Optineurin - Mus musculus (Mouse)

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Q8K3K8 (OPTN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Optineurin

Gene names

Name:

Optn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) By similarity.
Subunit structure	Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A). Interacts with TRAF3, TBK1 and MYO6. Binds to ubiquitin By similarity.
Subcellular location	Cytoplasm › perinuclear region By similarity. Golgi apparatus. Golgi apparatus › trans-Golgi network By similarity. Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane By similarity. Ref.1
Tissue specificity	In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis. Ref.1
Developmental stage	Expressed from 7-day-old embryos. Ref.1
Domain	Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1 By similarity.
Post-translational modification	Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi ribbon formation Inferred from sequence or structural similarity. Source: UniProtKB Golgi to plasma membrane protein transport Inferred from electronic annotation. Source: Compara cellular protein localization Inferred from mutant phenotype Ref.1. Source: MGI protein targeting to Golgi Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from direct assay Ref.1. Source: MGI trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 584

584

Optineurin

PRO_0000058069

Regions

Region

415 – 524

110

Interaction with MYO6 By similarity

Coiled coil

38 – 180

143

Potential

Coiled coil

243 – 278

Potential

Coiled coil

307 – 511

205

Potential

Motif

477 – 482

UBAN

Amino acid modifications

Modified residue

187

Phosphoserine; by TBK1 By similarity

Modified residue

210

Phosphothreonine Ref.4

Modified residue

218

Phosphoserine Ref.4

Modified residue

345

Phosphoserine Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

Q8K3K8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 4BCF3BD4F71921F0
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FASTA

584

67,018

        10         20         30         40         50         60 
MSHQPLSCLT EKGDSPCETP GNGPSNMVHP SLDTFTPEEL LQQMKELLVE NHQLKEAMKL 

        70         80         90        100        110        120 
NNQAMKGRFE ELSAWTEKQK EERLLFEMQS KEVKERLKAL THENERLKEE LGKFKEKSEK 

       130        140        150        160        170        180 
PLEDLTGGYR YPRALEEEVE KLKTQVEQEV EHLKIQVMRL RAEKADLLGI VSELQLKLNS 

       190        200        210        220        230        240 
GGSSEDSFVE IRMTEGETEG AMKEMKNCPT PTRTDPISLS NCTEDARSCA EFEELTVSQL 

       250        260        270        280        290        300 
LLCLREGNQK VERLEVALRE AKERISDFEK KANGHSSTEK QTARRADREK EDKGQESVGS 

       310        320        330        340        350        360 
EVETLSIQVT SLFKELQEAH TKLSEAELMK KRLQEKCQAL ERKNSATPSE LNEKQELVYS 

       370        380        390        400        410        420 
NKKLELQVES MRSEIKMEQA KTEEEKSRLA TLQATHNKLL QEHNKALKTI EELTKQQAEK 

       430        440        450        460        470        480 
VDKMLLQELS EKLELAEQAL ASKQLQMDEM KQTLAKQEED LETMAVLRAQ MEVYCSDFHA 

       490        500        510        520        530        540 
ERAAREKIHE EKEQLALQLA ILLKENNDIE EGGSRQSLME MQCRHGARTS DSDQQTYLFQ 

       550        560        570        580 
RGAEDRSWQH GQQPRSIPIH SCPKCGEVLP DIDTLQIHVM DCII

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, genomic structure, and protein characterization of mouse optineurin." Rezaie T., Sarfarazi M. Genomics 85:131-138(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: 129.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; THR-210 AND SER-218, MASS SPECTROMETRY. Tissue: Liver.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY071834 mRNA. Translation: AAL61853.1. AY340635 AY340634 Genomic DNA. Translation: AAQ21118.1. AL928662 Genomic DNA. Translation: CAM22578.1. BC061185 mRNA. Translation: AAH61185.1.
IPI	IPI00170101.
RefSeq	NP_862896.1. NM_181848.4.
UniGene	Mm.116942.
3D structure databases
ProteinModelPortal	Q8K3K8.
SMR	Q8K3K8. Positions 424-510, 557-583.
ModBase	Search...
PTM databases
PhosphoSite	Q8K3K8.
Proteomic databases
PaxDb	Q8K3K8.
PRIDE	Q8K3K8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027986; ENSMUSP00000027986; ENSMUSG00000026672. ENSMUST00000114996; ENSMUSP00000110648; ENSMUSG00000026672.
GeneID	71648.
KEGG	mmu:71648.
UCSC	uc008ifm.1. mouse.
Organism-specific databases
CTD	10133.
MGI	MGI:1918898. Optn.
Phylogenomic databases
eggNOG	NOG138369.
GeneTree	ENSGT00530000063808.
HOGENOM	HOG000231899.
HOVERGEN	HBG106481.
InParanoid	A2ASP3.
OMA	LQVTTLF.
OrthoDB	EOG4ZPDVF.
Gene expression databases
Bgee	Q8K3K8.
CleanEx	MM_OPTN.
Genevestigator	Q8K3K8.
GermOnline	ENSMUSG00000026672. Mus musculus.
Family and domain databases
InterPro	IPR021063. NEMO_N. [Graphical view]
Pfam	PF11577. NEMO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	334153.
SOURCE	Search...

Entry information

Entry name

OPTN_MOUSE

Accession

Primary (citable) accession number: Q8K3K8
Secondary accession number(s): A2ASP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents