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Protein

Solute carrier family 35 member E4

Gene

Slc35e4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E4
Gene namesi
Name:Slc35e4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144150. Slc35e4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Solute carrier family 35 member E4PRO_0000298928Add
BLAST

Proteomic databases

PaxDbiQ8K3D6.
PRIDEiQ8K3D6.

PTM databases

PhosphoSiteiQ8K3D6.

Expressioni

Gene expression databases

BgeeiQ8K3D6.
CleanExiMM_SLC35E4.
GenevisibleiQ8K3D6. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 17955EamAAdd
BLAST

Sequence similaritiesi

Contains 1 EamA domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00730000111291.
HOGENOMiHOG000137347.
HOVERGENiHBG095658.
InParanoidiQ8K3D6.
KOiK15286.
OMAiKSVQQSA.
OrthoDBiEOG7XWPP4.
PhylomeDBiQ8K3D6.
TreeFamiTF328788.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K3D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRCPLEHHE GMMTSAEAVA VAGSAQEHGR PKWPPDKPQV LGQPAPARVV
60 70 80 90 100
VAALVWLLAG ASMSSLNKWI FTVHGFGRPL LLSALHMLAA ALACHWGAQR
110 120 130 140 150
PVPHSIHRRV LLLSLTFGTS MACGNVGLST VPLDLAQLAT TTTPLFTMAL
160 170 180 190 200
SALLLGRRHH PLQFAAMGPL CLGAACSLAG ELRAPPAGCG FLLVATCLRG
210 220 230 240 250
FKSVQQSGAL LQEERLDTVT LLYATSLPSF CLLASAALVL EAGTAPPLPP
260 270 280 290 300
TDSRLWACVL LSCFLSVVYN LASFSLLALT SALTVHVLGN LMVVGNLILS
310 320 330 340 350
RLLFGSHLSA LSYLGITLTL SGMFLYHNCE LVASWATRWG LWNRDQPGKG

L
Length:351
Mass (Da):37,253
Last modified:August 21, 2007 - v2
Checksum:iD1CCE2DF8DA36A44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081Missing in BAC30453 (PubMed:16141072).Curated
Sequence conflicti208 – 2081Missing in AAH20181 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039786 mRNA. Translation: BAC30453.1.
AL731853 Genomic DNA. Translation: CAI51862.1.
BC020181 mRNA. Translation: AAH20181.1.
RefSeqiNP_694782.1. NM_153142.3.
UniGeneiMm.171514.

Genome annotation databases

EnsembliENSMUST00000109995; ENSMUSP00000105622; ENSMUSG00000048807.
GeneIDi103710.
KEGGimmu:103710.
UCSCiuc007htv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039786 mRNA. Translation: BAC30453.1.
AL731853 Genomic DNA. Translation: CAI51862.1.
BC020181 mRNA. Translation: AAH20181.1.
RefSeqiNP_694782.1. NM_153142.3.
UniGeneiMm.171514.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K3D6.

Proteomic databases

PaxDbiQ8K3D6.
PRIDEiQ8K3D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109995; ENSMUSP00000105622; ENSMUSG00000048807.
GeneIDi103710.
KEGGimmu:103710.
UCSCiuc007htv.1. mouse.

Organism-specific databases

CTDi339665.
MGIiMGI:2144150. Slc35e4.

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00730000111291.
HOGENOMiHOG000137347.
HOVERGENiHBG095658.
InParanoidiQ8K3D6.
KOiK15286.
OMAiKSVQQSA.
OrthoDBiEOG7XWPP4.
PhylomeDBiQ8K3D6.
TreeFamiTF328788.

Miscellaneous databases

ChiTaRSiSlc35e4. mouse.
NextBioi356065.
PROiQ8K3D6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K3D6.
CleanExiMM_SLC35E4.
GenevisibleiQ8K3D6. MM.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS35E4_MOUSE
AccessioniPrimary (citable) accession number: Q8K3D6
Secondary accession number(s): Q5F205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: February 17, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.