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Protein

Short-chain dehydrogenase/reductase family 9C member 7

Gene

Sdr9c7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei160SubstrateBy similarity1
Active sitei172Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 53NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase family 9C member 7 (EC:1.1.1.-)
Alternative name(s):
Orphan short-chain dehydrogenase/reductase
Short name:
SDR-O
RDH-S
Gene namesi
Name:Sdr9c7
Synonyms:Rdhs, Sdro
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917311. Sdr9c7.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168861 – 313Short-chain dehydrogenase/reductase family 9C member 7Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K3P0.
PaxDbiQ8K3P0.
PRIDEiQ8K3P0.

PTM databases

PhosphoSitePlusiQ8K3P0.

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000040127.
CleanExiMM_RDH20.
GenevisibleiQ8K3P0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036628.

Structurei

3D structure databases

ProteinModelPortaliQ8K3P0.
SMRiQ8K3P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
InParanoidiQ8K3P0.
OMAiAEPRISD.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ8K3P0.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTDFAFM YRWFKNCNLV KNLSEKYVFI TGCDSGFGNL LAKQLVDRGM
60 70 80 90 100
KVLAACLTEE GAQKLLQDTS HQLQTFLLDV TKSENVKEAA QWVRDQVGEQ
110 120 130 140 150
GLWALVNNAG VGLPSGPNEW LTIKDFVKVI NINLVGLIDV TLNMLPMIKK
160 170 180 190 200
ARGRVVNMSS SGGRVAIFGG GYCVSKFGVE AFSDSIRREL HFFGVKVSII
210 220 230 240 250
EPGNYKTSIL GQEALESRMK KLWDRLPQET RDSYGEEYFQ TYTKKLVNLM
260 270 280 290 300
RSAEPRISDV TNSMEHAIVS RSPRIRYNPG LDVKFLYLTL AKLPTPVTDF
310
ILSRYLPRPA DSV
Length:313
Mass (Da):35,149
Last modified:October 1, 2002 - v1
Checksum:i8C93F6A4448911E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044433 mRNA. Translation: AAK95855.1.
AK037184 mRNA. Translation: BAC29742.1.
BC064820 mRNA. Translation: AAH64820.1.
CCDSiCCDS24256.1.
RefSeqiNP_081577.1. NM_027301.3.
UniGeneiMm.158320.

Genome annotation databases

EnsembliENSMUST00000047134; ENSMUSP00000036628; ENSMUSG00000040127.
GeneIDi70061.
KEGGimmu:70061.
UCSCiuc007hkw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044433 mRNA. Translation: AAK95855.1.
AK037184 mRNA. Translation: BAC29742.1.
BC064820 mRNA. Translation: AAH64820.1.
CCDSiCCDS24256.1.
RefSeqiNP_081577.1. NM_027301.3.
UniGeneiMm.158320.

3D structure databases

ProteinModelPortaliQ8K3P0.
SMRiQ8K3P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036628.

PTM databases

PhosphoSitePlusiQ8K3P0.

Proteomic databases

MaxQBiQ8K3P0.
PaxDbiQ8K3P0.
PRIDEiQ8K3P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047134; ENSMUSP00000036628; ENSMUSG00000040127.
GeneIDi70061.
KEGGimmu:70061.
UCSCiuc007hkw.1. mouse.

Organism-specific databases

CTDi121214.
MGIiMGI:1917311. Sdr9c7.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
InParanoidiQ8K3P0.
OMAiAEPRISD.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ8K3P0.
TreeFamiTF325617.

Miscellaneous databases

PROiQ8K3P0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040127.
CleanExiMM_RDH20.
GenevisibleiQ8K3P0. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDR9C7_MOUSE
AccessioniPrimary (citable) accession number: Q8K3P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.