Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8K3K8 (OPTN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Optineurin
Gene names
Name:Optn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) By similarity.

Subunit structure

Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A). Interacts with TRAF3, TBK1 and MYO6. Binds to ubiquitin By similarity.

Subcellular location

Cytoplasmperinuclear region By similarity. Golgi apparatus. Golgi apparatustrans-Golgi network By similarity. Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane By similarity. Ref.1

Tissue specificity

In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis. Ref.1

Developmental stage

Expressed from 7-day-old embryos. Ref.1

Domain

Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1 By similarity.

Post-translational modification

Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Optineurin
PRO_0000058069

Regions

Region415 – 524110Interaction with MYO6 By similarity
Coiled coil38 – 180143 Potential
Coiled coil243 – 27836 Potential
Coiled coil307 – 511205 Potential
Motif477 – 4826UBAN

Amino acid modifications

Modified residue1871Phosphoserine; by TBK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K3K8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 4BCF3BD4F71921F0

FASTA58467,018
        10         20         30         40         50         60 
MSHQPLSCLT EKGDSPCETP GNGPSNMVHP SLDTFTPEEL LQQMKELLVE NHQLKEAMKL 

        70         80         90        100        110        120 
NNQAMKGRFE ELSAWTEKQK EERLLFEMQS KEVKERLKAL THENERLKEE LGKFKEKSEK 

       130        140        150        160        170        180 
PLEDLTGGYR YPRALEEEVE KLKTQVEQEV EHLKIQVMRL RAEKADLLGI VSELQLKLNS 

       190        200        210        220        230        240 
GGSSEDSFVE IRMTEGETEG AMKEMKNCPT PTRTDPISLS NCTEDARSCA EFEELTVSQL 

       250        260        270        280        290        300 
LLCLREGNQK VERLEVALRE AKERISDFEK KANGHSSTEK QTARRADREK EDKGQESVGS 

       310        320        330        340        350        360 
EVETLSIQVT SLFKELQEAH TKLSEAELMK KRLQEKCQAL ERKNSATPSE LNEKQELVYS 

       370        380        390        400        410        420 
NKKLELQVES MRSEIKMEQA KTEEEKSRLA TLQATHNKLL QEHNKALKTI EELTKQQAEK 

       430        440        450        460        470        480 
VDKMLLQELS EKLELAEQAL ASKQLQMDEM KQTLAKQEED LETMAVLRAQ MEVYCSDFHA 

       490        500        510        520        530        540 
ERAAREKIHE EKEQLALQLA ILLKENNDIE EGGSRQSLME MQCRHGARTS DSDQQTYLFQ 

       550        560        570        580 
RGAEDRSWQH GQQPRSIPIH SCPKCGEVLP DIDTLQIHVM DCII 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, genomic structure, and protein characterization of mouse optineurin."
Rezaie T., Sarfarazi M.
Genomics 85:131-138(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: 129.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY071834 mRNA. Translation: AAL61853.1.
AY340635 expand/collapse EMBL AC list , AY340623, AY340624, AY340625, AY340626, AY340627, AY340628, AY340629, AY340630, AY340631, AY340632, AY340633, AY340634 Genomic DNA. Translation: AAQ21118.1.
AL928662 Genomic DNA. Translation: CAM22578.1.
BC061185 mRNA. Translation: AAH61185.1.
CCDSCCDS15663.1.
RefSeqNP_862896.1. NM_181848.4.
XP_006497609.1. XM_006497546.1.
XP_006497610.1. XM_006497547.1.
UniGeneMm.116942.

3D structure databases

ProteinModelPortalQ8K3K8.
SMRQ8K3K8. Positions 424-510, 557-584.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214832. 3 interactions.

PTM databases

PhosphoSiteQ8K3K8.

Proteomic databases

MaxQBQ8K3K8.
PaxDbQ8K3K8.
PRIDEQ8K3K8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027986; ENSMUSP00000027986; ENSMUSG00000026672.
ENSMUST00000114996; ENSMUSP00000110648; ENSMUSG00000026672.
GeneID71648.
KEGGmmu:71648.
UCSCuc008ifm.1. mouse.

Organism-specific databases

CTD10133.
MGIMGI:1918898. Optn.

Phylogenomic databases

eggNOGNOG138369.
GeneTreeENSGT00530000063808.
HOGENOMHOG000231899.
HOVERGENHBG106481.
InParanoidA2ASP3.
OMAAHPNLDT.
OrthoDBEOG7D2FD7.
PhylomeDBQ8K3K8.
TreeFamTF326608.

Gene expression databases

BgeeQ8K3K8.
CleanExMM_OPTN.
GenevestigatorQ8K3K8.

Family and domain databases

InterProIPR021063. NEMO_N.
[Graphical view]
PfamPF11577. NEMO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio334153.
PROQ8K3K8.
SOURCESearch...

Entry information

Entry nameOPTN_MOUSE
AccessionPrimary (citable) accession number: Q8K3K8
Secondary accession number(s): A2ASP3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot