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Q8K3K8

- OPTN_MOUSE

UniProt

Q8K3K8 - OPTN_MOUSE

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Protein

Optineurin

Gene
Optn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cellular protein localization Source: MGI
  2. Golgi ribbon formation Source: UniProtKB
  3. Golgi to plasma membrane protein transport Source: Ensembl
  4. protein targeting to Golgi Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:Optn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1918898. Optn.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Golgi apparatus. Golgi apparatustrans-Golgi network By similarity
Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane By similarity.1 Publication

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: MGI
  2. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584OptineurinPRO_0000058069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871Phosphoserine; by TBK1 By similarity

Post-translational modificationi

Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K3K8.
PaxDbiQ8K3K8.
PRIDEiQ8K3K8.

PTM databases

PhosphoSiteiQ8K3K8.

Expressioni

Tissue specificityi

In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis.1 Publication

Developmental stagei

Expressed from 7-day-old embryos.1 Publication

Gene expression databases

BgeeiQ8K3K8.
CleanExiMM_OPTN.
GenevestigatoriQ8K3K8.

Interactioni

Subunit structurei

Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A). Interacts with TRAF3, TBK1 and MYO6. Binds to ubiquitin By similarity.

Protein-protein interaction databases

BioGridi214832. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8K3K8.
SMRiQ8K3K8. Positions 424-510, 557-584.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni415 – 524110Interaction with MYO6 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 180143 Reviewed predictionAdd
BLAST
Coiled coili243 – 27836 Reviewed predictionAdd
BLAST
Coiled coili307 – 511205 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi477 – 4826UBAN

Domaini

Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1 By similarity.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiA2ASP3.
OMAiAHPNLDT.
OrthoDBiEOG7D2FD7.
PhylomeDBiQ8K3K8.
TreeFamiTF326608.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3K8-1 [UniParc]FASTAAdd to Basket

« Hide

MSHQPLSCLT EKGDSPCETP GNGPSNMVHP SLDTFTPEEL LQQMKELLVE    50
NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERLLFEMQS KEVKERLKAL 100
THENERLKEE LGKFKEKSEK PLEDLTGGYR YPRALEEEVE KLKTQVEQEV 150
EHLKIQVMRL RAEKADLLGI VSELQLKLNS GGSSEDSFVE IRMTEGETEG 200
AMKEMKNCPT PTRTDPISLS NCTEDARSCA EFEELTVSQL LLCLREGNQK 250
VERLEVALRE AKERISDFEK KANGHSSTEK QTARRADREK EDKGQESVGS 300
EVETLSIQVT SLFKELQEAH TKLSEAELMK KRLQEKCQAL ERKNSATPSE 350
LNEKQELVYS NKKLELQVES MRSEIKMEQA KTEEEKSRLA TLQATHNKLL 400
QEHNKALKTI EELTKQQAEK VDKMLLQELS EKLELAEQAL ASKQLQMDEM 450
KQTLAKQEED LETMAVLRAQ MEVYCSDFHA ERAAREKIHE EKEQLALQLA 500
ILLKENNDIE EGGSRQSLME MQCRHGARTS DSDQQTYLFQ RGAEDRSWQH 550
GQQPRSIPIH SCPKCGEVLP DIDTLQIHVM DCII 584
Length:584
Mass (Da):67,018
Last modified:October 1, 2002 - v1
Checksum:i4BCF3BD4F71921F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY071834 mRNA. Translation: AAL61853.1.
AY340635
, AY340623, AY340624, AY340625, AY340626, AY340627, AY340628, AY340629, AY340630, AY340631, AY340632, AY340633, AY340634 Genomic DNA. Translation: AAQ21118.1.
AL928662 Genomic DNA. Translation: CAM22578.1.
BC061185 mRNA. Translation: AAH61185.1.
CCDSiCCDS15663.1.
RefSeqiNP_862896.1. NM_181848.4.
XP_006497609.1. XM_006497546.1.
XP_006497610.1. XM_006497547.1.
UniGeneiMm.116942.

Genome annotation databases

EnsembliENSMUST00000027986; ENSMUSP00000027986; ENSMUSG00000026672.
ENSMUST00000114996; ENSMUSP00000110648; ENSMUSG00000026672.
GeneIDi71648.
KEGGimmu:71648.
UCSCiuc008ifm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY071834 mRNA. Translation: AAL61853.1 .
AY340635
, AY340623 , AY340624 , AY340625 , AY340626 , AY340627 , AY340628 , AY340629 , AY340630 , AY340631 , AY340632 , AY340633 , AY340634 Genomic DNA. Translation: AAQ21118.1 .
AL928662 Genomic DNA. Translation: CAM22578.1 .
BC061185 mRNA. Translation: AAH61185.1 .
CCDSi CCDS15663.1.
RefSeqi NP_862896.1. NM_181848.4.
XP_006497609.1. XM_006497546.1.
XP_006497610.1. XM_006497547.1.
UniGenei Mm.116942.

3D structure databases

ProteinModelPortali Q8K3K8.
SMRi Q8K3K8. Positions 424-510, 557-584.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214832. 3 interactions.

PTM databases

PhosphoSitei Q8K3K8.

Proteomic databases

MaxQBi Q8K3K8.
PaxDbi Q8K3K8.
PRIDEi Q8K3K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027986 ; ENSMUSP00000027986 ; ENSMUSG00000026672 .
ENSMUST00000114996 ; ENSMUSP00000110648 ; ENSMUSG00000026672 .
GeneIDi 71648.
KEGGi mmu:71648.
UCSCi uc008ifm.1. mouse.

Organism-specific databases

CTDi 10133.
MGIi MGI:1918898. Optn.

Phylogenomic databases

eggNOGi NOG138369.
GeneTreei ENSGT00530000063808.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
InParanoidi A2ASP3.
OMAi AHPNLDT.
OrthoDBi EOG7D2FD7.
PhylomeDBi Q8K3K8.
TreeFami TF326608.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 334153.
PROi Q8K3K8.
SOURCEi Search...

Gene expression databases

Bgeei Q8K3K8.
CleanExi MM_OPTN.
Genevestigatori Q8K3K8.

Family and domain databases

InterProi IPR021063. NEMO_N.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, genomic structure, and protein characterization of mouse optineurin."
    Rezaie T., Sarfarazi M.
    Genomics 85:131-138(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiOPTN_MOUSE
AccessioniPrimary (citable) accession number: Q8K3K8
Secondary accession number(s): A2ASP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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