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Q8K424

- TRPV3_MOUSE

UniProt

Q8K424 - TRPV3_MOUSE

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Protein

Transient receptor potential cation channel subfamily V member 3

Gene

Trpv3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. cation channel activity Source: MGI
  3. ion channel activity Source: MGI

GO - Biological processi

  1. negative regulation of hair cycle Source: Ensembl
  2. positive regulation of calcium ion import Source: Ensembl
  3. response to heat Source: Ensembl
  4. response to temperature stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name:
TrpV3
Gene namesi
Name:Trpv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2181407. Trpv3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 439439CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence AnalysisAdd
BLAST
Topological domaini461 – 48727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence AnalysisAdd
BLAST
Topological domaini509 – 52315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 5451ExtracellularSequence Analysis
Transmembranei546 – 56621HelicalSequence AnalysisAdd
BLAST
Topological domaini567 – 58923CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei590 – 61021HelicalSequence AnalysisAdd
BLAST
Intramembranei621 – 63717Pore-formingSequence AnalysisAdd
BLAST
Transmembranei650 – 67021HelicalSequence AnalysisAdd
BLAST
Topological domaini671 – 791121CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791Transient receptor potential cation channel subfamily V member 3PRO_0000215346Add
BLAST

Proteomic databases

PRIDEiQ8K424.

PTM databases

PhosphoSiteiQ8K424.

Expressioni

Tissue specificityi

Expressed in keratinocytes and hair follicles.1 Publication

Gene expression databases

BgeeiQ8K424.
GenevestigatoriQ8K424.

Interactioni

Subunit structurei

May form a heteromeric channel with TRPV1. Interacts with TRPV1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2650739,EBI-297353From a different organism.

Protein-protein interaction databases

IntActiQ8K424. 1 interaction.
MINTiMINT-4997769.

Structurei

Secondary structure

1
791
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi119 – 12911Combined sources
Helixi132 – 14514Combined sources
Helixi154 – 1618Combined sources
Turni165 – 1673Combined sources
Helixi171 – 1777Combined sources
Helixi183 – 19614Combined sources
Helixi200 – 2045Combined sources
Helixi211 – 2133Combined sources
Helixi218 – 2247Combined sources
Helixi228 – 2369Combined sources
Beta strandi253 – 2553Combined sources
Helixi265 – 2717Combined sources
Helixi275 – 2828Combined sources
Helixi299 – 3068Combined sources
Beta strandi311 – 3133Combined sources
Helixi316 – 32813Combined sources
Helixi331 – 3344Combined sources
Helixi344 – 3507Combined sources
Helixi354 – 3629Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N5QX-ray1.95A/B118-367[»]
ProteinModelPortaliQ8K424.
SMRiQ8K424. Positions 118-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati214 – 24330ANK 1Add
BLAST
Repeati261 – 29131ANK 2Add
BLAST
Repeati340 – 36930ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278734.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ8K424.
KOiK04972.
OMAiHEMLTLE.
OrthoDBiEOG7PCJG6.
PhylomeDBiQ8K424.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view]
PANTHERiPTHR10582:SF6. PTHR10582:SF6. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K424-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF
60 70 80 90 100
EPNPTVTKTS PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP
110 120 130 140 150
NSPSANLAKE EQRQKKKRLK KRIFAAVSEG CVEELRELLQ DLQDLCRRRR
160 170 180 190 200
GLDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL
210 220 230 240 250
DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD VNAHAKGVFF
260 270 280 290 300
NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL
310 320 330 340 350
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK
360 370 380 390 400
MGKAEILKYI LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD
410 420 430 440 450
NSVLEIIVYN TNIDNRHEML TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF
460 470 480 490 500
YNITLTLVSY YRPREDEDLP HPLALTHKMS WLQLLGRMFV LIWATCISVK
510 520 530 540 550
EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY LFAYKEYLAC
560 570 580 590 600
LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG
610 620 630 640 650
FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY
660 670 680 690 700
PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI
710 720 730 740 750
LEFEKMLPEW LRSRFRMGEL CKVADEDFRL CLRINEVKWT EWKTHVSFLN
760 770 780 790
EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF DELDEFPETS V
Length:791
Mass (Da):90,663
Last modified:April 26, 2005 - v2
Checksum:i76A244781D223C6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → V in AAM33069. (PubMed:12016205)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510316 mRNA. Translation: AAM33069.1.
AL645739 Genomic DNA. Translation: CAI24566.1.
CCDSiCCDS25004.1.
RefSeqiNP_659567.2. NM_145099.2.
UniGeneiMm.347652.
Mm.75196.

Genome annotation databases

EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
GeneIDi246788.
KEGGimmu:246788.
UCSCiuc007kaj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510316 mRNA. Translation: AAM33069.1 .
AL645739 Genomic DNA. Translation: CAI24566.1 .
CCDSi CCDS25004.1.
RefSeqi NP_659567.2. NM_145099.2.
UniGenei Mm.347652.
Mm.75196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4N5Q X-ray 1.95 A/B 118-367 [» ]
ProteinModelPortali Q8K424.
SMRi Q8K424. Positions 118-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K424. 1 interaction.
MINTi MINT-4997769.

Chemistry

GuidetoPHARMACOLOGYi 509.

PTM databases

PhosphoSitei Q8K424.

Proteomic databases

PRIDEi Q8K424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049676 ; ENSMUSP00000053755 ; ENSMUSG00000043029 .
GeneIDi 246788.
KEGGi mmu:246788.
UCSCi uc007kaj.1. mouse.

Organism-specific databases

CTDi 162514.
MGIi MGI:2181407. Trpv3.

Phylogenomic databases

eggNOGi NOG278734.
GeneTreei ENSGT00550000074425.
HOGENOMi HOG000234630.
HOVERGENi HBG054085.
InParanoidi Q8K424.
KOi K04972.
OMAi HEMLTLE.
OrthoDBi EOG7PCJG6.
PhylomeDBi Q8K424.
TreeFami TF314711.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 387320.
PROi Q8K424.
SOURCEi Search...

Gene expression databases

Bgeei Q8K424.
Genevestigatori Q8K424.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR008347. TRPV1-4_channel.
IPR024866. TRPV3_channel.
[Graphical view ]
PANTHERi PTHR10582:SF6. PTHR10582:SF6. 1 hit.
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR01768. TRPVRECEPTOR.
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTRPV3_MOUSE
AccessioniPrimary (citable) accession number: Q8K424
Secondary accession number(s): Q5SV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3