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Q8K3Z9

- PO121_MOUSE

UniProt

Q8K3Z9 - PO121_MOUSE

Protein

Nuclear envelope pore membrane protein POM 121

Gene

Pom121

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei531 – 5322Cleavage; by caspase-3By similarity

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear envelope pore membrane protein POM 121
    Alternative name(s):
    Nucleoporin Nup121
    Pore membrane protein of 121 kDa
    Gene namesi
    Name:Pom121
    Synonyms:Nup121
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2137624. Pom121.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity. Nucleus membrane By similarity; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
    Note: Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. nuclear membrane Source: UniProtKB-SubCell
    3. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12001200Nuclear envelope pore membrane protein POM 121PRO_0000204907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191Phosphoserine1 Publication
    Modified residuei322 – 3221Phosphoserine1 Publication
    Modified residuei325 – 3251Phosphoserine1 Publication
    Modified residuei408 – 4081Phosphoserine1 Publication
    Modified residuei409 – 4091Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved by caspase-3 during apoptosis.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8K3Z9.
    PRIDEiQ8K3Z9.

    PTM databases

    PhosphoSiteiQ8K3Z9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K3Z9.
    BgeeiQ8K3Z9.
    CleanExiMM_POM121.
    GenevestigatoriQ8K3Z9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K3Z9. 1 interaction.
    MINTiMINT-4997763.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3Z9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5656Cisternal sideSequence AnalysisAdd
    BLAST
    Regioni76 – 12001125Pore sideSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 85Poly-Ala
    Compositional biasi53 – 586Poly-Ala
    Compositional biasi438 – 4414Poly-Ser
    Compositional biasi497 – 5004Poly-Pro
    Compositional biasi685 – 6884Poly-Ser
    Compositional biasi719 – 7224Poly-Ser
    Compositional biasi1035 – 10406Poly-Ser

    Domaini

    Contains F-X-F-G repeats.

    Sequence similaritiesi

    Belongs to the POM121 family.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000110770.
    HOGENOMiHOG000015364.
    HOVERGENiHBG053628.
    InParanoidiQ8K3Z9.
    KOiK14316.
    OMAiPVFQFGK.
    OrthoDBiEOG7QG440.
    PhylomeDBiQ8K3Z9.
    TreeFamiTF323517.

    Family and domain databases

    InterProiIPR026090. POM121.
    [Graphical view]
    PANTHERiPTHR23193:SF5. PTHR23193:SF5. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K3Z9-1 [UniParc]FASTAAdd to Basket

