Q8K3R4 (Q8K3R4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
30 kDa adipocyte complement-related protein EMBL AAK61608.1

Submitted name:
Adiponectin, C1Q and collagen domain containing EMBL AAH92565.1
Submitted name:
Uncharacterized protein Ensembl ENSRNOP00000002492

Gene names

Name:	Adipoq EMBL EDL78080.1 RGD 628748 Ensembl ENSRNOP00000002492
Synonyms:	Acdc RGD 628748
ORF Names:	rCG_36676 EMBL EDL78080.1

Organism

Rattus norvegicus (Rat) EMBL AAK61608.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C1q domain. SAAS SAAS008160

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS008160
Domain	Collagen SAAS SAAS008160 EMBL AAH92565.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adiponectin-mediated signaling pathway Inferred from direct assay. Source: RGD brown fat cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB cellular response to drug Inferred from sequence or structural similarity. Source: UniProtKB cellular response to insulin stimulus Inferred from sequence or structural similarity. Source: UniProtKB detection of oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB fatty acid beta-oxidation Inferred from sequence or structural similarity. Source: UniProtKB glucose homeostasis Inferred from sequence or structural similarity. Source: UniProtKB glucose metabolic process Inferred from sequence or structural similarity. Source: UniProtKB low-density lipoprotein particle clearance Inferred from sequence or structural similarity. Source: UniProtKB membrane depolarization Inferred from direct assay. Source: RGD membrane hyperpolarization Inferred from direct assay. Source: RGD negative regulation of DNA biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of ERK1 and ERK2 cascade Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of blood pressure Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of eukaryotic cell surface binding Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of fat cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of gluconeogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of granulocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of heterotypic cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of hormone secretion Inferred from direct assay. Source: RGD negative regulation of inflammatory response Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of intracellular protein transport Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of low-density lipoprotein particle receptor biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of macrophage derived foam cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of macrophage differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of phagocytosis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of platelet-derived growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of smooth muscle cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of smooth muscle cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of tumor necrosis factor production Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of tumor necrosis factor-mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of blood pressure Inferred from direct assay. Source: RGD positive regulation of cAMP-dependent protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cholesterol efflux Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of fatty acid metabolic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of glucose import Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of glycogen (starch) synthase activity Inferred from direct assay. Source: UniProtKB positive regulation of interleukin-8 production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of metanephric glomerular visceral epithelial cell development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of monocyte chemotactic protein-1 production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of myeloid cell apoptosis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: RGD positive regulation of protein kinase A signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of renal albumin absorption Inferred from sequence or structural similarity. Source: UniProtKB protein homooligomerization Inferred from sequence or structural similarity. Source: UniProtKB protein localization in plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB response to ethanol Inferred from expression pattern. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern. Source: RGD response to glucose stimulus Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxia Inferred from expression pattern. Source: RGD response to nutrient Inferred from expression pattern. Source: RGD response to sucrose stimulus Inferred from expression pattern. Source: RGD response to tumor necrosis factor Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	collagen Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from direct assay. Source: RGD
Molecular function	eukaryotic cell surface binding Inferred from sequence or structural similarity. Source: UniProtKB hormone activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8K3R4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 75B2B1DF68E2633E	FASTA	244	26,410
	10 20 30 40 50 60 MLLLQALLFL LILPSHEGIT ATEGPGALVP PPKETCAGWM AGIPGYPGHN GIPGRDGRDG 70 80 90 100 110 120 TPGEKGEKGD AGVLGPKGDP GDAGMTGAEG PRGFPGTPGR KGEPGEAAYM YHSAFSVGLE 130 140 150 160 170 180 TRVTVPNVPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF SYHITVYMKD VKVSLFKKDK 190 200 210 220 230 240 AVLFTYDQYQ EKNVDQASGS MLLHLEVGDQ VWLQVYGEGD NNGLYADNVN DSTFTGFLLY HDTN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary EMBL AAH92565.1.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed: 15057822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000002492.
[3]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL78080.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000002492.
[5]	"Cloning of the rat homolog to murine adipocyte complement-related protein of 30 kDa." Berg A.H., Scherer P.E. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAK61608.1.
[6]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL78080.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC092565 mRNA. Translation: AAH92565.1. AY033885 mRNA. Translation: AAK61608.1. CH473999 Genomic DNA. Translation: EDL78080.1.
IPI	IPI00202515.
RefSeq	NP_653345.1. NM_144744.3.
UniGene	Rn.24299.
3D structure databases
HSSP	HSSP built from PDB template 1C28 based on UniProtKB Q60994.
ProteinModelPortal	Q8K3R4.
SMR	Q8K3R4. Positions 108-244.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K3R4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002492; ENSRNOP00000002492; ENSRNOG00000001821.
GeneID	246253.
KEGG	rno:246253.
UCSC	NM_144744. rat.
Organism-specific databases
CTD	9370.
RGD	628748. Adipoq.
Phylogenomic databases
eggNOG	roNOG04854.
GeneTree	ENSGT00590000082736.
HOVERGEN	HBG108220.
InParanoid	Q8K3R4.
OMA	QNHYDGS.
OrthoDB	EOG4FXR88.
PhylomeDB	Q8K3R4.
Gene expression databases
ArrayExpress	Q8K3R4.
Genevestigator	Q8K3R4.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
KO	K07296.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	623595.

Entry information

Entry name

Q8K3R4_RAT

Accession

Primary (citable) accession number: Q8K3R4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)