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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

Slc25a25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Mitochondrial ATP-Mg/Pi carrier protein
Peroxisomal Ca(2+)-dependent solute carrier-like protein
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:Slc25a25
Synonyms:Mcsc, Pcscl, Scamc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi628666. Slc25a25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189Mitochondrial intermembraneSequence analysisAdd BLAST189
Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 244Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei245 – 264Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini265 – 287Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei288 – 301Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini302 – 337Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei338 – 357Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini358 – 380Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini399 – 437Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei438 – 457Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini458 – 469Mitochondrial intermembraneSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176041 – 469Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST469

Proteomic databases

PaxDbiQ8K3P6.
PRIDEiQ8K3P6.

PTM databases

iPTMnetiQ8K3P6.
PhosphoSitePlusiQ8K3P6.

Expressioni

Tissue specificityi

Mainly present in the liver and the skeletal muscle (at protein level).1 Publication

Developmental stagei

In the liver, expression is higher in the adult stage than in the fetal stage.1 Publication

Inductioni

Up-regulated in dexamethasone-treated cells before the expression of albumin.1 Publication

Gene expression databases

BgeeiENSRNOG00000014338.
GenevisibleiQ8K3P6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020206.

Structurei

3D structure databases

ProteinModelPortaliQ8K3P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 149EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Repeati184 – 270Solcar 1Add BLAST87
Repeati278 – 363Solcar 2Add BLAST86
Repeati375 – 463Solcar 3Add BLAST89

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8K3P6.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG091G0C8S.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLCLYVPI AGEAQTEFQY FESKGLPTEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMCIIGGF TQMIREGGAK SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQMKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCAKRILAKE GVAAFYKGYI PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNTWLQRYAV NSADPGVFVL LACGTISSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKQILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,695
Last modified:October 1, 2002 - v1
Checksum:i95E5DA46B9942992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043169 mRNA. Translation: AAL05592.1.
RefSeqiNP_663710.1. NM_145677.1.
UniGeneiRn.17644.

Genome annotation databases

EnsembliENSRNOT00000020206; ENSRNOP00000020206; ENSRNOG00000014338.
GeneIDi246771.
KEGGirno:246771.
UCSCiRGD:628666. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043169 mRNA. Translation: AAL05592.1.
RefSeqiNP_663710.1. NM_145677.1.
UniGeneiRn.17644.

3D structure databases

ProteinModelPortaliQ8K3P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020206.

PTM databases

iPTMnetiQ8K3P6.
PhosphoSitePlusiQ8K3P6.

Proteomic databases

PaxDbiQ8K3P6.
PRIDEiQ8K3P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020206; ENSRNOP00000020206; ENSRNOG00000014338.
GeneIDi246771.
KEGGirno:246771.
UCSCiRGD:628666. rat.

Organism-specific databases

CTDi114789.
RGDi628666. Slc25a25.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ8K3P6.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG091G0C8S.

Miscellaneous databases

PROiQ8K3P6.

Gene expression databases

BgeeiENSRNOG00000014338.
GenevisibleiQ8K3P6. RN.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCMC2_RAT
AccessioniPrimary (citable) accession number: Q8K3P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.