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Q8K377

- LRRT1_MOUSE

UniProt

Q8K377 - LRRT1_MOUSE

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Protein
Leucine-rich repeat transmembrane neuronal protein 1
Gene
Lrrtm1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level By similarity.

GO - Biological processi

  1. exploration behavior Source: MGI
  2. locomotory behavior Source: MGI
  3. long-term synaptic potentiation Source: MGI
  4. negative regulation of receptor internalization Source: MGI
  5. protein localization to synapse Source: MGI
  6. synapse organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:Lrrtm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2389173. Lrrtm1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane; Single-pass type I membrane protein By similarity
Note: Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells (1 Publication).2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 427393Extracellular Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Reviewed prediction
Add
BLAST
Topological domaini449 – 52274Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. endoplasmic reticulum Source: Ensembl
  4. excitatory synapse Source: Ensembl
  5. growth cone Source: Ensembl
  6. integral component of membrane Source: MGI
  7. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1
PRO_0000018351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K377.
PRIDEiQ8K377.

PTM databases

PhosphoSiteiQ8K377.

Expressioni

Tissue specificityi

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate.2 Publications

Developmental stagei

Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages.1 Publication

Gene expression databases

ArrayExpressiQ8K377.
BgeeiQ8K377.
CleanExiMM_LRRTM1.
GenevestigatoriQ8K377.

Interactioni

Protein-protein interaction databases

IntActiQ8K377. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K377.
SMRiQ8K377. Positions 39-399.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 6329LRRNT
Add
BLAST
Repeati64 – 8724LRR 1
Add
BLAST
Repeati89 – 11123LRR 2
Add
BLAST
Repeati112 – 13524LRR 3
Add
BLAST
Repeati136 – 15924LRR 4
Add
BLAST
Repeati161 – 18323LRR 5
Add
BLAST
Repeati184 – 20724LRR 6
Add
BLAST
Repeati209 – 23123LRR 7
Add
BLAST
Repeati233 – 25523LRR 8
Add
BLAST
Repeati256 – 27823LRR 9
Add
BLAST
Repeati280 – 30223LRR 10
Add
BLAST
Domaini314 – 36552LRRCT
Add
BLAST

Sequence similaritiesi

Belongs to the LRRTM family.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117232.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8K377.
KOiK16665.
OMAiTLHMRSN.
OrthoDBiEOG7TBC1Q.
PhylomeDBiQ8K377.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K377-1 [UniParc]FASTAAdd to Basket

« Hide

MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL    50
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH 100
ICSVQGDAFQ KLRRVKELTL SSNQITELAN TTFRPMPNLR SVDLSYNKLQ 150
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL 200
ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL RRNKVAIVVS 250
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL 300
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG 350
EDVLDAVYAF HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE 400
GHDGTFEPIT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW 450
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA 500
LVIINEYGSC TCHQQPAREC EV 522
Length:522
Mass (Da):58,718
Last modified:October 1, 2002 - v1
Checksum:i6EBBA18034539DCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182025 mRNA. Translation: AAO67546.1.
AK053345 mRNA. Translation: BAC35354.1.
AK053364 mRNA. Translation: BAC35363.1.
AK136857 mRNA. Translation: BAE23148.1.
BC027803 mRNA. Translation: AAH27803.1.
CCDSiCCDS39522.1.
RefSeqiNP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGeneiMm.292568.

Genome annotation databases

EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
GeneIDi74342.
KEGGimmu:74342.
UCSCiuc009cjt.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182025 mRNA. Translation: AAO67546.1 .
AK053345 mRNA. Translation: BAC35354.1 .
AK053364 mRNA. Translation: BAC35363.1 .
AK136857 mRNA. Translation: BAE23148.1 .
BC027803 mRNA. Translation: AAH27803.1 .
CCDSi CCDS39522.1.
RefSeqi NP_083156.2. NM_028880.3.
XP_006506775.1. XM_006506712.1.
UniGenei Mm.292568.

3D structure databases

ProteinModelPortali Q8K377.
SMRi Q8K377. Positions 39-399.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8K377. 1 interaction.

PTM databases

PhosphoSitei Q8K377.

Proteomic databases

PaxDbi Q8K377.
PRIDEi Q8K377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020400 ; ENSMUSP00000020400 ; ENSMUSG00000060780 .
ENSMUST00000159616 ; ENSMUSP00000125207 ; ENSMUSG00000060780 .
ENSMUST00000161677 ; ENSMUSP00000124373 ; ENSMUSG00000060780 .
GeneIDi 74342.
KEGGi mmu:74342.
UCSCi uc009cjt.1. mouse.

Organism-specific databases

CTDi 347730.
MGIi MGI:2389173. Lrrtm1.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117232.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q8K377.
KOi K16665.
OMAi TLHMRSN.
OrthoDBi EOG7TBC1Q.
PhylomeDBi Q8K377.
TreeFami TF332659.

Miscellaneous databases

NextBioi 340493.
PROi Q8K377.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K377.
Bgeei Q8K377.
CleanExi MM_LRRTM1.
Genevestigatori Q8K377.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon and Eye.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis."
    Haines B.P., Rigby P.W.J.
    Gene Expr. Patterns 7:23-29(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: SUBCELLULAR LOCATION.
  6. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. "An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers."
    Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H., Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.
    Neuron 61:734-749(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiLRRT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K377
Secondary accession number(s): Q3UVX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi