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Q8K3R3

- PLCD4_MOUSE

UniProt

Q8K3R3 - PLCD4_MOUSE

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Gene

Plcd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.3 Publications

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Cofactori

    Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei305 – 3051PROSITE-ProRule annotation
    Metal bindingi306 – 3061Calcium 1; catalyticBy similarity
    Metal bindingi335 – 3351Calcium 1; catalyticBy similarity
    Metal bindingi337 – 3371Calcium 1; catalyticBy similarity
    Active sitei350 – 3501PROSITE-ProRule annotation
    Metal bindingi384 – 3841Calcium 1; catalyticBy similarity
    Binding sitei433 – 4331SubstrateBy similarity
    Binding sitei435 – 4351SubstrateBy similarity
    Binding sitei567 – 5671SubstrateBy similarity
    Binding sitei594 – 5941SubstrateBy similarity
    Metal bindingi697 – 6971Calcium 2By similarity
    Metal bindingi721 – 7211Calcium 2By similarity
    Metal bindingi750 – 7501Calcium 3By similarity
    Metal bindingi751 – 7511Calcium 3; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi147 – 158121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi183 – 194122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. phospholipase C activity Source: MGI
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. acrosome reaction Source: MGI
    2. intracellular signal transduction Source: InterPro
    3. lipid catabolic process Source: UniProtKB-KW
    4. phosphatidylinositol metabolic process Source: MGI
    5. signal transduction Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-delta-4
    Phospholipase C-delta-4
    Short name:
    PLC-delta-4
    Gene namesi
    Name:Plcd4
    Synonyms:Plcd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:107469. Plcd4.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Nucleus By similarity. Cytoplasm By similarity. Endoplasmic reticulum By similarity
    Note: Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. intracellular Source: MGI
    3. membrane Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are either sterile or produce few small litters. In these mice, fewer eggs become activated and the Ca2+ transients associated with fertilization are absent or delayed. Sperm are unable to initiate the acrosome reaction.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8078071-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4PRO_0000306826Add
    BLAST

    Proteomic databases

    MaxQBiQ8K3R3.
    PaxDbiQ8K3R3.
    PRIDEiQ8K3R3.

    PTM databases

    PhosphoSiteiQ8K3R3.

    Expressioni

    Inductioni

    By treatment with growth factors such as bradykinin, lysophosphatidic acid, and Ca2+ ionophore in addition to serum.1 Publication

    Gene expression databases

    ArrayExpressiQ8K3R3.
    BgeeiQ8K3R3.
    CleanExiMM_PLCD4.
    GenevestigatoriQ8K3R3.

    Interactioni

    Subunit structurei

    Interacts with GRIP1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3R3.
    SMRiQ8K3R3. Positions 9-453, 536-800.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 124109PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 16936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini170 – 20536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 23735EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini290 – 435146PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini538 – 654117PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 764106C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 5328Substrate bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi776 – 7794PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi445 – 45612Poly-GluAdd
    BLAST

    Domaini

    The PDZ-binding motif mediates the interaction with GRIP1.
    The C2 domain mediates pre-localization to the membrane prior to Ca2+ import and non-selective Ca2+-mediated targeting to various cellular membranes.By similarity
    The PH domain is not a critical determinant of the membrane localization.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 3 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00740000114979.
    HOGENOMiHOG000006871.
    HOVERGENiHBG053610.
    InParanoidiQ8K3R3.
    KOiK05857.
    OMAiRDYAFSS.
    OrthoDBiEOG7V49XT.
    PhylomeDBiQ8K3R3.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028387. PLC-delta4.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF31. PTHR10336:SF31. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00169. PH. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00054. EFh. 3 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K3R3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSQIQDLLA TDQDLLLMQE GTMMRKVRTK SWKKLRYFRL QNDGMTVWHG    50
    SQPESMPKPT FSISDVERIR KGQDSELLRY LVEEFPLEQG FTVVFHGRRP 100
    NLDLVANSVE EAQIWMRGLQ LLVDLVASMD HQEQMDQMLN EWFQQADRNQ 150
    DGRMSFREAQ RLLLLMNVEM DEEYAFSLFQ EADVTQSDDL GSEEFVQFYK 200
    ALTKRTEIEE IFEDFSSDKQ KLTLLEFVDF LRKEQKEKDH APDLALELID 250
    RYEPSENGRL LHVLSKDGFL KYLCSKDGNI FNSDCLPIYQ DMTQPLSHYY 300
    INSSHNTYLV GDQLCGQSSV EGYIRALKRG CRCVEVDTWD GPDGEPVVYH 350
    GHTLTSRILF KDVLATLAQY AFQSSDYPLI LSLENHCTWE QQRTMAHHLT 400
    EILGEQLLRN TLEGLLVDSM PSPEQLRGKI LVKGKKLRTI EVDKEEEEEE 450
    EEEELEKDEG PDLDPASPEL DTQPQPETQG QAAGNKKERK KKVMKCPMSC 500
    LLICGHVMAQ APSSIPESIL LSKQFLLLSS TTIMCPDLSA LVVYLRTVPF 550
    CSFTHSKENY HIYDISSFSE SKAKNLIKEA GNEFVQHNAR QLCRVYPSGL 600
    RTDSSNFNPQ EHWNVGCQMV AMNMQTAGSA MDICDGLFRQ NGGSGYVLKP 650
    EFLRDTQSSF NPERPISLYK AQILVVQVIS GQQLPKVDKT KETTVVDPLV 700
    KVELYGVPED TKEQETSHVE NNGINPYWGE TFYFRLQVPE LAMLRFVVKD 750
    YSRKSRNNFI GQYTLPWTCM KQGYRHVSLL SRDGTSLNPA SIFVYTCMQE 800
    DLDMDEP 807
    Length:807
    Mass (Da):92,694
    Last modified:October 2, 2007 - v2
    Checksum:iC109F6255CED45F7
    GO
    Isoform 2 (identifier: Q8K3R3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         493-524: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:775
    Mass (Da):89,296
    Checksum:iEFA6651F8635BBF7
    GO
    Isoform 3 (identifier: Q8K3R3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         493-524: Missing.
         773-807: GYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP → EMALASIQLP...LKIQSQPKDQ

    Note: No experimental confirmation available.

    Show »
    Length:798
    Mass (Da):92,091
    Checksum:i5D5EEC1B9028824D
    GO
    Isoform 4 (identifier: Q8K3R3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         494-496: MKC → SQD
         497-807: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:496
    Mass (Da):57,480
    Checksum:i85050CCD6471FB72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801Q → R in BAE24292. (PubMed:16141072)Curated
    Sequence conflicti310 – 3101V → A in AAH66156. (PubMed:15489334)Curated
    Sequence conflicti372 – 3721F → L in AAH66156. (PubMed:15489334)Curated
    Sequence conflicti445 – 4451Missing in BAE24292. (PubMed:16141072)Curated
    Sequence conflicti470 – 4701L → F in AAK61537. 1 PublicationCurated
    Sequence conflicti594 – 5941R → C in AAH66156. (PubMed:15489334)Curated
    Sequence conflicti653 – 6531L → V in AAK61537. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei493 – 52432Missing in isoform 2 and isoform 3. 2 PublicationsVSP_028503Add
    BLAST
    Alternative sequencei494 – 4963MKC → SQD in isoform 4. 1 PublicationVSP_028504
    Alternative sequencei497 – 807311Missing in isoform 4. 1 PublicationVSP_028505Add
    BLAST
    Alternative sequencei773 – 80735GYRHV…DMDEP → EMALASIQLPSLYTPACRKT WIWMSPEKHREGLEEQSTDA QSFPTYNFLKIQSQPKDQ in isoform 3. 1 PublicationVSP_028506Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033991 mRNA. Translation: AAK61537.1.
    AK016945 mRNA. Translation: BAB30513.1.
    AK039149 mRNA. Translation: BAC30256.1.
    AK140231 mRNA. Translation: BAE24292.1.
    BC066156 mRNA. Translation: AAH66156.1.
    CCDSiCCDS35616.1. [Q8K3R3-1]
    CCDS35617.1. [Q8K3R3-2]
    RefSeqiNP_001074925.1. NM_001081456.1. [Q8K3R3-2]
    NP_683739.2. NM_148937.2. [Q8K3R3-1]
    XP_006495851.1. XM_006495788.1. [Q8K3R3-1]
    UniGeneiMm.290731.

    Genome annotation databases

    EnsembliENSMUST00000027362; ENSMUSP00000027362; ENSMUSG00000026173. [Q8K3R3-1]
    ENSMUST00000067916; ENSMUSP00000064413; ENSMUSG00000026173. [Q8K3R3-2]
    ENSMUST00000113745; ENSMUSP00000109374; ENSMUSG00000026173. [Q8K3R3-4]
    ENSMUST00000113747; ENSMUSP00000109376; ENSMUSG00000026173. [Q8K3R3-2]
    ENSMUST00000113749; ENSMUSP00000109378; ENSMUSG00000026173. [Q8K3R3-1]
    ENSMUST00000113750; ENSMUSP00000109379; ENSMUSG00000026173. [Q8K3R3-3]
    GeneIDi18802.
    KEGGimmu:18802.
    UCSCiuc007bmg.1. mouse. [Q8K3R3-2]
    uc007bmh.1. mouse. [Q8K3R3-1]
    uc007bmi.1. mouse. [Q8K3R3-4]
    uc011wnb.1. mouse. [Q8K3R3-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033991 mRNA. Translation: AAK61537.1 .
    AK016945 mRNA. Translation: BAB30513.1 .
    AK039149 mRNA. Translation: BAC30256.1 .
    AK140231 mRNA. Translation: BAE24292.1 .
    BC066156 mRNA. Translation: AAH66156.1 .
    CCDSi CCDS35616.1. [Q8K3R3-1 ]
    CCDS35617.1. [Q8K3R3-2 ]
    RefSeqi NP_001074925.1. NM_001081456.1. [Q8K3R3-2 ]
    NP_683739.2. NM_148937.2. [Q8K3R3-1 ]
    XP_006495851.1. XM_006495788.1. [Q8K3R3-1 ]
    UniGenei Mm.290731.

    3D structure databases

    ProteinModelPortali Q8K3R3.
    SMRi Q8K3R3. Positions 9-453, 536-800.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K3R3.

    Proteomic databases

    MaxQBi Q8K3R3.
    PaxDbi Q8K3R3.
    PRIDEi Q8K3R3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027362 ; ENSMUSP00000027362 ; ENSMUSG00000026173 . [Q8K3R3-1 ]
    ENSMUST00000067916 ; ENSMUSP00000064413 ; ENSMUSG00000026173 . [Q8K3R3-2 ]
    ENSMUST00000113745 ; ENSMUSP00000109374 ; ENSMUSG00000026173 . [Q8K3R3-4 ]
    ENSMUST00000113747 ; ENSMUSP00000109376 ; ENSMUSG00000026173 . [Q8K3R3-2 ]
    ENSMUST00000113749 ; ENSMUSP00000109378 ; ENSMUSG00000026173 . [Q8K3R3-1 ]
    ENSMUST00000113750 ; ENSMUSP00000109379 ; ENSMUSG00000026173 . [Q8K3R3-3 ]
    GeneIDi 18802.
    KEGGi mmu:18802.
    UCSCi uc007bmg.1. mouse. [Q8K3R3-2 ]
    uc007bmh.1. mouse. [Q8K3R3-1 ]
    uc007bmi.1. mouse. [Q8K3R3-4 ]
    uc011wnb.1. mouse. [Q8K3R3-3 ]

    Organism-specific databases

    CTDi 84812.
    MGIi MGI:107469. Plcd4.

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00740000114979.
    HOGENOMi HOG000006871.
    HOVERGENi HBG053610.
    InParanoidi Q8K3R3.
    KOi K05857.
    OMAi RDYAFSS.
    OrthoDBi EOG7V49XT.
    PhylomeDBi Q8K3R3.
    TreeFami TF313216.

    Miscellaneous databases

    NextBioi 295100.
    PROi Q8K3R3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K3R3.
    Bgeei Q8K3R3.
    CleanExi MM_PLCD4.
    Genevestigatori Q8K3R3.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028387. PLC-delta4.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF31. PTHR10336:SF31. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00169. PH. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00054. EFh. 3 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of PLC delta4."
      Kim J., Kim H., Lee K.-H.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina, Hypothalamus and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: CD-1.
      Tissue: Neural stem cell.
    4. "Growth factor-induced promoter activation of murine phospholipase C delta4 gene."
      Fukami K., Takenaka K., Nagano K., Takenawa T.
      Eur. J. Biochem. 267:28-36(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction."
      Fukami K., Nakao K., Inoue T., Kataoka Y., Kurokawa M., Fissore R.A., Nakamura K., Katsuki M., Mikoshiba K., Yoshida N., Takenawa T.
      Science 292:920-923(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm."
      Fukami K., Yoshida M., Inoue T., Kurokawa M., Fissore R.A., Yoshida N., Mikoshiba K., Takenawa T.
      J. Cell Biol. 161:79-88(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis."
      Irino Y., Ichinohe M., Nakamura Y., Nakahara M., Fukami K.
      J. Biochem. 138:451-456(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRIP1.
    8. "Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C."
      Akutagawa A., Fukami K., Banno Y., Takenawa T., Kannagi R., Yokoyama Y., Oda K., Nagino M., Nimura Y., Yoshida S., Tamiya-Koizumi K.
      J. Biochem. 140:619-625(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPLCD4_MOUSE
    AccessioniPrimary (citable) accession number: Q8K3R3
    Secondary accession number(s): Q3USN9
    , Q6NZF7, Q8CAB1, Q9CUC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3