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Protein

Serpin B10

Gene

Serpinb10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Inhibits plasmin.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3632Reactive bondBy similarity

GO - Molecular functioni

  1. peptidase inhibitor activity Source: RGD
  2. serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GO_Central
  2. negative regulation of proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B10
Alternative name(s):
TGF-beta-repressible serine proteinase inhibitor
Short name:
Trespin
Transforming growth factor beta repressible serpin
Gene namesi
Name:Serpinb10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628853. Serpinb10.

Subcellular locationi

  1. Nucleus By similarity
  2. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: GO_Central
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Serpin B10PRO_0000094116Add
BLAST

Proteomic databases

PRIDEiQ8K3K4.

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, heart, kidney, liver, lung, prostate, skin, spleen and stomach.1 Publication

Gene expression databases

GenevestigatoriQ8K3K4.

Structurei

3D structure databases

ProteinModelPortaliQ8K3K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 774Nuclear localization signalBy similarity

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ8K3K4.
KOiK13963.
PhylomeDBiQ8K3K4.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLAVSINQ FAVEFSKKLA ESAEGRNIFF SPWGISTSLA MVYLGTKGTT
60 70 80 90 100
AAQMSQVLHF GSIQDFKFGP DSEKKRKMEC HSGKSEEMQS DFQTLTAKIL
110 120 130 140 150
KHGNSYVLKI ANRIYVEKTY LFHNKYLEDM KTYFGAEPQS VNFVEASGQI
160 170 180 190 200
RKEINSWVGS QTGDKIPNLL PDDAVDNKTT MVLVNALYFK GTWEHQFSVQ
210 220 230 240 250
NTTERPFRIN KTTSKPVQMM SMKQSLQVFH IEELQTIGVQ LHYQNREFSL
260 270 280 290 300
LLLLPEEVEG LKQLERAITY EKLDKWTSAD MMDTYEVRLY LPKFKMEESY
310 320 330 340 350
DLQSALRDMG MTDAFNQGKA NFSNMTSERN LFLSNVFHKT FLEINEEGTE
360 370 380 390
AAAGTGSEVN FRIKAPSIEL NADHPFLFLI RHNVTNTILF DGRFYSP
Length:397
Mass (Da):45,387
Last modified:October 1, 2002 - v1
Checksum:i19E7BF371A9D2F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881M → I in AAH61735 (PubMed:15489334).Curated
Sequence conflicti164 – 1641D → G in AAH61735 (PubMed:15489334).Curated
Sequence conflicti288 – 2881R → Q in AAH61735 (PubMed:15489334).Curated
Sequence conflicti391 – 3911D → Y in AAH61735 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY075037 mRNA. Translation: AAL78042.1.
BC061735 mRNA. Translation: AAH61735.1.
RefSeqiNP_714955.2. NM_153733.2.
UniGeneiRn.59484.

Genome annotation databases

GeneIDi266775.
KEGGirno:266775.
UCSCiRGD:628853. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY075037 mRNA. Translation: AAL78042.1.
BC061735 mRNA. Translation: AAH61735.1.
RefSeqiNP_714955.2. NM_153733.2.
UniGeneiRn.59484.

3D structure databases

ProteinModelPortaliQ8K3K4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.015.

Proteomic databases

PRIDEiQ8K3K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266775.
KEGGirno:266775.
UCSCiRGD:628853. rat.

Organism-specific databases

CTDi5273.
RGDi628853. Serpinb10.

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ8K3K4.
KOiK13963.
PhylomeDBiQ8K3K4.

Miscellaneous databases

NextBioi624656.
PROiQ8K3K4.

Gene expression databases

GenevestigatoriQ8K3K4.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel rat ov-serpin family member, trespin."
    Chipuk J.E., Stewart L.V., Ranieri A., Song K., Danielpour D.
    J. Biol. Chem. 277:26412-26421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiSPB10_RAT
AccessioniPrimary (citable) accession number: Q8K3K4
Secondary accession number(s): Q6P7C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.