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Q8K441

- ABCA6_MOUSE

UniProt

Q8K441 - ABCA6_MOUSE

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Protein
ATP-binding cassette sub-family A member 6
Gene
Abca6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transporter which may play a role in macrophage lipid homeostasis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1 Reviewed prediction
Nucleotide bindingi1320 – 13278ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 6
Gene namesi
Name:Abca6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1923434. Abca6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei222 – 24221Helical; Reviewed prediction
Add
BLAST
Transmembranei267 – 28721Helical; Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Reviewed prediction
Add
BLAST
Transmembranei326 – 34621Helical; Reviewed prediction
Add
BLAST
Transmembranei356 – 37621Helical; Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Reviewed prediction
Add
BLAST
Transmembranei854 – 87421Helical; Reviewed prediction
Add
BLAST
Transmembranei971 – 99121Helical; Reviewed prediction
Add
BLAST
Transmembranei1005 – 102521Helical; Reviewed prediction
Add
BLAST
Transmembranei1058 – 107821Helical; Reviewed prediction
Add
BLAST
Transmembranei1094 – 111421Helical; Reviewed prediction
Add
BLAST
Transmembranei1130 – 115021Helical; Reviewed prediction
Add
BLAST
Transmembranei1154 – 117421Helical; Reviewed prediction
Add
BLAST
Transmembranei1194 – 121421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16241624ATP-binding cassette sub-family A member 6
PRO_0000250673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi576 – 5761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K441.
PaxDbiQ8K441.
PRIDEiQ8K441.

PTM databases

PhosphoSiteiQ8K441.

Expressioni

Tissue specificityi

Widely expressed with higher expression in heart, lung, brain, spleen and testis.1 Publication

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiQ8K441.
GenevestigatoriQ8K441.

Interactioni

Protein-protein interaction databases

IntActiQ8K441. 1 interaction.
MINTiMINT-1857115.

Structurei

3D structure databases

ProteinModelPortaliQ8K441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 713236ABC transporter 1
Add
BLAST
Domaini1282 – 1520239ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000115040.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiA2A6R3.
KOiK05649.
OMAiCFQHQRT.
OrthoDBiEOG73Z2SB.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K441-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL     50
ARNIQVLEVP PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK 100
GTRIIGVPSI EDLDEVLLHN IPDALGVIFN DSFSYQLKVL RMYGNPFLKE 150
DLLAHCWDTH SQAFCSLSKY WERGFVALQT AINAGIIEVT TNHSVMEELM 200
SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS NVTKERKQCK 250
EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 300
FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE 350
LPPSLEWVLS IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF 400
FILAFDSLLY LVLALYFDKI LLYGAEHRSA PLFFLNPTSC FRKTANRNKV 450
IERDLDPELP SDEYFEPVDP EYQGKEAIRI RNIKKEYKGK SGKVKALKGL 500
FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV YNKNLSDMQD 550
LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS 600
ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR 650
QRIWGFLKER RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL 700
KRKWGLGYHL SLFMDETCDS ERLTSFINHH IPYAKLKAKT KEKLVYILPL 750
ERTSEFPEFF SDLDKYSGQG LMSYEVSMST LNDVFLNLEG EPSTKQDFEK 800
RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI ARLRILKLKR 850
ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP 900
QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA 950
IIVSGRQKDY RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED 1000
IFSPFIVLVW TGIQETCLFI LCVICSLSPH IAMSSVSDYK KKADSQLWIS 1050
GLYPSAYWCG QAVVDISLFS GMLLTSYFTS YTSKLLNIDM TSEIVFSVIV 1100
LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI TFEKVANGPF 1150
NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC 1200
LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID 1250
EDENVQAERL RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN 1300
MAVRNVSFCV NKGEILGLLG PDGAGKSSSI RMIAGITKPT AGQVELKRLS 1350
SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE HLELYAAVKG LRKEDAVVAI 1400
SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV LILDEPSTGL 1450
DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC 1500
IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL 1550
LTYKLPVTDV HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ 1600
ELGTVYEEAD MTLGRKLLPP SDEL 1624
Length:1,624
Mass (Da):183,283
Last modified:June 28, 2011 - v2
Checksum:i90C077C465B5F79C
GO
Isoform 2 (identifier: Q8K441-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
     389-1624: Missing.

