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Protein

ATP-binding cassette sub-family A member 8-B

Gene

Abca8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent lipophilic drug transporter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi515 – 5228ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1321 – 13288ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 8-B
Gene namesi
Name:Abca8b
Synonyms:Abca8, Kiaa0822
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351668. Abca8b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Transmembranei860 – 88021HelicalSequence analysisAdd
BLAST
Transmembranei979 – 99921HelicalSequence analysisAdd
BLAST
Transmembranei1023 – 104321HelicalSequence analysisAdd
BLAST
Transmembranei1069 – 108921HelicalSequence analysisAdd
BLAST
Transmembranei1105 – 112521HelicalSequence analysisAdd
BLAST
Transmembranei1135 – 115521HelicalSequence analysisAdd
BLAST
Transmembranei1164 – 118421HelicalSequence analysisAdd
BLAST
Transmembranei1194 – 121421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16201620ATP-binding cassette sub-family A member 8-BPRO_0000250679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K440.
PaxDbiQ8K440.
PRIDEiQ8K440.

PTM databases

iPTMnetiQ8K440.
PhosphoSiteiQ8K440.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, liver and skeletal muscle.1 Publication

Developmental stagei

Expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiQ8K440.
ExpressionAtlasiQ8K440. baseline and differential.
GenevisibleiQ8K440. MM.

Interactioni

Protein-protein interaction databases

BioGridi205211. 1 interaction.
IntActiQ8K440. 1 interaction.
MINTiMINT-4117763.
STRINGi10090.ENSMUSP00000020948.

Structurei

3D structure databases

ProteinModelPortaliQ8K440.
SMRiQ8K440. Positions 478-731, 1277-1521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini479 – 714236ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1283 – 1516234ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8K440.
KOiK05650.
OMAiHGKESIR.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8K440.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020846. MFS_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKREISVRQ QTCALLQKNL LKKWRLKRES LMEWVSSLLL LLFLYWYPHG
60 70 80 90 100
HGATDLSSVP TKDLGRVDSF RQSGFMIGYT PVTSMTQQIM EKVAATPFMA
110 120 130 140 150
DKKVLGLLDE ENIKELTESH AEIIRVIFSD TFSYHLKFQF DQRIPTSREL
160 170 180 190 200
RDHNAHCDGL YEDVNCLIAI FWKEGFVALQ AAINAAIIET TTNHSVMEEL
210 220 230 240 250
LSVSGKFMKI HPFVRQEGIL TDFFIFTCII SFSPITYYVS INVARERKRM
260 270 280 290 300
KGLMMMMGLR DPAFWLSWGL LYAGFVFIMA LSLALVIKSV QFFILTSFMV
310 320 330 340 350
VFSLFLLYGL SMITLAFLMS ALVRKSVLTG LSVFLLTIFW GSLGFTSLYR
360 370 380 390 400
YLPAPVEWTL SLFSPFAFTL GMAQLLRVDY DLNSNAPPDP ASGSNLIIAT
410 420 430 440 450
NFMLVFDAFL YLALMMYFEK VLPNEYGHQH SPLFFLKSSF WLQTRKPAHV
460 470 480 490 500
ILEDGIDPVP SSGDSFEPVS PEFHGKESIR IRNISKEYKG KPNKIEALKD
510 520 530 540 550
LTLDIYEGQI TAVLGHSGAG KSTLLNILSG LSVPTKGSVT IYNNNLSEMA
560 570 580 590 600
DLENILRIAG VCPQANVQFD FLTVRENLRL FAKIRGIPPQ DVEKEVQRVL
610 620 630 640 650
LELEMKNIQN ILAQNLSGGQ KRKLTFGIAI LGDSQIFLLD EPTAGLDPFS
660 670 680 690 700
RHRVWNLLKE RRADRVVLFS TQFMDEADIL ADRKVFISNG RLKCAGSSLF
710 720 730 740 750
LKKKWGVGYH LSLQLKEVCV PENITSLVKQ HIPAAKLSAE GEGKLLYTLP
760 770 780 790 800
LETTYRFPEL CQSLDSCPGL GIENYGVSMT TLNEVFLKLE GKASIDEPEV
810 820 830 840 850
DIVGEGQTER SGDTERLMEM EQTLSSLRET EKTDGMALWR QQTCAIAKVR
860 870 880 890 900
LLKLKHERKT LLSVLLILVV GICPFLFENI STKIRQSSYT WELSPHDYFL
910 920 930 940 950
APGQQPQGML TQLLIINKTE ASIDDFIHSV ERQNIALEVD ASGTRDGTDD
960 970 980 990 1000
PSYNGALIVS GNEKNHSFSF ACNTKRLNCF PVLMDILSNG LLGMVKPSAR
1010 1020 1030 1040 1050
IQTDRSTYLM DETIHPLEDL WKTAFWLILT SACPPYIAMS SVTDYKNRAW
1060 1070 1080 1090 1100
FQLRVSGLFP SAYWVGQAMV DIPLYCFVFL FMSLMDYLFR FPDTMFSIIS
1110 1120 1130 1140 1150
HVIQIPCSVG YAISLIFLTY VISFISRKGK KNSGIWSLSF YIITVFSVAV
1160 1170 1180 1190 1200
ILLAFDVDGT QYYIIFLIPP STLVGCLILS LHLFIGQIFE EGQVIEPFLV
1210 1220 1230 1240 1250
FLIPFLHVFI FIFTLRCLEW KFGKKTMRKD PIFRISPRNN DVYQNPEEPE
1260 1270 1280 1290 1300
DEDEDVQMER MRTANALVST SFDEKPVIIA SCLRKEYAGK QKHCLSKKKA
1310 1320 1330 1340 1350
KIATRNVSFC VRKGEILGLL GHNGAGKSTS LKMISGDTKV TAGQVLLKGS
1360 1370 1380 1390 1400
REGDTPGFLG YCPQENALWP NLTVKEHLEI FAAVRGLRKS HAAVAITRLA
1410 1420 1430 1440 1450
DALKLQDQLK SPVKTLSEGV KRKLCFVLSI LGNPSILLLD EPSTGLDPEG
1460 1470 1480 1490 1500
QQQIWQAIRA IIKNTDRGAL LTTHYMAEAE ALCDRVAILV SGRLRCIGSI
1510 1520 1530 1540 1550
QHLKSKFGKD YLLEMKVKTL EQVEPLNTEI LRLFPQASRQ ERYSSLMAYK
1560 1570 1580 1590 1600
LPVEAVQPLS QAFFKLEKVK QTFDLEEYSL SQSTLEQVFL ELSKEQELDG
1610 1620
LELEELDSSI KWKLLPQEEA
Length:1,620
Mass (Da):183,039
Last modified:October 3, 2006 - v2
Checksum:i4330378E6D820B62
GO
Isoform 2 (identifier: Q8K440-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-374: Missing.

Note: No experimental confirmation available.
Show »
Length:1,558
Mass (Da):176,165
Checksum:i7BFE98326CD9F38B
GO

Sequence cautioni

The sequence BAD32312.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti985 – 9851D → G in AAM90908 (PubMed:12532264).Curated
Sequence conflicti1447 – 14471D → V in AAF31432 (PubMed:10708515).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei313 – 37462Missing in isoform 2. 1 PublicationVSP_020704Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498362 mRNA. Translation: AAM90908.1.
AK173034 mRNA. Translation: BAD32312.1. Different initiation.
AL807245 Genomic DNA. Translation: CAM13339.1.
AK043744 mRNA. Translation: BAC31640.1.
AF213393 mRNA. Translation: AAF31432.1.
CCDSiCCDS25587.1. [Q8K440-1]
RefSeqiNP_038879.2. NM_013851.2. [Q8K440-1]
XP_006533522.1. XM_006533459.2. [Q8K440-1]
XP_006533525.1. XM_006533462.2. [Q8K440-2]
XP_006533526.1. XM_006533463.2. [Q8K440-2]
UniGeneiMm.341004.

Genome annotation databases

EnsembliENSMUST00000020948; ENSMUSP00000020948; ENSMUSG00000020620. [Q8K440-1]
ENSMUST00000106669; ENSMUSP00000102280; ENSMUSG00000020620. [Q8K440-2]
GeneIDi27404.
KEGGimmu:27404.
UCSCiuc007mdb.2. mouse. [Q8K440-1]
uc007mdc.2. mouse. [Q8K440-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498362 mRNA. Translation: AAM90908.1.
AK173034 mRNA. Translation: BAD32312.1. Different initiation.
AL807245 Genomic DNA. Translation: CAM13339.1.
AK043744 mRNA. Translation: BAC31640.1.
AF213393 mRNA. Translation: AAF31432.1.
CCDSiCCDS25587.1. [Q8K440-1]
RefSeqiNP_038879.2. NM_013851.2. [Q8K440-1]
XP_006533522.1. XM_006533459.2. [Q8K440-1]
XP_006533525.1. XM_006533462.2. [Q8K440-2]
XP_006533526.1. XM_006533463.2. [Q8K440-2]
UniGeneiMm.341004.

3D structure databases

ProteinModelPortaliQ8K440.
SMRiQ8K440. Positions 478-731, 1277-1521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205211. 1 interaction.
IntActiQ8K440. 1 interaction.
MINTiMINT-4117763.
STRINGi10090.ENSMUSP00000020948.

PTM databases

iPTMnetiQ8K440.
PhosphoSiteiQ8K440.

Proteomic databases

MaxQBiQ8K440.
PaxDbiQ8K440.
PRIDEiQ8K440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020948; ENSMUSP00000020948; ENSMUSG00000020620. [Q8K440-1]
ENSMUST00000106669; ENSMUSP00000102280; ENSMUSG00000020620. [Q8K440-2]
GeneIDi27404.
KEGGimmu:27404.
UCSCiuc007mdb.2. mouse. [Q8K440-1]
uc007mdc.2. mouse. [Q8K440-2]

Organism-specific databases

CTDi27404.
MGIiMGI:1351668. Abca8b.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
InParanoidiQ8K440.
KOiK05650.
OMAiHGKESIR.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8K440.
TreeFamiTF105192.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ8K440.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K440.
ExpressionAtlasiQ8K440. baseline and differential.
GenevisibleiQ8K440. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020846. MFS_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes."
    Annilo T., Chen Z.-Q., Shulenin S., Dean M.
    Mamm. Genome 14:7-20(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pancreatic islet.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1415-1620 (ISOFORMS 1/2).
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  5. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1433-1620 (ISOFORMS 1/2).
  6. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
    Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
    Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Liver and Lung.

Entry informationi

Entry nameiABC8B_MOUSE
AccessioniPrimary (citable) accession number: Q8K440
Secondary accession number(s): A2AM55
, Q69ZY4, Q8BRQ1, Q9JL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.