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Protein

G-protein coupled receptor family C group 5 member C

Gene

Gprc5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Alternative name(s):
Retinoic acid-induced gene 3 protein
Short name:
RAIG-3
Gene namesi
Name:Gprc5c
Synonyms:Raig3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917605. Gprc5c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 4927ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini71 – 8414CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini106 – 11914ExtracellularSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini141 – 15515CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 20731ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini229 – 24012CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini300 – 440141CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 440418G-protein coupled receptor family C group 5 member CPRO_0000012968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei402 – 4021PhosphoserineCombined sources
Modified residuei405 – 4051PhosphoserineCombined sources
Modified residuei413 – 4131PhosphotyrosineCombined sources
Modified residuei422 – 4221PhosphothreonineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K3J9.
PaxDbiQ8K3J9.
PRIDEiQ8K3J9.

PTM databases

iPTMnetiQ8K3J9.
PhosphoSiteiQ8K3J9.

Expressioni

Gene expression databases

BgeeiQ8K3J9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061760.

Structurei

3D structure databases

ProteinModelPortaliQ8K3J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ8K3J9.
KOiK04620.

Family and domain databases

InterProiIPR002956. Bride_of_7less.
IPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR01223. BRIDEOF7LESS.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHRTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI
60 70 80 90 100
VSEAVAGAGI ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF
110 120 130 140 150
CLVFACVVKP DFSTCASRRF LFGVLFAICF SCLVAHVLSL NFLTRKNHGP
160 170 180 190 200
RGWVIFTVAL LLTLVEVIIN TEWLIITLVR GGGQVSPLGN VSADSTMTSP
210 220 230 240 250
CAIANMDFVM ALIYVMLLLL TAFLGAWPTL CGRFKRWRKH GVFVLLTTVI
260 270 280 290 300
SIAIWVVWIV MYTYGNEQHH SPTWDDPTLA IALAANAWTF VLFYVIPEVS
310 320 330 340 350
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA
360 370 380 390 400
KRPVSPYSGY NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM
410 420 430 440
GSANSTLRAE DMYMVQSHQV ATPPKDGKIS QVFRNPYVWD
Length:440
Mass (Da):48,422
Last modified:April 13, 2004 - v2
Checksum:iBA0B13B7631017B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521S → L in AAL87525 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079516 mRNA. Translation: AAL87525.1.
BC031439 mRNA. Translation: AAH31439.1.
CCDSiCCDS25612.1.
RefSeqiNP_001103808.1. NM_001110338.1.
NP_671750.2. NM_147217.3.
XP_006534228.1. XM_006534165.1.
UniGeneiMm.242413.

Genome annotation databases

GeneIDi70355.
KEGGimmu:70355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079516 mRNA. Translation: AAL87525.1.
BC031439 mRNA. Translation: AAH31439.1.
CCDSiCCDS25612.1.
RefSeqiNP_001103808.1. NM_001110338.1.
NP_671750.2. NM_147217.3.
XP_006534228.1. XM_006534165.1.
UniGeneiMm.242413.

3D structure databases

ProteinModelPortaliQ8K3J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061760.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8K3J9.
PhosphoSiteiQ8K3J9.

Proteomic databases

MaxQBiQ8K3J9.
PaxDbiQ8K3J9.
PRIDEiQ8K3J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70355.
KEGGimmu:70355.

Organism-specific databases

CTDi55890.
MGIiMGI:1917605. Gprc5c.

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ8K3J9.
KOiK04620.

Miscellaneous databases

PROiQ8K3J9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K3J9.

Family and domain databases

InterProiIPR002956. Bride_of_7less.
IPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR01223. BRIDEOF7LESS.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of mouse retinoic acid-inducible orphan G protein-coupled receptors."
    Tao Q., Lotan R.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; SER-405; TYR-413 AND THR-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiGPC5C_MOUSE
AccessioniPrimary (citable) accession number: Q8K3J9
Secondary accession number(s): Q8K0H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.