UniProtKB-SubCell
  6. lysosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display hypothyroidism and lethal heart abnormalities that may be due to altered autolysosomes processing.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16421642ATP-binding cassette sub-family A member 5PRO_0000250670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi919 – 9191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi996 – 9961N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K448.
PRIDEiQ8K448.

PTM databases

PhosphoSiteiQ8K448.

Expressioni

Tissue specificityi

Expressed in cardiomyocytes, oligodendrocytes and astrocytes in brain, alveolar type 2 cells in lung and follicular cells in the thyroid gland (at protein level). Detected in brain, testis, lung, heart, liver, kidney, skeletal muscle and placenta.2 Publications

Developmental stagei

Expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

ArrayExpressiQ8K448.
BgeeiQ8K448.
GenevestigatoriQ8K448.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047927.

Structurei

3D structure databases

ProteinModelPortaliQ8K448.
SMRiQ8K448. Positions 395-729, 1265-1561.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 713236ABC transporter 1Add
BLAST
Domaini1290 – 1533244ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000115040.
HOVERGENiHBG079884.
InParanoidiQ8K448.
KOiK05648.
OMAiDGFASIY.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8K448.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K448-1 [UniParc]FASTAAdd to Basket

« Hide

MATAIRDVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILVS     50
MMHPNKKYEE VSDIELSPMD KFSLSNVILG YTPVTNITSS IMQRVSTDHL 100
PKVIVTEEYA NEKELVAASL SKSSNFVGVV FKDTMSYELR FFPEMIPVSS 150
IYMNSREGCS KTCDAAQYWS LGFTVLQASI DAAIIQLKTN VSVWSELEST 200
KAVIMGEAAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKLKE 250
FLKIMGLHDT AFWLSWVLLY ASLIFLMSLL MAVIATASSL FPQSSSIVIF 300
LLFFLYGLSS VFFALMLTPL FKKSKHVGVV EFFVTVVFGF VGLLIVLIES 350
FPRSLVWLFS PLCQCAFLIG IAQVMHLEDF NEGALFSNLT EGPYPLIITI 400
IMLALDSVFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKNKRNYKEL 450
SEGNINGNIS LNEIVEPVSS EFIGKEAIRI SGIQKSYRKK TENVEALRNL 500
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE 550
MFEARKMIGI CPQSDINFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL 600
DLDMQAIKDN QAKKLSGGQK RKLSVGIAVL GNPKILLLDE PTAGMDPCSR 650
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSIFL 700
KSKWGIGYRL SMYIDRYCAT ESLSSLVRQH IPAAALLQQN DQQLVYSLPF 750
KDMDKFSGLF SALDIHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS 800
VFTQQPREEE TDSKSFDEME QSLLILSETK ASSVSTMSLW KQQVSTIAKF 850
HFLSLKRESK SVRAVLLLLL IFFAVQIFMF FLHHSFKNAV VPIKLVPDLY 900
FLKPGDKPHK YKTSLLLQNS TDSDINGLIE FFAHQNIMVA MFNDSDYVSA 950
APHSAALNVV RSEKDYVFSA VFNSTMVYCL PVMMNIISNY YLYHLNVTEA 1000
IQTWSTPFIQ EITDIVFKIE LYFQAALLGI IVTAMPPYFA MENAENHKIK 1050
AYTQLKLSGL LPSAYWVGQA VVDIPLFFVV LILMLGSLFA FHHGLYFYPA 1100
KFLAVVFCLI AYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVTALACVA 1150
ITETTFFLQY AVTAVFHYTF CIAIPIYPLL GCLISFIKGS WKNMPKNENT 1200
YNPWDRLLVA VIMPYLQCIL WIFLLQHYEK IHGGRSIRKD PFFRALSQKA 1250
KNKKFPEPPI NEDEDEDVKA ERLKVKELMG CQCCEEKPAI MVCNLHKEYD 1300
DKKDFLHSRK TTKVATKYIS FCVKKGEILG LLGPNGAGKS TVINTLVGDV 1350
EPTSGKIFLG DYGSHSSEDD ESIKCMGYCP QTNPLWPDLT LQEHFEIYGA 1400
VKGMSPGDMK EVISRITKAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN 1450
PQVTLLDEPS TGMDPRAKQH MWRAIRTAFK NKKRAALLTT HYMEEAEAVC 1500
DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEIDRLQREI 1550
QYIFPNASRQ ESFSSILAFK IPKEDVQSLS QSFAKLEEAK RTFAIEEYSF 1600
SQATLEQVFV ELTKEQEEED NSCGTLASTL WWERTQEDRV VF 1642
Length:1,642
Mass (Da):185,895
Last modified:October 3, 2006 - v2
Checksum:i177A5FC0B075DFC5
GO

