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Protein

Myosin-IIIa

Gene

Myo3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50ATPPROSITE-ProRule annotation1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 35ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • inner ear development Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • peptidyl-threonine phosphorylation Source: MGI
  • positive regulation of filopodium assembly Source: MGI
  • protein autophosphorylation Source: UniProtKB
  • response to stimulus Source: UniProtKB-KW
  • sensory perception of sound Source: UniProtKB
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Hearing, Sensory transduction, Vision

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-IIIa (EC:2.7.11.1)
Gene namesi
Name:Myo3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2183924. Myo3a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • filamentous actin Source: UniProtKB
  • filopodium Source: UniProtKB
  • filopodium tip Source: MGI
  • myosin complex Source: UniProtKB-KW
  • photoreceptor inner segment Source: MGI
  • stereocilium tip Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864141 – 1613Myosin-IIIaAdd BLAST1613

Proteomic databases

PaxDbiQ8K3H5.
PRIDEiQ8K3H5.

PTM databases

iPTMnetiQ8K3H5.
PhosphoSitePlusiQ8K3H5.

Expressioni

Gene expression databases

CleanExiMM_MYO3A.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: MGI
  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046329.

Structurei

3D structure databases

ProteinModelPortaliQ8K3H5.
SMRiQ8K3H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST267
Domaini338 – 1052Myosin motorAdd BLAST715
Domaini1054 – 1083IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1081 – 1110IQ 2PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.Curated
Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
KOG4229. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000007169.
HOVERGENiHBG052555.
InParanoidiQ8K3H5.
PhylomeDBiQ8K3H5.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLIGKTII FDNFPDPSDT WEIIETIGKG TYGKVFKVLN KKSGQKAAVK
60 70 80 90 100
ILDPIHDIDE EIEAEYNILR TLSDHPNVVR FYGIYFKKDK INGDKLWLVL
110 120 130 140 150
ELCNGGSVTD LVKGFLKRGE RMSEPVIAYI LHEALMGLQH LHSNKTIHRD
160 170 180 190 200
VKGNNILLTT EGGVKLVDFG VSAQLSSTRH RLNTSVGTPF WMAPEVIACE
210 220 230 240 250
QQLDTTYDAR CDTWSLGITA IELGDGDPPL AELHPMRALF KIPRNPPPKL
260 270 280 290 300
RQPELWSAEF NDFISKCLTK DYEKRPTVSD LLKHKFITQI EGKDVILQKQ
310 320 330 340 350
LMEFIDIHQC LGSTEKARHE RIHTKKGNLN RSLISSLKDV DDLATLDVLD
360 370 380 390 400
EPTASPHLHP CHSRDQIHIH VADILIALNP FQSLGIYSPK LSRLYIGAKR
410 420 430 440 450
TANPPHIFAM ADLGYQSMVT YNADQCIVIS GESGAGKTES AHLLVQQLTV
460 470 480 490 500
LGKANNRTLQ EKILQMNNLV EAFGNACTII NDNSSRFGKY LEMKFTSSGA
510 520 530 540 550
VVGAQISEYL LEKSRVIHQA MGEKNFHIFY YIYGGLAEKK KLALYKSPEH
560 570 580 590 600
KPPRYLQNDN LRTVQDMMNN SFYKSQYELI EQCFKVIGFT MEQLASVYSV
610 620 630 640 650
LAAILNVGNI EFSSVATEYQ MDKSYICNHT ALENCASLLC IQADELQEAL
660 670 680 690 700
TSHCVVTRGE TIIRPNTVEK AADVRDAMAK TLYGRLFSCI VNCINSLLKH
710 720 730 740 750
DTSPSGDEEL NIGILDIFGF ENFKRNSFEQ LCINIANEQI QYYFNQHVFA
760 770 780 790 800
WEQNEYLNED VDARVIEYED NRPLLDMFLQ KPMGLLSLLD EESRFPKATD
810 820 830 840 850
QTLIEKFEDN LKSQYFWRPK RMELSFGIHH YAGKVLYSAS GFLAKNRDTF
860 870 880 890 900
PTDIVLPLRS SENSVIRQLV NHPLTKTGNL PLSKTKNIVN YQMWNSEKST
910 920 930 940 950
NLTKGETRDV TCHACETTNV KTQTVSSYFR YSLMDLLSKM VVGQPHFVRC
960 970 980 990 1000
IKPNNERQAR KYDKEKVLLQ LRCTGILETA RIRRLGYSHR ILFANFIKRY
1010 1020 1030 1040 1050
YILCYKSSEE PPVSPDTCAA ILEKAGLDNW ALGKTKVFLK YYHVEQLNLM
1060 1070 1080 1090 1100
RKEATNKLVL IQASVRAFLG ARRYQELQQK RKSSAVIIQS AARGHLVRKQ
1110 1120 1130 1140 1150
RKEIVDMKNT AVTTIQTSDQ EFDYKKNFEN TRESFVKKQT ENAVPTNESN
1160 1170 1180 1190 1200
TSTPNNKESP SAGKTAPFIA ESKATNVESN NRRYHTQKKM SNVYAEGQNQ
1210 1220 1230 1240 1250
ELYIVEDTWA EVSPRQKYVQ DLEESRKMRK EEKGDAVIQS YCQWYTEGSN
1260 1270 1280 1290 1300
FEESKATCLE GRETWERTSC PGLWLTEEIY LRKTLDPTLS QKSVYQNADG
1310 1320 1330 1340 1350
KEKEHKVSVV TQNAPLGNLE RDYHLLGFLG EEDTGPVPQA QEEHKAVSIH
1360 1370 1380 1390 1400
SKYQSSKKKQ QLGKDRLAPP FKNQKILSSS TEVAKTTHNV YPCPTKQEGV
1410 1420 1430 1440 1450
HHSKMVDERD SKMASKKEAW DLAMFSRQIS KLSEEYFILQ KNLNEIILAQ
1460 1470 1480 1490 1500
QLKPFYLGIY RHKPINRHVS THQYLSGVSK GEEPKILRPP RRPRKPKTLN
1510 1520 1530 1540 1550
NPEDSTYYYL LHKSTQEEKR RPGKDSQGKL LGLEDFYYKE FLPTHYGPKA
1560 1570 1580 1590 1600
HSSNAREWKA LKEPQAQPIE SNERCWTTSE NESLEEERIS ANPYDYRRLL
1610
RKTSQRQRLV QQL
Length:1,613
Mass (Da):184,730
Last modified:October 1, 2002 - v1
Checksum:i19DFD980BF7B8847
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101368 mRNA. Translation: AAM34501.1.
UniGeneiMm.330033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101368 mRNA. Translation: AAM34501.1.
UniGeneiMm.330033.

3D structure databases

ProteinModelPortaliQ8K3H5.
SMRiQ8K3H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046329.

PTM databases

iPTMnetiQ8K3H5.
PhosphoSitePlusiQ8K3H5.

Proteomic databases

PaxDbiQ8K3H5.
PRIDEiQ8K3H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2183924. Myo3a.

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
KOG4229. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000007169.
HOVERGENiHBG052555.
InParanoidiQ8K3H5.
PhylomeDBiQ8K3H5.

Miscellaneous databases

PROiQ8K3H5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYO3A.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR011009. Kinase-like_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO3A_MOUSE
AccessioniPrimary (citable) accession number: Q8K3H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.