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Q8K3K4 (SPB10_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B10
Alternative name(s):
TGF-beta-repressible serine proteinase inhibitor
Short name=Trespin
Transforming growth factor beta repressible serpin
Gene names
Name:Serpinb10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus By similarity. Inhibits plasmin. Ref.1

Subcellular location

Nucleus By similarity. Cytoplasm Ref.1.

Tissue specificity

Expressed in many tissues, including brain, heart, kidney, liver, lung, prostate, skin, spleen and stomach. Ref.1

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Serpin B10
PRO_0000094116

Regions

Motif74 – 774Nuclear localization signal By similarity

Sites

Site362 – 3632Reactive bond By similarity

Experimental info

Sequence conflict881M → I in AAH61735. Ref.2
Sequence conflict1641D → G in AAH61735. Ref.2
Sequence conflict2881R → Q in AAH61735. Ref.2
Sequence conflict3911D → Y in AAH61735. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8K3K4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 19E7BF371A9D2F4C

FASTA39745,387
        10         20         30         40         50         60 
MASLAVSINQ FAVEFSKKLA ESAEGRNIFF SPWGISTSLA MVYLGTKGTT AAQMSQVLHF 

        70         80         90        100        110        120 
GSIQDFKFGP DSEKKRKMEC HSGKSEEMQS DFQTLTAKIL KHGNSYVLKI ANRIYVEKTY 

       130        140        150        160        170        180 
LFHNKYLEDM KTYFGAEPQS VNFVEASGQI RKEINSWVGS QTGDKIPNLL PDDAVDNKTT 

       190        200        210        220        230        240 
MVLVNALYFK GTWEHQFSVQ NTTERPFRIN KTTSKPVQMM SMKQSLQVFH IEELQTIGVQ 

       250        260        270        280        290        300 
LHYQNREFSL LLLLPEEVEG LKQLERAITY EKLDKWTSAD MMDTYEVRLY LPKFKMEESY 

       310        320        330        340        350        360 
DLQSALRDMG MTDAFNQGKA NFSNMTSERN LFLSNVFHKT FLEINEEGTE AAAGTGSEVN 

       370        380        390 
FRIKAPSIEL NADHPFLFLI RHNVTNTILF DGRFYSP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel rat ov-serpin family member, trespin."
Chipuk J.E., Stewart L.V., Ranieri A., Song K., Danielpour D.
J. Biol. Chem. 277:26412-26421(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Wistar.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY075037 mRNA. Translation: AAL78042.1.
BC061735 mRNA. Translation: AAH61735.1.
RefSeqNP_714955.2. NM_153733.2.
UniGeneRn.59484.

3D structure databases

ProteinModelPortalQ8K3K4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.015.

Proteomic databases

PRIDEQ8K3K4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID266775.
KEGGrno:266775.
UCSCRGD:628853. rat.

Organism-specific databases

CTD5273.
RGD628853. Serpinb10.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidQ8K3K4.
KOK13963.
PhylomeDBQ8K3K4.

Gene expression databases

GenevestigatorQ8K3K4.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624656.
PROQ8K3K4.

Entry information

Entry nameSPB10_RAT
AccessionPrimary (citable) accession number: Q8K3K4
Secondary accession number(s): Q6P7C1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families