Q8K441 (ABCA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-binding cassette sub-family A member 6

Gene names

Name:

Abca6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1624 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable transporter which may play a role in macrophage lipid homeostasis By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Widely expressed with higher expression in heart, lung, brain, spleen and testis. Ref.1
Developmental stage	Expressed during embryogenesis. Ref.1
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8K441-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8K441-2)

The sequence of this isoform differs from the canonical sequence as follows:
     375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
     389-1624: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1624	1624	ATP-binding cassette sub-family A member 6		PRO_0000250673
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Transmembrane	267 – 287	21	Helical; Potential
	Transmembrane	297 – 317	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Transmembrane	395 – 415	21	Helical; Potential
	Transmembrane	854 – 874	21	Helical; Potential
	Transmembrane	971 – 991	21	Helical; Potential
	Transmembrane	1005 – 1025	21	Helical; Potential
	Transmembrane	1058 – 1078	21	Helical; Potential
	Transmembrane	1094 – 1114	21	Helical; Potential
	Transmembrane	1130 – 1150	21	Helical; Potential
	Transmembrane	1154 – 1174	21	Helical; Potential
	Transmembrane	1194 – 1214	21	Helical; Potential
	Domain	478 – 713	236	ABC transporter 1
	Domain	1282 – 1520	239	ABC transporter 2
	Nucleotide binding	514 – 521	8	ATP 1 Potential
	Nucleotide binding	1320 – 1327	8	ATP 2 Potential
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	576	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	375 – 388	14	IFQDY…VVFPD → NTEVITDASNGINP in isoform 2.		VSP_020699
	Alternative sequence	389 – 1624	1236	Missing in isoform 2.		VSP_020700
Experimental info
	Sequence conflict	331	1	I → V in BAC35372. Ref.3
	Sequence conflict	1020	1	I → T in AAM90907. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: 90C077C465B5F79C	FASTA	1,624	183,283
	10 20 30 40 50 60 MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL ARNIQVLEVP 70 80 90 100 110 120 PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK GTRIIGVPSI EDLDEVLLHN 130 140 150 160 170 180 IPDALGVIFN DSFSYQLKVL RMYGNPFLKE DLLAHCWDTH SQAFCSLSKY WERGFVALQT 190 200 210 220 230 240 AINAGIIEVT TNHSVMEELM SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS 250 260 270 280 290 300 NVTKERKQCK EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 310 320 330 340 350 360 FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE LPPSLEWVLS 370 380 390 400 410 420 IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF FILAFDSLLY LVLALYFDKI 430 440 450 460 470 480 LLYGAEHRSA PLFFLNPTSC FRKTANRNKV IERDLDPELP SDEYFEPVDP EYQGKEAIRI 490 500 510 520 530 540 RNIKKEYKGK SGKVKALKGL FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV 550 560 570 580 590 600 YNKNLSDMQD LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS 610 620 630 640 650 660 ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR QRIWGFLKER 670 680 690 700 710 720 RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL KRKWGLGYHL SLFMDETCDS 730 740 750 760 770 780 ERLTSFINHH IPYAKLKAKT KEKLVYILPL ERTSEFPEFF SDLDKYSGQG LMSYEVSMST 790 800 810 820 830 840 LNDVFLNLEG EPSTKQDFEK RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI 850 860 870 880 890 900 ARLRILKLKR ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP 910 920 930 940 950 960 QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA IIVSGRQKDY 970 980 990 1000 1010 1020 RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED IFSPFIVLVW TGIQETCLFI 1030 1040 1050 1060 1070 1080 LCVICSLSPH IAMSSVSDYK KKADSQLWIS GLYPSAYWCG QAVVDISLFS GMLLTSYFTS 1090 1100 1110 1120 1130 1140 YTSKLLNIDM TSEIVFSVIV LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI 1150 1160 1170 1180 1190 1200 TFEKVANGPF NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC 1210 1220 1230 1240 1250 1260 LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID EDENVQAERL 1270 1280 1290 1300 1310 1320 RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN MAVRNVSFCV NKGEILGLLG 1330 1340 1350 1360 1370 1380 PDGAGKSSSI RMIAGITKPT AGQVELKRLS SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE 1390 1400 1410 1420 1430 1440 HLELYAAVKG LRKEDAVVAI SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV 1450 1460 1470 1480 1490 1500 LILDEPSTGL DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC 1510 1520 1530 1540 1550 1560 IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL LTYKLPVTDV 1570 1580 1590 1600 1610 1620 HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ ELGTVYEEAD MTLGRKLLPP SDEL
	Isoform 2 [UniParc]. Checksum: 9AAFD1942A53EB1E	FASTA	388	44,092
	10 20 30 40 50 60 MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL ARNIQVLEVP 70 80 90 100 110 120 PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK GTRIIGVPSI EDLDEVLLHN 130 140 150 160 170 180 IPDALGVIFN DSFSYQLKVL RMYGNPFLKE DLLAHCWDTH SQAFCSLSKY WERGFVALQT 190 200 210 220 230 240 AINAGIIEVT TNHSVMEELM SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS 250 260 270 280 290 300 NVTKERKQCK EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 310 320 330 340 350 360 FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE LPPSLEWVLS 370 380 IFSPFAFTSG MAKVNTEVIT DASNGINP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes." Annilo T., Chen Z.-Q., Shulenin S., Dean M. Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: BALB/c. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Aorta, Cerebellum, Eye and Vein.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF498361 mRNA. Translation: AAM90907.1. AK040652 mRNA. Translation: BAC30657.1. AK042934 mRNA. Translation: BAC31409.1. AK053384 mRNA. Translation: BAC35372.1. AL603792 Genomic DNA. Translation: CAM20973.1. BC132417 mRNA. Translation: AAI32418.1. BC132419 mRNA. Translation: AAI32420.1.
IPI	IPI00170146. IPI00954339.
RefSeq	NP_001160028.1. NM_001166556.1. NP_001160029.1. NM_001166557.1. NP_671751.2. NM_147218.2.
UniGene	Mm.159704.
3D structure databases
ProteinModelPortal	Q8K441.
ModBase	Search...
PTM databases
PhosphoSite	Q8K441.
Proteomic databases
PaxDb	Q8K441.
PRIDE	Q8K441.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749.
GeneID	76184.
KEGG	mmu:76184.
UCSC	uc007mdk.2. mouse.
Organism-specific databases
CTD	23460.
MGI	MGI:1923434. Abca6.
Phylogenomic databases
eggNOG	COG1131.
GeneTree	ENSGT00690000101975.
HOGENOM	HOG000231057.
HOVERGEN	HBG079884.
InParanoid	A2A6R3.
KO	K05649.
OMA	CFQHQRT.
OrthoDB	EOG40P45W.
Gene expression databases
Bgee	Q8K441.
Genevestigator	Q8K441.
GermOnline	ENSMUSG00000044749. Mus musculus.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026082. ABC_A. IPR003439. ABC_transporter-like. [Graphical view]
PANTHER	PTHR19229. PTHR19229. 1 hit.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	344731.
SOURCE	Search...

Entry information

Entry name

ABCA6_MOUSE

Accession

Primary (citable) accession number: Q8K441
Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program