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Protein

Heat shock factor-binding protein 1

Gene

Hsbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity).By similarity

GO - Biological processi

  • endodermal cell differentiation Source: Ensembl
  • muscle contraction Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-3371568. Attenuation phase.
R-RNO-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor-binding protein 1
Gene namesi
Name:Hsbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi628632. Hsbp1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: RGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Heat shock factor-binding protein 1PRO_0000124808Add
BLAST

Proteomic databases

PaxDbiQ8K3X8.
PRIDEiQ8K3X8.

PTM databases

iPTMnetiQ8K3X8.
PhosphoSiteiQ8K3X8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014415.
GenevisibleiQ8K3X8. RN.

Interactioni

Subunit structurei

Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019443.

Family & Domainsi

Sequence similaritiesi

Belongs to the HSBP1 family.Curated

Phylogenomic databases

eggNOGiKOG4117. Eukaryota.
ENOG41122JH. LUCA.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiQ8K3X8.
KOiK19765.
OMAiRIDEMGN.
OrthoDBiEOG091G14ZN.
PhylomeDBiQ8K3X8.
TreeFamiTF314005.

Family and domain databases

InterProiIPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETDPKTMQ DITLVVETLL QQMQDKFQIM SDQIIGRIDD MSSRIDDLEK
60 70
NIADLMTQAG VEELDAENKI PTAQKS
Length:76
Mass (Da):8,585
Last modified:October 1, 2002 - v1
Checksum:i3E86DF5C88E2CB56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522937 mRNA. Translation: AAM81322.1.
BC058131 mRNA. Translation: AAH58131.1.
RefSeqiNP_775142.1. NM_173119.2.
UniGeneiRn.2578.

Genome annotation databases

EnsembliENSRNOT00000019443; ENSRNOP00000019443; ENSRNOG00000014415.
GeneIDi286899.
KEGGirno:286899.
UCSCiRGD:628632. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522937 mRNA. Translation: AAM81322.1.
BC058131 mRNA. Translation: AAH58131.1.
RefSeqiNP_775142.1. NM_173119.2.
UniGeneiRn.2578.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019443.

PTM databases

iPTMnetiQ8K3X8.
PhosphoSiteiQ8K3X8.

Proteomic databases

PaxDbiQ8K3X8.
PRIDEiQ8K3X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019443; ENSRNOP00000019443; ENSRNOG00000014415.
GeneIDi286899.
KEGGirno:286899.
UCSCiRGD:628632. rat.

Organism-specific databases

CTDi3281.
RGDi628632. Hsbp1.

Phylogenomic databases

eggNOGiKOG4117. Eukaryota.
ENOG41122JH. LUCA.
GeneTreeiENSGT00390000006293.
HOGENOMiHOG000217518.
HOVERGENiHBG051930.
InParanoidiQ8K3X8.
KOiK19765.
OMAiRIDEMGN.
OrthoDBiEOG091G14ZN.
PhylomeDBiQ8K3X8.
TreeFamiTF314005.

Enzyme and pathway databases

ReactomeiR-RNO-3371568. Attenuation phase.
R-RNO-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ8K3X8.

Gene expression databases

BgeeiENSRNOG00000014415.
GenevisibleiQ8K3X8. RN.

Family and domain databases

InterProiIPR009643. HS1-bd.
[Graphical view]
PANTHERiPTHR19424. PTHR19424. 1 hit.
PfamiPF06825. HSBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSBP1_RAT
AccessioniPrimary (citable) accession number: Q8K3X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.