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Q8K3D9 (Q8K3D9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Toll-like receptor PIRNR PIRNR037595
Gene names
Name:Tlr2 EMBL AAH14693.1 MGI 1346060
OrganismMus musculus (Mouse) EMBL AAH14693.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length784 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595

Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
   Biological processImmunity
Inflammatory response PIRNR PIRNR037595
Innate immunity PIRNR PIRNR037595
   Cellular componentMembrane
   DomainLeucine-rich repeat SAAS SAAS000483
Repeat SAAS SAAS000483
Transmembrane
Transmembrane helix SAAS SAAS000483
   Molecular functionReceptor PIRNR PIRNR037595 EMBL AAH14693.1
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Inferred from genetic interaction PubMed 12719478. Source: MGI

cell surface pattern recognition receptor signaling pathway

Inferred from mutant phenotype PubMed 12719478. Source: MGI

cellular response to bacterial lipopeptide

Inferred from mutant phenotype PubMed 15690042. Source: MGI

cellular response to lipoteichoic acid

Inferred from mutant phenotype PubMed 15690042. Source: MGI

cellular response to peptidoglycan

Inferred from mutant phenotype PubMed 16949315. Source: MGI

chloramphenicol transport

Inferred from mutant phenotype PubMed 12091878. Source: MGI

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 11067888PubMed 15690042PubMed 19139201. Source: MGI

induction by symbiont of defense-related host nitric oxide production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 11067888PubMed 15690042. Source: MGI

negative regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 16949315. Source: MGI

negative regulation of interleukin-17 production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

positive regulation of chemokine production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

positive regulation of cytokine secretion

Inferred from genetic interaction PubMed 19770268. Source: MGI

positive regulation of inflammatory response

Inferred from electronic annotation. Source: InterPro

positive regulation of interleukin-6 production

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of leukocyte migration

Inferred from mutant phenotype PubMed 17114491. Source: MGI

positive regulation of macrophage cytokine production

Inferred from mutant phenotype PubMed 10549626. Source: MGI

positive regulation of nitric oxide biosynthetic process

Inferred from mutant phenotype PubMed 10549626PubMed 16239543. Source: MGI

positive regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype PubMed 16239543. Source: MGI

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 10549626PubMed 11067888PubMed 12719478PubMed 15690042PubMed 16239543. Source: MGI

response to molecule of fungal origin

Inferred from mutant phenotype PubMed 12719478. Source: MGI

toll-like receptor 2 signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentToll-like receptor 1-Toll-like receptor 2 protein complex

Inferred from sequence orthology PubMed 17889651. Source: MGI

Toll-like receptor 2-Toll-like receptor 6 protein complex

Inferred from physical interaction PubMed 19931471. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 15220916. Source: MGI

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondiacyl lipopeptide binding

Inferred from direct assay PubMed 17889651PubMed 19931471. Source: MGI

lipoteichoic acid binding

Inferred from direct assay PubMed 19931471. Source: MGI

protein heterodimerization activity

Inferred from sequence orthology PubMed 17889651. Source: MGI

transmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

triacyl lipopeptide binding

Inferred from direct assay PubMed 17889651. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8K3D9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A3FDE8A2994CADD0

FASTA78489,459
        10         20         30         40         50         60 
MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL TAAMKSLDLS 

        70         80         90        100        110        120 
FNKITYIGHG DLRACANLQV LILKSSRINT IEGDAFYSLG SLEHLDLSDN HLSSLSSSWF 

       130        140        150        160        170        180 
GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN LQTLRIGNVE TFSEIRRIDF AGLTSLNELE 

       190        200        210        220        230        240 
IKALSLRNYQ SQSLKSIRDI HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS 

       250        260        270        280        290        300 
PLPVDEVSSP MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 

       310        320        330        340        350        360 
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 

       370        380        390        400        410        420 
SLEFLDLSEN LMVEEYLKNS ACKGAWPPLQ TLVLSQNHLR SMQKTGEILL TLKNLTSLDI 

       430        440        450        460        470        480 
SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 

       490        500        510        520        530        540 
ELYISRNKLK TLPDASLFPV LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE 

       550        560        570        580        590        600 
LLSFTMETPA LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 

       610        620        630        640        650        660 
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ DSHWVENLMV 

       670        680        690        700        710        720 
QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 

       730        740        750        760        770        780 
HFRLFDENND AAILVLLEPI ERKAIPQRFC KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT 


AIKS

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH14693.1.
Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH14693.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC014693 mRNA. Translation: AAH14693.1.
IPIIPI00131898.
UniGeneMm.87596.

3D structure databases

HSSPHSSP built from PDB template 1O77 based on UniProtKB O60603.
ProteinModelPortalQ8K3D9.
SMRQ8K3D9. Positions 27-544, 639-784.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1346060. Tlr2.

Phylogenomic databases

HOVERGENHBG108574.
InParanoidQ8K3D9.

Gene expression databases

GenevestigatorQ8K3D9.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. TIR. 1 hit.
PROSITEPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8K3D9_MOUSE
AccessionPrimary (citable) accession number: Q8K3D9
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info