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Protein

Galectin-4

Gene

Lgals4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • galactoside binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
Lactose-binding lectin 4
Gene namesi
Name:Lgals4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107536. Lgals4.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Galectin-4PRO_0000076935Add
BLAST

Proteomic databases

MaxQBiQ8K419.
PaxDbiQ8K419.
PRIDEiQ8K419.

PTM databases

iPTMnetiQ8K419.
PhosphoSiteiQ8K419.

Expressioni

Tissue specificityi

Epithelial cells of the embryonic and adult gastrointestinal tract. Expressed at about equal levels in colon and small intestine but much less in stomach.1 Publication

Gene expression databases

BgeeiQ8K419.
CleanExiMM_LGALS4.
ExpressionAtlasiQ8K419. baseline and differential.
GenevisibleiQ8K419. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi201144. 1 interaction.
IntActiQ8K419. 3 interactions.
STRINGi10090.ENSMUSP00000066461.

Structurei

Secondary structure

1
326
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 226Combined sources
Beta strandi32 – 398Combined sources
Beta strandi45 – 5511Combined sources
Beta strandi60 – 678Combined sources
Beta strandi69 – 713Combined sources
Beta strandi73 – 808Combined sources
Beta strandi88 – 914Combined sources
Beta strandi100 – 1078Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi119 – 1257Combined sources
Helixi130 – 1323Combined sources
Beta strandi135 – 15016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYCX-ray2.40A9-159[»]
3I8TX-ray2.10A2-152[»]
ProteinModelPortaliQ8K419.
SMRiQ8K419. Positions 13-159, 188-326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K419.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 326129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 2657Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ8K419.
KOiK10091.
OMAiKVVFNTM.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ8K419.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSVYIQGMAK ENMRRFHVNF
60 70 80 90 100
AVGQDDGADV AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGKH
110 120 130 140 150
FELVFMVMPE HYKVVVNGNS FYEYGHRLPV QMVTHLQVDG DLELQSINFL
160 170 180 190 200
GGQPAAAPYP GAMTIPAYPA GSPGYNPPQM NTLPVMTGPP VFNPRVPYVG
210 220 230 240 250
ALQGGLTVRR TIIIKGYVLP TARNFVINFK VGSSGDIALH LNPRIGDSVV
260 270 280 290 300
RNSFMNGSWG AEERKVAYNP FGPGQFFDLS IRCGMDRFKV FANGQHLFDF
310 320
SHRFQAFQMV DTLEINGDIT LSYVQI
Length:326
Mass (Da):36,372
Last modified:February 2, 2004 - v2
Checksum:i7F3DD89862A853B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771N → K (Ref. 2) Curated
Sequence conflicti77 – 771N → K (PubMed:9446608).Curated
Sequence conflicti160 – 1601P → A in AAC27245 (PubMed:9446608).Curated
Sequence conflicti208 – 2092VR → LP in AAC27245 (PubMed:9446608).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044870 mRNA. Translation: AAK97790.1.
AF510729 mRNA. Translation: AAM44060.1.
BC011236 mRNA. Translation: AAH11236.1.
BC021632 mRNA. Translation: AAH21632.1.
BC030297 mRNA. Translation: AAH30297.1.
AF026795 mRNA. Translation: AAC27245.1.
CCDSiCCDS21058.1.
RefSeqiNP_034836.1. NM_010706.2.
UniGeneiMm.210336.

Genome annotation databases

EnsembliENSMUST00000066723; ENSMUSP00000066461; ENSMUSG00000053964.
GeneIDi16855.
KEGGimmu:16855.
UCSCiuc009gac.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044870 mRNA. Translation: AAK97790.1.
AF510729 mRNA. Translation: AAM44060.1.
BC011236 mRNA. Translation: AAH11236.1.
BC021632 mRNA. Translation: AAH21632.1.
BC030297 mRNA. Translation: AAH30297.1.
AF026795 mRNA. Translation: AAC27245.1.
CCDSiCCDS21058.1.
RefSeqiNP_034836.1. NM_010706.2.
UniGeneiMm.210336.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYCX-ray2.40A9-159[»]
3I8TX-ray2.10A2-152[»]
ProteinModelPortaliQ8K419.
SMRiQ8K419. Positions 13-159, 188-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201144. 1 interaction.
IntActiQ8K419. 3 interactions.
STRINGi10090.ENSMUSP00000066461.

PTM databases

iPTMnetiQ8K419.
PhosphoSiteiQ8K419.

Proteomic databases

MaxQBiQ8K419.
PaxDbiQ8K419.
PRIDEiQ8K419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066723; ENSMUSP00000066461; ENSMUSG00000053964.
GeneIDi16855.
KEGGimmu:16855.
UCSCiuc009gac.2. mouse.

Organism-specific databases

CTDi3960.
MGIiMGI:107536. Lgals4.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ8K419.
KOiK10091.
OMAiKVVFNTM.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ8K419.
TreeFamiTF315551.

Miscellaneous databases

EvolutionaryTraceiQ8K419.
NextBioi290796.
PROiQ8K419.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K419.
CleanExiMM_LGALS4.
ExpressionAtlasiQ8K419. baseline and differential.
GenevisibleiQ8K419. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and tissue distribution of mouse galectin-4."
    Maly P., Jenikova G., Cummings R.D.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. Hokama A., Tanaka Y., Mizoguchi A.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract."
    Gitt M.A., Colnot C., Poirier F., Nani K.J., Barondes S.H., Leffler H.
    J. Biol. Chem. 273:2954-2960(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-321, TISSUE SPECIFICITY.
    Strain: 129/Sv.
    Tissue: Colon.
  5. "Crystal structure of the N-terminal domain of mouse galectin-4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 8-159.

Entry informationi

Entry nameiLEG4_MOUSE
AccessioniPrimary (citable) accession number: Q8K419
Secondary accession number(s): O88353, Q91X74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: January 20, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.