ID TBX22_MOUSE Reviewed; 517 AA. AC Q8K402; DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 24-JAN-2024, entry version 143. DE RecName: Full=T-box transcription factor TBX22; DE Short=T-box protein 22; GN Name=Tbx22; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6J; RX PubMed=12374769; DOI=10.1093/hmg/11.22.2793; RA Braybrook C., Lisgo S., Doudney K., Henderson D., Marcano A.C.B., RA Strachan T., Patton M.A., Villard L., Moore G.E., Stanier P., Lindsay S.; RT "Craniofacial expression of human and murine TBX22 correlates with the RT cleft palate and ankyloglossia phenotype observed in CPX patients."; RL Hum. Mol. Genet. 11:2793-2804(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE. RC STRAIN=C57BL/6J; RX PubMed=12412015; DOI=10.1002/dvdy.10154; RA Bush J.O., Lan Y., Maltby K.M., Jiang R.; RT "Isolation and developmental expression analysis of Tbx22, the mouse RT homolog of the human X-linked cleft palate gene."; RL Dev. Dyn. 225:322-326(2002). CC -!- FUNCTION: Probable transcriptional regulator involved in developmental CC processes. This is major determinant crucial to palatogenesis. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. CC -!- DEVELOPMENTAL STAGE: Expressed in a temporally and spatially highly CC restricted pattern during mouse palate and tongue development. CC {ECO:0000269|PubMed:12412015}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF516208; AAM64167.1; -; mRNA. DR EMBL; AY125891; AAM94354.1; -; mRNA. DR CCDS; CCDS30350.1; -. DR RefSeq; NP_001277676.1; NM_001290747.1. DR RefSeq; NP_660259.1; NM_145224.3. DR RefSeq; NP_851836.2; NM_181319.5. DR RefSeq; XP_017173980.1; XM_017318491.1. DR AlphaFoldDB; Q8K402; -. DR SMR; Q8K402; -. DR STRING; 10090.ENSMUSP00000128247; -. DR PhosphoSitePlus; Q8K402; -. DR PaxDb; 10090-ENSMUSP00000128247; -. DR ProteomicsDB; 263258; -. DR Antibodypedia; 510; 255 antibodies from 28 providers. DR DNASU; 245572; -. DR Ensembl; ENSMUST00000118986.8; ENSMUSP00000112544.2; ENSMUSG00000031241.18. DR GeneID; 245572; -. DR KEGG; mmu:245572; -. DR UCSC; uc012hnt.2; mouse. DR AGR; MGI:2389465; -. DR CTD; 50945; -. DR MGI; MGI:2389465; Tbx22. DR VEuPathDB; HostDB:ENSMUSG00000031241; -. DR eggNOG; KOG3586; Eukaryota. DR GeneTree; ENSGT00940000161206; -. DR HOGENOM; CLU_030727_1_0_1; -. DR InParanoid; Q8K402; -. DR OrthoDB; 5323209at2759; -. DR PhylomeDB; Q8K402; -. DR BioGRID-ORCS; 245572; 0 hits in 77 CRISPR screens. DR PRO; PR:Q8K402; -. DR Proteomes; UP000000589; Chromosome X. DR RNAct; Q8K402; Protein. DR Bgee; ENSMUSG00000031241; Expressed in secondary palatal shelf mesenchyme and 47 other cell types or tissues. DR ExpressionAtlas; Q8K402; baseline and differential. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0003677; F:DNA binding; ISO:MGI. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI. DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:MGI. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR046360; T-box_DNA-bd. DR InterPro; IPR036960; T-box_sf. DR InterPro; IPR001699; TF_T-box. DR InterPro; IPR018186; TF_T-box_CS. DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1. DR PANTHER; PTHR11267:SF116; T-BOX TRANSCRIPTION FACTOR TBX22; 1. DR Pfam; PF00907; T-box; 1. DR PRINTS; PR00937; TBOX. DR SMART; SM00425; TBOX; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS01283; TBOX_1; 1. DR PROSITE; PS01264; TBOX_2; 1. DR PROSITE; PS50252; TBOX_3; 1. PE 2: Evidence at transcript level; KW DNA-binding; Nucleus; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1..517 FT /note="T-box transcription factor TBX22" FT /id="PRO_0000184456" FT DNA_BIND 93..280 FT /note="T-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201" FT REGION 1..83 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 312..333 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 19..35 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 42..66 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 67..83 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 517 AA; 58498 MW; C2B7C4F813BA4B5E CRC64; MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF VEEGEEILRS PSRDSQQPEK RLKAESSKTV FSCSDESNSQ ESLQEESVIQ VELQGSDLWK RFHDIGTEMI ITKAGRRMFP SVRIKVKGMD PVKQYYVILD VVPVDSKRYR YVYHSSQWMV AGNTDHSCIT PRFYVHPDSP CSGENWMRQI ISFDRVKLTN NEMDDKGHII LQSMHKYNPR VHVVEQDSRI DLSLIESFPT EGVKTFSFKE TEFTTVTAYQ NQQITKLKID RNPFAKGFRD PGRNRGVLDG FLETYPWMPS FSMDFKTFVT DTQSGSSGSS PVTSSGGAPS PLNSLLSPSC SPPMVYIPPS SFGMTYPDAY LHSVNIPFCY RICPTNNWRS QPFVLPTPER LPSFIIPQTL PPLMMEVPVV SSRGIINPNS GLHEDCNGQC LQASHSANQM LYGLQNPGNI FHPNAIAQEA ISYPFHPPNG CYRYTISMPP RLENVASHLS ENGTSQISFT EGSCDHSHWY PAINHYL //