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Q8K377

- LRRT1_MOUSE

UniProt

Q8K377 - LRRT1_MOUSE

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Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

Lrrtm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

GO - Biological processi

  1. exploration behavior Source: MGI
  2. locomotory behavior Source: MGI
  3. long-term synaptic potentiation Source: MGI
  4. negative regulation of receptor internalization Source: MGI
  5. protein localization to synapse Source: MGI
  6. synapse organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:Lrrtm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2389173. Lrrtm1.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells.2 Publications

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. endoplasmic reticulum Source: Ensembl
  4. excitatory synapse Source: Ensembl
  5. growth cone Source: Ensembl
  6. integral component of membrane Source: MGI
  7. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1PRO_0000018351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K377.
PaxDbiQ8K377.
PRIDEiQ8K377.

PTM databases

PhosphoSiteiQ8K377.

Expressioni

Tissue specificityi

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate.2 Publications

Developmental stagei

Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages.1 Publication

Gene expression databases

BgeeiQ8K377.
CleanExiMM_LRRTM1.
ExpressionAtlasiQ8K377. baseline and differential.
GenevestigatoriQ8K377.

Interactioni

Protein-protein interaction databases

IntActiQ8K377. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K377.
SMRiQ8K377. Positions 39-399.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 427393ExtracellularSequence AnalysisAdd
BLAST
Topological domaini449 – 52274CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 6329LRRNTAdd
BLAST
Repeati64 – 8724LRR 1Add
BLAST
Repeati89 – 11123LRR 2Add
BLAST
Repeati112 – 13524LRR 3Add
BLAST
Repeati136 – 15924LRR 4Add
BLAST
Repeati161 – 18323LRR 5Add
BLAST
Repeati184 – 20724LRR 6Add
BLAST
Repeati209 – 23123LRR 7Add
BLAST
Repeati233 – 25523LRR 8Add
BLAST
Repeati256 – 27823LRR 9Add
BLAST
Repeati280 – 30223LRR 10Add
BLAST
Domaini314 – 36552LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8K377.
KOiK16665.
OMAiTLHMRSN.
OrthoDBiEOG7TBC1Q.
PhylomeDBiQ8K377.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K377-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL
60 70 80 90 100
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH
110 120 130 140 150
ICSVQGDAFQ KLRRVKELTL SSNQITELAN TTFRPMPNLR SVDLSYNKLQ
160 170 180 190 200
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL
210 220 230 240 250
ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL RRNKVAIVVS
260 270 280 290 300
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL
310 320 330 340 350
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG
360 370 380 390 400
EDVLDAVYAF HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE
410 420 430 440 450
GHDGTFEPIT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW
460 470 480 490 500
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA
510 520
LVIINEYGSC TCHQQPAREC EV
Length:522
Mass (Da):58,718
Last modified:October 1, 2002 - v1
Checksum:i6EBBA18034539DCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182025 mRNA. Translation: AAO67546.1.
AK053345 mRNA. Translation: BAC35354.1.
AK053364 mRNA. Translation: BAC35363.1.
AK136857 mRNA. Translation: BAE23148.1.
BC027803 mRNA. Translation: AAH27803.1.
CCDSiCCDS39522.1.
RefSeqiNP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGeneiMm.292568.

Genome annotation databases

EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
GeneIDi74342.
KEGGimmu:74342.
UCSCiuc009cjt.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182025 mRNA. Translation: AAO67546.1 .
AK053345 mRNA. Translation: BAC35354.1 .
AK053364 mRNA. Translation: BAC35363.1 .
AK136857 mRNA. Translation: BAE23148.1 .
BC027803 mRNA. Translation: AAH27803.1 .
CCDSi CCDS39522.1.
RefSeqi NP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGenei Mm.292568.

3D structure databases

ProteinModelPortali Q8K377.
SMRi Q8K377. Positions 39-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K377. 1 interaction.

PTM databases

PhosphoSitei Q8K377.

Proteomic databases

MaxQBi Q8K377.
PaxDbi Q8K377.
PRIDEi Q8K377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020400 ; ENSMUSP00000020400 ; ENSMUSG00000060780 .
ENSMUST00000159616 ; ENSMUSP00000125207 ; ENSMUSG00000060780 .
ENSMUST00000161677 ; ENSMUSP00000124373 ; ENSMUSG00000060780 .
GeneIDi 74342.
KEGGi mmu:74342.
UCSCi uc009cjt.1. mouse.

Organism-specific databases

CTDi 347730.
MGIi MGI:2389173. Lrrtm1.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q8K377.
KOi K16665.
OMAi TLHMRSN.
OrthoDBi EOG7TBC1Q.
PhylomeDBi Q8K377.
TreeFami TF332659.

Miscellaneous databases

NextBioi 340493.
PROi Q8K377.
SOURCEi Search...

Gene expression databases

Bgeei Q8K377.
CleanExi MM_LRRTM1.
ExpressionAtlasi Q8K377. baseline and differential.
Genevestigatori Q8K377.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon and Eye.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis."
    Haines B.P., Rigby P.W.J.
    Gene Expr. Patterns 7:23-29(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: SUBCELLULAR LOCATION.
  6. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. "An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers."
    Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H., Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.
    Neuron 61:734-749(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiLRRT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K377
Secondary accession number(s): Q3UVX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3