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Protein

DCC-interacting protein 13-beta

Gene

Appl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
DCC-interacting protein 13-beta
Short name:
Dip13-beta
Alternative name(s):
Adapter protein containing PH domain, PTB domain and leucine zipper motif 2
Gene namesi
Name:Appl2
Synonyms:Dip13b, Dip3bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384914. Appl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662DCC-interacting protein 13-betaPRO_0000079988Add
BLAST

Proteomic databases

EPDiQ8K3G9.
MaxQBiQ8K3G9.
PaxDbiQ8K3G9.
PRIDEiQ8K3G9.

PTM databases

iPTMnetiQ8K3G9.
PhosphoSiteiQ8K3G9.

Expressioni

Gene expression databases

BgeeiQ8K3G9.
ExpressionAtlasiQ8K3G9. baseline and differential.
GenevisibleiQ8K3G9. MM.

Interactioni

Subunit structurei

Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229720. 1 interaction.
IntActiQ8K3G9. 2 interactions.
STRINGi10090.ENSMUSP00000020500.

Structurei

3D structure databases

ProteinModelPortaliQ8K3G9.
SMRiQ8K3G9. Positions 5-378, 485-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 37599PHPROSITE-ProRule annotationAdd
BLAST
Domaini486 – 635150PIDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 428428Required for RAB5A bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
KOG3536. Eukaryota.
ENOG410ZISK. LUCA.
GeneTreeiENSGT00710000106752.
HOGENOMiHOG000285988.
HOVERGENiHBG051394.
InParanoidiQ8K3G9.
OMAiFAHGQIN.
OrthoDBiEOG79PJPK.
PhylomeDBiQ8K3G9.
TreeFamiTF328669.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVDKLLLE EALQDSPQAR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA
60 70 80 90 100
QNEMCLATQQ LSRQLLAYEK QNFALGKGDE EVISTLHYFS KVMDELNGLH
110 120 130 140 150
TELAKQLADT MVLPVIQFRE KDLTEVSTLK DLFGLASSEH DLSMAKYSRL
160 170 180 190 200
PKKKENEKAK TEIVKEVAAA RRKQHLSSLQ YYCALNALQY RKRAAMMEPL
210 220 230 240 250
IGFAHGQINF FKRGAEMFSK SMDGFLSSVK DMVQSIQVEL EAEADKMRVS
260 270 280 290 300
QQELLSVSES VYTPDIDVAT AQINRNLIQK TGYLNLRNKT GLVTTTWERL
310 320 330 340 350
YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQISTPSGK
360 370 380 390 400
PGIILQAESR KEYEEWICAV NNISRQIYLT DNPEAVAIKL NQTALQAVTP
410 420 430 440 450
ITSFGKKQES SCSSQNIKNS DIEDDNIVPK ATASIPETEE LIAPGTPIQF
460 470 480 490 500
DIVLPATEFL DQNRGGRRTN PFGETEDGSF PEAEDSLLQQ MFIVRFLGSM
510 520 530 540 550
AVKTDSTAEV IYEAMRQVLA ARAIHNIFRM TESHLMVTSQ TLRLIDPQTQ
560 570 580 590 600
VSRACFELTS VTQFAAHQEN KRLVGFVIRV PESTGEESLS TYIFESNSEG
610 620 630 640 650
EKICYAINLG KEIIEVQKDP EALARLMLSV PLTNDGKYVL LNDQADDTGG
660
SPSENRGAES EA
Length:662
Mass (Da):73,854
Last modified:October 1, 2002 - v1
Checksum:i8917BDE1CF13FC3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4281V → D in AAH02232 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113706 mRNA. Translation: AAM55532.1.
BC002232 mRNA. Translation: AAH02232.1.
BC048906 mRNA. Translation: AAH48906.1.
CCDSiCCDS24078.1.
RefSeqiNP_660255.1. NM_145220.2.
UniGeneiMm.282985.

Genome annotation databases

EnsembliENSMUST00000020500; ENSMUSP00000020500; ENSMUSG00000020263.
GeneIDi216190.
KEGGimmu:216190.
UCSCiuc007gkk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113706 mRNA. Translation: AAM55532.1.
BC002232 mRNA. Translation: AAH02232.1.
BC048906 mRNA. Translation: AAH48906.1.
CCDSiCCDS24078.1.
RefSeqiNP_660255.1. NM_145220.2.
UniGeneiMm.282985.

3D structure databases

ProteinModelPortaliQ8K3G9.
SMRiQ8K3G9. Positions 5-378, 485-613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229720. 1 interaction.
IntActiQ8K3G9. 2 interactions.
STRINGi10090.ENSMUSP00000020500.

PTM databases

iPTMnetiQ8K3G9.
PhosphoSiteiQ8K3G9.

Proteomic databases

EPDiQ8K3G9.
MaxQBiQ8K3G9.
PaxDbiQ8K3G9.
PRIDEiQ8K3G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020500; ENSMUSP00000020500; ENSMUSG00000020263.
GeneIDi216190.
KEGGimmu:216190.
UCSCiuc007gkk.1. mouse.

Organism-specific databases

CTDi55198.
MGIiMGI:2384914. Appl2.

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
KOG3536. Eukaryota.
ENOG410ZISK. LUCA.
GeneTreeiENSGT00710000106752.
HOGENOMiHOG000285988.
HOVERGENiHBG051394.
InParanoidiQ8K3G9.
OMAiFAHGQIN.
OrthoDBiEOG79PJPK.
PhylomeDBiQ8K3G9.
TreeFamiTF328669.

Miscellaneous databases

ChiTaRSiAppl2. mouse.
NextBioi375066.
PROiQ8K3G9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K3G9.
ExpressionAtlasiQ8K3G9. baseline and differential.
GenevisibleiQ8K3G9. MM.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00462. PTB. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01179. PID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse DIP13 alpha and beta."
    Chen Y.Q.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: ColonImported and Mammary tumorImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiDP13B_MOUSE
AccessioniPrimary (citable) accession number: Q8K3G9
Secondary accession number(s): Q99LT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.