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Q8K377

- LRRT1_MOUSE

UniProt

Q8K377 - LRRT1_MOUSE

Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

Lrrtm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

    GO - Biological processi

    1. exploration behavior Source: MGI
    2. locomotory behavior Source: MGI
    3. long-term synaptic potentiation Source: MGI
    4. negative regulation of receptor internalization Source: MGI
    5. protein localization to synapse Source: MGI
    6. synapse organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 1
    Gene namesi
    Name:Lrrtm1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2389173. Lrrtm1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells.2 Publications

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. endoplasmic reticulum Source: Ensembl
    4. excitatory synapse Source: Ensembl
    5. growth cone Source: Ensembl
    6. integral component of membrane Source: MGI
    7. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1PRO_0000018351Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8K377.
    PRIDEiQ8K377.

    PTM databases

    PhosphoSiteiQ8K377.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate.2 Publications

    Developmental stagei

    Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages.1 Publication

    Gene expression databases

    ArrayExpressiQ8K377.
    BgeeiQ8K377.
    CleanExiMM_LRRTM1.
    GenevestigatoriQ8K377.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K377. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K377.
    SMRiQ8K377. Positions 39-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 427393ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini449 – 52274CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 6329LRRNTAdd
    BLAST
    Repeati64 – 8724LRR 1Add
    BLAST
    Repeati89 – 11123LRR 2Add
    BLAST
    Repeati112 – 13524LRR 3Add
    BLAST
    Repeati136 – 15924LRR 4Add
    BLAST
    Repeati161 – 18323LRR 5Add
    BLAST
    Repeati184 – 20724LRR 6Add
    BLAST
    Repeati209 – 23123LRR 7Add
    BLAST
    Repeati233 – 25523LRR 8Add
    BLAST
    Repeati256 – 27823LRR 9Add
    BLAST
    Repeati280 – 30223LRR 10Add
    BLAST
    Domaini314 – 36552LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LRRTM family.Curated
    Contains 10 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117232.
    HOGENOMiHOG000290681.
    HOVERGENiHBG052362.
    InParanoidiQ8K377.
    KOiK16665.
    OMAiTLHMRSN.
    OrthoDBiEOG7TBC1Q.
    PhylomeDBiQ8K377.
    TreeFamiTF332659.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL    50
    YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH 100
    ICSVQGDAFQ KLRRVKELTL SSNQITELAN TTFRPMPNLR SVDLSYNKLQ 150
    ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL 200
    ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL RRNKVAIVVS 250
    SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL 300
    NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG 350
    EDVLDAVYAF HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE 400
    GHDGTFEPIT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW 450
    KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA 500
    LVIINEYGSC TCHQQPAREC EV 522
    Length:522
    Mass (Da):58,718
    Last modified:October 1, 2002 - v1
    Checksum:i6EBBA18034539DCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182025 mRNA. Translation: AAO67546.1.
    AK053345 mRNA. Translation: BAC35354.1.
    AK053364 mRNA. Translation: BAC35363.1.
    AK136857 mRNA. Translation: BAE23148.1.
    BC027803 mRNA. Translation: AAH27803.1.
    CCDSiCCDS39522.1.
    RefSeqiNP_083156.2. NM_028880.3.
    XP_006506775.1. XM_006506712.1.
    UniGeneiMm.292568.

    Genome annotation databases

    EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780.
    ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780.
    ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780.
    GeneIDi74342.
    KEGGimmu:74342.
    UCSCiuc009cjt.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The hands to say it - Issue 91 of February 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182025 mRNA. Translation: AAO67546.1 .
    AK053345 mRNA. Translation: BAC35354.1 .
    AK053364 mRNA. Translation: BAC35363.1 .
    AK136857 mRNA. Translation: BAE23148.1 .
    BC027803 mRNA. Translation: AAH27803.1 .
    CCDSi CCDS39522.1.
    RefSeqi NP_083156.2. NM_028880.3.
    XP_006506775.1. XM_006506712.1.
    UniGenei Mm.292568.

    3D structure databases

    ProteinModelPortali Q8K377.
    SMRi Q8K377. Positions 39-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K377. 1 interaction.

    PTM databases

    PhosphoSitei Q8K377.

    Proteomic databases

    PaxDbi Q8K377.
    PRIDEi Q8K377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020400 ; ENSMUSP00000020400 ; ENSMUSG00000060780 .
    ENSMUST00000159616 ; ENSMUSP00000125207 ; ENSMUSG00000060780 .
    ENSMUST00000161677 ; ENSMUSP00000124373 ; ENSMUSG00000060780 .
    GeneIDi 74342.
    KEGGi mmu:74342.
    UCSCi uc009cjt.1. mouse.

    Organism-specific databases

    CTDi 347730.
    MGIi MGI:2389173. Lrrtm1.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117232.
    HOGENOMi HOG000290681.
    HOVERGENi HBG052362.
    InParanoidi Q8K377.
    KOi K16665.
    OMAi TLHMRSN.
    OrthoDBi EOG7TBC1Q.
    PhylomeDBi Q8K377.
    TreeFami TF332659.

    Miscellaneous databases

    NextBioi 340493.
    PROi Q8K377.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K377.
    Bgeei Q8K377.
    CleanExi MM_LRRTM1.
    Genevestigatori Q8K377.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
      Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon and Eye.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis."
      Haines B.P., Rigby P.W.J.
      Gene Expr. Patterns 7:23-29(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    5. Cited for: SUBCELLULAR LOCATION.
    6. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    7. "An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers."
      Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H., Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.
      Neuron 61:734-749(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiLRRT1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K377
    Secondary accession number(s): Q3UVX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3