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Q8K3X6

- ANS4B_MOUSE

UniProt

Q8K3X6 - ANS4B_MOUSE

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Protein
Ankyrin repeat and SAM domain-containing protein 4B
Gene
Anks4b, Harp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SAM domain-containing protein 4B
Alternative name(s):
Harmonin-interacting ankyrin repeat-containing protein
Short name:
Harp
Gene namesi
Name:Anks4b
Synonyms:Harp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1919324. Anks4b.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Ankyrin repeat and SAM domain-containing protein 4B
PRO_0000066997Add
BLAST

Proteomic databases

MaxQBiQ8K3X6.
PaxDbiQ8K3X6.
PRIDEiQ8K3X6.

PTM databases

PhosphoSiteiQ8K3X6.

Expressioni

Tissue specificityi

Cochlea, kidney, lung, liver, pancreas, salivary gland and small intestine (at protein level). Expressed in kidney, small intestine, pancreas, liver and colon. Not detected in heart, spleen and brain.

Gene expression databases

BgeeiQ8K3X6.
GenevestigatoriQ8K3X6.

Interactioni

Subunit structurei

Interacts through its C-terminus with USH1C PDZ 1 domain.1 Publication

Protein-protein interaction databases

BioGridi215131. 1 interaction.
IntActiQ8K3X6. 1 interaction.
STRINGi10090.ENSMUSP00000033201.

Structurei

3D structure databases

ProteinModelPortaliQ8K3X6.
SMRiQ8K3X6. Positions 14-159, 350-423.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6030ANK 1
Add
BLAST
Repeati64 – 9330ANK 2
Add
BLAST
Repeati97 – 12630ANK 3
Add
BLAST
Domaini357 – 40953SAM
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 16940 Reviewed prediction
Add
BLAST
Coiled coili301 – 33535 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 4233PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi312 – 34635Glu-rich
Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000017548.
HOGENOMiHOG000007847.
HOVERGENiHBG051882.
InParanoidiQ148R3.
OMAiNGHAHCV.
OrthoDBiEOG70GMFR.
PhylomeDBiQ8K3X6.
TreeFamiTF324946.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3X6-1 [UniParc]FASTAAdd to Basket

« Hide

MSTRYHQAAS DSYLELLKEA TKRDLNLSDE DGMTPTLLAA YHGNLEALEI    50
ICSRGGDPDK CDIWGNTPLH YAASNGHTHC ISFLVNFGAN IFALDNDLKS 100
PLDAAASREQ KECVALLDKA ATVQNTMNPK RVTRLKEQAL KNARKQMKEC 150
ERLQERHQNK MARTYSKEDS GTISSSHSTL SRSFLSTTSA GRFGSLSKGI 200
KDTFKIKSKK NKDTTEQLEK DGRSGQRPVM EVFREEEEDS FPKDFKEKLH 250
FSVEEDDDVQ HESILNRPGL GSIVFSRNRV LDFEDISDSK RELGFKMPSE 300
LFQRQGAAGT VEEEEEEEEE EEEEKREANG TAGDLPWDEE EVEWEEDAVD 350
ATPLEVFLQS QHLEEFLPIF MREQIDLEAL LLCSDEDLQN IHMQLGPRKK 400
VLSAIDKRKQ VLQQPGQLVD TSL 423
Length:423
Mass (Da):47,975
Last modified:October 1, 2002 - v1
Checksum:i65886645CB15AB48
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241E → G in BAB25545. 1 Publication
Sequence conflicti332 – 3321A → E in BAB25545. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF524030 mRNA. Translation: AAM81375.1.
AK008229 mRNA. Translation: BAB25545.1.
BC115784 mRNA. Translation: AAI15785.1.
BC118013 mRNA. Translation: AAI18014.1.
CCDSiCCDS21793.1.
RefSeqiNP_082361.2. NM_028085.2.
UniGeneiMm.23165.

Genome annotation databases

EnsembliENSMUST00000033201; ENSMUSP00000033201; ENSMUSG00000030909.
GeneIDi72074.
KEGGimmu:72074.
UCSCiuc009jmj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF524030 mRNA. Translation: AAM81375.1 .
AK008229 mRNA. Translation: BAB25545.1 .
BC115784 mRNA. Translation: AAI15785.1 .
BC118013 mRNA. Translation: AAI18014.1 .
CCDSi CCDS21793.1.
RefSeqi NP_082361.2. NM_028085.2.
UniGenei Mm.23165.

3D structure databases

ProteinModelPortali Q8K3X6.
SMRi Q8K3X6. Positions 14-159, 350-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215131. 1 interaction.
IntActi Q8K3X6. 1 interaction.
STRINGi 10090.ENSMUSP00000033201.

PTM databases

PhosphoSitei Q8K3X6.

Proteomic databases

MaxQBi Q8K3X6.
PaxDbi Q8K3X6.
PRIDEi Q8K3X6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033201 ; ENSMUSP00000033201 ; ENSMUSG00000030909 .
GeneIDi 72074.
KEGGi mmu:72074.
UCSCi uc009jmj.2. mouse.

Organism-specific databases

CTDi 257629.
MGIi MGI:1919324. Anks4b.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00390000017548.
HOGENOMi HOG000007847.
HOVERGENi HBG051882.
InParanoidi Q148R3.
OMAi NGHAHCV.
OrthoDBi EOG70GMFR.
PhylomeDBi Q8K3X6.
TreeFami TF324946.

Miscellaneous databases

NextBioi 335364.
PROi Q8K3X6.
SOURCEi Search...

Gene expression databases

Bgeei Q8K3X6.
Genevestigatori Q8K3X6.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues."
    Johnston A.M., Naselli G., Niwa H., Brodnicki T., Harrison L.C., Gonez L.J.
    Genes Cells 9:967-982(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH USH1C.
    Strain: BALB/c.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANS4B_MOUSE
AccessioniPrimary (citable) accession number: Q8K3X6
Secondary accession number(s): Q148R3, Q9D8A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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