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Q8K3K4

- SPB10_RAT

UniProt

Q8K3K4 - SPB10_RAT

Protein

Serpin B10

Gene

Serpinb10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus By similarity. Inhibits plasmin.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei362 – 3632Reactive bondBy similarity

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: RGD
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. negative regulation of proteolysis Source: RGD

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.015.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B10
    Alternative name(s):
    TGF-beta-repressible serine proteinase inhibitor
    Short name:
    Trespin
    Transforming growth factor beta repressible serpin
    Gene namesi
    Name:Serpinb10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628853. Serpinb10.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: InterPro
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Serpin B10PRO_0000094116Add
    BLAST

    Proteomic databases

    PRIDEiQ8K3K4.

    Expressioni

    Tissue specificityi

    Expressed in many tissues, including brain, heart, kidney, liver, lung, prostate, skin, spleen and stomach.1 Publication

    Gene expression databases

    GenevestigatoriQ8K3K4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3K4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 774Nuclear localization signalBy similarity

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiQ8K3K4.
    KOiK13963.
    PhylomeDBiQ8K3K4.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K3K4-1 [UniParc]FASTAAdd to Basket

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    MASLAVSINQ FAVEFSKKLA ESAEGRNIFF SPWGISTSLA MVYLGTKGTT    50
    AAQMSQVLHF GSIQDFKFGP DSEKKRKMEC HSGKSEEMQS DFQTLTAKIL 100
    KHGNSYVLKI ANRIYVEKTY LFHNKYLEDM KTYFGAEPQS VNFVEASGQI 150
    RKEINSWVGS QTGDKIPNLL PDDAVDNKTT MVLVNALYFK GTWEHQFSVQ 200
    NTTERPFRIN KTTSKPVQMM SMKQSLQVFH IEELQTIGVQ LHYQNREFSL 250
    LLLLPEEVEG LKQLERAITY EKLDKWTSAD MMDTYEVRLY LPKFKMEESY 300
    DLQSALRDMG MTDAFNQGKA NFSNMTSERN LFLSNVFHKT FLEINEEGTE 350
    AAAGTGSEVN FRIKAPSIEL NADHPFLFLI RHNVTNTILF DGRFYSP 397
    Length:397
    Mass (Da):45,387
    Last modified:October 1, 2002 - v1
    Checksum:i19E7BF371A9D2F4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881M → I in AAH61735. (PubMed:15489334)Curated
    Sequence conflicti164 – 1641D → G in AAH61735. (PubMed:15489334)Curated
    Sequence conflicti288 – 2881R → Q in AAH61735. (PubMed:15489334)Curated
    Sequence conflicti391 – 3911D → Y in AAH61735. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY075037 mRNA. Translation: AAL78042.1.
    BC061735 mRNA. Translation: AAH61735.1.
    RefSeqiNP_714955.2. NM_153733.2.
    UniGeneiRn.59484.

    Genome annotation databases

    GeneIDi266775.
    KEGGirno:266775.
    UCSCiRGD:628853. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY075037 mRNA. Translation: AAL78042.1 .
    BC061735 mRNA. Translation: AAH61735.1 .
    RefSeqi NP_714955.2. NM_153733.2.
    UniGenei Rn.59484.

    3D structure databases

    ProteinModelPortali Q8K3K4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.015.

    Proteomic databases

    PRIDEi Q8K3K4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 266775.
    KEGGi rno:266775.
    UCSCi RGD:628853. rat.

    Organism-specific databases

    CTDi 5273.
    RGDi 628853. Serpinb10.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi Q8K3K4.
    KOi K13963.
    PhylomeDBi Q8K3K4.

    Miscellaneous databases

    NextBioi 624656.
    PROi Q8K3K4.

    Gene expression databases

    Genevestigatori Q8K3K4.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel rat ov-serpin family member, trespin."
      Chipuk J.E., Stewart L.V., Ranieri A., Song K., Danielpour D.
      J. Biol. Chem. 277:26412-26421(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Wistar.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiSPB10_RAT
    AccessioniPrimary (citable) accession number: Q8K3K4
    Secondary accession number(s): Q6P7C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3