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Protein

Leucine-rich repeat-containing protein 10

Gene

Lrrc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play important roles in cardiac development and/or cardiac function.

GO - Molecular functioni

  • actin binding Source: MGI
  • alpha-actinin binding Source: MGI

GO - Biological processi

  • cardiac muscle cell development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10
Alternative name(s):
Heart-restricted leucine-rich repeat protein
Gene namesi
Name:Lrrc10
Synonyms:Hrlrrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2448063. Lrrc10.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: MGI
  • mitochondrion Source: MGI
  • myofibril Source: MGI
  • nucleus Source: MGI
  • sarcomere Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844711 – 274Leucine-rich repeat-containing protein 10Add BLAST274

Proteomic databases

PaxDbiQ8K3W2.
PRIDEiQ8K3W2.

PTM databases

iPTMnetiQ8K3W2.
PhosphoSitePlusiQ8K3W2.

Expressioni

Tissue specificityi

Detected specifically in the heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000060187.
CleanExiMM_LRRC10.

Interactioni

GO - Molecular functioni

  • actin binding Source: MGI
  • alpha-actinin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073502.

Structurei

3D structure databases

ProteinModelPortaliQ8K3W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 51LRR 1Add BLAST22
Repeati52 – 74LRR 2Add BLAST23
Repeati76 – 97LRR 3Add BLAST22
Repeati98 – 120LRR 4Add BLAST23
Repeati121 – 143LRR 5Add BLAST23
Repeati145 – 166LRR 6Add BLAST22
Repeati167 – 189LRR 7Add BLAST23
Repeati191 – 213LRR 8Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi265 – 268Poly-Pro4

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiQ8K3W2.
OMAiIDVDRNS.
OrthoDBiEOG091G0HMZ.
PhylomeDBiQ8K3W2.
TreeFamiTF332853.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 5 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 7 hits.

Sequencei

Sequence statusi: Complete.

Q8K3W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTIRAFVA FIPTDRCQSY VVGDLREMPL DRMVDLSGSQ LRRFPLHVCS
60 70 80 90 100
FTELVKLYLS DNHLHSLPPD LAQLQNLQIL ALDFNNFKAL PRVVCTLKQL
110 120 130 140 150
CILYLGNNKL CDLPDELSLL QNLRTLWLES NCLTRLPDVV CELSLLKTLH
160 170 180 190 200
AGSNALRLLP GQLRRLRELR TIWLSGNQLA DFPSVLLRMP FLEVIDVDRN
210 220 230 240 250
SIRYFPSLAH LTNLKLVIYD HNPCRNAPKV GKGVRRVGRW AEETPEPDPR
260 270
KARRYALAKE ENQEPPPPLL PSSS
Length:274
Mass (Da):31,263
Last modified:October 1, 2002 - v1
Checksum:i826B76D4FA4EDDD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26R → Q in BAC39192 (PubMed:16141072).Curated1
Sequence conflicti75Q → R in BAC39192 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527781 mRNA. Translation: AAM89260.1.
AB091100 mRNA. Translation: BAC57985.1.
AK084466 mRNA. Translation: BAC39192.1.
AK085779 mRNA. Translation: BAC39536.1.
BC086911 mRNA. Translation: AAH86911.1.
CCDSiCCDS24189.1.
RefSeqiNP_666354.1. NM_146242.2.
UniGeneiMm.37320.

Genome annotation databases

EnsembliENSMUST00000073834; ENSMUSP00000073502; ENSMUSG00000060187.
GeneIDi237560.
KEGGimmu:237560.
UCSCiuc007hcr.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLRC10_MOUSE
AccessioniPrimary (citable) accession number: Q8K3W2
Secondary accession number(s): Q8BUL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2002
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot