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Q8K402 (TBX22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX22

Short name=T-box protein 22
Gene names
Name:Tbx22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

Subcellular location

Nucleus Potential.

Developmental stage

Expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development. Ref.2

Sequence similarities

Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517T-box transcription factor TBX22
PRO_0000184456

Regions

DNA binding93 – 280188T-box

Sequences

Sequence LengthMass (Da)Tools
Q8K402 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C2B7C4F813BA4B5E

FASTA51758,498
        10         20         30         40         50         60 
MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF VEEGEEILRS PSRDSQQPEK 

        70         80         90        100        110        120 
RLKAESSKTV FSCSDESNSQ ESLQEESVIQ VELQGSDLWK RFHDIGTEMI ITKAGRRMFP 

       130        140        150        160        170        180 
SVRIKVKGMD PVKQYYVILD VVPVDSKRYR YVYHSSQWMV AGNTDHSCIT PRFYVHPDSP 

       190        200        210        220        230        240 
CSGENWMRQI ISFDRVKLTN NEMDDKGHII LQSMHKYNPR VHVVEQDSRI DLSLIESFPT 

       250        260        270        280        290        300 
EGVKTFSFKE TEFTTVTAYQ NQQITKLKID RNPFAKGFRD PGRNRGVLDG FLETYPWMPS 

       310        320        330        340        350        360 
FSMDFKTFVT DTQSGSSGSS PVTSSGGAPS PLNSLLSPSC SPPMVYIPPS SFGMTYPDAY 

       370        380        390        400        410        420 
LHSVNIPFCY RICPTNNWRS QPFVLPTPER LPSFIIPQTL PPLMMEVPVV SSRGIINPNS 

       430        440        450        460        470        480 
GLHEDCNGQC LQASHSANQM LYGLQNPGNI FHPNAIAQEA ISYPFHPPNG CYRYTISMPP 

       490        500        510 
RLENVASHLS ENGTSQISFT EGSCDHSHWY PAINHYL 

« Hide

References

[1]"Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients."
Braybrook C., Lisgo S., Doudney K., Henderson D., Marcano A.C.B., Strachan T., Patton M.A., Villard L., Moore G.E., Stanier P., Lindsay S.
Hum. Mol. Genet. 11:2793-2804(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene."
Bush J.O., Lan Y., Maltby K.M., Jiang R.
Dev. Dyn. 225:322-326(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF516208 mRNA. Translation: AAM64167.1.
AY125891 mRNA. Translation: AAM94354.1.
CCDSCCDS30350.1.
RefSeqNP_001277676.1. NM_001290747.1.
NP_660259.1. NM_145224.3.
NP_851836.2. NM_181319.5.
XP_006528099.1. XM_006528036.1.
UniGeneMm.137011.

3D structure databases

ProteinModelPortalQ8K402.
SMRQ8K402. Positions 89-280.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K402.

Proteomic databases

PRIDEQ8K402.

Protocols and materials databases

DNASU245572.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000118986; ENSMUSP00000112544; ENSMUSG00000031241.
GeneID245572.
KEGGmmu:245572.
UCSCuc012hnt.1. mouse.

Organism-specific databases

CTD50945.
MGIMGI:2389465. Tbx22.

Phylogenomic databases

eggNOGNOG263167.
GeneTreeENSGT00740000115189.
HOGENOMHOG000039966.
HOVERGENHBG055831.
InParanoidQ8K402.
KOK10186.
PhylomeDBQ8K402.

Gene expression databases

BgeeQ8K402.
CleanExMM_TBX22.
GenevestigatorQ8K402.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386810.
PROQ8K402.
SOURCESearch...

Entry information

Entry nameTBX22_MOUSE
AccessionPrimary (citable) accession number: Q8K402
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot