Transient receptor potential cation channel subfamily V member 3

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Q8K424 (TRPV3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name=TrpV3

Gene names

Name:

Trpv3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	791 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) By similarity. Ref.1
Subunit structure	May form a heteromeric channel with TRPV1. Interacts with TRPV1 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Expressed in keratinocytes and hair follicles. Ref.1
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. [View classification] Contains 3 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of hair cycle Inferred from electronic annotation. Source: Compara response to temperature stimulus Inferred from direct assay Ref.1 PubMed 15194687. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay Ref.1. Source: MGI
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW cation channel activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EGFR	P00533	2	EBI-2650739,EBI-297353	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 791

791

Transient receptor potential cation channel subfamily V member 3

PRO_0000215346

Regions

Topological domain

1 – 439

439

Cytoplasmic Potential

Transmembrane

440 – 460

Helical; Potential

Topological domain

461 – 487

Extracellular Potential

Transmembrane

488 – 508

Helical; Potential

Topological domain

509 – 523

Cytoplasmic Potential

Transmembrane

524 – 544

Helical; Potential

Topological domain

545

Extracellular Potential

Transmembrane

546 – 566

Helical; Potential

Topological domain

567 – 589

Cytoplasmic Potential

Transmembrane

590 – 610

Helical; Potential

Intramembrane

621 – 637

Pore-forming; Potential

Transmembrane

650 – 670

Helical; Potential

Topological domain

671 – 791

121

Cytoplasmic Potential

Repeat

214 – 243

ANK 1

Repeat

261 – 291

ANK 2

Repeat

340 – 369

ANK 3

Experimental info

Sequence conflict

A → V in AAM33069. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q8K424 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 76A244781D223C6E
Show »

FASTA

791

90,663

        10         20         30         40         50         60 
MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF EPNPTVTKTS 

        70         80         90        100        110        120 
PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP NSPSANLAKE EQRQKKKRLK 

       130        140        150        160        170        180 
KRIFAAVSEG CVEELRELLQ DLQDLCRRRR GLDVPDFLMH KLTASDTGKT CLMKALLNIN 

       190        200        210        220        230        240 
PNTKEIVRIL LAFAEENDIL DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD 

       250        260        270        280        290        300 
VNAHAKGVFF NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL 

       310        320        330        340        350        360 
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK MGKAEILKYI 

       370        380        390        400        410        420 
LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD NSVLEIIVYN TNIDNRHEML 

       430        440        450        460        470        480 
TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF YNITLTLVSY YRPREDEDLP HPLALTHKMS 

       490        500        510        520        530        540 
WLQLLGRMFV LIWATCISVK EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY 

       550        560        570        580        590        600 
LFAYKEYLAC LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG 

       610        620        630        640        650        660 
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY PILFLFLLIT 

       670        680        690        700        710        720 
YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI LEFEKMLPEW LRSRFRMGEL 

       730        740        750        760        770        780 
CKVADEDFRL CLRINEVKWT EWKTHVSFLN EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF 

       790 
DELDEFPETS V

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A heat-sensitive TRP channel expressed in keratinocytes." Peier A.M., Reeve A.J., Andersson D.A., Moqrich A., Earley T.J., Hergarden A.C., Story G.M., Colley S., Hogenesch J., McIntyre P., Bevan S., Patapoutian A. Science 296:2046-2049(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6J.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF510316 mRNA. Translation: AAM33069.1. AL645739 Genomic DNA. Translation: CAI24566.1.
IPI	IPI00170135.
RefSeq	NP_659567.2. NM_145099.2.
UniGene	Mm.347652. Mm.75196.
3D structure databases
ProteinModelPortal	Q8K424.
SMR	Q8K424. Positions 123-367.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8K424. 1 interaction.
PTM databases
PhosphoSite	Q8K424.
Proteomic databases
PRIDE	Q8K424.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneID	246788.
KEGG	mmu:246788.
UCSC	uc007kaj.1. mouse.
Organism-specific databases
CTD	162514.
MGI	MGI:2181407. Trpv3.
Phylogenomic databases
eggNOG	NOG278734.
GeneTree	ENSGT00550000074425.
HOGENOM	HOG000234630.
HOVERGEN	HBG054085.
InParanoid	Q8K424.
KO	K04972.
OMA	SAHFFLE.
OrthoDB	EOG42BX7Z.
Gene expression databases
Bgee	Q8K424.
Genevestigator	Q8K424.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR008347. TRPV1-4_channel. IPR024866. TRPV3_channel. IPR024862. TRPV_channel. [Graphical view]
PANTHER	PTHR10582. PTHR10582. 1 hit. PTHR10582:SF6. PTHR10582:SF6. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01768. TRPVRECEPTOR.
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	387320.
SOURCE	Search...

Entry information

Entry name

TRPV3_MOUSE

Accession

Primary (citable) accession number: Q8K424
Secondary accession number(s): Q5SV08

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents