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Protein

ATP-binding cassette sub-family A member 5

Gene

Abca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the processing of autolysosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 521ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1333 – 1340ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 5
Gene namesi
Name:Abca5
Synonyms:Kiaa1888
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2386607. Abca5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei864 – 884HelicalSequence analysisAdd BLAST21
Transmembranei967 – 987HelicalSequence analysisAdd BLAST21
Transmembranei1021 – 1041HelicalSequence analysisAdd BLAST21
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Transmembranei1102 – 1122HelicalSequence analysisAdd BLAST21
Transmembranei1138 – 1158HelicalSequence analysisAdd BLAST21
Transmembranei1164 – 1184HelicalSequence analysisAdd BLAST21
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: BHF-UCL
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display hypothyroidism and lethal heart abnormalities that may be due to altered autolysosomes processing.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506701 – 1642ATP-binding cassette sub-family A member 5Add BLAST1642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi919N-linked (GlcNAc...)Sequence analysis1
Glycosylationi996N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K448.
PaxDbiQ8K448.
PeptideAtlasiQ8K448.
PRIDEiQ8K448.

PTM databases

iPTMnetiQ8K448.
PhosphoSitePlusiQ8K448.

Expressioni

Tissue specificityi

Expressed in cardiomyocytes, oligodendrocytes and astrocytes in brain, alveolar type 2 cells in lung and follicular cells in the thyroid gland (at protein level). Detected in brain, testis, lung, heart, liver, kidney, skeletal muscle and placenta.2 Publications

Developmental stagei

Expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiENSMUSG00000018800.
ExpressionAtlasiQ8K448. baseline and differential.
GenevisibleiQ8K448. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047927.

Structurei

3D structure databases

ProteinModelPortaliQ8K448.
SMRiQ8K448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini478 – 713ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1290 – 1533ABC transporter 2PROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOVERGENiHBG079884.
InParanoidiQ8K448.
KOiK05648.
OMAiYIDRYCA.
OrthoDBiEOG091G00AG.
PhylomeDBiQ8K448.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030367. ABCA5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF100. PTHR19229:SF100. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAIRDVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILVS
60 70 80 90 100
MMHPNKKYEE VSDIELSPMD KFSLSNVILG YTPVTNITSS IMQRVSTDHL
110 120 130 140 150
PKVIVTEEYA NEKELVAASL SKSSNFVGVV FKDTMSYELR FFPEMIPVSS
160 170 180 190 200
IYMNSREGCS KTCDAAQYWS LGFTVLQASI DAAIIQLKTN VSVWSELEST
210 220 230 240 250
KAVIMGEAAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKLKE
260 270 280 290 300
FLKIMGLHDT AFWLSWVLLY ASLIFLMSLL MAVIATASSL FPQSSSIVIF
310 320 330 340 350
LLFFLYGLSS VFFALMLTPL FKKSKHVGVV EFFVTVVFGF VGLLIVLIES
360 370 380 390 400
FPRSLVWLFS PLCQCAFLIG IAQVMHLEDF NEGALFSNLT EGPYPLIITI
410 420 430 440 450
IMLALDSVFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKNKRNYKEL
460 470 480 490 500
SEGNINGNIS LNEIVEPVSS EFIGKEAIRI SGIQKSYRKK TENVEALRNL
510 520 530 540 550
SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE
560 570 580 590 600
MFEARKMIGI CPQSDINFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL
610 620 630 640 650
DLDMQAIKDN QAKKLSGGQK RKLSVGIAVL GNPKILLLDE PTAGMDPCSR
660 670 680 690 700
HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSIFL
710 720 730 740 750
KSKWGIGYRL SMYIDRYCAT ESLSSLVRQH IPAAALLQQN DQQLVYSLPF
760 770 780 790 800
KDMDKFSGLF SALDIHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS
810 820 830 840 850
VFTQQPREEE TDSKSFDEME QSLLILSETK ASSVSTMSLW KQQVSTIAKF
860 870 880 890 900
HFLSLKRESK SVRAVLLLLL IFFAVQIFMF FLHHSFKNAV VPIKLVPDLY
910 920 930 940 950
FLKPGDKPHK YKTSLLLQNS TDSDINGLIE FFAHQNIMVA MFNDSDYVSA
960 970 980 990 1000
APHSAALNVV RSEKDYVFSA VFNSTMVYCL PVMMNIISNY YLYHLNVTEA
1010 1020 1030 1040 1050
IQTWSTPFIQ EITDIVFKIE LYFQAALLGI IVTAMPPYFA MENAENHKIK
1060 1070 1080 1090 1100
AYTQLKLSGL LPSAYWVGQA VVDIPLFFVV LILMLGSLFA FHHGLYFYPA
1110 1120 1130 1140 1150
KFLAVVFCLI AYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVTALACVA
1160 1170 1180 1190 1200
ITETTFFLQY AVTAVFHYTF CIAIPIYPLL GCLISFIKGS WKNMPKNENT
1210 1220 1230 1240 1250
YNPWDRLLVA VIMPYLQCIL WIFLLQHYEK IHGGRSIRKD PFFRALSQKA
1260 1270 1280 1290 1300
KNKKFPEPPI NEDEDEDVKA ERLKVKELMG CQCCEEKPAI MVCNLHKEYD
1310 1320 1330 1340 1350
DKKDFLHSRK TTKVATKYIS FCVKKGEILG LLGPNGAGKS TVINTLVGDV
1360 1370 1380 1390 1400
EPTSGKIFLG DYGSHSSEDD ESIKCMGYCP QTNPLWPDLT LQEHFEIYGA
1410 1420 1430 1440 1450
VKGMSPGDMK EVISRITKAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN
1460 1470 1480 1490 1500
PQVTLLDEPS TGMDPRAKQH MWRAIRTAFK NKKRAALLTT HYMEEAEAVC
1510 1520 1530 1540 1550
DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEIDRLQREI
1560 1570 1580 1590 1600
QYIFPNASRQ ESFSSILAFK IPKEDVQSLS QSFAKLEEAK RTFAIEEYSF
1610 1620 1630 1640
SQATLEQVFV ELTKEQEEED NSCGTLASTL WWERTQEDRV VF
Length:1,642
Mass (Da):185,895
Last modified:October 3, 2006 - v2
Checksum:i177A5FC0B075DFC5
GO

