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Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.1 Publication

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi414Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi446Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi482Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Alternative name(s):
Stromal cell-derived receptor 2
Short name:
SDR-2
Gene namesi
Name:FRRS1
Synonyms:Sdfr2, Sdr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108076 Frrs1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei415 – 435Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei446 – 466Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei477 – 499Helical; Name=5Sequence analysisAdd BLAST23
Transmembranei515 – 535Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei569 – 589Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148441 – 592Ferric-chelate reductase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi353N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K385
PaxDbiQ8K385
PeptideAtlasiQ8K385
PRIDEiQ8K385

PTM databases

iPTMnetiQ8K385

Expressioni

Tissue specificityi

Expressed in spleen, liver and kidney with low expression in brain. Localizes in adult brain to the choroid plexus of the fourth, third, and lateral ventricles and to ependymal cells that line the ventricles.2 Publications

Inductioni

Down-regulated in kidney and liver of mice lacking hypotransferrinemic (hpx), which have iron overload of the liver and pancreas.1 Publication

Gene expression databases

CleanExiMM_FRRS1

Interactioni

Protein-protein interaction databases

BioGridi203144, 1 interactor
STRINGi10090.ENSMUSP00000039487

Structurei

3D structure databases

ProteinModelPortaliQ8K385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 179ReelinPROSITE-ProRule annotationAdd BLAST167
Domaini216 – 331DOMONPROSITE-ProRule annotationAdd BLAST116
Domaini335 – 534Cytochrome b561PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the FRRS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4293 Eukaryota
ENOG410XR70 LUCA
HOGENOMiHOG000112648
HOVERGENiHBG107929
InParanoidiQ8K385
PhylomeDBiQ8K385
TreeFamiTF316169

Family and domain databases

CDDicd08544 Reeler, 1 hit
InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
IPR005018 DOMON_domain
IPR002861 Reeler_dom
PfamiView protein in Pfam
PF03351 DOMON, 1 hit
PF02014 Reeler, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
SM00664 DoH, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit
PS50836 DOMON, 1 hit
PS51019 REELIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQITLSV LVIALLTCSV TAYPNGKVPM SCGGMIPQHN HSPQSEPIHQ
60 70 80 90 100
ITVSQTTFKP GDQIEVTLSG PPFRGFLLEA RDAENLSGPP IGSFTLIDSE
110 120 130 140 150
ESQLLTCTDV QGLAVSHTRS SKKTEIKVYW DAPSPAPDHI RFLATVVQKF
160 170 180 190 200
KIYWVKIPSP VISQPNAPPF TTPKATTQPL TTPPSVSHLT KPFSAFECGN
210 220 230 240 250
KKFCVRSPLN CDPEKEPACV FLSFTRDNQS VMVEMSGPSD GYVSFAFSHD
260 270 280 290 300
QWMGDDDAYL CIREDQTVDI QPSYLTGRSY PVMDSRGTLE DMAWRLADGV
310 320 330 340 350
IQCSFRRNIT LPEAKNRFVL NESYYIFFAE GPSHDGRIFR HSQQPLITYE
360 370 380 390 400
KYNVTDTPKS VGGSRSSPLL KAHGALMFVA WMTTVSIGVL VARFFRSVWS
410 420 430 440 450
KAFFLREAAW FQVHRMLMVA TSLLTCVAFV LPFVYRGGWS WRAGYHPYLG
460 470 480 490 500
CTVMTLAVLQ PLLATFRPPL HDPRRQVFNW THWSVGTAAR IIAVAAMFLG
510 520 530 540 550
MDLPGLNLPS PQKTYAMMGF VVWHIGTEVI LEIHAYRLSR KVEILDNDRI
560 570 580 590
QILQSLTVAE AEGHVFKKVV LAVYICGNVI FLSIFLSAIN HI
Length:592
Mass (Da):66,047
Last modified:October 1, 2002 - v1
Checksum:iEAC9146163E85ED3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti61G → E in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti65E → K in BAE26143 (PubMed:16141072).Curated1
Sequence conflicti65E → K in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti65E → K in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti272P → S in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti272P → S in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti299G → S in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti299G → S in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti419V → I in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti428A → G in BAA09055 (PubMed:8938438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50464 mRNA Translation: BAA09055.1
AK144933 mRNA Translation: BAE26143.1
AK162693 mRNA Translation: BAE37025.1
AK167289 mRNA Translation: BAE39395.1
BC027770 mRNA Translation: AAH27770.1
CCDSiCCDS17792.1
RefSeqiNP_001106950.1, NM_001113478.1
NP_033172.2, NM_009146.3
UniGeneiMm.66293

Genome annotation databases

GeneIDi20321
KEGGimmu:20321
UCSCiuc008rcv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFRRS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K385
Secondary accession number(s): P97301, Q3TJV0, Q3UMF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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