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Protein

Tumor necrosis factor ligand superfamily member

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi240ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily memberUniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 42HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSitePlusiQ8K3G0

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8K3G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 287TNF_2InterPro annotationAdd BLAST161

Sequence similaritiesi

Belongs to the tumor necrosis factor family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IIX7 Eukaryota
ENOG410YS4F LUCA
HOVERGENiHBG059007
PhylomeDBiQ8K3G0

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR017355 TNF_ligand_10/11
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF038013 TNF10_TNF11, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K3G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGNLKGP SFSQHFTMTV ICIVLLQVLL QALTVAVTYM YFNNEVKQLQ
60 70 80 90 100
DNYSKIGLAC FSKEDGDFWD STDEGILNRP CLQVKRQLYQ LIEEVTLRTF
110 120 130 140 150
EKTISTVPEK QLSTPPLPRG RRPQRVAAHI TGITRRSNLA LIPISKDGKT
160 170 180 190 200
LGQKIETWES SRRGHSFLNH VHLRNGELVI QEEGLYYIYS QTYYRFKEAK
210 220 230 240 250
EASKTVSKDG GRIKQMVQYI YKYTSYPDPI LLMKSARNSC WSREAEYGLY
260 270 280
SIYQGGLFEL KENDRIFVSV TNEHLMDLDH EASFFGA
Length:287
Mass (Da):32,980
Last modified:October 1, 2002 - v1
Checksum:iCA4F5B5D7C833FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY115578 mRNA Translation: AAM49797.1
UniGeneiRn.133346
Rn.83627

Genome annotation databases

UCSCiRGD:628734 rat

Similar proteinsi

Entry informationi

Entry nameiQ8K3G0_RAT
AccessioniPrimary (citable) accession number: Q8K3G0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health