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Protein

Leucine-rich repeat-containing protein 10

Gene

Lrrc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play important roles in cardiac development and/or cardiac function.

GO - Molecular functioni

  • actin binding Source: MGI
  • alpha-actinin binding Source: MGI

GO - Biological processi

  • cardiac muscle cell development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10
Alternative name(s):
Heart-restricted leucine-rich repeat protein
Gene namesi
Name:Lrrc10
Synonyms:Hrlrrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2448063. Lrrc10.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: MGI
  • mitochondrion Source: MGI
  • myofibril Source: MGI
  • nucleus Source: MGI
  • sarcomere Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Leucine-rich repeat-containing protein 10PRO_0000084471Add
BLAST

Proteomic databases

PaxDbiQ8K3W2.
PRIDEiQ8K3W2.

PTM databases

iPTMnetiQ8K3W2.
PhosphoSiteiQ8K3W2.

Expressioni

Tissue specificityi

Detected specifically in the heart.1 Publication

Gene expression databases

BgeeiQ8K3W2.
CleanExiMM_LRRC10.

Interactioni

GO - Molecular functioni

  • actin binding Source: MGI
  • alpha-actinin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073502.

Structurei

3D structure databases

ProteinModelPortaliQ8K3W2.
SMRiQ8K3W2. Positions 22-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 5122LRR 1Add
BLAST
Repeati52 – 7423LRR 2Add
BLAST
Repeati76 – 9722LRR 3Add
BLAST
Repeati98 – 12023LRR 4Add
BLAST
Repeati121 – 14323LRR 5Add
BLAST
Repeati145 – 16622LRR 6Add
BLAST
Repeati167 – 18923LRR 7Add
BLAST
Repeati191 – 21323LRR 8Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi265 – 2684Poly-Pro

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiQ8K3W2.
OMAiIDVDRNS.
OrthoDBiEOG7TF79V.
PhylomeDBiQ8K3W2.
TreeFamiTF332853.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTIRAFVA FIPTDRCQSY VVGDLREMPL DRMVDLSGSQ LRRFPLHVCS
60 70 80 90 100
FTELVKLYLS DNHLHSLPPD LAQLQNLQIL ALDFNNFKAL PRVVCTLKQL
110 120 130 140 150
CILYLGNNKL CDLPDELSLL QNLRTLWLES NCLTRLPDVV CELSLLKTLH
160 170 180 190 200
AGSNALRLLP GQLRRLRELR TIWLSGNQLA DFPSVLLRMP FLEVIDVDRN
210 220 230 240 250
SIRYFPSLAH LTNLKLVIYD HNPCRNAPKV GKGVRRVGRW AEETPEPDPR
260 270
KARRYALAKE ENQEPPPPLL PSSS
Length:274
Mass (Da):31,263
Last modified:October 1, 2002 - v1
Checksum:i826B76D4FA4EDDD0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261R → Q in BAC39192 (PubMed:16141072).Curated
Sequence conflicti75 – 751Q → R in BAC39192 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527781 mRNA. Translation: AAM89260.1.
AB091100 mRNA. Translation: BAC57985.1.
AK084466 mRNA. Translation: BAC39192.1.
AK085779 mRNA. Translation: BAC39536.1.
BC086911 mRNA. Translation: AAH86911.1.
CCDSiCCDS24189.1.
RefSeqiNP_666354.1. NM_146242.2.
UniGeneiMm.37320.

Genome annotation databases

EnsembliENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187.
GeneIDi237560.
KEGGimmu:237560.
UCSCiuc007hcr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527781 mRNA. Translation: AAM89260.1.
AB091100 mRNA. Translation: BAC57985.1.
AK084466 mRNA. Translation: BAC39192.1.
AK085779 mRNA. Translation: BAC39536.1.
BC086911 mRNA. Translation: AAH86911.1.
CCDSiCCDS24189.1.
RefSeqiNP_666354.1. NM_146242.2.
UniGeneiMm.37320.

3D structure databases

ProteinModelPortaliQ8K3W2.
SMRiQ8K3W2. Positions 22-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073502.

PTM databases

iPTMnetiQ8K3W2.
PhosphoSiteiQ8K3W2.

Proteomic databases

PaxDbiQ8K3W2.
PRIDEiQ8K3W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187.
GeneIDi237560.
KEGGimmu:237560.
UCSCiuc007hcr.1. mouse.

Organism-specific databases

CTDi376132.
MGIiMGI:2448063. Lrrc10.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiQ8K3W2.
OMAiIDVDRNS.
OrthoDBiEOG7TF79V.
PhylomeDBiQ8K3W2.
TreeFamiTF332853.

Miscellaneous databases

PROiQ8K3W2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K3W2.
CleanExiMM_LRRC10.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization and expression of Lrrc10, a novel mouse heart specific member of leucine rich repeat superfamily."
    Chen X.G., Li Y., Zhao R.-B., Pei X.-R., Zang M.-X., Fang L.-F., Chen J.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 30:617-622(2003)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Heart.
  2. "Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein."
    Nakane T., Satoh T., Inada Y., Nakayama J., Itoh F., Chiba S.
    Biochem. Biophys. Res. Commun. 314:1086-1092(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiLRC10_MOUSE
AccessioniPrimary (citable) accession number: Q8K3W2
Secondary accession number(s): Q8BUL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.