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Protein

Tumor necrosis factor ligand superfamily member 15

Gene

Tnfsf15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Important for binding TNFRSF6BBy similarity1
Sitei191Important for binding TNFRSF6BBy similarity1

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • death receptor binding Source: RGD
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Gene namesi
Name:Tnfsf15
Synonyms:Tl1, Vegi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628735. Tnfsf15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 252ExtracellularSequence analysisAdd BLAST192

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332331 – 252Tumor necrosis factor ligand superfamily member 15Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 203By similarity
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K3Y7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008930.

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • death receptor binding Source: RGD
  • tumor necrosis factor receptor binding Source: InterPro

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011845.

Structurei

3D structure databases

ProteinModelPortaliQ8K3Y7.
SMRiQ8K3Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFSK. Eukaryota.
ENOG4111Y6F. LUCA.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ8K3Y7.
KOiK05478.
OrthoDBiEOG091G0MFC.
PhylomeDBiQ8K3Y7.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
PANTHERiPTHR11471:SF41. PTHR11471:SF41. 1 hit.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELGLGFG EAVPVEMLPE GCRHRREART GLAARSKACL ALTCCLLSFP
60 70 80 90 100
ILAGLSTLLM TGQLRIPGKD CMFPTVTEER SAPSAQPVYT PSRDKPKAHL
110 120 130 140 150
TIMRQTPVPH LKNELAALHW ENNLGMAFTK NRMNYTNKFL VIPESGDYFI
160 170 180 190 200
YSQITFRGTT SECGDISRVR RPKKPDSITV VITKVADSYP EPAHLLTGTK
210 220 230 240 250
SVCEISSNWF QPIYLGAMFS LEEGDRLMVN VSDISLVDYT KEDKTFFGAF

LI
Length:252
Mass (Da):28,029
Last modified:October 1, 2002 - v1
Checksum:i7789E6556D46F293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520787 mRNA. Translation: AAM77368.1.
RefSeqiNP_665708.1. NM_145765.1.
UniGeneiRn.84873.

Genome annotation databases

GeneIDi252878.
KEGGirno:252878.
UCSCiRGD:628735. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTNF15_RAT
AccessioniPrimary (citable) accession number: Q8K3Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families