Sequence cautioni

The sequence BAC28896 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96S → C in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti113K → E in BAE41431 (PubMed:16141072).Curated1
Sequence conflicti132K → E in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti188K → E in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti303F → V in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti384A → P in BAC32984 (PubMed:16141072).Curated1
Sequence conflicti530L → P in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti551M → I in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti809E → G in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti839L → P in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti856K → N in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti880F → V in AAM90895 (PubMed:12532264).Curated1
Sequence conflicti1231I → K in AAH64823 (PubMed:15489334).Curated1
Sequence conflicti1503V → G in AAM90895 (PubMed:12532264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491842 mRNA. Translation: AAM90895.1.
AB097675 mRNA. Translation: BAC66658.1.
AK034961 mRNA. Translation: BAC28896.2. Different initiation.
AK047188 mRNA. Translation: BAC32984.1.
AK138604 mRNA. Translation: BAE23713.1.
AK169879 mRNA. Translation: BAE41431.1.
BC064823 mRNA. Translation: AAH64823.1. Sequence problems.
AK129463 mRNA. Translation: BAC98273.1.
CCDSiCCDS25591.1.
RefSeqiNP_671752.2. NM_147219.2.
XP_006533128.1. XM_006533065.3.
UniGeneiMm.41942.

Genome annotation databases

EnsembliENSMUST00000043961; ENSMUSP00000047927; ENSMUSG00000018800.
GeneIDi217265.
KEGGimmu:217265.
UCSCiuc007mdm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491842 mRNA. Translation: AAM90895.1.
AB097675 mRNA. Translation: BAC66658.1.
AK034961 mRNA. Translation: BAC28896.2. Different initiation.
AK047188 mRNA. Translation: BAC32984.1.
AK138604 mRNA. Translation: BAE23713.1.
AK169879 mRNA. Translation: BAE41431.1.
BC064823 mRNA. Translation: AAH64823.1. Sequence problems.
AK129463 mRNA. Translation: BAC98273.1.
CCDSiCCDS25591.1.
RefSeqiNP_671752.2. NM_147219.2.
XP_006533128.1. XM_006533065.3.
UniGeneiMm.41942.

3D structure databases

ProteinModelPortaliQ8K448.
SMRiQ8K448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047927.

PTM databases

iPTMnetiQ8K448.
PhosphoSitePlusiQ8K448.

Proteomic databases

MaxQBiQ8K448.
PaxDbiQ8K448.
PeptideAtlasiQ8K448.
PRIDEiQ8K448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043961; ENSMUSP00000047927; ENSMUSG00000018800.
GeneIDi217265.
KEGGimmu:217265.
UCSCiuc007mdm.1. mouse.

Organism-specific databases

CTDi23461.
MGIiMGI:2386607. Abca5.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOVERGENiHBG079884.
InParanoidiQ8K448.
KOiK05648.
OMAiYIDRYCA.
OrthoDBiEOG091G00AG.
PhylomeDBiQ8K448.
TreeFamiTF105192.

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Miscellaneous databases

PROiQ8K448.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018800.
ExpressionAtlasiQ8K448. baseline and differential.
GenevisibleiQ8K448. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030367. ABCA5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PTHR19229:SF100. PTHR19229:SF100. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCA5_MOUSE
AccessioniPrimary (citable) accession number: Q8K448
Secondary accession number(s): Q3TE17
, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.