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Q8K402

- TBX22_MOUSE

UniProt

Q8K402 - TBX22_MOUSE

Protein

T-box transcription factor TBX22

Gene

Tbx22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi93 – 280188T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX22
    Short name:
    T-box protein 22
    Gene namesi
    Name:Tbx22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2389465. Tbx22.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517T-box transcription factor TBX22PRO_0000184456Add
    BLAST

    Proteomic databases

    PRIDEiQ8K402.

    PTM databases

    PhosphoSiteiQ8K402.

    Expressioni

    Developmental stagei

    Expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development.1 Publication

    Gene expression databases

    BgeeiQ8K402.
    CleanExiMM_TBX22.
    GenevestigatoriQ8K402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K402.
    SMRiQ8K402. Positions 89-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG263167.
    GeneTreeiENSGT00740000115189.
    HOGENOMiHOG000039966.
    HOVERGENiHBG055831.
    InParanoidiQ8K402.
    KOiK10186.
    PhylomeDBiQ8K402.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K402-1 [UniParc]FASTAAdd to Basket

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    MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF VEEGEEILRS    50
    PSRDSQQPEK RLKAESSKTV FSCSDESNSQ ESLQEESVIQ VELQGSDLWK 100
    RFHDIGTEMI ITKAGRRMFP SVRIKVKGMD PVKQYYVILD VVPVDSKRYR 150
    YVYHSSQWMV AGNTDHSCIT PRFYVHPDSP CSGENWMRQI ISFDRVKLTN 200
    NEMDDKGHII LQSMHKYNPR VHVVEQDSRI DLSLIESFPT EGVKTFSFKE 250
    TEFTTVTAYQ NQQITKLKID RNPFAKGFRD PGRNRGVLDG FLETYPWMPS 300
    FSMDFKTFVT DTQSGSSGSS PVTSSGGAPS PLNSLLSPSC SPPMVYIPPS 350
    SFGMTYPDAY LHSVNIPFCY RICPTNNWRS QPFVLPTPER LPSFIIPQTL 400
    PPLMMEVPVV SSRGIINPNS GLHEDCNGQC LQASHSANQM LYGLQNPGNI 450
    FHPNAIAQEA ISYPFHPPNG CYRYTISMPP RLENVASHLS ENGTSQISFT 500
    EGSCDHSHWY PAINHYL 517
    Length:517
    Mass (Da):58,498
    Last modified:October 1, 2002 - v1
    Checksum:iC2B7C4F813BA4B5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516208 mRNA. Translation: AAM64167.1.
    AY125891 mRNA. Translation: AAM94354.1.
    CCDSiCCDS30350.1.
    RefSeqiNP_001277676.1. NM_001290747.1.
    NP_660259.1. NM_145224.3.
    NP_851836.2. NM_181319.5.
    XP_006528099.1. XM_006528036.1.
    UniGeneiMm.137011.

    Genome annotation databases

    EnsembliENSMUST00000118986; ENSMUSP00000112544; ENSMUSG00000031241.
    GeneIDi245572.
    KEGGimmu:245572.
    UCSCiuc012hnt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516208 mRNA. Translation: AAM64167.1 .
    AY125891 mRNA. Translation: AAM94354.1 .
    CCDSi CCDS30350.1.
    RefSeqi NP_001277676.1. NM_001290747.1.
    NP_660259.1. NM_145224.3.
    NP_851836.2. NM_181319.5.
    XP_006528099.1. XM_006528036.1.
    UniGenei Mm.137011.

    3D structure databases

    ProteinModelPortali Q8K402.
    SMRi Q8K402. Positions 89-280.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K402.

    Proteomic databases

    PRIDEi Q8K402.

    Protocols and materials databases

    DNASUi 245572.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000118986 ; ENSMUSP00000112544 ; ENSMUSG00000031241 .
    GeneIDi 245572.
    KEGGi mmu:245572.
    UCSCi uc012hnt.1. mouse.

    Organism-specific databases

    CTDi 50945.
    MGIi MGI:2389465. Tbx22.

    Phylogenomic databases

    eggNOGi NOG263167.
    GeneTreei ENSGT00740000115189.
    HOGENOMi HOG000039966.
    HOVERGENi HBG055831.
    InParanoidi Q8K402.
    KOi K10186.
    PhylomeDBi Q8K402.

    Miscellaneous databases

    NextBioi 386810.
    PROi Q8K402.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K402.
    CleanExi MM_TBX22.
    Genevestigatori Q8K402.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients."
      Braybrook C., Lisgo S., Doudney K., Henderson D., Marcano A.C.B., Strachan T., Patton M.A., Villard L., Moore G.E., Stanier P., Lindsay S.
      Hum. Mol. Genet. 11:2793-2804(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene."
      Bush J.O., Lan Y., Maltby K.M., Jiang R.
      Dev. Dyn. 225:322-326(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: C57BL/6.

    Entry informationi

    Entry nameiTBX22_MOUSE
    AccessioniPrimary (citable) accession number: Q8K402
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3