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Q8K3F2

- MMP21_MOUSE

UniProt

Q8K3F2 - MMP21_MOUSE

Protein

Matrix metalloproteinase-21

Gene

Mmp21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity
    Calcium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi112 – 1121Zinc; in inhibited formBy similarity
    Metal bindingi282 – 2821Zinc; catalyticPROSITE-ProRule annotation
    Active sitei283 – 2831PROSITE-ProRule annotation
    Metal bindingi286 – 2861Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi292 – 2921Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. metallopeptidase activity Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. hematopoietic progenitor cell differentiation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM10.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix metalloproteinase-21 (EC:3.4.24.-)
    Short name:
    MMP-21
    Gene namesi
    Name:Mmp21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2664387. Mmp21.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular matrix Source: InterPro
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 568544Matrix metalloproteinase-21PRO_0000028841Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi328 ↔ 559By similarity
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ8K3F2.

    PTM databases

    PhosphoSiteiQ8K3F2.

    Expressioni

    Gene expression databases

    CleanExiMM_MMP21.
    GenevestigatoriQ8K3F2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3F2.
    SMRiQ8K3F2. Positions 68-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati329 – 38860Hemopexin 1Add
    BLAST
    Repeati390 – 44657Hemopexin 2Add
    BLAST
    Repeati447 – 49549Hemopexin 3Add
    BLAST
    Repeati502 – 55857Hemopexin 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi110 – 1178Cysteine switchBy similarity

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated
    Contains 4 hemopexin repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG115777.
    GeneTreeiENSGT00730000110410.
    HOGENOMiHOG000113608.
    HOVERGENiHBG052483.
    InParanoidiQ8K3F2.
    KOiK08000.
    OMAiLYENRNN.
    OrthoDBiEOG7X9G6K.
    PhylomeDBiQ8K3F2.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di1.10.101.10. 1 hit.
    2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PfamiPF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEiPS51642. HEMOPEXIN_2. 4 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K3F2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAASVLRLT LPLCWLVAPQ PTQPERLFHS RDRSDLEPSP LSQAKPIADL    50
    HDAQSFLLKY GWSEIPSPKE SAGVPVGFTL AQAVRRFQKA NRLPASGELD 100
    SPTLAAMNKP RCGVPDTRLP PRAALPTPPA LLTSLGLRPR ARQKRFLQML 150
    FPKPDGQQED ASDTGASRAF SKKTLTWRLV GDAYSSQLSG DEQRYIFRLA 200
    FRMWSEVTPL DFREDRTAPG TMVDIKLGFG RGRHLGCPRV FDGSGQEFAH 250
    AWRLGEIHFD DDEHFTPLSS DTGISLLKVA VHEIGHVLGL PHTYRVGSIM 300
    QPNYIPQEPA FELDWADRKA IQRLYGSCKG SFDTVFDWIR KERNQYGEVR 350
    VRFNTYFFRN SWYWLYENRN NRTRYGDPLQ ILTGWRGIPT QSIDAYVHVW 400
    SWGKDERYFF KGSQYWRYDS ENDQAHTEDE QGRSYPKLIS EGFPGIPSPL 450
    DTAFYDRRQQ LIYFFKESLV FAFDVNRNQV LNSYPKKMSQ VFPAIMPQNH 500
    PFRNLDSAYY SYAHNSIFFF KGNSYWKVVS DKDKQQNTRL PLNGLFPKKP 550
    VSEKWFDVCD VHTSTLNM 568
    Length:568
    Mass (Da):65,454
    Last modified:October 1, 2002 - v1
    Checksum:iEDDBDDD9B6E00546
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY124569 mRNA. Translation: AAM94032.1.
    AF507967 mRNA. Translation: AAN09805.1.
    CCDSiCCDS21933.1.
    RefSeqiNP_694423.1. NM_152944.1.
    UniGeneiMm.222952.

    Genome annotation databases

    EnsembliENSMUST00000033278; ENSMUSP00000033278; ENSMUSG00000030981.
    GeneIDi214766.
    KEGGimmu:214766.
    UCSCiuc009kdd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY124569 mRNA. Translation: AAM94032.1 .
    AF507967 mRNA. Translation: AAN09805.1 .
    CCDSi CCDS21933.1.
    RefSeqi NP_694423.1. NM_152944.1.
    UniGenei Mm.222952.

    3D structure databases

    ProteinModelPortali Q8K3F2.
    SMRi Q8K3F2. Positions 68-527.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M10.026.

    PTM databases

    PhosphoSitei Q8K3F2.

    Proteomic databases

    PRIDEi Q8K3F2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033278 ; ENSMUSP00000033278 ; ENSMUSG00000030981 .
    GeneIDi 214766.
    KEGGi mmu:214766.
    UCSCi uc009kdd.1. mouse.

    Organism-specific databases

    CTDi 118856.
    MGIi MGI:2664387. Mmp21.

    Phylogenomic databases

    eggNOGi NOG115777.
    GeneTreei ENSGT00730000110410.
    HOGENOMi HOG000113608.
    HOVERGENi HBG052483.
    InParanoidi Q8K3F2.
    KOi K08000.
    OMAi LYENRNN.
    OrthoDBi EOG7X9G6K.
    PhylomeDBi Q8K3F2.
    TreeFami TF315428.

    Miscellaneous databases

    NextBioi 374464.
    PROi Q8K3F2.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MMP21.
    Genevestigatori Q8K3F2.

    Family and domain databases

    Gene3Di 1.10.101.10. 1 hit.
    2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    Pfami PF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEi PS51642. HEMOPEXIN_2. 4 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein."
      Marchenko G.N., Marchenko N.D., Strongin A.Y.
      Biochem. J. 372:503-515(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "Mouse MMP-21, a novel matrix metalloproteinase."
      Lopez-Otin C., Pendas A.M., Llano E.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A/J.

    Entry informationi

    Entry nameiMMP21_MOUSE
    AccessioniPrimary (citable) accession number: Q8K3F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3