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Q8K441

- ABCA6_MOUSE

UniProt

Q8K441 - ABCA6_MOUSE

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Protein

ATP-binding cassette sub-family A member 6

Gene

Abca6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable transporter which may play a role in macrophage lipid homeostasis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1320 – 13278ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 6
Gene namesi
Name:Abca6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1923434. Abca6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16241624ATP-binding cassette sub-family A member 6PRO_0000250673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K441.
PaxDbiQ8K441.
PRIDEiQ8K441.

PTM databases

PhosphoSiteiQ8K441.

Expressioni

Tissue specificityi

Widely expressed with higher expression in heart, lung, brain, spleen and testis.1 Publication

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiQ8K441.
GenevestigatoriQ8K441.

Interactioni

Protein-protein interaction databases

IntActiQ8K441. 1 interaction.
MINTiMINT-1857115.

Structurei

3D structure databases

ProteinModelPortaliQ8K441.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei854 – 87421HelicalSequence AnalysisAdd
BLAST
Transmembranei971 – 99121HelicalSequence AnalysisAdd
BLAST
Transmembranei1005 – 102521HelicalSequence AnalysisAdd
BLAST
Transmembranei1058 – 107821HelicalSequence AnalysisAdd
BLAST
Transmembranei1094 – 111421HelicalSequence AnalysisAdd
BLAST
Transmembranei1130 – 115021HelicalSequence AnalysisAdd
BLAST
Transmembranei1154 – 117421HelicalSequence AnalysisAdd
BLAST
Transmembranei1194 – 121421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 713236ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1282 – 1520239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8K441.
KOiK05649.
OMAiCFQHQRT.
OrthoDBiEOG73Z2SB.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K441-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL
60 70 80 90 100
ARNIQVLEVP PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK
110 120 130 140 150
GTRIIGVPSI EDLDEVLLHN IPDALGVIFN DSFSYQLKVL RMYGNPFLKE
160 170 180 190 200
DLLAHCWDTH SQAFCSLSKY WERGFVALQT AINAGIIEVT TNHSVMEELM
210 220 230 240 250
SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS NVTKERKQCK
260 270 280 290 300
EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI
310 320 330 340 350
FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE
360 370 380 390 400
LPPSLEWVLS IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF
410 420 430 440 450
FILAFDSLLY LVLALYFDKI LLYGAEHRSA PLFFLNPTSC FRKTANRNKV
460 470 480 490 500
IERDLDPELP SDEYFEPVDP EYQGKEAIRI RNIKKEYKGK SGKVKALKGL
510 520 530 540 550
FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV YNKNLSDMQD
560 570 580 590 600
LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS
610 620 630 640 650
ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR
660 670 680 690 700
QRIWGFLKER RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL
710 720 730 740 750
KRKWGLGYHL SLFMDETCDS ERLTSFINHH IPYAKLKAKT KEKLVYILPL
760 770 780 790 800
ERTSEFPEFF SDLDKYSGQG LMSYEVSMST LNDVFLNLEG EPSTKQDFEK
810 820 830 840 850
RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI ARLRILKLKR
860 870 880 890 900
ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP
910 920 930 940 950
QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA
960 970 980 990 1000
IIVSGRQKDY RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED
1010 1020 1030 1040 1050
IFSPFIVLVW TGIQETCLFI LCVICSLSPH IAMSSVSDYK KKADSQLWIS
1060 1070 1080 1090 1100
GLYPSAYWCG QAVVDISLFS GMLLTSYFTS YTSKLLNIDM TSEIVFSVIV
1110 1120 1130 1140 1150
LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI TFEKVANGPF
1160 1170 1180 1190 1200
NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC
1210 1220 1230 1240 1250
LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID
1260 1270 1280 1290 1300
EDENVQAERL RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN
1310 1320 1330 1340 1350
MAVRNVSFCV NKGEILGLLG PDGAGKSSSI RMIAGITKPT AGQVELKRLS
1360 1370 1380 1390 1400
SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE HLELYAAVKG LRKEDAVVAI
1410 1420 1430 1440 1450
SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV LILDEPSTGL
1460 1470 1480 1490 1500
DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC
1510 1520 1530 1540 1550
IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL
1560 1570 1580 1590 1600
LTYKLPVTDV HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ
1610 1620
ELGTVYEEAD MTLGRKLLPP SDEL
Length:1,624
Mass (Da):183,283
Last modified:June 28, 2011 - v2
Checksum:i90C077C465B5F79C
GO
Isoform 2 (identifier: Q8K441-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-388: IFQDYNLNGVVFPD → NTEVITDASNGINP
     389-1624: Missing.

Show »
Length:388
Mass (Da):44,092
Checksum:i9AAFD1942A53EB1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311I → V in BAC35372. (PubMed:19468303)Curated
Sequence conflicti1020 – 10201I → T in AAM90907. (PubMed:12532264)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei375 – 38814IFQDY…VVFPD → NTEVITDASNGINP in isoform 2. 1 PublicationVSP_020699Add
BLAST
Alternative sequencei389 – 16241236Missing in isoform 2. 1 PublicationVSP_020700Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498361 mRNA. Translation: AAM90907.1.
AK040652 mRNA. Translation: BAC30657.1.
AK042934 mRNA. Translation: BAC31409.1.
AK053384 mRNA. Translation: BAC35372.1.
AL603792 Genomic DNA. Translation: CAM20973.1.
BC132417 mRNA. Translation: AAI32418.1.
BC132419 mRNA. Translation: AAI32420.1.
CCDSiCCDS25590.1. [Q8K441-1]
RefSeqiNP_001160028.1. NM_001166556.1. [Q8K441-2]
NP_001160029.1. NM_001166557.1.
NP_671751.2. NM_147218.2. [Q8K441-1]
XP_006534476.1. XM_006534413.1. [Q8K441-1]
XP_006534477.1. XM_006534414.1. [Q8K441-1]
UniGeneiMm.159704.

Genome annotation databases

EnsembliENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749. [Q8K441-1]
GeneIDi76184.
KEGGimmu:76184.
UCSCiuc007mdj.3. mouse. [Q8K441-1]
uc007mdk.2. mouse. [Q8K441-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498361 mRNA. Translation: AAM90907.1 .
AK040652 mRNA. Translation: BAC30657.1 .
AK042934 mRNA. Translation: BAC31409.1 .
AK053384 mRNA. Translation: BAC35372.1 .
AL603792 Genomic DNA. Translation: CAM20973.1 .
BC132417 mRNA. Translation: AAI32418.1 .
BC132419 mRNA. Translation: AAI32420.1 .
CCDSi CCDS25590.1. [Q8K441-1 ]
RefSeqi NP_001160028.1. NM_001166556.1. [Q8K441-2 ]
NP_001160029.1. NM_001166557.1.
NP_671751.2. NM_147218.2. [Q8K441-1 ]
XP_006534476.1. XM_006534413.1. [Q8K441-1 ]
XP_006534477.1. XM_006534414.1. [Q8K441-1 ]
UniGenei Mm.159704.

3D structure databases

ProteinModelPortali Q8K441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K441. 1 interaction.
MINTi MINT-1857115.

PTM databases

PhosphoSitei Q8K441.

Proteomic databases

MaxQBi Q8K441.
PaxDbi Q8K441.
PRIDEi Q8K441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044003 ; ENSMUSP00000035458 ; ENSMUSG00000044749 . [Q8K441-1 ]
GeneIDi 76184.
KEGGi mmu:76184.
UCSCi uc007mdj.3. mouse. [Q8K441-1 ]
uc007mdk.2. mouse. [Q8K441-2 ]

Organism-specific databases

CTDi 23460.
MGIi MGI:1923434. Abca6.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00760000118965.
HOGENOMi HOG000231057.
HOVERGENi HBG079884.
InParanoidi Q8K441.
KOi K05649.
OMAi CFQHQRT.
OrthoDBi EOG73Z2SB.
TreeFami TF105192.

Miscellaneous databases

NextBioi 344731.
PROi Q8K441.
SOURCEi Search...

Gene expression databases

Bgeei Q8K441.
Genevestigatori Q8K441.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
    Annilo T., Chen Z.-Q., Shulenin S., Dean M.
    Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Aorta, Cerebellum, Eye and Vein.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiABCA6_MOUSE
AccessioniPrimary (citable) accession number: Q8K441
Secondary accession number(s): A2A6R3, Q8BGH0, Q8BPT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3