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Q8K441 (ABCA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family A member 6
Gene names
Name:Abca6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1624 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transporter which may play a role in macrophage lipid homeostasis By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed with higher expression in heart, lung, brain, spleen and testis. Ref.1

Developmental stage

Expressed during embryogenesis. Ref.1

Sequence similarities

Belongs to the ABC transporter superfamily. ABCA family.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K441-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K441-2)

The sequence of this isoform differs from the canonical sequence as follows:
     375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
     389-1624: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16241624ATP-binding cassette sub-family A member 6
PRO_0000250673

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane267 – 28721Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane326 – 34621Helical; Potential
Transmembrane356 – 37621Helical; Potential
Transmembrane395 – 41521Helical; Potential
Transmembrane854 – 87421Helical; Potential
Transmembrane971 – 99121Helical; Potential
Transmembrane1005 – 102521Helical; Potential
Transmembrane1058 – 107821Helical; Potential
Transmembrane1094 – 111421Helical; Potential
Transmembrane1130 – 115021Helical; Potential
Transmembrane1154 – 117421Helical; Potential
Transmembrane1194 – 121421Helical; Potential
Domain478 – 713236ABC transporter 1
Domain1282 – 1520239ABC transporter 2
Nucleotide binding514 – 5218ATP 1 Potential
Nucleotide binding1320 – 13278ATP 2 Potential

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation5761N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence375 – 38814IFQDY…VVFPD → NTEVITDASNGINP in isoform 2.
VSP_020699
Alternative sequence389 – 16241236Missing in isoform 2.
VSP_020700

Experimental info

Sequence conflict3311I → V in BAC35372. Ref.3
Sequence conflict10201I → T in AAM90907. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 90C077C465B5F79C

FASTA1,624183,283
        10         20         30         40         50         60 
MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL ARNIQVLEVP 

        70         80         90        100        110        120 
PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK GTRIIGVPSI EDLDEVLLHN 

       130        140        150        160        170        180 
IPDALGVIFN DSFSYQLKVL RMYGNPFLKE DLLAHCWDTH SQAFCSLSKY WERGFVALQT 

       190        200        210        220        230        240 
AINAGIIEVT TNHSVMEELM SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS 

       250        260        270        280        290        300 
NVTKERKQCK EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI 

       310        320        330        340        350        360 
FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE LPPSLEWVLS 

       370        380        390        400        410        420 
IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF FILAFDSLLY LVLALYFDKI 

       430        440        450        460        470        480 
LLYGAEHRSA PLFFLNPTSC FRKTANRNKV IERDLDPELP SDEYFEPVDP EYQGKEAIRI 

       490        500        510        520        530        540 
RNIKKEYKGK SGKVKALKGL FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV 

       550        560        570        580        590        600 
YNKNLSDMQD LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS 

       610        620        630        640        650        660 
ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR QRIWGFLKER 

       670        680        690        700        710        720 
RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL KRKWGLGYHL SLFMDETCDS 

       730        740        750        760        770        780 
ERLTSFINHH IPYAKLKAKT KEKLVYILPL ERTSEFPEFF SDLDKYSGQG LMSYEVSMST 

       790        800        810        820        830        840 
LNDVFLNLEG EPSTKQDFEK RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI 

       850        860        870        880        890        900 
ARLRILKLKR ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP 

       910        920        930        940        950        960 
QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA IIVSGRQKDY 

       970        980        990       1000       1010       1020 
RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED IFSPFIVLVW TGIQETCLFI 

      1030       1040       1050       1060       1070       1080 
LCVICSLSPH IAMSSVSDYK KKADSQLWIS GLYPSAYWCG QAVVDISLFS GMLLTSYFTS 

      1090       1100       1110       1120       1130       1140 
YTSKLLNIDM TSEIVFSVIV LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI 

      1150       1160       1170       1180       1190       1200 
TFEKVANGPF NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC 

      1210       1220       1230       1240       1250       1260 
LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID EDENVQAERL 

      1270       1280       1290       1300       1310       1320 
RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN MAVRNVSFCV NKGEILGLLG 

      1330       1340       1350       1360       1370       1380 
PDGAGKSSSI RMIAGITKPT AGQVELKRLS SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE 

      1390       1400       1410       1420       1430       1440 
HLELYAAVKG LRKEDAVVAI SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV 

      1450       1460       1470       1480       1490       1500 
LILDEPSTGL DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC 

      1510       1520       1530       1540       1550       1560 
IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL LTYKLPVTDV 

      1570       1580       1590       1600       1610       1620 
HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ ELGTVYEEAD MTLGRKLLPP 


SDEL 

« Hide

Isoform 2 [UniParc].

Checksum: 9AAFD1942A53EB1E
Show »

FASTA38844,092

References

« Hide 'large scale' references
[1]"Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
Annilo T., Chen Z.-Q., Shulenin S., Dean M.
Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: BALB/c.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Aorta, Cerebellum, Eye and Vein.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF498361 mRNA. Translation: AAM90907.1.
AK040652 mRNA. Translation: BAC30657.1.
AK042934 mRNA. Translation: BAC31409.1.
AK053384 mRNA. Translation: BAC35372.1.
AL603792 Genomic DNA. Translation: CAM20973.1.
BC132417 mRNA. Translation: AAI32418.1.
BC132419 mRNA. Translation: AAI32420.1.
RefSeqNP_001160028.1. NM_001166556.1.
NP_001160029.1. NM_001166557.1.
NP_671751.2. NM_147218.2.
XP_006534476.1. XM_006534413.1.
XP_006534477.1. XM_006534414.1.
UniGeneMm.159704.

3D structure databases

ProteinModelPortalQ8K441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K441. 1 interaction.
MINTMINT-1857115.

PTM databases

PhosphoSiteQ8K441.

Proteomic databases

PaxDbQ8K441.
PRIDEQ8K441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749. [Q8K441-1]
GeneID76184.
KEGGmmu:76184.
UCSCuc007mdj.3. mouse. [Q8K441-1]
uc007mdk.2. mouse. [Q8K441-2]

Organism-specific databases

CTD23460.
MGIMGI:1923434. Abca6.

Phylogenomic databases

eggNOGCOG1131.
GeneTreeENSGT00740000115040.
HOGENOMHOG000231057.
HOVERGENHBG079884.
InParanoidA2A6R3.
KOK05649.
OMACFQHQRT.
OrthoDBEOG73Z2SB.
TreeFamTF105192.

Gene expression databases

BgeeQ8K441.
GenevestigatorQ8K441.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR19229. PTHR19229. 1 hit.
PfamPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio344731.
PROQ8K441.
SOURCESearch...

Entry information

Entry nameABCA6_MOUSE
AccessionPrimary (citable) accession number: Q8K441
Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot