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Protein

Leucine-rich repeat LGI family member 3

Gene

Lgi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in the regulation of neuronal exocytosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • regulation of exocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

ReactomeiR-MMU-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 3
Alternative name(s):
Leubrin
Leucine-rich glioma-inactivated protein 3
Gene namesi
Name:Lgi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2182619. Lgi3.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular region Source: UniProtKB-SubCell
  • neuron projection Source: UniProtKB-SubCell
  • synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Secreted, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001771131 – 548Leucine-rich repeat LGI family member 3Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K406.
PaxDbiQ8K406.
PRIDEiQ8K406.

PTM databases

iPTMnetiQ8K406.
PhosphoSitePlusiQ8K406.
SwissPalmiQ8K406.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033595.
CleanExiMM_LGI3.
GenevisibleiQ8K406. MM.

Interactioni

Subunit structurei

Interacts with STX1A.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046705.

Structurei

3D structure databases

ProteinModelPortaliQ8K406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 64LRRNTAdd BLAST34
Repeati89 – 110LRR 1Add BLAST22
Repeati113 – 134LRR 2Add BLAST22
Repeati137 – 158LRR 3Add BLAST22
Domaini170 – 220LRRCTAdd BLAST51
Repeati221 – 264EAR 1Add BLAST44
Repeati267 – 310EAR 2Add BLAST44
Repeati313 – 361EAR 3Add BLAST49
Repeati362 – 406EAR 4Add BLAST45
Repeati409 – 453EAR 5Add BLAST45
Repeati454 – 497EAR 6Add BLAST44
Repeati500 – 543EAR 7Add BLAST44

Sequence similaritiesi

Contains 7 EAR repeats.PROSITE-ProRule annotation
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJD3. Eukaryota.
ENOG4110HT0. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8K406.
KOiK19999.
OMAiTLGFCLM.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8K406.
TreeFamiTF333155.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
PS51450. LRR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLRARRGP GRRLLVLSTL GFCLMLQVSA KRPPKTPPCP PSCSCTRDTA
60 70 80 90 100
FCVDSKSVPK NLPSEVISLT LVNAAFSEIQ DGAFSHLPLL QFLLLNSNKF
110 120 130 140 150
TLIGDNAFIG LSHLQYLFIE NNDIWALSKF TFRGLKSLTH LSLANNNLQT
160 170 180 190 200
LPRDIFRPLD ILSDLDLRGN ALNCDCKVKW LVEWLAHTNT TVAPIYCASP
210 220 230 240 250
PRFQEHKVQD LPLREFDCIT TDFVLYQTLS FPAVSAEPFL YSSDLYLALA
260 270 280 290 300
QPGASACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDG QLYVVVAQLF
310 320 330 340 350
GGSYIYHWDP NTTRFTKLQD IDPQRVRKPN DLEAFRIDGD WFFAVADSSK
360 370 380 390 400
AGATSLYRWH QNGFYSHQAL HAWHRDTDLE FVDGEGKPRL IVSSSSQAPV
410 420 430 440 450
IYQWSRSQKQ FVAQGEVTQV PDAQAVKHFR AGRDSYLCLS RYIGDSKILR
460 470 480 490 500
WEGTRFSEVQ ALPSRGSLAL QPFLVGGHRY LALGSDFSFT QIYQWDEGRQ
510 520 530 540
KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR HVVVDLSA
Length:548
Mass (Da):61,818
Last modified:October 1, 2002 - v1
Checksum:i2DB303936354B958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515590 mRNA. Translation: AAM55219.1.
AY174077 mRNA. Translation: AAO19739.1.
AK049831 mRNA. Translation: BAC33943.1.
BC055315 mRNA. Translation: AAH55315.1.
BC061460 mRNA. Translation: AAH61460.1.
CCDSiCCDS27255.1.
RefSeqiNP_660254.1. NM_145219.4.
UniGeneiMm.41708.

Genome annotation databases

EnsembliENSMUST00000047331; ENSMUSP00000046705; ENSMUSG00000033595.
GeneIDi213469.
KEGGimmu:213469.
UCSCiuc007uoh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515590 mRNA. Translation: AAM55219.1.
AY174077 mRNA. Translation: AAO19739.1.
AK049831 mRNA. Translation: BAC33943.1.
BC055315 mRNA. Translation: AAH55315.1.
BC061460 mRNA. Translation: AAH61460.1.
CCDSiCCDS27255.1.
RefSeqiNP_660254.1. NM_145219.4.
UniGeneiMm.41708.

3D structure databases

ProteinModelPortaliQ8K406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046705.

PTM databases

iPTMnetiQ8K406.
PhosphoSitePlusiQ8K406.
SwissPalmiQ8K406.

Proteomic databases

MaxQBiQ8K406.
PaxDbiQ8K406.
PRIDEiQ8K406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047331; ENSMUSP00000046705; ENSMUSG00000033595.
GeneIDi213469.
KEGGimmu:213469.
UCSCiuc007uoh.2. mouse.

Organism-specific databases

CTDi203190.
MGIiMGI:2182619. Lgi3.

Phylogenomic databases

eggNOGiENOG410IJD3. Eukaryota.
ENOG4110HT0. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8K406.
KOiK19999.
OMAiTLGFCLM.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8K406.
TreeFamiTF333155.

Enzyme and pathway databases

ReactomeiR-MMU-5682910. LGI-ADAM interactions.

Miscellaneous databases

PROiQ8K406.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033595.
CleanExiMM_LGI3.
GenevisibleiQ8K406. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
PS51450. LRR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGI3_MOUSE
AccessioniPrimary (citable) accession number: Q8K406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.