Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K3Z9

- PO121_MOUSE

UniProt

Q8K3Z9 - PO121_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear envelope pore membrane protein POM 121

Gene

Pom121

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei531 – 5322Cleavage; by caspase-3By similarity

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear envelope pore membrane protein POM 121
Alternative name(s):
Nucleoporin Nup121
Pore membrane protein of 121 kDa
Gene namesi
Name:Pom121
Synonyms:Nup121
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2137624. Pom121.

Subcellular locationi

Nucleusnuclear pore complex By similarity. Nucleus membrane By similarity; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
Note: Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. nuclear pore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12001200Nuclear envelope pore membrane protein POM 121PRO_0000204907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei322 – 3221Phosphoserine1 Publication
Modified residuei325 – 3251Phosphoserine1 Publication
Modified residuei408 – 4081Phosphoserine1 Publication
Modified residuei409 – 4091Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K3Z9.
PaxDbiQ8K3Z9.
PRIDEiQ8K3Z9.

PTM databases

PhosphoSiteiQ8K3Z9.

Expressioni

Gene expression databases

BgeeiQ8K3Z9.
CleanExiMM_POM121.
ExpressionAtlasiQ8K3Z9. baseline and differential.
GenevestigatoriQ8K3Z9.

Interactioni

Protein-protein interaction databases

IntActiQ8K3Z9. 1 interaction.
MINTiMINT-4997763.

Structurei

3D structure databases

ProteinModelPortaliQ8K3Z9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Cisternal sideSequence AnalysisAdd
BLAST
Regioni76 – 12001125Pore sideSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 85Poly-Ala
Compositional biasi53 – 586Poly-Ala
Compositional biasi438 – 4414Poly-Ser
Compositional biasi497 – 5004Poly-Pro
Compositional biasi685 – 6884Poly-Ser
Compositional biasi719 – 7224Poly-Ser
Compositional biasi1035 – 10406Poly-Ser

Domaini

Contains F-X-F-G repeats.

Sequence similaritiesi

Belongs to the POM121 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000110770.
HOGENOMiHOG000015364.
HOVERGENiHBG053628.
InParanoidiQ8K3Z9.
KOiK14316.
OMAiPVFQFGK.
OrthoDBiEOG7QG440.
PhylomeDBiQ8K3Z9.
TreeFamiTF323517.

Family and domain databases

InterProiIPR026090. POM121.
[Graphical view]
PANTHERiPTHR23193:SF5. PTHR23193:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K3Z9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPAAAAADG GERRRPPLGG REGRSRARGY GGPAGAAALG LALLGLALYL
60 70 80 90 100
VPAAAALAWL AVGASAAWWG LSREPRGPRA LSSFVRDARR HPRPALTASP
110 120 130 140 150
PPAKSPVNGS LCEPRSPLGG PDPAELLLMG SYLGKPGPPE PALRQDPRER
160 170 180 190 200
PGRRPPARSP PPASAVQRVH HVYPALPTPL LRPSRRPPHR DCGPLSSRFV
210 220 230 240 250
ITPRRRYPIQ QAQYSLLGAL PTVCWNGGHK KAVLSPRNSR MVCSPVTVRI
260 270 280 290 300
APPDSKLFRS SMSEQILDTT LSSPSSNAPD PCAKETVLNA LKEKKKRTVA
310 320 330 340 350
EEDQLHLDGQ ENKRRRHDSG GSGHSAFEPL VANGVPAAFV PKPGSLKRSL
360 370 380 390 400
ASQSSDDHLN KRSRTSSVSS LASACTGGIP SSSRNAITSS YSSTRGISQL
410 420 430 440 450
WKRSGPTSSP FSSPASSRSQ TPERPAKKTR EEEPCQQSSS SPPLVTDKES
460 470 480 490 500
PGEKVTDTTT GKQQSSWTSP PTPGSSGQRK RKIQLLPSRR GDQLTLPPPP
510 520 530 540 550
ELGYSITAED LDMERKASLQ WFNKVLEDKP DDASASATDG PPSTSPPFTF
560 570 580 590 600
TLPAVGPAAS PASLPAPSSN PLLESLKKMQ ESPAPSSSEP AEAATVAAPS
610 620 630 640 650
PPKTPSLLAP LVSPLAGPLA STSSDSKPAA TFLGLASASS ITPLTDSKSS
660 670 680 690 700
GVSQAEQSVS TPASTASSPT PKPSMLFGML SPPASSSSLA TPAPACASPM
710 720 730 740 750
FKPIFPATPK SESDSPLPSS SSAATTASSS TAPPTAASTT PTFKPIFDKM
760 770 780 790 800
EPFTAMPLST PFSLKQTTAT ATTTATSAPL FTGLGTATST VASGTAASAS
810 820 830 840 850
KPVFGFGVTT AASTASSTMT STSQSVLFGG APPVTTSSSA PALASIFQFG
860 870 880 890 900
KPLAPAASAA GTSFSQPLAS STQTAASNSG FSGFGSTLTT STSAPATTSQ
910 920 930 940 950
PTLTFSNTVT PTFNIPFSSS AKPALPTYPG ANSQPTFGAT DGATKPALAP
960 970 980 990 1000
SFGSSFTFGN SVASAPSAAP APATFGSAAQ PAFGGLKAAA STFGAPASTQ
1010 1020 1030 1040 1050
PAFGSTTSVF SFGSATTSGF GAAATAATTT QTTNSGSSSS LFGSSAPSPF
1060 1070 1080 1090 1100
TFGGSAAPAG SGGFGLSATP GTSSTSGTFS FGSGQSGTPG TTTSFGSLSQ
1110 1120 1130 1140 1150
NTLGAPSQGS PFAFSVGSTP ESKPVFGGTS TPTFGQSAPA PGVGTTGSSL
1160 1170 1180 1190 1200
SFGASSTPAQ GFVGVGPFGS AAPSFSIGAG SKTPGARQRL QARRQHTRKK
Length:1,200
Mass (Da):121,022
Last modified:August 16, 2004 - v2
Checksum:iC15B5D6C204D445E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti500 – 5001Missing in AAM64199. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF516680 mRNA. Translation: AAM64199.1.
BC053101 mRNA. Translation: AAH53101.1.
CCDSiCCDS51662.1.
RefSeqiNP_683734.2. NM_148932.2.
UniGeneiMm.28399.

Genome annotation databases

EnsembliENSMUST00000111171; ENSMUSP00000106801; ENSMUSG00000053293.
GeneIDi107939.
KEGGimmu:107939.
UCSCiuc008zyi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF516680 mRNA. Translation: AAM64199.1 .
BC053101 mRNA. Translation: AAH53101.1 .
CCDSi CCDS51662.1.
RefSeqi NP_683734.2. NM_148932.2.
UniGenei Mm.28399.

3D structure databases

ProteinModelPortali Q8K3Z9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K3Z9. 1 interaction.
MINTi MINT-4997763.

PTM databases

PhosphoSitei Q8K3Z9.

Proteomic databases

MaxQBi Q8K3Z9.
PaxDbi Q8K3Z9.
PRIDEi Q8K3Z9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111171 ; ENSMUSP00000106801 ; ENSMUSG00000053293 .
GeneIDi 107939.
KEGGi mmu:107939.
UCSCi uc008zyi.1. mouse.

Organism-specific databases

CTDi 9883.
MGIi MGI:2137624. Pom121.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000110770.
HOGENOMi HOG000015364.
HOVERGENi HBG053628.
InParanoidi Q8K3Z9.
KOi K14316.
OMAi PVFQFGK.
OrthoDBi EOG7QG440.
PhylomeDBi Q8K3Z9.
TreeFami TF323517.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

NextBioi 359749.
PROi Q8K3Z9.
SOURCEi Search...

Gene expression databases

Bgeei Q8K3Z9.
CleanExi MM_POM121.
ExpressionAtlasi Q8K3Z9. baseline and differential.
Genevestigatori Q8K3Z9.

Family and domain databases

InterProi IPR026090. POM121.
[Graphical view ]
PANTHERi PTHR23193:SF5. PTHR23193:SF5. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of mouse genes mapping to the Williams syndrome critical region."
    Tassabehji M., Cunliffe P.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322; SER-325; SER-408 AND SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPO121_MOUSE
AccessioniPrimary (citable) accession number: Q8K3Z9
Secondary accession number(s): Q7TSH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3