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Protein

Protein phosphatase 1 regulatory subunit 14B

Gene

Ppp1r14b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).By similarity

GO - Molecular functioni

  • phosphatase inhibitor activity Source: RGD
  • protein phosphatase type 1 regulator activity Source: RGD
  • protein serine/threonine phosphatase inhibitor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14B
Alternative name(s):
Phosphatase holoenzyme inhibitor 1
Short name:
PHI-1
Ubiquitous PKC-potentiated PP1 inhibitor
Gene namesi
Name:Ppp1r14b
Synonyms:Phi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628702. Ppp1r14b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 147146Protein phosphatase 1 regulatory subunit 14BPRO_0000071493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei29 – 291PhosphotyrosineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei57 – 571PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8K3F3.
PRIDEiQ8K3F3.

Expressioni

Gene expression databases

GenevisibleiQ8K3F3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040750.

Structurei

3D structure databases

ProteinModelPortaliQ8K3F3.
SMRiQ8K3F3. Positions 55-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 10343Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ8K3F3.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG7RNK21.
PhylomeDBiQ8K3F3.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGPAGGA ALAAPAPGPG SGSTGPRVYF QSPPGAAGEG PGGADDDGPV
60 70 80 90 100
RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL
110 120 130 140
LDMESDDTRA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK
Length:147
Mass (Da):15,957
Last modified:October 1, 2002 - v1
Checksum:iD1E0383A3A9DF822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122323 mRNA. Translation: AAM89292.1.
RefSeqiNP_742042.1. NM_172045.1.
UniGeneiRn.2773.

Genome annotation databases

EnsembliENSRNOT00000051749; ENSRNOP00000040750; ENSRNOG00000021151.
GeneIDi259225.
KEGGirno:259225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122323 mRNA. Translation: AAM89292.1.
RefSeqiNP_742042.1. NM_172045.1.
UniGeneiRn.2773.

3D structure databases

ProteinModelPortaliQ8K3F3.
SMRiQ8K3F3. Positions 55-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040750.

Proteomic databases

PaxDbiQ8K3F3.
PRIDEiQ8K3F3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051749; ENSRNOP00000040750; ENSRNOG00000021151.
GeneIDi259225.
KEGGirno:259225.

Organism-specific databases

CTDi26472.
RGDi628702. Ppp1r14b.

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ8K3F3.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG7RNK21.
PhylomeDBiQ8K3F3.
TreeFamiTF105546.

Miscellaneous databases

PROiQ8K3F3.

Gene expression databases

GenevisibleiQ8K3F3. RN.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."
    Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J., Uhl G.R.
    Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPP14B_RAT
AccessioniPrimary (citable) accession number: Q8K3F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.