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Protein
Submitted name:

TNF-related apoptosis inducing ligand

Gene

Tnfsf10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • immune response Source: InterPro
  • male gonad development Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • response to insulin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TNF-related apoptosis inducing ligandImported
Gene namesi
Name:Tnfsf10Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628734. Tnfsf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ8K3G0.

Expressioni

Gene expression databases

GenevestigatoriQ8K3G0.

Structurei

3D structure databases

ProteinModelPortaliQ8K3G0.
SMRiQ8K3G0. Positions 123-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG059007.
KOiK04721.
PhylomeDBiQ8K3G0.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGNLKGP SFSQHFTMTV ICIVLLQVLL QALTVAVTYM YFNNEVKQLQ
60 70 80 90 100
DNYSKIGLAC FSKEDGDFWD STDEGILNRP CLQVKRQLYQ LIEEVTLRTF
110 120 130 140 150
EKTISTVPEK QLSTPPLPRG RRPQRVAAHI TGITRRSNLA LIPISKDGKT
160 170 180 190 200
LGQKIETWES SRRGHSFLNH VHLRNGELVI QEEGLYYIYS QTYYRFKEAK
210 220 230 240 250
EASKTVSKDG GRIKQMVQYI YKYTSYPDPI LLMKSARNSC WSREAEYGLY
260 270 280
SIYQGGLFEL KENDRIFVSV TNEHLMDLDH EASFFGA
Length:287
Mass (Da):32,980
Last modified:October 1, 2002 - v1
Checksum:iCA4F5B5D7C833FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY115578 mRNA. Translation: AAM49797.1.
RefSeqiNP_663714.1. NM_145681.1.
UniGeneiRn.83627.

Genome annotation databases

GeneIDi246775.
KEGGirno:246775.
UCSCiRGD:628734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY115578 mRNA. Translation: AAM49797.1.
RefSeqiNP_663714.1. NM_145681.1.
UniGeneiRn.83627.

3D structure databases

ProteinModelPortaliQ8K3G0.
SMRiQ8K3G0. Positions 123-287.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K3G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246775.
KEGGirno:246775.
UCSCiRGD:628734. rat.

Organism-specific databases

CTDi8743.
RGDi628734. Tnfsf10.

Phylogenomic databases

HOVERGENiHBG059007.
KOiK04721.
PhylomeDBiQ8K3G0.

Miscellaneous databases

NextBioi623869.

Gene expression databases

GenevestigatoriQ8K3G0.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rattus norvegicus TNF-related apoptosis inducing ligand (TRAIL)."
    Mueller A.M., Giegerich G.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DAImported.

Entry informationi

Entry nameiQ8K3G0_RAT
AccessioniPrimary (citable) accession number: Q8K3G0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.