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Unreviewed, UniProtKB/TrEMBL Q8K3B3 (Q8K3B3_MOUSE)

Last modified February 9, 2010. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (P85 alpha) EMBL AAH26146.1
Gene names
Name: Pik3r1 EMBL AAH26146.1
ORF Names: mCG_115224 EMBL EDL00772.1
OrganismMus musculus (Mouse) EMBL AAH26146.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length724 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Molecular functionKinase EMBL AAH26146.1
Transferase
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: Compara

negative regulation of cell-cell adhesion

Inferred from electronic annotation. Source: Compara

negative regulation of proteolysis

Inferred from electronic annotation. Source: Compara

positive regulation of anti-apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of cell migration

Inferred from electronic annotation. Source: Compara

positive regulation of myoblast differentiation

Inferred from electronic annotation. Source: Compara

response to cAMP

Inferred from electronic annotation. Source: Compara

response to estrogen stimulus

Inferred from electronic annotation. Source: Compara

response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Compara

response to insulin stimulus

Inferred from electronic annotation. Source: Compara

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentphosphoinositide 3-kinase complex

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionkinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoinositide 3-kinase regulator activity

Inferred from electronic annotation. Source: InterPro

protein C-terminus binding

Inferred from electronic annotation. Source: Compara

protein domain specific binding

Inferred from electronic annotation. Source: Compara

protein kinase binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q8K3B3-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9975D7AD8BABBA9C

FASTA72483,517
        10         20         30         40         50         60 
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EDIGWLNGYN 

        70         80         90        100        110        120 
ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 

       130        140        150        160        170        180 
QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 

       190        200        210        220        230        240 
VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 

       250        260        270        280        290        300 
QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 

       310        320        330        340        350        360 
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 

       370        380        390        400        410        420 
STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 

       430        440        450        460        470        480 
DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 

       490        500        510        520        530        540 
RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID 

       550        560        570        580        590        600 
SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 

       610        620        630        640        650        660 
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 

       670        680        690        700        710        720 
VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA 


QQRR

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References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH26146.1.
Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH26146.1.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL00772.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL00772.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC026146 mRNA. Translation: AAH26146.1.
CH466567 Genomic DNA. Translation: EDL00772.1.
IPIIPI00322466.
PIRA38747.
RefSeqNP_001070963.1.
UniGeneMm.259333

3D structure databases

HSSPHSSP built from PDB template 1BFI based on UniProtKB P23727.
SMRQ8K3B3. Positions 1-84, 89-294, 115-309, 328-431, 431-600, 614-724.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8K3B3.

Proteomic databases

PRIDEQ8K3B3.

Genome annotation databases

EnsemblENSMUST00000055518; ENSMUSP00000056774; ENSMUSG00000041417; Mus musculus. [Genome view]
GeneID18708.
UCSCuc007rrt.1. mouse.

Organism-specific databases

CTD18708.
MGIMGI:97583. Pik3r1.

Phylogenomic databases

HOVERGENQ8K3B3.
InParanoidQ8K3B3.
OMADLEMIDV.
OrthoDBEOG9HDWCT.
PhylomeDBQ8K3B3.

Gene expression databases

ArrayExpressQ8K3B3.
BgeeQ8K3B3.
GenevestigatorQ8K3B3.

Family and domain databases

InterProIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
Gene3DG3DSA:1.10.555.10. RhoGAP. 1 hit.
G3DSA:3.30.505.10. SH2. 2 hits.
PANTHERPTHR10155. PI3kinase_P85. 1 hit.
PfamPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
PROSITEPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio294779.
SOURCESearch...

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Entry information

Entry nameQ8K3B3_MOUSE
AccessionPrimary (citable) accession number: Q8K3B3
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information