Unreviewed, UniProtKB/TrEMBL Q8K3R4 (Q8K3R4_RAT)

Names and origin

Protein names

Submitted name:
    30 kDa adipocyte complement-related protein EMBL AAK61608.1
Submitted name:
    Adiponectin, C1Q and collagen domain containing EMBL EDL78080.1

Gene names

Name:	Adipoq RGD 628748
Synonyms:	Acdc RGD 628748
ORF Names:	rCG_36676 EMBL EDL78080.1

Organism

Rattus norvegicus (Rat) EMBL AAK61608.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C1q domain. Spearmint SPM001073

Ontologies

Keywords
Domain	Collagen Spearmint SPM001073 EMBL EDL78080.1
Gene Ontology (GO)
Biological process	adiponectin-mediated signaling pathway Inferred from direct assay. Source: RGD brown fat cell differentiation Inferred from electronic annotation. Source: Compara fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara membrane depolarization Inferred from direct assay. Source: RGD membrane hyperpolarization Inferred from direct assay. Source: RGD negative regulation of gluconeogenesis Inferred from electronic annotation. Source: Compara negative regulation of hormone secretion Inferred from direct assay. Source: RGD positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from direct assay. Source: RGD positive regulation of fatty acid metabolic process Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: RGD protein homooligomerization Inferred from electronic annotation. Source: Compara response to drug Inferred from expression pattern. Source: RGD response to ethanol Inferred from expression pattern. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern. Source: RGD response to glucose stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from expression pattern. Source: RGD response to nutrient Inferred from expression pattern. Source: RGD response to sucrose stimulus Inferred from expression pattern. Source: RGD
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay. Source: RGD
Molecular function	hormone activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8K3R4-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 75B2B1DF68E2633E	FASTA	244	26,410
	10 20 30 40 50 60 MLLLQALLFL LILPSHEGIT ATEGPGALVP PPKETCAGWM AGIPGYPGHN GIPGRDGRDG 70 80 90 100 110 120 TPGEKGEKGD AGVLGPKGDP GDAGMTGAEG PRGFPGTPGR KGEPGEAAYM YHSAFSVGLE 130 140 150 160 170 180 TRVTVPNVPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF SYHITVYMKD VKVSLFKKDK 190 200 210 220 230 240 AVLFTYDQYQ EKNVDQASGS MLLHLEVGDQ VWLQVYGEGD NNGLYADNVN DSTFTGFLLY HDTN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the rat homolog to murine adipocyte complement-related protein of 30 kDa." Berg A.H., Scherer P.E. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAK61608.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL78080.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL78080.1.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary EMBL AAH92565.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC092565 mRNA. Translation: AAH92565.1. AY033885 mRNA. Translation: AAK61608.1. CH473999 Genomic DNA. Translation: EDL78080.1.
IPI	IPI00202515.
RefSeq	NP_653345.1.
UniGene	Rn.24299
3D structure databases
HSSP	HSSP built from PDB template 1C28 based on UniProtKB Q60994.
SMR	Q8K3R4. Positions 108-244.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K3R4.
Genome annotation databases
Ensembl	ENSRNOT00000002492; ENSRNOP00000002492; ENSRNOG00000001821; Rattus norvegicus. [Genome view]
GeneID	246253.
KEGG	rno:246253.
UCSC	NM_144744. rat.
Organism-specific databases
CTD	246253.
RGD	628748. Adipoq.
Phylogenomic databases
HOVERGEN	Q8K3R4.
OMA	YHITVYM.
Gene expression databases
ArrayExpress	Q8K3R4.
Genevestigator	Q8K3R4.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
ProDom	PD000007. Clg_helix. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00110. C1Q. 1 hit. [Graphical view]
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	623595.

Entry information

Entry name

Q8K3R4_RAT

Accession

Primary (citable) accession number: Q8K3R4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)