Sequence cautioni

The sequence BAC28896.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961S → C in BAC32984. 1 Publication
Sequence conflicti113 – 1131K → E in BAE41431. 1 Publication
Sequence conflicti132 – 1321K → E in BAC32984. 1 Publication
Sequence conflicti188 – 1881K → E in AAM90895. 1 Publication
Sequence conflicti303 – 3031F → V in AAM90895. 1 Publication
Sequence conflicti384 – 3841A → P in BAC32984. 1 Publication
Sequence conflicti530 – 5301L → P in AAM90895. 1 Publication
Sequence conflicti551 – 5511M → I in AAM90895. 1 Publication
Sequence conflicti809 – 8091E → G in AAM90895. 1 Publication
Sequence conflicti839 – 8391L → P in AAM90895. 1 Publication
Sequence conflicti856 – 8561K → N in AAM90895. 1 Publication
Sequence conflicti880 – 8801F → V in AAM90895. 1 Publication
Sequence conflicti1231 – 12311I → K in AAH64823. 1 Publication
Sequence conflicti1503 – 15031V → G in AAM90895. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491842 mRNA. Translation: AAM90895.1.
AB097675 mRNA. Translation: BAC66658.1.
AK034961 mRNA. Translation: BAC28896.2. Different initiation.
AK047188 mRNA. Translation: BAC32984.1.
AK138604 mRNA. Translation: BAE23713.1.
AK169879 mRNA. Translation: BAE41431.1.
BC064823 mRNA. Translation: AAH64823.1. Sequence problems.
AK129463 mRNA. Translation: BAC98273.1.
CCDSiCCDS25591.1.
RefSeqiNP_671752.2. NM_147219.2.
XP_006533128.1. XM_006533065.1.
UniGeneiMm.41942.

Genome annotation databases

EnsembliENSMUST00000043961; ENSMUSP00000047927; ENSMUSG00000018800.
GeneIDi217265.
KEGGimmu:217265.
UCSCiuc007mdm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491842 mRNA. Translation: AAM90895.1 .
AB097675 mRNA. Translation: BAC66658.1 .
AK034961 mRNA. Translation: BAC28896.2 . Different initiation.
AK047188 mRNA. Translation: BAC32984.1 .
AK138604 mRNA. Translation: BAE23713.1 .
AK169879 mRNA. Translation: BAE41431.1 .
BC064823 mRNA. Translation: AAH64823.1 . Sequence problems.
AK129463 mRNA. Translation: BAC98273.1 .
CCDSi CCDS25591.1.
RefSeqi NP_671752.2. NM_147219.2.
XP_006533128.1. XM_006533065.1.
UniGenei Mm.41942.

3D structure databases

ProteinModelPortali Q8K448.
SMRi Q8K448. Positions 395-729, 1265-1561.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047927.

PTM databases

PhosphoSitei Q8K448.

Proteomic databases

PaxDbi Q8K448.
PRIDEi Q8K448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043961 ; ENSMUSP00000047927 ; ENSMUSG00000018800 .
GeneIDi 217265.
KEGGi mmu:217265.
UCSCi uc007mdm.1. mouse.

Organism-specific databases

CTDi 23461.
MGIi MGI:2386607. Abca5.
Rougei Search...

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000115040.
HOVERGENi HBG079884.
InParanoidi Q8K448.
KOi K05648.
OMAi DGFASIY.
OrthoDBi EOG73Z2SB.
PhylomeDBi Q8K448.
TreeFami TF105192.

Miscellaneous databases

NextBioi 375715.
PROi Q8K448.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K448.
Bgeei Q8K448.
Genevestigatori Q8K448.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
    Annilo T., Chen Z.-Q., Shulenin S., Dean M.
    Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Liver.
  2. "ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms."
    Kubo Y., Sekiya S., Ohigashi M., Takenaka C., Tamura K., Nada S., Nishi T., Yamamoto A., Yamaguchi A.
    Mol. Cell. Biol. 25:4138-4149(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1589.
    Strain: C57BL/6J.
    Tissue: Cerebellum, Dendritic cell, Embryo and Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1480.
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1034-1642.
    Tissue: Brain.
  6. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
    Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
    Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiABCA5_MOUSE
AccessioniPrimary (citable) accession number: Q8K448
Secondary accession number(s): Q3TE17
, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi