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Protein

Nuclear envelope pore membrane protein POM 121

Gene

Pom121

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear envelope pore membrane protein POM 121
Alternative name(s):
Nucleoporin Nup121
Pore membrane protein of 121 kDa
Gene namesi
Name:Pom121
Synonyms:Nup121
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2137624 Pom121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002049071 – 1200Nuclear envelope pore membrane protein POM 121Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei370PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei531 – 532Cleavage; by caspase-3By similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K3Z9
MaxQBiQ8K3Z9
PaxDbiQ8K3Z9
PRIDEiQ8K3Z9

PTM databases

iPTMnetiQ8K3Z9
PhosphoSitePlusiQ8K3Z9

Expressioni

Gene expression databases

BgeeiENSMUSG00000053293
CleanExiMM_POM121
ExpressionAtlasiQ8K3Z9 baseline and differential
GenevisibleiQ8K3Z9 MM

Interactioni

Protein-protein interaction databases

BioGridi223706, 1 interactor
IntActiQ8K3Z9, 1 interactor
MINTiQ8K3Z9
STRINGi10090.ENSMUSP00000106801

Structurei

3D structure databases

ProteinModelPortaliQ8K3Z9
SMRiQ8K3Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56Cisternal sideSequence analysisAdd BLAST56
Regioni76 – 1200Pore sideSequence analysisAdd BLAST1125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 8Poly-Ala5
Compositional biasi53 – 58Poly-Ala6
Compositional biasi438 – 441Poly-Ser4
Compositional biasi497 – 500Poly-Pro4
Compositional biasi685 – 688Poly-Ser4
Compositional biasi719 – 722Poly-Ser4
Compositional biasi1035 – 1040Poly-Ser6

Domaini

Contains F-X-F-G repeats.

Sequence similaritiesi

Belongs to the POM121 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM0V Eukaryota
ENOG4112BJY LUCA
GeneTreeiENSGT00730000110770
HOGENOMiHOG000015364
HOVERGENiHBG053628
InParanoidiQ8K3Z9
KOiK14316
OMAiWFNKALE
OrthoDBiEOG091G04SC
PhylomeDBiQ8K3Z9
TreeFamiTF323517

Family and domain databases

InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR026090 POM121
PANTHERiPTHR23193 PTHR23193, 1 hit
PTHR23193:SF5 PTHR23193:SF5, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAAAAADG GERRRPPLGG REGRSRARGY GGPAGAAALG LALLGLALYL
60 70 80 90 100
VPAAAALAWL AVGASAAWWG LSREPRGPRA LSSFVRDARR HPRPALTASP
110 120 130 140 150
PPAKSPVNGS LCEPRSPLGG PDPAELLLMG SYLGKPGPPE PALRQDPRER
160 170 180 190 200
PGRRPPARSP PPASAVQRVH HVYPALPTPL LRPSRRPPHR DCGPLSSRFV
210 220 230 240 250
ITPRRRYPIQ QAQYSLLGAL PTVCWNGGHK KAVLSPRNSR MVCSPVTVRI
260 270 280 290 300
APPDSKLFRS SMSEQILDTT LSSPSSNAPD PCAKETVLNA LKEKKKRTVA
310 320 330 340 350
EEDQLHLDGQ ENKRRRHDSG GSGHSAFEPL VANGVPAAFV PKPGSLKRSL
360 370 380 390 400
ASQSSDDHLN KRSRTSSVSS LASACTGGIP SSSRNAITSS YSSTRGISQL
410 420 430 440 450
WKRSGPTSSP FSSPASSRSQ TPERPAKKTR EEEPCQQSSS SPPLVTDKES
460 470 480 490 500
PGEKVTDTTT GKQQSSWTSP PTPGSSGQRK RKIQLLPSRR GDQLTLPPPP
510 520 530 540 550
ELGYSITAED LDMERKASLQ WFNKVLEDKP DDASASATDG PPSTSPPFTF
560 570 580 590 600
TLPAVGPAAS PASLPAPSSN PLLESLKKMQ ESPAPSSSEP AEAATVAAPS
610 620 630 640 650
PPKTPSLLAP LVSPLAGPLA STSSDSKPAA TFLGLASASS ITPLTDSKSS
660 670 680 690 700
GVSQAEQSVS TPASTASSPT PKPSMLFGML SPPASSSSLA TPAPACASPM
710 720 730 740 750
FKPIFPATPK SESDSPLPSS SSAATTASSS TAPPTAASTT PTFKPIFDKM
760 770 780 790 800
EPFTAMPLST PFSLKQTTAT ATTTATSAPL FTGLGTATST VASGTAASAS
810 820 830 840 850
KPVFGFGVTT AASTASSTMT STSQSVLFGG APPVTTSSSA PALASIFQFG
860 870 880 890 900
KPLAPAASAA GTSFSQPLAS STQTAASNSG FSGFGSTLTT STSAPATTSQ
910 920 930 940 950
PTLTFSNTVT PTFNIPFSSS AKPALPTYPG ANSQPTFGAT DGATKPALAP
960 970 980 990 1000
SFGSSFTFGN SVASAPSAAP APATFGSAAQ PAFGGLKAAA STFGAPASTQ
1010 1020 1030 1040 1050
PAFGSTTSVF SFGSATTSGF GAAATAATTT QTTNSGSSSS LFGSSAPSPF
1060 1070 1080 1090 1100
TFGGSAAPAG SGGFGLSATP GTSSTSGTFS FGSGQSGTPG TTTSFGSLSQ
1110 1120 1130 1140 1150
NTLGAPSQGS PFAFSVGSTP ESKPVFGGTS TPTFGQSAPA PGVGTTGSSL
1160 1170 1180 1190 1200
SFGASSTPAQ GFVGVGPFGS AAPSFSIGAG SKTPGARQRL QARRQHTRKK
Length:1,200
Mass (Da):121,022
Last modified:August 16, 2004 - v2
Checksum:iC15B5D6C204D445E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti500Missing in AAM64199 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516680 mRNA Translation: AAM64199.1
BC053101 mRNA Translation: AAH53101.1
CCDSiCCDS51662.1
RefSeqiNP_683734.2, NM_148932.2
UniGeneiMm.28399

Genome annotation databases

EnsembliENSMUST00000111171; ENSMUSP00000106801; ENSMUSG00000053293
GeneIDi107939
KEGGimmu:107939
UCSCiuc008zyi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPO121_MOUSE
AccessioniPrimary (citable) accession number: Q8K3Z9
Secondary accession number(s): Q7TSH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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