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Q8K3Z9 (PO121_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear envelope pore membrane protein POM 121
Alternative name(s):
Nucleoporin Nup121
Pore membrane protein of 121 kDa
Gene names
Name:Pom121
Synonyms:Nup121
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1200 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) By similarity.

Subcellular location

Nucleusnuclear pore complex By similarity. Nucleus membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Note: Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase By similarity.

Domain

Contains F-X-F-G repeats.

Post-translational modification

Proteolytically cleaved by caspase-3 during apoptosis By similarity.

Sequence similarities

Belongs to the POM121 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12001200Nuclear envelope pore membrane protein POM 121
PRO_0000204907

Regions

Transmembrane57 – 7721Helical; Potential
Region1 – 5656Cisternal side Potential
Region76 – 12001125Pore side Potential
Compositional bias4 – 85Poly-Ala
Compositional bias53 – 586Poly-Ala
Compositional bias438 – 4414Poly-Ser
Compositional bias497 – 5004Poly-Pro
Compositional bias685 – 6884Poly-Ser
Compositional bias719 – 7224Poly-Ser
Compositional bias1035 – 10406Poly-Ser

Sites

Site531 – 5322Cleavage; by caspase-3 By similarity

Amino acid modifications

Modified residue3191Phosphoserine Ref.3
Modified residue3221Phosphoserine Ref.3
Modified residue3251Phosphoserine Ref.3
Modified residue4081Phosphoserine Ref.3
Modified residue4091Phosphoserine Ref.3

Experimental info

Sequence conflict5001Missing in AAM64199. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K3Z9 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: C15B5D6C204D445E

FASTA1,200121,022
        10         20         30         40         50         60 
MSPAAAAADG GERRRPPLGG REGRSRARGY GGPAGAAALG LALLGLALYL VPAAAALAWL 

        70         80         90        100        110        120 
AVGASAAWWG LSREPRGPRA LSSFVRDARR HPRPALTASP PPAKSPVNGS LCEPRSPLGG 

       130        140        150        160        170        180 
PDPAELLLMG SYLGKPGPPE PALRQDPRER PGRRPPARSP PPASAVQRVH HVYPALPTPL 

       190        200        210        220        230        240 
LRPSRRPPHR DCGPLSSRFV ITPRRRYPIQ QAQYSLLGAL PTVCWNGGHK KAVLSPRNSR 

       250        260        270        280        290        300 
MVCSPVTVRI APPDSKLFRS SMSEQILDTT LSSPSSNAPD PCAKETVLNA LKEKKKRTVA 

       310        320        330        340        350        360 
EEDQLHLDGQ ENKRRRHDSG GSGHSAFEPL VANGVPAAFV PKPGSLKRSL ASQSSDDHLN 

       370        380        390        400        410        420 
KRSRTSSVSS LASACTGGIP SSSRNAITSS YSSTRGISQL WKRSGPTSSP FSSPASSRSQ 

       430        440        450        460        470        480 
TPERPAKKTR EEEPCQQSSS SPPLVTDKES PGEKVTDTTT GKQQSSWTSP PTPGSSGQRK 

       490        500        510        520        530        540 
RKIQLLPSRR GDQLTLPPPP ELGYSITAED LDMERKASLQ WFNKVLEDKP DDASASATDG 

       550        560        570        580        590        600 
PPSTSPPFTF TLPAVGPAAS PASLPAPSSN PLLESLKKMQ ESPAPSSSEP AEAATVAAPS 

       610        620        630        640        650        660 
PPKTPSLLAP LVSPLAGPLA STSSDSKPAA TFLGLASASS ITPLTDSKSS GVSQAEQSVS 

       670        680        690        700        710        720 
TPASTASSPT PKPSMLFGML SPPASSSSLA TPAPACASPM FKPIFPATPK SESDSPLPSS 

       730        740        750        760        770        780 
SSAATTASSS TAPPTAASTT PTFKPIFDKM EPFTAMPLST PFSLKQTTAT ATTTATSAPL 

       790        800        810        820        830        840 
FTGLGTATST VASGTAASAS KPVFGFGVTT AASTASSTMT STSQSVLFGG APPVTTSSSA 

       850        860        870        880        890        900 
PALASIFQFG KPLAPAASAA GTSFSQPLAS STQTAASNSG FSGFGSTLTT STSAPATTSQ 

       910        920        930        940        950        960 
PTLTFSNTVT PTFNIPFSSS AKPALPTYPG ANSQPTFGAT DGATKPALAP SFGSSFTFGN 

       970        980        990       1000       1010       1020 
SVASAPSAAP APATFGSAAQ PAFGGLKAAA STFGAPASTQ PAFGSTTSVF SFGSATTSGF 

      1030       1040       1050       1060       1070       1080 
GAAATAATTT QTTNSGSSSS LFGSSAPSPF TFGGSAAPAG SGGFGLSATP GTSSTSGTFS 

      1090       1100       1110       1120       1130       1140 
FGSGQSGTPG TTTSFGSLSQ NTLGAPSQGS PFAFSVGSTP ESKPVFGGTS TPTFGQSAPA 

      1150       1160       1170       1180       1190       1200 
PGVGTTGSSL SFGASSTPAQ GFVGVGPFGS AAPSFSIGAG SKTPGARQRL QARRQHTRKK 

« Hide

References

« Hide 'large scale' references
[1]"Identification of mouse genes mapping to the Williams syndrome critical region."
Tassabehji M., Cunliffe P.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322; SER-325; SER-408 AND SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF516680 mRNA. Translation: AAM64199.1.
BC053101 mRNA. Translation: AAH53101.1.
RefSeqNP_683734.2. NM_148932.2.
UniGeneMm.28399.

3D structure databases

ProteinModelPortalQ8K3Z9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K3Z9. 1 interaction.
MINTMINT-4997763.

PTM databases

PhosphoSiteQ8K3Z9.

Proteomic databases

PaxDbQ8K3Z9.
PRIDEQ8K3Z9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111171; ENSMUSP00000106801; ENSMUSG00000053293.
GeneID107939.
KEGGmmu:107939.
UCSCuc008zyi.1. mouse.

Organism-specific databases

CTD9883.
MGIMGI:2137624. Pom121.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00730000110770.
HOGENOMHOG000015364.
HOVERGENHBG053628.
InParanoidQ8K3Z9.
KOK14316.
OMAWFNKALE.
OrthoDBEOG7QG440.
PhylomeDBQ8K3Z9.
TreeFamTF323517.

Gene expression databases

ArrayExpressQ8K3Z9.
BgeeQ8K3Z9.
CleanExMM_POM121.
GenevestigatorQ8K3Z9.

Family and domain databases

InterProIPR026054. Nucleoporin.
IPR026090. POM121.
[Graphical view]
PANTHERPTHR23193. PTHR23193. 1 hit.
PTHR23193:SF5. PTHR23193:SF5. 1 hit.
ProtoNetSearch...

Other

NextBio359749.
PROQ8K3Z9.
SOURCESearch...

Entry information

Entry namePO121_MOUSE
AccessionPrimary (citable) accession number: Q8K3Z9
Secondary accession number(s): Q7TSH5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot