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Q8K424

- TRPV3_MOUSE

UniProt

Q8K424 - TRPV3_MOUSE

Protein

Transient receptor potential cation channel subfamily V member 3

Gene

Trpv3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) By similarity.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. cation channel activity Source: MGI
    3. ion channel activity Source: MGI
    4. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of hair cycle Source: Ensembl
    2. positive regulation of calcium ion import Source: Ensembl
    3. response to heat Source: Ensembl
    4. response to temperature stimulus Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_227861. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily V member 3
    Short name:
    TrpV3
    Gene namesi
    Name:Trpv3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2181407. Trpv3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 791791Transient receptor potential cation channel subfamily V member 3PRO_0000215346Add
    BLAST

    Proteomic databases

    PRIDEiQ8K424.

    PTM databases

    PhosphoSiteiQ8K424.

    Expressioni

    Tissue specificityi

    Expressed in keratinocytes and hair follicles.1 Publication

    Gene expression databases

    BgeeiQ8K424.
    GenevestigatoriQ8K424.

    Interactioni

    Subunit structurei

    May form a heteromeric channel with TRPV1. Interacts with TRPV1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005332EBI-2650739,EBI-297353From a different organism.

    Protein-protein interaction databases

    IntActiQ8K424. 1 interaction.
    MINTiMINT-4997769.

    Structurei

    Secondary structure

    1
    791
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi119 – 12911
    Helixi132 – 14514
    Helixi154 – 1618
    Turni165 – 1673
    Helixi171 – 1777
    Helixi183 – 19614
    Helixi200 – 2045
    Helixi211 – 2133
    Helixi218 – 2247
    Helixi228 – 2369
    Beta strandi253 – 2553
    Helixi265 – 2717
    Helixi275 – 2828
    Helixi299 – 3068
    Beta strandi311 – 3133
    Helixi316 – 32813
    Helixi331 – 3344
    Helixi344 – 3507
    Helixi354 – 3629

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4N5QX-ray1.95A/B118-367[»]
    ProteinModelPortaliQ8K424.
    SMRiQ8K424. Positions 118-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 439439CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini461 – 48727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini545 – 5451ExtracellularSequence Analysis
    Topological domaini567 – 58923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini671 – 791121CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei621 – 63717Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei440 – 46021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei590 – 61021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei650 – 67021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati214 – 24330ANK 1Add
    BLAST
    Repeati261 – 29131ANK 2Add
    BLAST
    Repeati340 – 36930ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278734.
    GeneTreeiENSGT00550000074425.
    HOGENOMiHOG000234630.
    HOVERGENiHBG054085.
    InParanoidiQ8K424.
    KOiK04972.
    OMAiHEMLTLE.
    OrthoDBiEOG7PCJG6.
    PhylomeDBiQ8K424.
    TreeFamiTF314711.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR008347. TRPV1-4_channel.
    IPR024866. TRPV3_channel.
    [Graphical view]
    PANTHERiPTHR10582:SF6. PTHR10582:SF6. 1 hit.
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01768. TRPVRECEPTOR.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K424-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAHSKEMAP LMGKRTTAPG GNPVVLTEKR PADLTPTKKS AHFFLEIEGF    50
    EPNPTVTKTS PPIFSKPMDS NIRQCLSGNC DDMDSPQSPQ DDVTETPSNP 100
    NSPSANLAKE EQRQKKKRLK KRIFAAVSEG CVEELRELLQ DLQDLCRRRR 150
    GLDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL 200
    DRFINAEYTE EAYEGQTALN IAIERRQGDI TAVLIAAGAD VNAHAKGVFF 250
    NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMENEQTDIT SQDSRGNNIL 300
    HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETMRNND GLTPLQLAAK 350
    MGKAEILKYI LSREIKEKPL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD 400
    NSVLEIIVYN TNIDNRHEML TLEPLHTLLH TKWKKFAKYM FFLSFCFYFF 450
    YNITLTLVSY YRPREDEDLP HPLALTHKMS WLQLLGRMFV LIWATCISVK 500
    EGIAIFLLRP SDLQSILSDA WFHFVFFVQA VLVILSVFLY LFAYKEYLAC 550
    LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYILFLLG 600
    FGVALASLIE KCSKDKKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSTY 650
    PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI 700
    LEFEKMLPEW LRSRFRMGEL CKVADEDFRL CLRINEVKWT EWKTHVSFLN 750
    EDPGPIRRTA DLNKIQDSSR SNSKTTLYAF DELDEFPETS V 791
    Length:791
    Mass (Da):90,663
    Last modified:April 26, 2005 - v2
    Checksum:i76A244781D223C6E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91A → V in AAM33069. (PubMed:12016205)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510316 mRNA. Translation: AAM33069.1.
    AL645739 Genomic DNA. Translation: CAI24566.1.
    CCDSiCCDS25004.1.
    RefSeqiNP_659567.2. NM_145099.2.
    UniGeneiMm.347652.
    Mm.75196.

    Genome annotation databases

    EnsembliENSMUST00000049676; ENSMUSP00000053755; ENSMUSG00000043029.
    GeneIDi246788.
    KEGGimmu:246788.
    UCSCiuc007kaj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF510316 mRNA. Translation: AAM33069.1 .
    AL645739 Genomic DNA. Translation: CAI24566.1 .
    CCDSi CCDS25004.1.
    RefSeqi NP_659567.2. NM_145099.2.
    UniGenei Mm.347652.
    Mm.75196.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4N5Q X-ray 1.95 A/B 118-367 [» ]
    ProteinModelPortali Q8K424.
    SMRi Q8K424. Positions 118-712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K424. 1 interaction.
    MINTi MINT-4997769.

    Chemistry

    GuidetoPHARMACOLOGYi 509.

    PTM databases

    PhosphoSitei Q8K424.

    Proteomic databases

    PRIDEi Q8K424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049676 ; ENSMUSP00000053755 ; ENSMUSG00000043029 .
    GeneIDi 246788.
    KEGGi mmu:246788.
    UCSCi uc007kaj.1. mouse.

    Organism-specific databases

    CTDi 162514.
    MGIi MGI:2181407. Trpv3.

    Phylogenomic databases

    eggNOGi NOG278734.
    GeneTreei ENSGT00550000074425.
    HOGENOMi HOG000234630.
    HOVERGENi HBG054085.
    InParanoidi Q8K424.
    KOi K04972.
    OMAi HEMLTLE.
    OrthoDBi EOG7PCJG6.
    PhylomeDBi Q8K424.
    TreeFami TF314711.

    Enzyme and pathway databases

    Reactomei REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 387320.
    PROi Q8K424.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K424.
    Genevestigatori Q8K424.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR008347. TRPV1-4_channel.
    IPR024866. TRPV3_channel.
    [Graphical view ]
    PANTHERi PTHR10582:SF6. PTHR10582:SF6. 1 hit.
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01768. TRPVRECEPTOR.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiTRPV3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K424
    Secondary accession number(s): Q5SV08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3