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Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

Lrrtm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • exploration behavior Source: MGI
  • locomotory behavior Source: MGI
  • long-term synaptic potentiation Source: MGI
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • negative regulation of receptor internalization Source: MGI
  • positive regulation of synapse assembly Source: MGI
  • protein localization to synapse Source: MGI
  • synapse organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:Lrrtm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2389173 Lrrtm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 427ExtracellularSequence analysisAdd BLAST393
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 522CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutant animals survive in the expected Mendelian ratios, are fertile and display no overt phenotype. Brain morphology appears grossly normal, except for rare cases of anomalous ventroculomegaly. Increase in the presynaptic area occupied by SLC17A7/VGLUT1 in some strata of the hippocampal neuropil of the CA1 region.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001835135 – 522Leucine-rich repeat transmembrane neuronal protein 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K377
PaxDbiQ8K377
PeptideAtlasiQ8K377
PRIDEiQ8K377

PTM databases

PhosphoSitePlusiQ8K377
SwissPalmiQ8K377

Expressioni

Tissue specificityi

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate.2 Publications

Developmental stagei

Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression is also seen in the dorsal otic vesicle in the presumptive endolymphatic appendage. Neural expression is present in the forebrain and midbrain with a sharp boundary across the central midbrain. Expression is also seen in the hindbrain. A stripe of expression can be detected in the neural tube. At 10 and 11 dpc expression is restricted to the apical ectodermal ridge. Expression persists in the endolymphatic diverticular appendage of the otic vesicle the forebrain/midbrain and the ventricular layer of the central neural tube through these stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000060780
CleanExiMM_LRRTM1
ExpressionAtlasiQ8K377 baseline and differential
GenevisibleiQ8K377 MM

Interactioni

Protein-protein interaction databases

BioGridi216677, 1 interactor
IntActiQ8K377, 2 interactors
STRINGi10090.ENSMUSP00000020400

Structurei

3D structure databases

ProteinModelPortaliQ8K377
SMRiQ8K377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 63LRRNTAdd BLAST29
Repeati64 – 87LRR 1Add BLAST24
Repeati89 – 111LRR 2Add BLAST23
Repeati112 – 135LRR 3Add BLAST24
Repeati136 – 159LRR 4Add BLAST24
Repeati161 – 183LRR 5Add BLAST23
Repeati184 – 207LRR 6Add BLAST24
Repeati209 – 231LRR 7Add BLAST23
Repeati233 – 255LRR 8Add BLAST23
Repeati256 – 278LRR 9Add BLAST23
Repeati280 – 302LRR 10Add BLAST23
Domaini314 – 365LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the LRRTM family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118777
HOGENOMiHOG000290681
HOVERGENiHBG052362
InParanoidiQ8K377
KOiK16665
OMAiTLHMRSN
OrthoDBiEOG091G03BI
PhylomeDBiQ8K377
TreeFamiTF332659

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL
60 70 80 90 100
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH
110 120 130 140 150
ICSVQGDAFQ KLRRVKELTL SSNQITELAN TTFRPMPNLR SVDLSYNKLQ
160 170 180 190 200
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL
210 220 230 240 250
ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLHSLCL RRNKVAIVVS
260 270 280 290 300
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQTLQLDSN RLTYIEPRIL
310 320 330 340 350
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG
360 370 380 390 400
EDVLDAVYAF HLCEDGAEPT SGHLLSVAVT NRSDLTPPES SATTLVDGGE
410 420 430 440 450
GHDGTFEPIT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW
460 470 480 490 500
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA
510 520
LVIINEYGSC TCHQQPAREC EV
Length:522
Mass (Da):58,718
Last modified:October 1, 2002 - v1
Checksum:i6EBBA18034539DCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182025 mRNA Translation: AAO67546.1
AK053345 mRNA Translation: BAC35354.1
AK053364 mRNA Translation: BAC35363.1
AK136857 mRNA Translation: BAE23148.1
BC027803 mRNA Translation: AAH27803.1
CCDSiCCDS39522.1
RefSeqiNP_083156.2, NM_028880.3
XP_006506775.1, XM_006506712.1
UniGeneiMm.292568

Genome annotation databases

EnsembliENSMUST00000020400; ENSMUSP00000020400; ENSMUSG00000060780
ENSMUST00000159616; ENSMUSP00000125207; ENSMUSG00000060780
ENSMUST00000161677; ENSMUSP00000124373; ENSMUSG00000060780
GeneIDi74342
KEGGimmu:74342
UCSCiuc009cjt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLRRT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K377
Secondary accession number(s): Q3UVX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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