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Protein

ATP-dependent RNA helicase DDX18

Gene

Ddx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable RNA-dependent helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 220ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX18 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 18
Gene namesi
Name:Ddx18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914192. Ddx18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550021 – 660ATP-dependent RNA helicase DDX18Add BLAST660

Proteomic databases

EPDiQ8K363.
MaxQBiQ8K363.
PaxDbiQ8K363.
PRIDEiQ8K363.

PTM databases

iPTMnetiQ8K363.
PhosphoSitePlusiQ8K363.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001674.
CleanExiMM_DDX18.
ExpressionAtlasiQ8K363. baseline and differential.
GenevisibleiQ8K363. MM.

Interactioni

Subunit structurei

Interacts with NOL8; the interaction is RNA-dependent.By similarity

Protein-protein interaction databases

BioGridi211826. 3 interactors.
CORUMiQ8K363.
IntActiQ8K363. 1 interactor.
MINTiMINT-4092945.
STRINGi10090.ENSMUSP00000001724.

Structurei

3D structure databases

ProteinModelPortaliQ8K363.
SMRiQ8K363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 375Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini389 – 559Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi169 – 197Q motifAdd BLAST29
Motifi323 – 326DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00680000100037.
HOGENOMiHOG000268799.
HOVERGENiHBG105702.
InParanoidiQ8K363.
KOiK13179.
OMAiEMRQIVK.
OrthoDBiEOG091G06N7.
PhylomeDBiQ8K363.
TreeFamiTF300471.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLQMKLLR RKIEKRNAKL RQRNLKLQET SDTSLSQPQN GDVPKETGKG
60 70 80 90 100
GKVKKALKRS VPVDSAEAQS GGMPEETLEN GKVKKSPQKL TTLANGEAAP
110 120 130 140 150
TPPPDSEVKK KKKKKRKMAN DAGPDTKKAK TEESAEACEE PEDDVKKADD
160 170 180 190 200
SEVPSLPLGL TGAFEDTSFA SLSNLVNENT LKAIEEMGFK RMTEIQHKSI
210 220 230 240 250
RPLLEGRDLL AAAKTGSGKT LAFLIPVIEL IVKLKFMPRN GTGVLILSPT
260 270 280 290 300
RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEVQKLLN GINIIVATPG
310 320 330 340 350
RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI IKLLPARRQT
360 370 380 390 400
MLFSATQTRK VEDLARISLK KEPLYVGVDD DKEVATVDGL EQGYVVCPSE
410 420 430 440 450
KRFLLLFTFL KKNRKKKVMV FFSSCMSVKY HYELLNYIDL PVLAIHGKQK
460 470 480 490 500
QNKRTTTFFQ FCNADSGILL CTDVAARGLD IPEVDWIVQY DPPDDPKEYI
510 520 530 540 550
HRVGRTARGL NGRGHALLIL RPEELGFLRY LKQSKVPLNQ FDFSWSKVSD
560 570 580 590 600
IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN VNNLNLPQVA
610 620 630 640 650
LSFGFKVPPF VDLNVSSHDG KLKKRGGGGG FGYQKTKKVE KSKIFKHISK
660
KPADRRQFSH
Length:660
Mass (Da):74,181
Last modified:October 1, 2002 - v1
Checksum:iF80EFC0E741C2D7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259G → D in BAB31877 (PubMed:16141072).Curated1
Sequence conflicti499Y → C in BAC36015 (PubMed:16141072).Curated1
Sequence conflicti637K → R in BAC36015 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075864 mRNA. Translation: BAC36015.1.
AK019845 mRNA. Translation: BAB31877.1.
BC028246 mRNA. Translation: AAH28246.1.
BC103776 mRNA. Translation: AAI03777.1.
CCDSiCCDS15240.1.
RefSeqiNP_080136.2. NM_025860.3.
UniGeneiMm.44219.

Genome annotation databases

EnsembliENSMUST00000001724; ENSMUSP00000001724; ENSMUSG00000001674.
GeneIDi66942.
KEGGimmu:66942.
UCSCiuc007cjw.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDDX18_MOUSE
AccessioniPrimary (citable) accession number: Q8K363
Secondary accession number(s): Q3MIB0, Q8BVZ2, Q9D2E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families