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Protein

Interferon regulatory factor 2-binding protein-like

Gene

Irf2bpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the control of female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein-like
Alternative name(s):
Enhanced at puberty protein 1
Gene namesi
Name:Irf2bpl
Synonyms:Eap1, Kiaa1865
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2442463. Irf2bpl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564121 – 775Interferon regulatory factor 2-binding protein-likeAdd BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineBy similarity1
Modified residuei195PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei618PhosphoserineBy similarity1
Modified residuei636PhosphoserineCombined sources1
Modified residuei637PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K3X4.
MaxQBiQ8K3X4.
PaxDbiQ8K3X4.
PeptideAtlasiQ8K3X4.
PRIDEiQ8K3X4.

PTM databases

iPTMnetiQ8K3X4.
PhosphoSitePlusiQ8K3X4.

Miscellaneous databases

PMAP-CutDBQ8K3X4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034168.
CleanExiMM_6430527G18RIK.
GenevisibleiQ8K3X4. MM.

Interactioni

Protein-protein interaction databases

BioGridi231970. 1 interactor.
IntActiQ8K3X4. 1 interactor.
MINTiMINT-4091112.
STRINGi10090.ENSMUSP00000041070.

Structurei

3D structure databases

ProteinModelPortaliQ8K3X4.
SMRiQ8K3X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 113Sequence analysisAdd BLAST31
Coiled coili314 – 350Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 95Poly-Ala8
Compositional biasi96 – 108Poly-GlnAdd BLAST13
Compositional biasi134 – 144Poly-AlaAdd BLAST11
Compositional biasi154 – 282Pro-richAdd BLAST129
Compositional biasi575 – 602Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the IRF2BP family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri694 – 741RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ8K3X4.
OMAiQNGPSPM.
OrthoDBiEOG091G040R.
PhylomeDBiQ8K3X4.
TreeFamiTF317075.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAQQQQQ
110 120 130 140 150
QQQQQQQQLN HVDGSTKPAV LAAPSGLERY GLSAAAAAAA AAAAVEQRSR
160 170 180 190 200
FEYPPPPVSL GSSSHAARLP NGLGGPNGFP KPAPEEGPPE LNRQSPNSSS
210 220 230 240 250
AATSVASRRG THSGLVTGLP NPGGGGGPQL TVPPNLLPQT LLNGPASAAV
260 270 280 290 300
LPPPHGLGGS RGPPTPAPPG APGGPACLGG PPGVSATVSS APSSTSSTVA
310 320 330 340 350
EVGVGAAGKR PGSVSSTDQE RELKEKQRNA EALAELSESL RNRAEEWANK
360 370 380 390 400
PKMVRDTLLT LAGCTPYEVR FKKDHSLLGR VFAFDAVSKP GMDYELKLFI
410 420 430 440 450
EYPTGSGNVY SSASGVAKQM YQDCMKDFGR GLSSGFKYLE YEKKHGSGDW
460 470 480 490 500
RLLGDLLPEA VRFFKEGVPG ADMLPQPYLD ASCPMLPTAL VSLSRAPSAP
510 520 530 540 550
PGTGALPPAA PTGRGAASSL RKRKASPEPP DSAESALKLG EEQQRQQWMA
560 570 580 590 600
NQSEALKLTM SAGGFAAPGH SAGGPPPPPP PLGPHSNRTT PPESAPQNGP
610 620 630 640 650
SPMAALMSVA DTLGTAHSPK DGSSVHSTTA SARRNSSSPV SPASVPGQRR
660 670 680 690 700
LASRNGDLNL QVAPPPPSAH PGMDQVHPQN IPDSPMANSG PLCCTICHER
710 720 730 740 750
LEDTHFVQCP SVPSHKFCFP CSRESIKAQG ATGEVYCPSG EKCPLVGSNV
760 770
PWAFMQGEIA TILAGDVKVK KERDP
Length:775
Mass (Da):80,565
Last modified:October 1, 2002 - v1
Checksum:iECB11652F2F7C2AB
GO

Sequence cautioni

The sequence BAD32560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226G → E in BAC38621 (PubMed:16141072).Curated1
Sequence conflicti227G → E in BAE32550 (PubMed:16141072).Curated1
Sequence conflicti330A → P in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti442E → G in BAC27955 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE33226 (PubMed:16141072).Curated1
Sequence conflicti619P → S in BAE42208 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525300 mRNA. Translation: AAM82165.1.
AK173282 mRNA. Translation: BAD32560.1. Different initiation.
AK032366 mRNA. Translation: BAC27837.1.
AK032622 mRNA. Translation: BAC27955.1.
AK082791 mRNA. Translation: BAC38621.1.
AK140441 mRNA. Translation: BAE24388.1.
AK154383 mRNA. Translation: BAE32550.1.
AK155373 mRNA. Translation: BAE33226.1.
AK171043 mRNA. Translation: BAE42208.1.
BC057128 mRNA. Translation: AAH57128.1.
BC063253 mRNA. Translation: AAH63253.1.
CCDSiCCDS26068.1.
RefSeqiNP_665835.1. NM_145836.2.
UniGeneiMm.248358.

Genome annotation databases

EnsembliENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168.
GeneIDi238330.
KEGGimmu:238330.
UCSCiuc007oia.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525300 mRNA. Translation: AAM82165.1.
AK173282 mRNA. Translation: BAD32560.1. Different initiation.
AK032366 mRNA. Translation: BAC27837.1.
AK032622 mRNA. Translation: BAC27955.1.
AK082791 mRNA. Translation: BAC38621.1.
AK140441 mRNA. Translation: BAE24388.1.
AK154383 mRNA. Translation: BAE32550.1.
AK155373 mRNA. Translation: BAE33226.1.
AK171043 mRNA. Translation: BAE42208.1.
BC057128 mRNA. Translation: AAH57128.1.
BC063253 mRNA. Translation: AAH63253.1.
CCDSiCCDS26068.1.
RefSeqiNP_665835.1. NM_145836.2.
UniGeneiMm.248358.

3D structure databases

ProteinModelPortaliQ8K3X4.
SMRiQ8K3X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231970. 1 interactor.
IntActiQ8K3X4. 1 interactor.
MINTiMINT-4091112.
STRINGi10090.ENSMUSP00000041070.

PTM databases

iPTMnetiQ8K3X4.
PhosphoSitePlusiQ8K3X4.

Proteomic databases

EPDiQ8K3X4.
MaxQBiQ8K3X4.
PaxDbiQ8K3X4.
PeptideAtlasiQ8K3X4.
PRIDEiQ8K3X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038422; ENSMUSP00000041070; ENSMUSG00000034168.
GeneIDi238330.
KEGGimmu:238330.
UCSCiuc007oia.2. mouse.

Organism-specific databases

CTDi64207.
MGIiMGI:2442463. Irf2bpl.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOVERGENiHBG108364.
InParanoidiQ8K3X4.
OMAiQNGPSPM.
OrthoDBiEOG091G040R.
PhylomeDBiQ8K3X4.
TreeFamiTF317075.

Miscellaneous databases

PMAP-CutDBQ8K3X4.
PROiQ8K3X4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034168.
CleanExiMM_6430527G18RIK.
GenevisibleiQ8K3X4. MM.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI2BPL_MOUSE
AccessioniPrimary (citable) accession number: Q8K3X4
Secondary accession number(s): Q3TBU9
, Q3U483, Q3USE5, Q69Z84, Q8BUS1, Q8C011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.