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Protein

Beta-defensin 19

Gene

Defb19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 19
Short name:
BD-19
Short name:
mBD-19
Alternative name(s):
Defensin, beta 19
Testis-specific beta-defensin-like protein
Gene namesi
Name:Defb19
Synonyms:Defb24, Tdl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385955. Defb19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Peptidei20 – 8364Beta-defensin 19PRO_0000006944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8K3I8.
PRIDEiQ8K3I8.

Expressioni

Tissue specificityi

Specifically expressed in male gonads (Sertoli cells).1 Publication

Developmental stagei

Not detected at 11.5 dpc. Specific signals are observed within seminiferous cords in male gonads at 12.5, 13.5, 14.5, and 16.5 dpc and in newborn testes. In 16.5 and newborn testes, its expression is also found in epididymis. No specific signal is found in female gonads.1 Publication

Gene expression databases

BgeeiENSMUSG00000050645.
CleanExiMM_DEFB19.
GenevisibleiQ8K3I8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059585.

Structurei

3D structure databases

ProteinModelPortaliQ8K3I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEX6. Eukaryota.
ENOG41118Y9. LUCA.
GeneTreeiENSGT00510000050451.
HOGENOMiHOG000112157.
HOVERGENiHBG107794.
InParanoidiQ8K3I8.
OMAiNRWPKIS.
OrthoDBiEOG091G153Z.
PhylomeDBiQ8K3I8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR028060. Defensin_big.
[Graphical view]
PfamiPF14862. Defensin_big. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLALLLLAI LVATELVVSG KNPILQCMGN RGFCRSSCKK SEQAYFYCRT
60 70 80
FQMCCLQSYV RISLTGVDDN TNWSYEKHWP RIP
Length:83
Mass (Da):9,568
Last modified:October 1, 2002 - v1
Checksum:i9D7B69BD9AA30B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098993 mRNA. Translation: AAM28243.1.
AF532614 mRNA. Translation: AAO27571.1.
DQ012035 mRNA. Translation: AAY59771.1.
AK133049 mRNA. Translation: BAE21487.1.
AL845162 Genomic DNA. Translation: CAM46150.1.
BC049701 mRNA. Translation: AAH49701.1.
CCDSiCCDS38277.1.
RefSeqiNP_660139.1. NM_145157.3.
UniGeneiMm.82820.

Genome annotation databases

EnsembliENSMUST00000053180; ENSMUSP00000059585; ENSMUSG00000050645.
GeneIDi246700.
KEGGimmu:246700.
UCSCiuc008nfs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098993 mRNA. Translation: AAM28243.1.
AF532614 mRNA. Translation: AAO27571.1.
DQ012035 mRNA. Translation: AAY59771.1.
AK133049 mRNA. Translation: BAE21487.1.
AL845162 Genomic DNA. Translation: CAM46150.1.
BC049701 mRNA. Translation: AAH49701.1.
CCDSiCCDS38277.1.
RefSeqiNP_660139.1. NM_145157.3.
UniGeneiMm.82820.

3D structure databases

ProteinModelPortaliQ8K3I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059585.

Proteomic databases

PaxDbiQ8K3I8.
PRIDEiQ8K3I8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053180; ENSMUSP00000059585; ENSMUSG00000050645.
GeneIDi246700.
KEGGimmu:246700.
UCSCiuc008nfs.1. mouse.

Organism-specific databases

CTDi246700.
MGIiMGI:2385955. Defb19.

Phylogenomic databases

eggNOGiENOG410JEX6. Eukaryota.
ENOG41118Y9. LUCA.
GeneTreeiENSGT00510000050451.
HOGENOMiHOG000112157.
HOVERGENiHBG107794.
InParanoidiQ8K3I8.
OMAiNRWPKIS.
OrthoDBiEOG091G153Z.
PhylomeDBiQ8K3I8.

Miscellaneous databases

PROiQ8K3I8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050645.
CleanExiMM_DEFB19.
GenevisibleiQ8K3I8. MM.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR028060. Defensin_big.
[Graphical view]
PfamiPF14862. Defensin_big. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiDFB19_MOUSE
AccessioniPrimary (citable) accession number: Q8K3I8
Secondary accession number(s): Q3V0L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.