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Protein

Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Gene

Hscb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.By similarity

Pathwayi: iron-sulfur cluster biosynthesis

This protein is involved in the pathway iron-sulfur cluster biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway iron-sulfur cluster biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Divalent metal cationBy similarity
Metal bindingi43 – 431Divalent metal cationBy similarity
Metal bindingi57 – 571Divalent metal cationBy similarity
Metal bindingi60 – 601Divalent metal cationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00266.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
Alternative name(s):
Hsc20
Gene namesi
Name:Hscb
Synonyms:Hsc20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2141135. Hscb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence analysisAdd
BLAST
Chaini30 – 234205Iron-sulfur cluster co-chaperone protein HscB, mitochondrialPRO_0000007263Add
BLAST

Proteomic databases

EPDiQ8K3A0.
MaxQBiQ8K3A0.
PaxDbiQ8K3A0.
PeptideAtlasiQ8K3A0.
PRIDEiQ8K3A0.

2D gel databases

REPRODUCTION-2DPAGEIPI00170051.
Q8K3A0.

PTM databases

iPTMnetiQ8K3A0.
PhosphoSiteiQ8K3A0.

Expressioni

Gene expression databases

BgeeiQ8K3A0.

Interactioni

Subunit structurei

Interacts with ISCU and HSPA9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062811.

Structurei

3D structure databases

ProteinModelPortaliQ8K3A0.
SMRiQ8K3A0. Positions 38-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 14373JAdd
BLAST

Sequence similaritiesi

Belongs to the HscB family.Curated
Contains 1 J domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3192. Eukaryota.
COG1076. LUCA.
HOGENOMiHOG000006786.
HOVERGENiHBG051931.
InParanoidiQ8K3A0.
KOiK04082.
OrthoDBiEOG7B8S5Q.
PhylomeDBiQ8K3A0.
TreeFamiTF319992.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
1.20.1280.20. 1 hit.
HAMAPiMF_00682. HscB.
InterProiIPR001623. DnaJ_domain.
IPR004640. HscB.
IPR009073. HscB_oligo_C.
[Graphical view]
PANTHERiPTHR14021. PTHR14021. 1 hit.
PfamiPF07743. HSCB_C. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF47144. SSF47144. 1 hit.
TIGRFAMsiTIGR00714. hscB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K3A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGCGARALL GVWEVRLAGF LGRRLLGSNA AAGKSIAPQC WNCGHAREAG
60 70 80 90 100
CGDEFFCSHC RALQPPDPTR DYFSLMNCNR SFRVDVTKLQ HRYQQLQRLV
110 120 130 140 150
HPDFFSQKSQ TEKHFSDKHS TLVNDAYKTL QAPLTRGLYL LKLQGIEIPE
160 170 180 190 200
GTDYKADSQF LVEIMEINER LADAQSEAAM EEIEATVRAK QKEFTDNINS
210 220 230
AFEQGDFEKA KELLTKMRYF SNIEEKIKLS KTPL
Length:234
Mass (Da):26,645
Last modified:March 29, 2004 - v2
Checksum:iAA9544500EC4F59B
GO

Sequence cautioni

The sequence AAH27641.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → V in BAE20904 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131961 mRNA. Translation: BAE20904.1.
BC027641 mRNA. Translation: AAH27641.1. Different initiation.
CCDSiCCDS51613.1.
RefSeqiNP_705799.2. NM_153571.2.
UniGeneiMm.200231.

Genome annotation databases

GeneIDi100900.
KEGGimmu:100900.
UCSCiuc008yrv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131961 mRNA. Translation: BAE20904.1.
BC027641 mRNA. Translation: AAH27641.1. Different initiation.
CCDSiCCDS51613.1.
RefSeqiNP_705799.2. NM_153571.2.
UniGeneiMm.200231.

3D structure databases

ProteinModelPortaliQ8K3A0.
SMRiQ8K3A0. Positions 38-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062811.

PTM databases

iPTMnetiQ8K3A0.
PhosphoSiteiQ8K3A0.

2D gel databases

REPRODUCTION-2DPAGEIPI00170051.
Q8K3A0.

Proteomic databases

EPDiQ8K3A0.
MaxQBiQ8K3A0.
PaxDbiQ8K3A0.
PeptideAtlasiQ8K3A0.
PRIDEiQ8K3A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100900.
KEGGimmu:100900.
UCSCiuc008yrv.2. mouse.

Organism-specific databases

CTDi150274.
MGIiMGI:2141135. Hscb.

Phylogenomic databases

eggNOGiKOG3192. Eukaryota.
COG1076. LUCA.
HOGENOMiHOG000006786.
HOVERGENiHBG051931.
InParanoidiQ8K3A0.
KOiK04082.
OrthoDBiEOG7B8S5Q.
PhylomeDBiQ8K3A0.
TreeFamiTF319992.

Enzyme and pathway databases

UniPathwayiUPA00266.

Miscellaneous databases

ChiTaRSiHscb. mouse.
PROiQ8K3A0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K3A0.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
1.20.1280.20. 1 hit.
HAMAPiMF_00682. HscB.
InterProiIPR001623. DnaJ_domain.
IPR004640. HscB.
IPR009073. HscB_oligo_C.
[Graphical view]
PANTHERiPTHR14021. PTHR14021. 1 hit.
PfamiPF07743. HSCB_C. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF47144. SSF47144. 1 hit.
TIGRFAMsiTIGR00714. hscB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiHSC20_MOUSE
AccessioniPrimary (citable) accession number: Q8K3A0
Secondary accession number(s): Q3V294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.