Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

Lrrtm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • exploration behavior Source: MGI
  • locomotory behavior Source: MGI
  • long-term synaptic potentiation Source: MGI
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • negative regulation of receptor internalization Source: MGI
  • positive regulation of synapse assembly Source: MGI
  • protein localization to synapse Source: MGI
  • synapse organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:Lrrtm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2389173. Lrrtm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 427ExtracellularSequence analysisAdd BLAST393
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 522CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001835135 – 522Leucine-rich repeat transmembrane neuronal protein 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K377.
PaxDbiQ8K377.
PeptideAtlasiQ8K377.
PRIDEiQ8K377.

PTM databases

PhosphoSitePlusiQ8K377.

Expressioni

Tissue specificityi

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate.2 Publications

Developmental stagei

Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000060780.
CleanExiMM_LRRTM1.
ExpressionAtlasiQ8K377. baseline and differential.
GenevisibleiQ8K377. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8K377. 1 interactor.
STRINGi10090.ENSMUSP00000020400.

Structurei

3D structure databases

ProteinModelPortaliQ8K377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 63LRRNTAdd BLAST29
Repeati64 – 87LRR 1Add BLAST24
Repeati89 – 111LRR 2Add BLAST23
Repeati112 – 135LRR 3Add BLAST24
Repeati136 – 159LRR 4Add BLAST24
Repeati161 – 183LRR 5Add BLAST23
Repeati184 – 207LRR 6Add BLAST24
Repeati209 – 231LRR 7Add BLAST23
Repeati233 – 255LRR 8Add BLAST23
Repeati256 – 278LRR 9Add BLAST23
Repeati280 – 302LRR 10Add BLAST23
Domaini314 – 365LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8K377.
KOiK16665.
OMAiSRNVCAL.
OrthoDBiEOG091G03BI.
PhylomeDBiQ8K377.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL
60 70 80 90 100
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH
110 120 130 140 150
ICSVQGDAFQ KLRRVKELTL SSNQITELAN TTFRPMPNLR SVDLSYNKLQ
160 170 180 190 200
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL
210 220 230 240 250
ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL RRNKVAIVVS
260 270 280 290 300
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL
310 320 330 340 350
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG
360 370 380 390 400
EDVLDAVYAF HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE
410 420 430 440 450
GHDGTFEPIT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW
460 470 480 490 500
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA
510 520
LVIINEYGSC TCHQQPAREC EV
Length:522
Mass (Da):58,718
Last modified:October 1, 2002 - v1
Checksum:i6EBBA18034539DCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182025 mRNA. Translation: AAO67546.1.
AK053345 mRNA. Translation: BAC35354.1.
AK053364 mRNA. Translation: BAC35363.1.
AK136857 mRNA. Translation: BAE23148.1.
BC027803 mRNA. Translation: AAH27803.1.
CCDSiCCDS39522.1.
RefSeqiNP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGeneiMm.292568.

Genome annotation databases

EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
GeneIDi74342.
KEGGimmu:74342.
UCSCiuc009cjt.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182025 mRNA. Translation: AAO67546.1.
AK053345 mRNA. Translation: BAC35354.1.
AK053364 mRNA. Translation: BAC35363.1.
AK136857 mRNA. Translation: BAE23148.1.
BC027803 mRNA. Translation: AAH27803.1.
CCDSiCCDS39522.1.
RefSeqiNP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGeneiMm.292568.

3D structure databases

ProteinModelPortaliQ8K377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K377. 1 interactor.
STRINGi10090.ENSMUSP00000020400.

PTM databases

PhosphoSitePlusiQ8K377.

Proteomic databases

MaxQBiQ8K377.
PaxDbiQ8K377.
PeptideAtlasiQ8K377.
PRIDEiQ8K377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
GeneIDi74342.
KEGGimmu:74342.
UCSCiuc009cjt.1. mouse.

Organism-specific databases

CTDi347730.
MGIiMGI:2389173. Lrrtm1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8K377.
KOiK16665.
OMAiSRNVCAL.
OrthoDBiEOG091G03BI.
PhylomeDBiQ8K377.
TreeFamiTF332659.

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

PROiQ8K377.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060780.
CleanExiMM_LRRTM1.
ExpressionAtlasiQ8K377. baseline and differential.
GenevisibleiQ8K377. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K377
Secondary accession number(s): Q3UVX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.