Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bombesin receptor subtype-3

Gene

Brs3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor subtype-3
Short name:
BRS-3
Gene namesi
Name:Brs3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi628645. Brs3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6322Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8219CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12118ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini144 – 16320CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 22036ExtracellularSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini242 – 27231CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini294 – 31320ExtracellularSequence analysisAdd
BLAST
Transmembranei314 – 33320Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 39966CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075111.
GuidetoPHARMACOLOGYi40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Bombesin receptor subtype-3PRO_0000263005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 203PROSITE-ProRule annotation
Lipidationi347 – 3471S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8K418.

PTM databases

PhosphoSiteiQ8K418.

Interactioni

Subunit structurei

Interacts with C6orf89.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001164.

Chemistry

BindingDBiQ8K418.

Structurei

3D structure databases

ProteinModelPortaliQ8K418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiQ8K418.
KOiK04170.
OMAiEEHGHAR.
OrthoDBiEOG73V6KG.
PhylomeDBiQ8K418.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRQPQSPN QTLISITNDT ETSSSAVSND TTPKGWTGDN SPGIEALCAI
60 70 80 90 100
YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC
110 120 130 140 150
VPVDATHYLA EGWLFGKVGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV
160 170 180 190 200
KPLERQPSNA ILKTCAKAGG IWIMAMIFAL PEAIFSNVYT FQDPNRNVTF
210 220 230 240 250
ESCNSYPISE RLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN
260 270 280 290 300
IPTEEQSHAR KQIESRKRIA KTVLVLVALF ALCWLPNHLL YLYHSFTYES
310 320 330 340 350
YAEPSDVPFV VTIFSRVLAF SNSCVNPFAL YWLSKTFQKH FKAQLCCFKA
360 370 380 390
EQPEPPLGDT PLNNLTVMGR VPATGSAHVS EISVTLFSGS TAKKGEDKV
Length:399
Mass (Da):44,204
Last modified:October 1, 2002 - v1
Checksum:i13034C6D44451338
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510984 mRNA. Translation: AAM95932.1.
RefSeqiNP_690058.1. NM_152845.1.
UniGeneiRn.86415.

Genome annotation databases

EnsembliENSRNOT00000001164; ENSRNOP00000001164; ENSRNOG00000000873.
GeneIDi260319.
KEGGirno:260319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510984 mRNA. Translation: AAM95932.1.
RefSeqiNP_690058.1. NM_152845.1.
UniGeneiRn.86415.

3D structure databases

ProteinModelPortaliQ8K418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001164.

Chemistry

BindingDBiQ8K418.
ChEMBLiCHEMBL1075111.
GuidetoPHARMACOLOGYi40.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8K418.

Proteomic databases

PaxDbiQ8K418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001164; ENSRNOP00000001164; ENSRNOG00000000873.
GeneIDi260319.
KEGGirno:260319.

Organism-specific databases

CTDi680.
RGDi628645. Brs3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiQ8K418.
KOiK04170.
OMAiEEHGHAR.
OrthoDBiEOG73V6KG.
PhylomeDBiQ8K418.
TreeFamiTF331292.

Miscellaneous databases

NextBioi624343.
PROiQ8K418.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)."
    Liu J., Lao Z.J., Zhang J., Schaeffer M.T., Jiang M.M., Guan X.M., van der Ploeg L.H.T., Fong T.M.
    Biochemistry 41:8954-8960(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiBRS3_RAT
AccessioniPrimary (citable) accession number: Q8K418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.