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Q8K3F2 (MMP21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Matrix metalloproteinase-21

Short name=MMP-21
EC=3.4.24.-
Gene names
Name:Mmp21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Calcium By similarity.

Subcellular location

Secreted Potential.

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Post-translational modification

The precursor is cleaved by a furin endopeptidase By similarity.

Sequence similarities

Belongs to the peptidase M10A family.

Contains 4 hemopexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 568544Matrix metalloproteinase-21
PRO_0000028841

Regions

Repeat329 – 38860Hemopexin 1
Repeat390 – 44657Hemopexin 2
Repeat447 – 49549Hemopexin 3
Repeat502 – 55857Hemopexin 4
Motif110 – 1178Cysteine switch By similarity

Sites

Active site2831 By similarity
Metal binding1121Zinc; in inhibited form By similarity
Metal binding2821Zinc; catalytic By similarity
Metal binding2861Zinc; catalytic By similarity
Metal binding2921Zinc; catalytic By similarity

Amino acid modifications

Glycosylation3711N-linked (GlcNAc...) Potential
Disulfide bond328 ↔ 559 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K3F2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: EDDBDDD9B6E00546

FASTA56865,454
        10         20         30         40         50         60 
MLAASVLRLT LPLCWLVAPQ PTQPERLFHS RDRSDLEPSP LSQAKPIADL HDAQSFLLKY 

        70         80         90        100        110        120 
GWSEIPSPKE SAGVPVGFTL AQAVRRFQKA NRLPASGELD SPTLAAMNKP RCGVPDTRLP 

       130        140        150        160        170        180 
PRAALPTPPA LLTSLGLRPR ARQKRFLQML FPKPDGQQED ASDTGASRAF SKKTLTWRLV 

       190        200        210        220        230        240 
GDAYSSQLSG DEQRYIFRLA FRMWSEVTPL DFREDRTAPG TMVDIKLGFG RGRHLGCPRV 

       250        260        270        280        290        300 
FDGSGQEFAH AWRLGEIHFD DDEHFTPLSS DTGISLLKVA VHEIGHVLGL PHTYRVGSIM 

       310        320        330        340        350        360 
QPNYIPQEPA FELDWADRKA IQRLYGSCKG SFDTVFDWIR KERNQYGEVR VRFNTYFFRN 

       370        380        390        400        410        420 
SWYWLYENRN NRTRYGDPLQ ILTGWRGIPT QSIDAYVHVW SWGKDERYFF KGSQYWRYDS 

       430        440        450        460        470        480 
ENDQAHTEDE QGRSYPKLIS EGFPGIPSPL DTAFYDRRQQ LIYFFKESLV FAFDVNRNQV 

       490        500        510        520        530        540 
LNSYPKKMSQ VFPAIMPQNH PFRNLDSAYY SYAHNSIFFF KGNSYWKVVS DKDKQQNTRL 

       550        560 
PLNGLFPKKP VSEKWFDVCD VHTSTLNM 

« Hide

References

[1]"The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein."
Marchenko G.N., Marchenko N.D., Strongin A.Y.
Biochem. J. 372:503-515(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Mouse MMP-21, a novel matrix metalloproteinase."
Lopez-Otin C., Pendas A.M., Llano E.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A/J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY124569 mRNA. Translation: AAM94032.1.
AF507967 mRNA. Translation: AAN09805.1.
RefSeqNP_694423.1. NM_152944.1.
UniGeneMm.222952.

3D structure databases

ProteinModelPortalQ8K3F2.
SMRQ8K3F2. Positions 50-560.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM10.026.

PTM databases

PhosphoSiteQ8K3F2.

Proteomic databases

PRIDEQ8K3F2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033278; ENSMUSP00000033278; ENSMUSG00000030981.
GeneID214766.
KEGGmmu:214766.
UCSCuc009kdd.1. mouse.

Organism-specific databases

CTD118856.
MGIMGI:2664387. Mmp21.

Phylogenomic databases

eggNOGNOG115777.
GeneTreeENSGT00730000110410.
HOGENOMHOG000113608.
HOVERGENHBG052483.
InParanoidQ8K3F2.
KOK08000.
OMALYENRNN.
OrthoDBEOG7X9G6K.
PhylomeDBQ8K3F2.
TreeFamTF315428.

Gene expression databases

CleanExMM_MMP21.
GenevestigatorQ8K3F2.

Family and domain databases

Gene3D1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028719. MMP21.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERPTHR10201. PTHR10201. 1 hit.
PTHR10201:SF14. PTHR10201:SF14. 1 hit.
PfamPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSPR00138. MATRIXIN.
SMARTSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEPS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374464.
PROQ8K3F2.
SOURCESearch...

Entry information

Entry nameMMP21_MOUSE
AccessionPrimary (citable) accession number: Q8K3F2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot