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Protein

Transient receptor potential cation channel subfamily V member 3

Gene

Trpv3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium channel activity Source: GO_Central
  • cation channel activity Source: MGI
  • ion channel activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name:
TrpV3
Gene namesi
Name:Trpv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2181407. Trpv3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 439CytoplasmicSequence analysisAdd BLAST439
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 487ExtracellularSequence analysisAdd BLAST27
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 523CytoplasmicSequence analysisAdd BLAST15
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545ExtracellularSequence analysis1
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 589CytoplasmicSequence analysisAdd BLAST23
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
Intramembranei621 – 637Pore-formingSequence analysisAdd BLAST17
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 791CytoplasmicSequence analysisAdd BLAST121

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153461 – 791Transient receptor potential cation channel subfamily V member 3Add BLAST791

Proteomic databases

PaxDbiQ8K424.
PRIDEiQ8K424.

PTM databases

iPTMnetiQ8K424.
PhosphoSitePlusiQ8K424.

Expressioni

Tissue specificityi

Expressed in keratinocytes and hair follicles.1 Publication

Gene expression databases

BgeeiENSMUSG00000043029.

Interactioni

Subunit structurei

May form a heteromeric channel with TRPV1. Interacts with TRPV1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2650739,EBI-297353From a different organism.

Protein-protein interaction databases

IntActiQ8K424. 1 interactor.
MINTiMINT-4997769.
STRINGi10090.ENSMUSP00000053755.

Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi119 – 129Combined sources11
Helixi132 – 145Combined sources14
Helixi154 – 161Combined sources8
Turni165 – 167Combined sources3
Helixi171 – 177Combined sources7
Helixi183 – 196Combined sources14
Helixi200 – 204Combined sources5
Helixi211 – 213Combined sources3
Helixi218 – 224Combined sources7
Helixi228 – 236Combined sources9
Beta strandi253 – 255Combined sources3
Helixi265 – 271Combined sources7
Helixi275 – 282Combined sources8
Helixi299 – 306Combined sources8
Beta strandi311 – 313Combined sources3
Helixi316 – 328Combined sources13
Helixi331 – 334Combined sources4
Helixi344 – 350Combined sources7
Helixi354 – 362Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N5QX-ray1.95A/B118-367[»]
ProteinModelPortaliQ8K424.
SMRiQ8K424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati214 – 243ANK 1Add BLAST30
Repeati261 – 291ANK 2Add BLAST31
Repeati340 – 369ANK 3Add BLAST30

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ8K424.
KOiK04972.
OMAiFVKRMYD.
OrthoDBiEOG091G020O.
PhylomeDBiQ8K424.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view]
PANTHERiPTHR10582:SF6. PTHR10582:SF6. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF
60 70 80 90 100
EPNPTVTKTS PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP
110 120 130 140 150
NSPSANLAKE EQRQKKKRLK KRIFAAVSEG CVEELRELLQ DLQDLCRRRR
160 170 180 190 200
GLDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL
210 220 230 240 250
DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD VNAHAKGVFF
260 270 280 290 300
NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL
310 320 330 340 350
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK
360 370 380 390 400
MGKAEILKYI LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD
410 420 430 440 450
NSVLEIIVYN TNIDNRHEML TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF
460 470 480 490 500
YNITLTLVSY YRPREDEDLP HPLALTHKMS WLQLLGRMFV LIWATCISVK
510 520 530 540 550
EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY LFAYKEYLAC
560 570 580 590 600
LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG
610 620 630 640 650
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY
660 670 680 690 700
PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI
710 720 730 740 750
LEFEKMLPEW LRSRFRMGEL CKVADEDFRL CLRINEVKWT EWKTHVSFLN
760 770 780 790
EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF DELDEFPETS V
Length:791
Mass (Da):90,663
Last modified:April 26, 2005 - v2
Checksum:i76A244781D223C6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → V in AAM33069 (PubMed:12016205).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510316 mRNA. Translation: AAM33069.1.
AL645739 Genomic DNA. Translation: CAI24566.1.
CCDSiCCDS25004.1.
RefSeqiNP_659567.2. NM_145099.2.
UniGeneiMm.347652.
Mm.75196.

Genome annotation databases

EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneIDi246788.
KEGGimmu:246788.
UCSCiuc007kaj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510316 mRNA. Translation: AAM33069.1.
AL645739 Genomic DNA. Translation: CAI24566.1.
CCDSiCCDS25004.1.
RefSeqiNP_659567.2. NM_145099.2.
UniGeneiMm.347652.
Mm.75196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N5QX-ray1.95A/B118-367[»]
ProteinModelPortaliQ8K424.
SMRiQ8K424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K424. 1 interactor.
MINTiMINT-4997769.
STRINGi10090.ENSMUSP00000053755.

Chemistry databases

GuidetoPHARMACOLOGYi509.

PTM databases

iPTMnetiQ8K424.
PhosphoSitePlusiQ8K424.

Proteomic databases

PaxDbiQ8K424.
PRIDEiQ8K424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneIDi246788.
KEGGimmu:246788.
UCSCiuc007kaj.1. mouse.

Organism-specific databases

CTDi162514.
MGIiMGI:2181407. Trpv3.

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ8K424.
KOiK04972.
OMAiFVKRMYD.
OrthoDBiEOG091G020O.
PhylomeDBiQ8K424.
TreeFamiTF314711.

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Miscellaneous databases

PROiQ8K424.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043029.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view]
PANTHERiPTHR10582:SF6. PTHR10582:SF6. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV3_MOUSE
AccessioniPrimary (citable) accession number: Q8K424
Secondary accession number(s): Q5SV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.