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Q8K441

- ABCA6_MOUSE

UniProt

Q8K441 - ABCA6_MOUSE

Protein

ATP-binding cassette sub-family A member 6

Gene

Abca6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Probable transporter which may play a role in macrophage lipid homeostasis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1320 – 13278ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family A member 6
    Gene namesi
    Name:Abca6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1923434. Abca6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16241624ATP-binding cassette sub-family A member 6PRO_0000250673Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8K441.
    PaxDbiQ8K441.
    PRIDEiQ8K441.

    PTM databases

    PhosphoSiteiQ8K441.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in heart, lung, brain, spleen and testis.1 Publication

    Developmental stagei

    Expressed during embryogenesis.1 Publication

    Gene expression databases

    BgeeiQ8K441.
    GenevestigatoriQ8K441.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K441. 1 interaction.
    MINTiMINT-1857115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K441.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei854 – 87421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei971 – 99121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1005 – 102521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1058 – 107821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1094 – 111421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1130 – 115021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1154 – 117421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1194 – 121421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini478 – 713236ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1282 – 1520239ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00740000115040.
    HOGENOMiHOG000231057.
    HOVERGENiHBG079884.
    InParanoidiA2A6R3.
    KOiK05649.
    OMAiCFQHQRT.
    OrthoDBiEOG73Z2SB.
    TreeFamiTF105192.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K441-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL     50
    ARNIQVLEVP PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK 100
    GTRIIGVPSI EDLDEVLLHN IPDALGVIFN DSFSYQLKVL RMYGNPFLKE 150
    DLLAHCWDTH SQAFCSLSKY WERGFVALQT AINAGIIEVT TNHSVMEELM 200
    SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS NVTKERKQCK 250
    EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 300
    FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE 350
    LPPSLEWVLS IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF 400
    FILAFDSLLY LVLALYFDKI LLYGAEHRSA PLFFLNPTSC FRKTANRNKV 450
    IERDLDPELP SDEYFEPVDP EYQGKEAIRI RNIKKEYKGK SGKVKALKGL 500
    FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV YNKNLSDMQD 550
    LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS 600
    ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR 650
    QRIWGFLKER RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL 700
    KRKWGLGYHL SLFMDETCDS ERLTSFINHH IPYAKLKAKT KEKLVYILPL 750
    ERTSEFPEFF SDLDKYSGQG LMSYEVSMST LNDVFLNLEG EPSTKQDFEK 800
    RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI ARLRILKLKR 850
    ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP 900
    QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA 950
    IIVSGRQKDY RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED 1000
    IFSPFIVLVW TGIQETCLFI LCVICSLSPH IAMSSVSDYK KKADSQLWIS 1050
    GLYPSAYWCG QAVVDISLFS GMLLTSYFTS YTSKLLNIDM TSEIVFSVIV 1100
    LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI TFEKVANGPF 1150
    NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC 1200
    LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID 1250
    EDENVQAERL RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN 1300
    MAVRNVSFCV NKGEILGLLG PDGAGKSSSI RMIAGITKPT AGQVELKRLS 1350
    SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE HLELYAAVKG LRKEDAVVAI 1400
    SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV LILDEPSTGL 1450
    DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC 1500
    IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL 1550
    LTYKLPVTDV HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ 1600
    ELGTVYEEAD MTLGRKLLPP SDEL 1624
    Length:1,624
    Mass (Da):183,283
    Last modified:June 28, 2011 - v2
    Checksum:i90C077C465B5F79C
    GO
    Isoform 2 (identifier: Q8K441-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
         389-1624: Missing.

    Show »
    Length:388
    Mass (Da):44,092
    Checksum:i9AAFD1942A53EB1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti331 – 3311I → V in BAC35372. (PubMed:19468303)Curated
    Sequence conflicti1020 – 10201I → T in AAM90907. (PubMed:12532264)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei375 – 38814IFQDY…VVFPD → NTEVITDASNGINP in isoform 2. 1 PublicationVSP_020699Add
    BLAST
    Alternative sequencei389 – 16241236Missing in isoform 2. 1 PublicationVSP_020700Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498361 mRNA. Translation: AAM90907.1.
    AK040652 mRNA. Translation: BAC30657.1.
    AK042934 mRNA. Translation: BAC31409.1.
    AK053384 mRNA. Translation: BAC35372.1.
    AL603792 Genomic DNA. Translation: CAM20973.1.
    BC132417 mRNA. Translation: AAI32418.1.
    BC132419 mRNA. Translation: AAI32420.1.
    CCDSiCCDS25590.1. [Q8K441-1]
    RefSeqiNP_001160028.1. NM_001166556.1. [Q8K441-2]
    NP_001160029.1. NM_001166557.1.
    NP_671751.2. NM_147218.2. [Q8K441-1]
    XP_006534476.1. XM_006534413.1. [Q8K441-1]
    XP_006534477.1. XM_006534414.1. [Q8K441-1]
    UniGeneiMm.159704.

    Genome annotation databases

    EnsembliENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749. [Q8K441-1]
    GeneIDi76184.
    KEGGimmu:76184.
    UCSCiuc007mdj.3. mouse. [Q8K441-1]
    uc007mdk.2. mouse. [Q8K441-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498361 mRNA. Translation: AAM90907.1 .
    AK040652 mRNA. Translation: BAC30657.1 .
    AK042934 mRNA. Translation: BAC31409.1 .
    AK053384 mRNA. Translation: BAC35372.1 .
    AL603792 Genomic DNA. Translation: CAM20973.1 .
    BC132417 mRNA. Translation: AAI32418.1 .
    BC132419 mRNA. Translation: AAI32420.1 .
    CCDSi CCDS25590.1. [Q8K441-1 ]
    RefSeqi NP_001160028.1. NM_001166556.1. [Q8K441-2 ]
    NP_001160029.1. NM_001166557.1.
    NP_671751.2. NM_147218.2. [Q8K441-1 ]
    XP_006534476.1. XM_006534413.1. [Q8K441-1 ]
    XP_006534477.1. XM_006534414.1. [Q8K441-1 ]
    UniGenei Mm.159704.

    3D structure databases

    ProteinModelPortali Q8K441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K441. 1 interaction.
    MINTi MINT-1857115.

    PTM databases

    PhosphoSitei Q8K441.

    Proteomic databases

    MaxQBi Q8K441.
    PaxDbi Q8K441.
    PRIDEi Q8K441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044003 ; ENSMUSP00000035458 ; ENSMUSG00000044749 . [Q8K441-1 ]
    GeneIDi 76184.
    KEGGi mmu:76184.
    UCSCi uc007mdj.3. mouse. [Q8K441-1 ]
    uc007mdk.2. mouse. [Q8K441-2 ]

    Organism-specific databases

    CTDi 23460.
    MGIi MGI:1923434. Abca6.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00740000115040.
    HOGENOMi HOG000231057.
    HOVERGENi HBG079884.
    InParanoidi A2A6R3.
    KOi K05649.
    OMAi CFQHQRT.
    OrthoDBi EOG73Z2SB.
    TreeFami TF105192.

    Miscellaneous databases

    NextBioi 344731.
    PROi Q8K441.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K441.
    Genevestigatori Q8K441.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
      Annilo T., Chen Z.-Q., Shulenin S., Dean M.
      Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: BALB/c.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Aorta, Cerebellum, Eye and Vein.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiABCA6_MOUSE
    AccessioniPrimary (citable) accession number: Q8K441
    Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3