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Protein

Ferric-chelate reductase 1

Gene

FRRS1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.1 Publication

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi414Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi446Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi482Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric-chelate reductase 1 (EC:1.-.-.-)
Alternative name(s):
Stromal cell-derived receptor 2
Short name:
SDR-2
Gene namesi
Name:FRRS1
Synonyms:Sdfr2, Sdr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108076. Frrs1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei415 – 435Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei446 – 466Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei477 – 499Helical; Name=5Sequence analysisAdd BLAST23
Transmembranei515 – 535Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei569 – 589Helical; Name=7Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148441 – 592Ferric-chelate reductase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)1 Publication1
Glycosylationi353N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K385.
PaxDbiQ8K385.
PeptideAtlasiQ8K385.
PRIDEiQ8K385.

Expressioni

Tissue specificityi

Expressed in spleen, liver and kidney with low expression in brain. Localizes in adult brain to the choroid plexus of the fourth, third, and lateral ventricles and to ependymal cells that line the ventricles.2 Publications

Inductioni

Down-regulated in kidney and liver of mice lacking hypotransferrinemic (hpx), which have iron overload of the liver and pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000033386.
CleanExiMM_FRRS1.

Interactioni

Protein-protein interaction databases

BioGridi203144. 1 interactor.
STRINGi10090.ENSMUSP00000039487.

Structurei

3D structure databases

ProteinModelPortaliQ8K385.
SMRiQ8K385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 179ReelinPROSITE-ProRule annotationAdd BLAST167
Domaini216 – 331DOMONPROSITE-ProRule annotationAdd BLAST116
Domaini335 – 534Cytochrome b561PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the FRRS1 family.Curated
Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation
Contains 1 DOMON domain.PROSITE-ProRule annotation
Contains 1 reelin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiQ8K385.
PhylomeDBiQ8K385.
TreeFamiTF316169.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQITLSV LVIALLTCSV TAYPNGKVPM SCGGMIPQHN HSPQSEPIHQ
60 70 80 90 100
ITVSQTTFKP GDQIEVTLSG PPFRGFLLEA RDAENLSGPP IGSFTLIDSE
110 120 130 140 150
ESQLLTCTDV QGLAVSHTRS SKKTEIKVYW DAPSPAPDHI RFLATVVQKF
160 170 180 190 200
KIYWVKIPSP VISQPNAPPF TTPKATTQPL TTPPSVSHLT KPFSAFECGN
210 220 230 240 250
KKFCVRSPLN CDPEKEPACV FLSFTRDNQS VMVEMSGPSD GYVSFAFSHD
260 270 280 290 300
QWMGDDDAYL CIREDQTVDI QPSYLTGRSY PVMDSRGTLE DMAWRLADGV
310 320 330 340 350
IQCSFRRNIT LPEAKNRFVL NESYYIFFAE GPSHDGRIFR HSQQPLITYE
360 370 380 390 400
KYNVTDTPKS VGGSRSSPLL KAHGALMFVA WMTTVSIGVL VARFFRSVWS
410 420 430 440 450
KAFFLREAAW FQVHRMLMVA TSLLTCVAFV LPFVYRGGWS WRAGYHPYLG
460 470 480 490 500
CTVMTLAVLQ PLLATFRPPL HDPRRQVFNW THWSVGTAAR IIAVAAMFLG
510 520 530 540 550
MDLPGLNLPS PQKTYAMMGF VVWHIGTEVI LEIHAYRLSR KVEILDNDRI
560 570 580 590
QILQSLTVAE AEGHVFKKVV LAVYICGNVI FLSIFLSAIN HI
Length:592
Mass (Da):66,047
Last modified:October 1, 2002 - v1
Checksum:iEAC9146163E85ED3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti61G → E in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti65E → K in BAE26143 (PubMed:16141072).Curated1
Sequence conflicti65E → K in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti65E → K in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti272P → S in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti272P → S in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti299G → S in BAE39395 (PubMed:16141072).Curated1
Sequence conflicti299G → S in BAE37025 (PubMed:16141072).Curated1
Sequence conflicti419V → I in BAA09055 (PubMed:8938438).Curated1
Sequence conflicti428A → G in BAA09055 (PubMed:8938438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50464 mRNA. Translation: BAA09055.1.
AK144933 mRNA. Translation: BAE26143.1.
AK162693 mRNA. Translation: BAE37025.1.
AK167289 mRNA. Translation: BAE39395.1.
BC027770 mRNA. Translation: AAH27770.1.
CCDSiCCDS17792.1.
RefSeqiNP_001106950.1. NM_001113478.1.
NP_033172.2. NM_009146.3.
UniGeneiMm.66293.

Genome annotation databases

GeneIDi20321.
KEGGimmu:20321.
UCSCiuc008rcv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50464 mRNA. Translation: BAA09055.1.
AK144933 mRNA. Translation: BAE26143.1.
AK162693 mRNA. Translation: BAE37025.1.
AK167289 mRNA. Translation: BAE39395.1.
BC027770 mRNA. Translation: AAH27770.1.
CCDSiCCDS17792.1.
RefSeqiNP_001106950.1. NM_001113478.1.
NP_033172.2. NM_009146.3.
UniGeneiMm.66293.

3D structure databases

ProteinModelPortaliQ8K385.
SMRiQ8K385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203144. 1 interactor.
STRINGi10090.ENSMUSP00000039487.

Proteomic databases

MaxQBiQ8K385.
PaxDbiQ8K385.
PeptideAtlasiQ8K385.
PRIDEiQ8K385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20321.
KEGGimmu:20321.
UCSCiuc008rcv.2. mouse.

Organism-specific databases

CTDi391059.
MGIiMGI:108076. Frrs1.

Phylogenomic databases

eggNOGiKOG4293. Eukaryota.
ENOG410XR70. LUCA.
HOGENOMiHOG000112648.
HOVERGENiHBG107929.
InParanoidiQ8K385.
PhylomeDBiQ8K385.
TreeFamiTF316169.

Miscellaneous databases

ChiTaRSiFrrs1. mouse.
PROiQ8K385.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033386.
CleanExiMM_FRRS1.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR005018. DOMON_domain.
IPR002861. Reeler_dom.
[Graphical view]
PfamiPF03351. DOMON. 1 hit.
PF02014. Reeler. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
SM00664. DoH. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
PS50836. DOMON. 1 hit.
PS51019. REELIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRRS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K385
Secondary accession number(s): P97301, Q3TJV0, Q3UMF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.