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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

Slc25a25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi60 – 71121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Mitochondrial ATP-Mg/Pi carrier protein
Peroxisomal Ca(2+)-dependent solute carrier-like protein
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:Slc25a25
Synonyms:Mcsc, Pcscl, Scamc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi628666. Slc25a25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei190 – 20718Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini208 – 24437Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei245 – 26420Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini265 – 28723Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei288 – 30114Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini302 – 33736Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei338 – 35720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini358 – 38023Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei381 – 39818Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini399 – 43739Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei438 – 45720Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini458 – 46912Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Calcium-binding mitochondrial carrier protein SCaMC-2PRO_0000317604Add
BLAST

Proteomic databases

PaxDbiQ8K3P6.
PRIDEiQ8K3P6.

PTM databases

iPTMnetiQ8K3P6.
PhosphoSiteiQ8K3P6.

Expressioni

Tissue specificityi

Mainly present in the liver and the skeletal muscle (at protein level).1 Publication

Developmental stagei

In the liver, expression is higher in the adult stage than in the fetal stage.1 Publication

Inductioni

Up-regulated in dexamethasone-treated cells before the expression of albumin.1 Publication

Gene expression databases

GenevisibleiQ8K3P6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020206.

Structurei

3D structure databases

ProteinModelPortaliQ8K3P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 8034EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 11336EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 14936EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Repeati184 – 27087Solcar 1Add
BLAST
Repeati278 – 36386Solcar 2Add
BLAST
Repeati375 – 46389Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8K3P6.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG7V7661.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLCLYVPI AGEAQTEFQY FESKGLPTEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMCIIGGF TQMIREGGAK SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQMKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCAKRILAKE GVAAFYKGYI PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNTWLQRYAV NSADPGVFVL LACGTISSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKQILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,695
Last modified:October 1, 2002 - v1
Checksum:i95E5DA46B9942992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043169 mRNA. Translation: AAL05592.1.
RefSeqiNP_663710.1. NM_145677.1.
UniGeneiRn.17644.

Genome annotation databases

EnsembliENSRNOT00000020206; ENSRNOP00000020206; ENSRNOG00000014338.
GeneIDi246771.
KEGGirno:246771.
UCSCiRGD:628666. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043169 mRNA. Translation: AAL05592.1.
RefSeqiNP_663710.1. NM_145677.1.
UniGeneiRn.17644.

3D structure databases

ProteinModelPortaliQ8K3P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020206.

PTM databases

iPTMnetiQ8K3P6.
PhosphoSiteiQ8K3P6.

Proteomic databases

PaxDbiQ8K3P6.
PRIDEiQ8K3P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020206; ENSRNOP00000020206; ENSRNOG00000014338.
GeneIDi246771.
KEGGirno:246771.
UCSCiRGD:628666. rat.

Organism-specific databases

CTDi114789.
RGDi628666. Slc25a25.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8K3P6.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG7V7661.

Miscellaneous databases

PROiQ8K3P6.

Gene expression databases

GenevisibleiQ8K3P6. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display."
    Mashima H., Ueda N., Ohno H., Suzuki J., Ohnishi H., Yasuda H., Tsuchida T., Kanamaru C., Makita N., Iiri T., Omata M., Kojima I.
    J. Biol. Chem. 278:9520-9527(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, CALCIUM-BINDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiSCMC2_RAT
AccessioniPrimary (citable) accession number: Q8K3P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.