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Q8K3X6

- ANS4B_MOUSE

UniProt

Q8K3X6 - ANS4B_MOUSE

Protein

Ankyrin repeat and SAM domain-containing protein 4B

Gene

Anks4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. response to endoplasmic reticulum stress Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SAM domain-containing protein 4B
    Alternative name(s):
    Harmonin-interacting ankyrin repeat-containing protein
    Short name:
    Harp
    Gene namesi
    Name:Anks4b
    Synonyms:Harp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1919324. Anks4b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: MGI
    2. plasma membrane Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Ankyrin repeat and SAM domain-containing protein 4BPRO_0000066997Add
    BLAST

    Proteomic databases

    MaxQBiQ8K3X6.
    PaxDbiQ8K3X6.
    PRIDEiQ8K3X6.

    PTM databases

    PhosphoSiteiQ8K3X6.

    Expressioni

    Tissue specificityi

    Cochlea, kidney, lung, liver, pancreas, salivary gland and small intestine (at protein level). Expressed in kidney, small intestine, pancreas, liver and colon. Not detected in heart, spleen and brain.

    Gene expression databases

    BgeeiQ8K3X6.
    GenevestigatoriQ8K3X6.

    Interactioni

    Subunit structurei

    Interacts through its C-terminus with USH1C PDZ 1 domain.1 Publication

    Protein-protein interaction databases

    BioGridi215131. 1 interaction.
    IntActiQ8K3X6. 1 interaction.
    STRINGi10090.ENSMUSP00000033201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3X6.
    SMRiQ8K3X6. Positions 14-159, 350-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati31 – 6030ANK 1Add
    BLAST
    Repeati64 – 9330ANK 2Add
    BLAST
    Repeati97 – 12630ANK 3Add
    BLAST
    Domaini357 – 40953SAMAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili130 – 16940Sequence AnalysisAdd
    BLAST
    Coiled coili301 – 33535Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi421 – 4233PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi312 – 34635Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00390000017548.
    HOGENOMiHOG000007847.
    HOVERGENiHBG051882.
    InParanoidiQ148R3.
    OMAiNGHAHCV.
    OrthoDBiEOG70GMFR.
    PhylomeDBiQ8K3X6.
    TreeFamiTF324946.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K3X6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTRYHQAAS DSYLELLKEA TKRDLNLSDE DGMTPTLLAA YHGNLEALEI    50
    ICSRGGDPDK CDIWGNTPLH YAASNGHTHC ISFLVNFGAN IFALDNDLKS 100
    PLDAAASREQ KECVALLDKA ATVQNTMNPK RVTRLKEQAL KNARKQMKEC 150
    ERLQERHQNK MARTYSKEDS GTISSSHSTL SRSFLSTTSA GRFGSLSKGI 200
    KDTFKIKSKK NKDTTEQLEK DGRSGQRPVM EVFREEEEDS FPKDFKEKLH 250
    FSVEEDDDVQ HESILNRPGL GSIVFSRNRV LDFEDISDSK RELGFKMPSE 300
    LFQRQGAAGT VEEEEEEEEE EEEEKREANG TAGDLPWDEE EVEWEEDAVD 350
    ATPLEVFLQS QHLEEFLPIF MREQIDLEAL LLCSDEDLQN IHMQLGPRKK 400
    VLSAIDKRKQ VLQQPGQLVD TSL 423
    Length:423
    Mass (Da):47,975
    Last modified:October 1, 2002 - v1
    Checksum:i65886645CB15AB48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti324 – 3241E → G in BAB25545. (PubMed:16141072)Curated
    Sequence conflicti332 – 3321A → E in BAB25545. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF524030 mRNA. Translation: AAM81375.1.
    AK008229 mRNA. Translation: BAB25545.1.
    BC115784 mRNA. Translation: AAI15785.1.
    BC118013 mRNA. Translation: AAI18014.1.
    CCDSiCCDS21793.1.
    RefSeqiNP_082361.2. NM_028085.2.
    UniGeneiMm.23165.

    Genome annotation databases

    EnsembliENSMUST00000033201; ENSMUSP00000033201; ENSMUSG00000030909.
    GeneIDi72074.
    KEGGimmu:72074.
    UCSCiuc009jmj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF524030 mRNA. Translation: AAM81375.1 .
    AK008229 mRNA. Translation: BAB25545.1 .
    BC115784 mRNA. Translation: AAI15785.1 .
    BC118013 mRNA. Translation: AAI18014.1 .
    CCDSi CCDS21793.1.
    RefSeqi NP_082361.2. NM_028085.2.
    UniGenei Mm.23165.

    3D structure databases

    ProteinModelPortali Q8K3X6.
    SMRi Q8K3X6. Positions 14-159, 350-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215131. 1 interaction.
    IntActi Q8K3X6. 1 interaction.
    STRINGi 10090.ENSMUSP00000033201.

    PTM databases

    PhosphoSitei Q8K3X6.

    Proteomic databases

    MaxQBi Q8K3X6.
    PaxDbi Q8K3X6.
    PRIDEi Q8K3X6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033201 ; ENSMUSP00000033201 ; ENSMUSG00000030909 .
    GeneIDi 72074.
    KEGGi mmu:72074.
    UCSCi uc009jmj.2. mouse.

    Organism-specific databases

    CTDi 257629.
    MGIi MGI:1919324. Anks4b.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00390000017548.
    HOGENOMi HOG000007847.
    HOVERGENi HBG051882.
    InParanoidi Q148R3.
    OMAi NGHAHCV.
    OrthoDBi EOG70GMFR.
    PhylomeDBi Q8K3X6.
    TreeFami TF324946.

    Miscellaneous databases

    NextBioi 335364.
    PROi Q8K3X6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K3X6.
    Genevestigatori Q8K3X6.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues."
      Johnston A.M., Naselli G., Niwa H., Brodnicki T., Harrison L.C., Gonez L.J.
      Genes Cells 9:967-982(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH USH1C.
      Strain: BALB/c.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiANS4B_MOUSE
    AccessioniPrimary (citable) accession number: Q8K3X6
    Secondary accession number(s): Q148R3, Q9D8A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3