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Protein

T-box transcription factor TBX22

Gene

Tbx22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi93 – 280188T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX22
Short name:
T-box protein 22
Gene namesi
Name:Tbx22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2389465. Tbx22.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517T-box transcription factor TBX22PRO_0000184456Add
BLAST

Proteomic databases

PRIDEiQ8K402.

PTM databases

PhosphoSiteiQ8K402.

Expressioni

Developmental stagei

Expressed in a temporally and spatially highly restricted pattern during mouse palate and tongue development.1 Publication

Gene expression databases

BgeeiQ8K402.
CleanExiMM_TBX22.
ExpressionAtlasiQ8K402. baseline and differential.
GenevestigatoriQ8K402.

Structurei

3D structure databases

ProteinModelPortaliQ8K402.
SMRiQ8K402. Positions 89-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG263167.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000039966.
HOVERGENiHBG055831.
InParanoidiQ8K402.
KOiK10186.
PhylomeDBiQ8K402.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF VEEGEEILRS
60 70 80 90 100
PSRDSQQPEK RLKAESSKTV FSCSDESNSQ ESLQEESVIQ VELQGSDLWK
110 120 130 140 150
RFHDIGTEMI ITKAGRRMFP SVRIKVKGMD PVKQYYVILD VVPVDSKRYR
160 170 180 190 200
YVYHSSQWMV AGNTDHSCIT PRFYVHPDSP CSGENWMRQI ISFDRVKLTN
210 220 230 240 250
NEMDDKGHII LQSMHKYNPR VHVVEQDSRI DLSLIESFPT EGVKTFSFKE
260 270 280 290 300
TEFTTVTAYQ NQQITKLKID RNPFAKGFRD PGRNRGVLDG FLETYPWMPS
310 320 330 340 350
FSMDFKTFVT DTQSGSSGSS PVTSSGGAPS PLNSLLSPSC SPPMVYIPPS
360 370 380 390 400
SFGMTYPDAY LHSVNIPFCY RICPTNNWRS QPFVLPTPER LPSFIIPQTL
410 420 430 440 450
PPLMMEVPVV SSRGIINPNS GLHEDCNGQC LQASHSANQM LYGLQNPGNI
460 470 480 490 500
FHPNAIAQEA ISYPFHPPNG CYRYTISMPP RLENVASHLS ENGTSQISFT
510
EGSCDHSHWY PAINHYL
Length:517
Mass (Da):58,498
Last modified:October 1, 2002 - v1
Checksum:iC2B7C4F813BA4B5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516208 mRNA. Translation: AAM64167.1.
AY125891 mRNA. Translation: AAM94354.1.
CCDSiCCDS30350.1.
RefSeqiNP_001277676.1. NM_001290747.1.
NP_660259.1. NM_145224.3.
NP_851836.2. NM_181319.5.
XP_006528099.1. XM_006528036.2.
UniGeneiMm.137011.

Genome annotation databases

EnsembliENSMUST00000118986; ENSMUSP00000112544; ENSMUSG00000031241.
GeneIDi245572.
KEGGimmu:245572.
UCSCiuc012hnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516208 mRNA. Translation: AAM64167.1.
AY125891 mRNA. Translation: AAM94354.1.
CCDSiCCDS30350.1.
RefSeqiNP_001277676.1. NM_001290747.1.
NP_660259.1. NM_145224.3.
NP_851836.2. NM_181319.5.
XP_006528099.1. XM_006528036.2.
UniGeneiMm.137011.

3D structure databases

ProteinModelPortaliQ8K402.
SMRiQ8K402. Positions 89-280.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K402.

Proteomic databases

PRIDEiQ8K402.

Protocols and materials databases

DNASUi245572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118986; ENSMUSP00000112544; ENSMUSG00000031241.
GeneIDi245572.
KEGGimmu:245572.
UCSCiuc012hnt.1. mouse.

Organism-specific databases

CTDi50945.
MGIiMGI:2389465. Tbx22.

Phylogenomic databases

eggNOGiNOG263167.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000039966.
HOVERGENiHBG055831.
InParanoidiQ8K402.
KOiK10186.
PhylomeDBiQ8K402.

Miscellaneous databases

NextBioi386810.
PROiQ8K402.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K402.
CleanExiMM_TBX22.
ExpressionAtlasiQ8K402. baseline and differential.
GenevestigatoriQ8K402.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients."
    Braybrook C., Lisgo S., Doudney K., Henderson D., Marcano A.C.B., Strachan T., Patton M.A., Villard L., Moore G.E., Stanier P., Lindsay S.
    Hum. Mol. Genet. 11:2793-2804(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene."
    Bush J.O., Lan Y., Maltby K.M., Jiang R.
    Dev. Dyn. 225:322-326(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: C57BL/6.

Entry informationi

Entry nameiTBX22_MOUSE
AccessioniPrimary (citable) accession number: Q8K402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2002
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.