Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toll-like receptor

Gene

Tlr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: MGI
  2. lipoteichoic acid binding Source: MGI
  3. peptidoglycan binding Source: MGI
  4. protein heterodimerization activity Source: MGI
  5. receptor activity Source: MGI
  6. signaling pattern recognition receptor activity Source: MGI
  7. transmembrane signaling receptor activity Source: InterPro
  8. triacyl lipopeptide binding Source: MGI

GO - Biological processi

  1. cell surface pattern recognition receptor signaling pathway Source: MGI
  2. cellular response to bacterial lipopeptide Source: MGI
  3. cellular response to diacyl bacterial lipopeptide Source: MGI
  4. cellular response to lipoteichoic acid Source: MGI
  5. cellular response to peptidoglycan Source: MGI
  6. cellular response to triacyl bacterial lipopeptide Source: MGI
  7. chloramphenicol transport Source: MGI
  8. defense response to Gram-positive bacterium Source: MGI
  9. detection of diacyl bacterial lipopeptide Source: MGI
  10. detection of triacyl bacterial lipopeptide Source: MGI
  11. I-kappaB phosphorylation Source: MGI
  12. induction by symbiont of defense-related host nitric oxide production Source: MGI
  13. inflammatory response Source: UniProtKB-KW
  14. innate immune response Source: UniProtKB-KW
  15. MyD88-dependent toll-like receptor signaling pathway Source: MGI
  16. negative regulation of growth of symbiont in host Source: MGI
  17. negative regulation of interleukin-12 production Source: MGI
  18. negative regulation of interleukin-17 production Source: MGI
  19. positive regulation of chemokine production Source: MGI
  20. positive regulation of cytokine secretion Source: MGI
  21. positive regulation of inflammatory response Source: InterPro
  22. positive regulation of interleukin-6 production Source: MGI
  23. positive regulation of interleukin-8 production Source: MGI
  24. positive regulation of leukocyte migration Source: MGI
  25. positive regulation of macrophage cytokine production Source: MGI
  26. positive regulation of NF-kappaB import into nucleus Source: MGI
  27. positive regulation of NF-kappaB transcription factor activity Source: MGI
  28. positive regulation of nitric oxide biosynthetic process Source: MGI
  29. positive regulation of toll-like receptor signaling pathway Source: MGI
  30. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  31. positive regulation of tumor necrosis factor production Source: MGI
  32. positive regulation of Wnt signaling pathway Source: MGI
  33. response to bacterium Source: MGI
  34. response to molecule of fungal origin Source: MGI
  35. response to peptidoglycan Source: MGI
  36. toll-like receptor 2 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:Tlr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1346060. Tlr2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. external side of plasma membrane Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: MGI
  6. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
  7. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ8K3D9.

Structurei

3D structure databases

ProteinModelPortaliQ8K3D9.
SMRiQ8K3D9. Positions 27-544, 639-784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation
Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG108574.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13504. LRR_7. 2 hits.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL
60 70 80 90 100
TAAMKSLDLS FNKITYIGHG DLRACANLQV LILKSSRINT IEGDAFYSLG
110 120 130 140 150
SLEHLDLSDN HLSSLSSSWF GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN
160 170 180 190 200
LQTLRIGNVE TFSEIRRIDF AGLTSLNELE IKALSLRNYQ SQSLKSIRDI
210 220 230 240 250
HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS PLPVDEVSSP
260 270 280 290 300
MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES
310 320 330 340 350
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL
360 370 380 390 400
VPCSFSQHLK SLEFLDLSEN LMVEEYLKNS ACKGAWPPLQ TLVLSQNHLR
410 420 430 440 450
SMQKTGEILL TLKNLTSLDI SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV
460 470 480 490 500
VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ ELYISRNKLK TLPDASLFPV
510 520 530 540 550
LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE LLSFTMETPA
560 570 580 590 600
LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL
610 620 630 640 650
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ
660 670 680 690 700
DSHWVENLMV QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVRS EWCKYELDFS HFRLFDENND AAILVLLEPI ERKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS
Length:784
Mass (Da):89,459
Last modified:September 30, 2002 - v1
Checksum:iA3FDE8A2994CADD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014693 mRNA. Translation: AAH14693.1.
UniGeneiMm.87596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014693 mRNA. Translation: AAH14693.1.
UniGeneiMm.87596.

3D structure databases

ProteinModelPortaliQ8K3D9.
SMRiQ8K3D9. Positions 27-544, 639-784.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346060. Tlr2.

Phylogenomic databases

HOVERGENiHBG108574.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8K3D9.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13504. LRR_7. 2 hits.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K3D9_MOUSE
AccessioniPrimary (citable) accession number: Q8K3D9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2002
Last sequence update: September 30, 2002
Last modified: March 31, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.