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Q8K424 (TRPV3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transient receptor potential cation channel subfamily V member 3

Short name=TrpV3
Gene names
Name:Trpv3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length791 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) By similarity. Ref.1

Subunit structure

May form a heteromeric channel with TRPV1. Interacts with TRPV1 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed in keratinocytes and hair follicles. Ref.1

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. [View classification]

Contains 3 ANK repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EGFRP005332EBI-2650739,EBI-297353From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 791791Transient receptor potential cation channel subfamily V member 3
PRO_0000215346

Regions

Topological domain1 – 439439Cytoplasmic Potential
Transmembrane440 – 46021Helical; Potential
Topological domain461 – 48727Extracellular Potential
Transmembrane488 – 50821Helical; Potential
Topological domain509 – 52315Cytoplasmic Potential
Transmembrane524 – 54421Helical; Potential
Topological domain5451Extracellular Potential
Transmembrane546 – 56621Helical; Potential
Topological domain567 – 58923Cytoplasmic Potential
Transmembrane590 – 61021Helical; Potential
Intramembrane621 – 63717Pore-forming; Potential
Transmembrane650 – 67021Helical; Potential
Topological domain671 – 791121Cytoplasmic Potential
Repeat214 – 24330ANK 1
Repeat261 – 29131ANK 2
Repeat340 – 36930ANK 3

Experimental info

Sequence conflict91A → V in AAM33069. Ref.1

Secondary structure

....................................... 791
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8K424 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 76A244781D223C6E

FASTA79190,663
        10         20         30         40         50         60 
MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF EPNPTVTKTS 

        70         80         90        100        110        120 
PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP NSPSANLAKE EQRQKKKRLK 

       130        140        150        160        170        180 
KRIFAAVSEG CVEELRELLQ DLQDLCRRRR GLDVPDFLMH KLTASDTGKT CLMKALLNIN 

       190        200        210        220        230        240 
PNTKEIVRIL LAFAEENDIL DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD 

       250        260        270        280        290        300 
VNAHAKGVFF NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL 

       310        320        330        340        350        360 
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK MGKAEILKYI 

       370        380        390        400        410        420 
LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD NSVLEIIVYN TNIDNRHEML 

       430        440        450        460        470        480 
TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF YNITLTLVSY YRPREDEDLP HPLALTHKMS 

       490        500        510        520        530        540 
WLQLLGRMFV LIWATCISVK EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY 

       550        560        570        580        590        600 
LFAYKEYLAC LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG 

       610        620        630        640        650        660 
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY PILFLFLLIT 

       670        680        690        700        710        720 
YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI LEFEKMLPEW LRSRFRMGEL 

       730        740        750        760        770        780 
CKVADEDFRL CLRINEVKWT EWKTHVSFLN EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF 

       790 
DELDEFPETS V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF510316 mRNA. Translation: AAM33069.1.
AL645739 Genomic DNA. Translation: CAI24566.1.
RefSeqNP_659567.2. NM_145099.2.
UniGeneMm.347652.
Mm.75196.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4N5QX-ray1.95A/B118-367[»]
ProteinModelPortalQ8K424.
SMRQ8K424. Positions 123-367.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K424. 1 interaction.
MINTMINT-4997769.

Chemistry

GuidetoPHARMACOLOGY509.

PTM databases

PhosphoSiteQ8K424.

Proteomic databases

PRIDEQ8K424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneID246788.
KEGGmmu:246788.
UCSCuc007kaj.1. mouse.

Organism-specific databases

CTD162514.
MGIMGI:2181407. Trpv3.

Phylogenomic databases

eggNOGNOG278734.
GeneTreeENSGT00550000074425.
HOGENOMHOG000234630.
HOVERGENHBG054085.
InParanoidQ8K424.
KOK04972.
OMAHEMLTLE.
OrthoDBEOG7PCJG6.
PhylomeDBQ8K424.
TreeFamTF314711.

Gene expression databases

BgeeQ8K424.
GenevestigatorQ8K424.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR024862. TRPV.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view]
PANTHERPTHR10582. PTHR10582. 1 hit.
PTHR10582:SF6. PTHR10582:SF6. 1 hit.
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR01768. TRPVRECEPTOR.
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio387320.
PROQ8K424.
SOURCESearch...

Entry information

Entry nameTRPV3_MOUSE
AccessionPrimary (citable) accession number: Q8K424
Secondary accession number(s): Q5SV08
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot