Q8K377 (LRRT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 87.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Leucine-rich repeat transmembrane neuronal protein 1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 522 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May play a role during the development of specific forebrain structures by influencing neuronal differentiation and connectivity, with a possible role in intracellular trafficking within axons. |
| Subcellular location | Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.5 Ref.6. |
| Tissue specificity | Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate. Ref.1 Ref.6 |
| Developmental stage | Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages. Ref.4 |
| Sequence similarities | Belongs to the LRRTM family. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 34 | 34 | Potential | ||||||
| Chain | 35 – 522 | 488 | Leucine-rich repeat transmembrane neuronal protein 1 | PRO_0000018351 | |||||
Regions | |||||||||
| Topological domain | 35 – 427 | 393 | Lumenal Potential | ||||||
| Transmembrane | 428 – 448 | 21 | Helical; Potential | ||||||
| Topological domain | 449 – 522 | 74 | Cytoplasmic Potential | ||||||
| Domain | 35 – 66 | 32 | LRRNT | ||||||
| Repeat | 90 – 111 | 22 | LRR 1 | ||||||
| Repeat | 114 – 135 | 22 | LRR 2 | ||||||
| Repeat | 138 – 159 | 22 | LRR 3 | ||||||
| Repeat | 162 – 183 | 22 | LRR 4 | ||||||
| Repeat | 186 – 207 | 22 | LRR 5 | ||||||
| Repeat | 210 – 230 | 21 | LRR 6 | ||||||
| Repeat | 234 – 255 | 22 | LRR 7 | ||||||
| Repeat | 257 – 278 | 22 | LRR 8 | ||||||
| Repeat | 281 – 302 | 22 | LRR 9 | ||||||
| Domain | 314 – 365 | 52 | LRRCT | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 56 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 63 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 130 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 381 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
Web resources
| Protein Spotlight The hands to say it - Issue 91 of February 2008 |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY182025 mRNA. Translation: AAO67546.1. AK053345 mRNA. Translation: BAC35354.1. AK053364 mRNA. Translation: BAC35363.1. AK136857 mRNA. Translation: BAE23148.1. BC027803 mRNA. Translation: AAH27803.1. |
| IPI | IPI00170022. |
| RefSeq | NP_083156.2. NM_028880.3. |
| UniGene | Mm.292568. |
3D structure databases | |
| ProteinModelPortal | Q8K377. |
| SMR | Q8K377. Positions 38-363. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8K377. 1 interaction. |
| STRING | Q8K377. |
Proteomic databases | |
| PRIDE | Q8K377. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780. ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780. ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780. |
| GeneID | 74342. |
| KEGG | mmu:74342. |
| UCSC | uc009cjt.1. mouse. |
Organism-specific databases | |
| CTD | 347730. |
| MGI | MGI:2389173. Lrrtm1. |
Phylogenomic databases | |
| eggNOG | maNOG05298. |
| GeneTree | ENSGT00600000084202. |
| HOGENOM | HBG443538. |
| HOVERGEN | HBG052362. |
| InParanoid | Q8K377. |
| OMA | AFHLCED. |
| OrthoDB | EOG4FN4HG. |
| PhylomeDB | Q8K377. |
Gene expression databases | |
| ArrayExpress | Q8K377. |
| Bgee | Q8K377. |
| CleanEx | MM_LRRTM1. |
| Genevestigator | Q8K377. |
| GermOnline | ENSMUSG00000060780. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view] |
| Pfam | PF00560. LRR_1. 2 hits. [Graphical view] |
| SMART | SM00369. LRR_TYP. 3 hits. SM00013. LRRNT. 1 hit. [Graphical view] |
| PROSITE | PS51450. LRR. 9 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 340493. |
| SOURCE | Search... |
Entry information
| Entry name | LRRT1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K377 Secondary accession number(s): Q3UVX1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |

Clusters with