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    MSPAAAAADG GERRRPPLGG REGRSRARGY GGPAGAAALG LALLGLALYL     50
    VPAAAALAWL AVGASAAWWG LSREPRGPRA LSSFVRDARR HPRPALTASP 100
    PPAKSPVNGS LCEPRSPLGG PDPAELLLMG SYLGKPGPPE PALRQDPRER 150
    PGRRPPARSP PPASAVQRVH HVYPALPTPL LRPSRRPPHR DCGPLSSRFV 200
    ITPRRRYPIQ QAQYSLLGAL PTVCWNGGHK KAVLSPRNSR MVCSPVTVRI 250
    APPDSKLFRS SMSEQILDTT LSSPSSNAPD PCAKETVLNA LKEKKKRTVA 300
    EEDQLHLDGQ ENKRRRHDSG GSGHSAFEPL VANGVPAAFV PKPGSLKRSL 350
    ASQSSDDHLN KRSRTSSVSS LASACTGGIP SSSRNAITSS YSSTRGISQL 400
    WKRSGPTSSP FSSPASSRSQ TPERPAKKTR EEEPCQQSSS SPPLVTDKES 450
    PGEKVTDTTT GKQQSSWTSP PTPGSSGQRK RKIQLLPSRR GDQLTLPPPP 500
    ELGYSITAED LDMERKASLQ WFNKVLEDKP DDASASATDG PPSTSPPFTF 550
    TLPAVGPAAS PASLPAPSSN PLLESLKKMQ ESPAPSSSEP AEAATVAAPS 600
    PPKTPSLLAP LVSPLAGPLA STSSDSKPAA TFLGLASASS ITPLTDSKSS 650
    GVSQAEQSVS TPASTASSPT PKPSMLFGML SPPASSSSLA TPAPACASPM 700
    FKPIFPATPK SESDSPLPSS SSAATTASSS TAPPTAASTT PTFKPIFDKM 750
    EPFTAMPLST PFSLKQTTAT ATTTATSAPL FTGLGTATST VASGTAASAS 800
    KPVFGFGVTT AASTASSTMT STSQSVLFGG APPVTTSSSA PALASIFQFG 850
    KPLAPAASAA GTSFSQPLAS STQTAASNSG FSGFGSTLTT STSAPATTSQ 900
    PTLTFSNTVT PTFNIPFSSS AKPALPTYPG ANSQPTFGAT DGATKPALAP 950
    SFGSSFTFGN SVASAPSAAP APATFGSAAQ PAFGGLKAAA STFGAPASTQ 1000
    PAFGSTTSVF SFGSATTSGF GAAATAATTT QTTNSGSSSS LFGSSAPSPF 1050
    TFGGSAAPAG SGGFGLSATP GTSSTSGTFS FGSGQSGTPG TTTSFGSLSQ 1100
    NTLGAPSQGS PFAFSVGSTP ESKPVFGGTS TPTFGQSAPA PGVGTTGSSL 1150
    SFGASSTPAQ GFVGVGPFGS AAPSFSIGAG SKTPGARQRL QARRQHTRKK 1200
    Length:1,200
    Mass (Da):121,022
    Last modified:August 16, 2004 - v2
    Checksum:iC15B5D6C204D445E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti500 – 5001Missing in AAM64199. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516680 mRNA. Translation: AAM64199.1.
    BC053101 mRNA. Translation: AAH53101.1.
    CCDSiCCDS51662.1.
    RefSeqiNP_683734.2. NM_148932.2.
    UniGeneiMm.28399.

    Genome annotation databases

    EnsembliENSMUST00000111171; ENSMUSP00000106801; ENSMUSG00000053293.
    GeneIDi107939.
    KEGGimmu:107939.
    UCSCiuc008zyi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516680 mRNA. Translation: AAM64199.1 .
    BC053101 mRNA. Translation: AAH53101.1 .
    CCDSi CCDS51662.1.
    RefSeqi NP_683734.2. NM_148932.2.
    UniGenei Mm.28399.

    3D structure databases

    ProteinModelPortali Q8K3Z9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K3Z9. 1 interaction.
    MINTi MINT-4997763.

    PTM databases

    PhosphoSitei Q8K3Z9.

    Proteomic databases

    PaxDbi Q8K3Z9.
    PRIDEi Q8K3Z9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111171 ; ENSMUSP00000106801 ; ENSMUSG00000053293 .
    GeneIDi 107939.
    KEGGi mmu:107939.
    UCSCi uc008zyi.1. mouse.

    Organism-specific databases

    CTDi 9883.
    MGIi MGI:2137624. Pom121.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000110770.
    HOGENOMi HOG000015364.
    HOVERGENi HBG053628.
    InParanoidi Q8K3Z9.
    KOi K14316.
    OMAi PVFQFGK.
    OrthoDBi EOG7QG440.
    PhylomeDBi Q8K3Z9.
    TreeFami TF323517.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Miscellaneous databases

    NextBioi 359749.
    PROi Q8K3Z9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K3Z9.
    Bgeei Q8K3Z9.
    CleanExi MM_POM121.
    Genevestigatori Q8K3Z9.

    Family and domain databases

    InterProi IPR026090. POM121.
    [Graphical view ]
    PANTHERi PTHR23193:SF5. PTHR23193:SF5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mouse genes mapping to the Williams syndrome critical region."
      Tassabehji M., Cunliffe P.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322; SER-325; SER-408 AND SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPO121_MOUSE
    AccessioniPrimary (citable) accession number: Q8K3Z9
    Secondary accession number(s): Q7TSH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3