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Protein

Tumor necrosis factor ligand superfamily member 15

Gene

Tnfsf15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei188 – 1881Important for binding TNFRSF6BBy similarity
Sitei191 – 1911Important for binding TNFRSF6BBy similarity

GO - Molecular functioni

  • death receptor binding Source: RGD

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • immune response Source: InterPro
  • positive regulation of cytokine secretion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Gene namesi
Name:Tnfsf15
Synonyms:Tl1, Vegi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628735. Tnfsf15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini61 – 252192ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Tumor necrosis factor ligand superfamily member 15PRO_0000333233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi163 ↔ 203By similarity
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K3Y7.

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

  • death receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011845.

Structurei

3D structure databases

ProteinModelPortaliQ8K3Y7.
SMRiQ8K3Y7. Positions 94-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFSK. Eukaryota.
ENOG4111Y6F. LUCA.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ8K3Y7.
KOiK05478.
OMAiGTTSECG.
OrthoDBiEOG7V4B0Q.
PhylomeDBiQ8K3Y7.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELGLGFG EAVPVEMLPE GCRHRREART GLAARSKACL ALTCCLLSFP
60 70 80 90 100
ILAGLSTLLM TGQLRIPGKD CMFPTVTEER SAPSAQPVYT PSRDKPKAHL
110 120 130 140 150
TIMRQTPVPH LKNELAALHW ENNLGMAFTK NRMNYTNKFL VIPESGDYFI
160 170 180 190 200
YSQITFRGTT SECGDISRVR RPKKPDSITV VITKVADSYP EPAHLLTGTK
210 220 230 240 250
SVCEISSNWF QPIYLGAMFS LEEGDRLMVN VSDISLVDYT KEDKTFFGAF

LI
Length:252
Mass (Da):28,029
Last modified:October 1, 2002 - v1
Checksum:i7789E6556D46F293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520787 mRNA. Translation: AAM77368.1.
RefSeqiNP_665708.1. NM_145765.1.
UniGeneiRn.84873.

Genome annotation databases

GeneIDi252878.
KEGGirno:252878.
UCSCiRGD:628735. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520787 mRNA. Translation: AAM77368.1.
RefSeqiNP_665708.1. NM_145765.1.
UniGeneiRn.84873.

3D structure databases

ProteinModelPortaliQ8K3Y7.
SMRiQ8K3Y7. Positions 94-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011845.

Proteomic databases

PaxDbiQ8K3Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252878.
KEGGirno:252878.
UCSCiRGD:628735. rat.

Organism-specific databases

CTDi9966.
RGDi628735. Tnfsf15.

Phylogenomic databases

eggNOGiENOG410IFSK. Eukaryota.
ENOG4111Y6F. LUCA.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ8K3Y7.
KOiK05478.
OMAiGTTSECG.
OrthoDBiEOG7V4B0Q.
PhylomeDBiQ8K3Y7.
TreeFamiTF332169.

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

NextBioi623952.
PROiQ8K3Y7.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiTNF15_RAT
AccessioniPrimary (citable) accession number: Q8K3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2002
Last modified: February 17, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.