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Q8K3D9

- Q8K3D9_MOUSE

UniProt

Q8K3D9 - Q8K3D9_MOUSE

Protein

Toll-like receptor

Gene

Tlr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. diacyl lipopeptide binding Source: MGI
    2. lipoteichoic acid binding Source: MGI
    3. protein heterodimerization activity Source: MGI
    4. transmembrane signaling receptor activity Source: InterPro
    5. triacyl lipopeptide binding Source: MGI

    GO - Biological processi

    1. cell surface pattern recognition receptor signaling pathway Source: MGI
    2. cellular response to bacterial lipopeptide Source: MGI
    3. cellular response to lipoteichoic acid Source: MGI
    4. cellular response to peptidoglycan Source: MGI
    5. chloramphenicol transport Source: MGI
    6. defense response to Gram-positive bacterium Source: MGI
    7. induction by symbiont of defense-related host nitric oxide production Source: MGI
    8. inflammatory response Source: UniProtKB-KW
    9. innate immune response Source: UniProtKB-KW
    10. MyD88-dependent toll-like receptor signaling pathway Source: MGI
    11. negative regulation of growth of symbiont in host Source: MGI
    12. negative regulation of interleukin-12 production Source: MGI
    13. negative regulation of interleukin-17 production Source: MGI
    14. positive regulation of chemokine production Source: MGI
    15. positive regulation of cytokine secretion Source: MGI
    16. positive regulation of inflammatory response Source: InterPro
    17. positive regulation of interleukin-6 production Source: MGI
    18. positive regulation of leukocyte migration Source: MGI
    19. positive regulation of macrophage cytokine production Source: MGI
    20. positive regulation of nitric oxide biosynthetic process Source: MGI
    21. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
    22. positive regulation of tumor necrosis factor production Source: MGI
    23. response to bacterium Source: MGI
    24. response to molecule of fungal origin Source: MGI
    25. response to peptidoglycan Source: MGI
    26. toll-like receptor 2 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptorUniRule annotation
    Gene namesi
    Name:Tlr2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1346060. Tlr2.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI
    4. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
    5. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K3D9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K3D9.
    SMRiQ8K3D9. Positions 27-544, 639-784.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.UniRule annotation
    Contains TIR domain.SAAS annotation

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG108574.
    InParanoidiQ8K3D9.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
    PfamiPF13504. LRR_7. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K3D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL    50
    TAAMKSLDLS FNKITYIGHG DLRACANLQV LILKSSRINT IEGDAFYSLG 100
    SLEHLDLSDN HLSSLSSSWF GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN 150
    LQTLRIGNVE TFSEIRRIDF AGLTSLNELE IKALSLRNYQ SQSLKSIRDI 200
    HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS PLPVDEVSSP 250
    MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 300
    DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL 350
    VPCSFSQHLK SLEFLDLSEN LMVEEYLKNS ACKGAWPPLQ TLVLSQNHLR 400
    SMQKTGEILL TLKNLTSLDI SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV 450
    VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ ELYISRNKLK TLPDASLFPV 500
    LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE LLSFTMETPA 550
    LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 600
    LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ 650
    DSHWVENLMV QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV 700
    FVLSENFVRS EWCKYELDFS HFRLFDENND AAILVLLEPI ERKAIPQRFC 750
    KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS 784
    Length:784
    Mass (Da):89,459
    Last modified:October 1, 2002 - v1
    Checksum:iA3FDE8A2994CADD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014693 mRNA. Translation: AAH14693.1.
    UniGeneiMm.87596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014693 mRNA. Translation: AAH14693.1 .
    UniGenei Mm.87596.

    3D structure databases

    ProteinModelPortali Q8K3D9.
    SMRi Q8K3D9. Positions 27-544, 639-784.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1346060. Tlr2.

    Phylogenomic databases

    HOVERGENi HBG108574.
    InParanoidi Q8K3D9.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8K3D9.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
    Pfami PF13504. LRR_7. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ8K3D9_MOUSE
    AccessioniPrimary (citable) accession number: Q8K3D9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)