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Protein

G-protein coupled receptor family C group 5 member C

Gene

Gprc5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Alternative name(s):
Retinoic acid-induced gene 3 protein
Short name:
RAIG-3
Gene namesi
Name:Gprc5c
Synonyms:Raig3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917605 Gprc5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 49ExtracellularSequence analysisAdd BLAST27
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 84CytoplasmicSequence analysisAdd BLAST14
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 119ExtracellularSequence analysisAdd BLAST14
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 155CytoplasmicSequence analysisAdd BLAST15
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 207ExtracellularSequence analysisAdd BLAST31
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 240CytoplasmicSequence analysisAdd BLAST12
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 440CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001296823 – 440G-protein coupled receptor family C group 5 member CAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei343PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei413PhosphotyrosineCombined sources1
Modified residuei422PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K3J9
PaxDbiQ8K3J9
PRIDEiQ8K3J9

PTM databases

iPTMnetiQ8K3J9
PhosphoSitePlusiQ8K3J9

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061760

Structurei

3D structure databases

ProteinModelPortaliQ8K3J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6 Eukaryota
ENOG4110E9P LUCA
HOGENOMiHOG000116197
HOVERGENiHBG051794
InParanoidiQ8K3J9
KOiK04620

Family and domain databases

InterProiView protein in InterPro
IPR002956 Bride_of_7less
IPR017978 GPCR_3_C
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PRINTSiPR01223 BRIDEOF7LESS
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHRTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VSEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLVAHVLSL NFLTRKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSPLGN VSADSTMTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL TAFLGAWPTL CGRFKRWRKH GVFVLLTTVI
260 270 280 290 300
SIAIWVVWIV MYTYGNEQHH SPTWDDPTLA IALAANAWTF VLFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPPKDGKIS QVFRNPYVWD
Length:440
Mass (Da):48,422
Last modified:April 13, 2004 - v2
Checksum:iBA0B13B7631017B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52S → L in AAL87525 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079516 mRNA Translation: AAL87525.1
BC031439 mRNA Translation: AAH31439.1
CCDSiCCDS25612.1
RefSeqiNP_001103808.1, NM_001110338.1
NP_671750.2, NM_147217.3
XP_006534228.1, XM_006534165.1
UniGeneiMm.242413

Genome annotation databases

GeneIDi70355
KEGGimmu:70355

Similar proteinsi

Entry informationi

Entry nameiGPC5C_MOUSE
AccessioniPrimary (citable) accession number: Q8K3J9
Secondary accession number(s): Q8K0H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health