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Q8K377 (LRRT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene names
Name:Lrrtm1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane; Single-pass type I membrane protein By similarity. Note: Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells (Ref.6). Ref.5 Ref.6

Tissue specificity

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate. Ref.1 Ref.6

Developmental stage

Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages. Ref.4

Disruption phenotype

Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region. Ref.7

Sequence similarities

Belongs to the LRRTM family.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 522488Leucine-rich repeat transmembrane neuronal protein 1
PRO_0000018351

Regions

Topological domain35 – 427393Extracellular Potential
Transmembrane428 – 44821Helical; Potential
Topological domain449 – 52274Cytoplasmic Potential
Domain35 – 6329LRRNT
Repeat64 – 8724LRR 1
Repeat89 – 11123LRR 2
Repeat112 – 13524LRR 3
Repeat136 – 15924LRR 4
Repeat161 – 18323LRR 5
Repeat184 – 20724LRR 6
Repeat209 – 23123LRR 7
Repeat233 – 25523LRR 8
Repeat256 – 27823LRR 9
Repeat280 – 30223LRR 10
Domain314 – 36552LRRCT

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K377 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6EBBA18034539DCC

FASTA52258,718
        10         20         30         40         50         60 
MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL YCEALNLTEA 

        70         80         90        100        110        120 
PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL 

       130        140        150        160        170        180 
SSNQITELAN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI 

       190        200        210        220        230        240 
FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL 

       250        260        270        280        290        300 
RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL 

       310        320        330        340        350        360 
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG EDVLDAVYAF 

       370        380        390        400        410        420 
HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE GHDGTFEPIT VALPGGEHAE 

       430        440        450        460        470        480 
NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM 

       490        500        510        520 
AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Diencephalon and Eye.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis."
Haines B.P., Rigby P.W.J.
Gene Expr. Patterns 7:23-29(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[5]"LRRTM1 protein is located in the endoplasmic reticulum (ER) in mammalian cells."
Francks C., Maegawa S., Lauren J., Abrahams B.S., Velayos-Baeza A., Medland S.E., Colella S., Groszer M., McAuley E.Z., Caffrey T.M., Timmusk T., Pruunsild P., Koppel I., Lind P.A., Matsumoto-Itaba N., Nicod J., Xiong L., Joober R. expand/collapse author list , Enard W., Krinsky B., Nanba E., Richardson A.J., Riley B.P., Martin N.G., Strittmatter S.M., Moeller H.J., Rujescu D., St Clair D., Muglia P., Roos J.L., Fisher S.E., Wade-Martins R., Rouleau G.A., Stein J.F., Karayiorgou M., Geschwind D.H., Ragoussis J., Kendler K.S., Airaksinen M.S., Oshimura M., DeLisi L.E., Monaco A.P.
Mol. Psychiatry 12:1057-1057(2007)
Cited for: SUBCELLULAR LOCATION.
[6]"LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia."
Francks C., Maegawa S., Lauren J., Abrahams B.S., Velayos-Baeza A., Medland S.E., Colella S., Groszer M., McAuley E.Z., Caffrey T.M., Timmusk T., Pruunsild P., Koppel I., Lind P.A., Matsumoto-Itaba N., Nicod J., Xiong L., Joober R. expand/collapse author list , Enard W., Krinsky B., Nanba E., Richardson A.J., Riley B.P., Martin N.G., Strittmatter S.M., Moeller H.J., Rujescu D., St Clair D., Muglia P., Roos J.L., Fisher S.E., Wade-Martins R., Rouleau G.A., Stein J.F., Karayiorgou M., Geschwind D.H., Ragoussis J., Kendler K.S., Airaksinen M.S., Oshimura M., DeLisi L.E., Monaco A.P.
Mol. Psychiatry 12:1129-1139(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[7]"An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers."
Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H., Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.
Neuron 61:734-749(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY182025 mRNA. Translation: AAO67546.1.
AK053345 mRNA. Translation: BAC35354.1.
AK053364 mRNA. Translation: BAC35363.1.
AK136857 mRNA. Translation: BAE23148.1.
BC027803 mRNA. Translation: AAH27803.1.
RefSeqNP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGeneMm.292568.

3D structure databases

ProteinModelPortalQ8K377.
SMRQ8K377. Positions 38-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K377. 1 interaction.

PTM databases

PhosphoSiteQ8K377.

Proteomic databases

PaxDbQ8K377.
PRIDEQ8K377.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
GeneID74342.
KEGGmmu:74342.
UCSCuc009cjt.1. mouse.

Organism-specific databases

CTD347730.
MGIMGI:2389173. Lrrtm1.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117232.
HOGENOMHOG000290681.
HOVERGENHBG052362.
InParanoidQ8K377.
KOK16665.
OMALHMRSNA.
OrthoDBEOG7TBC1Q.
PhylomeDBQ8K377.
TreeFamTF332659.

Gene expression databases

ArrayExpressQ8K377.
BgeeQ8K377.
CleanExMM_LRRTM1.
GenevestigatorQ8K377.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
SMARTSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio340493.
PROQ8K377.
SOURCESearch...

Entry information

Entry nameLRRT1_MOUSE
AccessionPrimary (citable) accession number: Q8K377
Secondary accession number(s): Q3UVX1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot