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Protein

Toll-like receptor

Gene

Tlr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • diacyl lipopeptide binding Source: MGI
  • lipopolysaccharide binding Source: MGI
  • lipoteichoic acid binding Source: MGI
  • peptidoglycan binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • receptor activity Source: MGI
  • signaling pattern recognition receptor activity Source: MGI
  • transmembrane signaling receptor activity Source: InterPro
  • triacyl lipopeptide binding Source: MGI

GO - Biological processi

  • cell surface pattern recognition receptor signaling pathway Source: MGI
  • cellular response to bacterial lipopeptide Source: MGI
  • cellular response to diacyl bacterial lipopeptide Source: MGI
  • cellular response to lipoteichoic acid Source: MGI
  • cellular response to peptidoglycan Source: MGI
  • cellular response to triacyl bacterial lipopeptide Source: MGI
  • chloramphenicol transport Source: MGI
  • cytokine secretion involved in immune response Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • detection of diacyl bacterial lipopeptide Source: MGI
  • detection of triacyl bacterial lipopeptide Source: MGI
  • I-kappaB phosphorylation Source: MGI
  • induction by symbiont of defense-related host nitric oxide production Source: MGI
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • interleukin-10 production Source: MGI
  • MyD88-dependent toll-like receptor signaling pathway Source: MGI
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of interleukin-12 production Source: MGI
  • negative regulation of interleukin-17 production Source: MGI
  • positive regulation of chemokine production Source: MGI
  • positive regulation of cytokine secretion Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of inflammatory response Source: InterPro
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of interleukin-8 production Source: MGI
  • positive regulation of leukocyte migration Source: MGI
  • positive regulation of macrophage cytokine production Source: MGI
  • positive regulation of NF-kappaB import into nucleus Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of NIK/NF-kappaB signaling Source: MGI
  • positive regulation of nitric oxide biosynthetic process Source: MGI
  • positive regulation of toll-like receptor signaling pathway Source: MGI
  • positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • positive regulation of xenophagy Source: MGI
  • regulation of dendritic cell cytokine production Source: MGI
  • response to bacterium Source: MGI
  • response to molecule of fungal origin Source: MGI
  • response to peptidoglycan Source: MGI
  • toll-like receptor 2 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationSAAS annotationImported

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:Tlr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1346060. Tlr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei589 – 61224HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 784760Toll-like receptorSequence analysisPRO_5004309049Add
BLAST

Proteomic databases

PaxDbiQ8K3D9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029623.

Structurei

3D structure databases

ProteinModelPortaliQ8K3D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini639 – 784146TIRInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation
Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiCOG4886. LUCA.
KOG4641. Eukaryota.
HOVERGENiHBG108574.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL
60 70 80 90 100
TAAMKSLDLS FNKITYIGHG DLRACANLQV LILKSSRINT IEGDAFYSLG
110 120 130 140 150
SLEHLDLSDN HLSSLSSSWF GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN
160 170 180 190 200
LQTLRIGNVE TFSEIRRIDF AGLTSLNELE IKALSLRNYQ SQSLKSIRDI
210 220 230 240 250
HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS PLPVDEVSSP
260 270 280 290 300
MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES
310 320 330 340 350
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL
360 370 380 390 400
VPCSFSQHLK SLEFLDLSEN LMVEEYLKNS ACKGAWPPLQ TLVLSQNHLR
410 420 430 440 450
SMQKTGEILL TLKNLTSLDI SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV
460 470 480 490 500
VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ ELYISRNKLK TLPDASLFPV
510 520 530 540 550
LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE LLSFTMETPA
560 570 580 590 600
LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL
610 620 630 640 650
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ
660 670 680 690 700
DSHWVENLMV QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVRS EWCKYELDFS HFRLFDENND AAILVLLEPI ERKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS
Length:784
Mass (Da):89,459
Last modified:October 1, 2002 - v1
Checksum:iA3FDE8A2994CADD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014693 mRNA. Translation: AAH14693.1.
UniGeneiMm.87596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014693 mRNA. Translation: AAH14693.1.
UniGeneiMm.87596.

3D structure databases

ProteinModelPortaliQ8K3D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029623.

Proteomic databases

PaxDbiQ8K3D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346060. Tlr2.

Phylogenomic databases

eggNOGiCOG4886. LUCA.
KOG4641. Eukaryota.
HOVERGENiHBG108574.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K3D9_MOUSE
AccessioniPrimary (citable) accession number: Q8K3D9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 20, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.