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Q8K424

- TRPV3_MOUSE

UniProt

Q8K424 - TRPV3_MOUSE

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Protein
Transient receptor potential cation channel subfamily V member 3
Gene
Trpv3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) By similarity.1 Publication

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. cation channel activity Source: MGI
  3. ion channel activity Source: MGI
  4. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of hair cycle Source: Ensembl
  2. positive regulation of calcium ion import Source: Ensembl
  3. response to heat Source: Ensembl
  4. response to temperature stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name:
TrpV3
Gene namesi
Name:Trpv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2181407. Trpv3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 439439Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei440 – 46021Helical; Reviewed prediction
Add
BLAST
Topological domaini461 – 48727Extracellular Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST
Topological domaini509 – 52315Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Reviewed prediction
Add
BLAST
Topological domaini545 – 5451Extracellular Reviewed prediction
Transmembranei546 – 56621Helical; Reviewed prediction
Add
BLAST
Topological domaini567 – 58923Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei590 – 61021Helical; Reviewed prediction
Add
BLAST
Intramembranei621 – 63717Pore-forming; Reviewed prediction
Add
BLAST
Transmembranei650 – 67021Helical; Reviewed prediction
Add
BLAST
Topological domaini671 – 791121Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791Transient receptor potential cation channel subfamily V member 3
PRO_0000215346Add
BLAST

Proteomic databases

PRIDEiQ8K424.

PTM databases

PhosphoSiteiQ8K424.

Expressioni

Tissue specificityi

Expressed in keratinocytes and hair follicles.1 Publication

Gene expression databases

BgeeiQ8K424.
GenevestigatoriQ8K424.

Interactioni

Subunit structurei

May form a heteromeric channel with TRPV1. Interacts with TRPV1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2650739,EBI-297353From a different organism.

Protein-protein interaction databases

IntActiQ8K424. 1 interaction.
MINTiMINT-4997769.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi119 – 12911
Helixi132 – 14514
Helixi154 – 1618
Turni165 – 1673
Helixi171 – 1777
Helixi183 – 19614
Helixi200 – 2045
Helixi211 – 2133
Helixi218 – 2247
Helixi228 – 2369
Beta strandi253 – 2553
Helixi265 – 2717
Helixi275 – 2828
Helixi299 – 3068
Beta strandi311 – 3133
Helixi316 – 32813
Helixi331 – 3344
Helixi344 – 3507
Helixi354 – 3629

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N5QX-ray1.95A/B118-367[»]
ProteinModelPortaliQ8K424.
SMRiQ8K424. Positions 118-712.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati214 – 24330ANK 1
Add
BLAST
Repeati261 – 29131ANK 2
Add
BLAST
Repeati340 – 36930ANK 3
Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278734.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ8K424.
KOiK04972.
OMAiHEMLTLE.
OrthoDBiEOG7PCJG6.
PhylomeDBiQ8K424.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view]
PANTHERiPTHR10582:SF6. PTHR10582:SF6. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K424-1 [UniParc]FASTAAdd to Basket

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MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF    50
EPNPTVTKTS PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP 100
NSPSANLAKE EQRQKKKRLK KRIFAAVSEG CVEELRELLQ DLQDLCRRRR 150
GLDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL 200
DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD VNAHAKGVFF 250
NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL 300
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK 350
MGKAEILKYI LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD 400
NSVLEIIVYN TNIDNRHEML TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF 450
YNITLTLVSY YRPREDEDLP HPLALTHKMS WLQLLGRMFV LIWATCISVK 500
EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY LFAYKEYLAC 550
LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG 600
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY 650
PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI 700
LEFEKMLPEW LRSRFRMGEL CKVADEDFRL CLRINEVKWT EWKTHVSFLN 750
EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF DELDEFPETS V 791
Length:791
Mass (Da):90,663
Last modified:April 26, 2005 - v2
Checksum:i76A244781D223C6E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → V in AAM33069. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510316 mRNA. Translation: AAM33069.1.
AL645739 Genomic DNA. Translation: CAI24566.1.
CCDSiCCDS25004.1.
RefSeqiNP_659567.2. NM_145099.2.
UniGeneiMm.347652.
Mm.75196.

Genome annotation databases

EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneIDi246788.
KEGGimmu:246788.
UCSCiuc007kaj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF510316 mRNA. Translation: AAM33069.1 .
AL645739 Genomic DNA. Translation: CAI24566.1 .
CCDSi CCDS25004.1.
RefSeqi NP_659567.2. NM_145099.2.
UniGenei Mm.347652.
Mm.75196.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4N5Q X-ray 1.95 A/B 118-367 [» ]
ProteinModelPortali