Show »
Length:388
Mass (Da):44,092
Checksum:i9AAFD1942A53EB1E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei375 – 38814IFQDY…VVFPD → NTEVITDASNGINP in isoform 2.
VSP_020699Add
BLAST
Alternative sequencei389 – 16241236Missing in isoform 2.
VSP_020700Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311I → V in BAC35372. 1 Publication
Sequence conflicti1020 – 10201I → T in AAM90907. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498361 mRNA. Translation: AAM90907.1.
AK040652 mRNA. Translation: BAC30657.1.
AK042934 mRNA. Translation: BAC31409.1.
AK053384 mRNA. Translation: BAC35372.1.
AL603792 Genomic DNA. Translation: CAM20973.1.
BC132417 mRNA. Translation: AAI32418.1.
BC132419 mRNA. Translation: AAI32420.1.
CCDSiCCDS25590.1. [Q8K441-1]
RefSeqiNP_001160028.1. NM_001166556.1. [Q8K441-2]
NP_001160029.1. NM_001166557.1.
NP_671751.2. NM_147218.2. [Q8K441-1]
XP_006534476.1. XM_006534413.1. [Q8K441-1]
XP_006534477.1. XM_006534414.1. [Q8K441-1]
UniGeneiMm.159704.

Genome annotation databases

EnsembliENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749. [Q8K441-1]
GeneIDi76184.
KEGGimmu:76184.
UCSCiuc007mdj.3. mouse. [Q8K441-1]
uc007mdk.2. mouse. [Q8K441-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498361 mRNA. Translation: AAM90907.1 .
AK040652 mRNA. Translation: BAC30657.1 .
AK042934 mRNA. Translation: BAC31409.1 .
AK053384 mRNA. Translation: BAC35372.1 .
AL603792 Genomic DNA. Translation: CAM20973.1 .
BC132417 mRNA. Translation: AAI32418.1 .
BC132419 mRNA. Translation: AAI32420.1 .
CCDSi CCDS25590.1. [Q8K441-1 ]
RefSeqi NP_001160028.1. NM_001166556.1. [Q8K441-2 ]
NP_001160029.1. NM_001166557.1.
NP_671751.2. NM_147218.2. [Q8K441-1 ]
XP_006534476.1. XM_006534413.1. [Q8K441-1 ]
XP_006534477.1. XM_006534414.1. [Q8K441-1 ]
UniGenei Mm.159704.

3D structure databases

ProteinModelPortali Q8K441.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8K441. 1 interaction.
MINTi MINT-1857115.

PTM databases

PhosphoSitei Q8K441.

Proteomic databases

MaxQBi Q8K441.
PaxDbi Q8K441.
PRIDEi Q8K441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044003 ; ENSMUSP00000035458 ; ENSMUSG00000044749 . [Q8K441-1 ]
GeneIDi 76184.
KEGGi mmu:76184.
UCSCi uc007mdj.3. mouse. [Q8K441-1 ]
uc007mdk.2. mouse. [Q8K441-2 ]

Organism-specific databases

CTDi 23460.
MGIi MGI:1923434. Abca6.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000115040.
HOGENOMi HOG000231057.
HOVERGENi HBG079884.
InParanoidi A2A6R3.
KOi K05649.
OMAi CFQHQRT.
OrthoDBi EOG73Z2SB.
TreeFami TF105192.

Miscellaneous databases

NextBioi 344731.
PROi Q8K441.
SOURCEi Search...

Gene expression databases

Bgeei Q8K441.
Genevestigatori Q8K441.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
    Annilo T., Chen Z.-Q., Shulenin S., Dean M.
    Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Aorta, Cerebellum, Eye and Vein.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiABCA6_MOUSE
AccessioniPrimary (citable) accession number: Q8K441
Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi