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Protein

ATP-dependent RNA helicase DDX18

Gene

Ddx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable RNA-dependent helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2208ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX18 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 18
Gene namesi
Name:Ddx18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914192. Ddx18.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Chromosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660ATP-dependent RNA helicase DDX18PRO_0000055002Add
BLAST

Proteomic databases

EPDiQ8K363.
MaxQBiQ8K363.
PaxDbiQ8K363.
PRIDEiQ8K363.

PTM databases

iPTMnetiQ8K363.
PhosphoSiteiQ8K363.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001674.
CleanExiMM_DDX18.
ExpressionAtlasiQ8K363. baseline and differential.
GenevisibleiQ8K363. MM.

Interactioni

Subunit structurei

Interacts with NOL8; the interaction is RNA-dependent.By similarity

Protein-protein interaction databases

BioGridi211826. 3 interactions.
IntActiQ8K363. 1 interaction.
MINTiMINT-4092945.
STRINGi10090.ENSMUSP00000001724.

Structurei

3D structure databases

ProteinModelPortaliQ8K363.
SMRiQ8K363. Positions 159-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 375176Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini389 – 559171Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi169 – 19729Q motifAdd
BLAST
Motifi323 – 3264DEAD box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00680000100037.
HOGENOMiHOG000268799.
HOVERGENiHBG105702.
InParanoidiQ8K363.
KOiK13179.
OMAiIQHKTIR.
OrthoDBiEOG091G06N7.
PhylomeDBiQ8K363.
TreeFamiTF300471.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLQMKLLR RKIEKRNAKL RQRNLKLQET SDTSLSQPQN GDVPKETGKG
60 70 80 90 100
GKVKKALKRS VPVDSAEAQS GGMPEETLEN GKVKKSPQKL TTLANGEAAP
110 120 130 140 150
TPPPDSEVKK KKKKKRKMAN DAGPDTKKAK TEESAEACEE PEDDVKKADD
160 170 180 190 200
SEVPSLPLGL TGAFEDTSFA SLSNLVNENT LKAIEEMGFK RMTEIQHKSI
210 220 230 240 250
RPLLEGRDLL AAAKTGSGKT LAFLIPVIEL IVKLKFMPRN GTGVLILSPT
260 270 280 290 300
RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEVQKLLN GINIIVATPG
310 320 330 340 350
RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI IKLLPARRQT
360 370 380 390 400
MLFSATQTRK VEDLARISLK KEPLYVGVDD DKEVATVDGL EQGYVVCPSE
410 420 430 440 450
KRFLLLFTFL KKNRKKKVMV FFSSCMSVKY HYELLNYIDL PVLAIHGKQK
460 470 480 490 500
QNKRTTTFFQ FCNADSGILL CTDVAARGLD IPEVDWIVQY DPPDDPKEYI
510 520 530 540 550
HRVGRTARGL NGRGHALLIL RPEELGFLRY LKQSKVPLNQ FDFSWSKVSD
560 570 580 590 600
IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN VNNLNLPQVA
610 620 630 640 650
LSFGFKVPPF VDLNVSSHDG KLKKRGGGGG FGYQKTKKVE KSKIFKHISK
660
KPADRRQFSH
Length:660
Mass (Da):74,181
Last modified:October 1, 2002 - v1
Checksum:iF80EFC0E741C2D7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591G → D in BAB31877 (PubMed:16141072).Curated
Sequence conflicti499 – 4991Y → C in BAC36015 (PubMed:16141072).Curated
Sequence conflicti637 – 6371K → R in BAC36015 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075864 mRNA. Translation: BAC36015.1.
AK019845 mRNA. Translation: BAB31877.1.
BC028246 mRNA. Translation: AAH28246.1.
BC103776 mRNA. Translation: AAI03777.1.
CCDSiCCDS15240.1.
RefSeqiNP_080136.2. NM_025860.3.
UniGeneiMm.44219.

Genome annotation databases

EnsembliENSMUST00000001724; ENSMUSP00000001724; ENSMUSG00000001674.
GeneIDi66942.
KEGGimmu:66942.
UCSCiuc007cjw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075864 mRNA. Translation: BAC36015.1.
AK019845 mRNA. Translation: BAB31877.1.
BC028246 mRNA. Translation: AAH28246.1.
BC103776 mRNA. Translation: AAI03777.1.
CCDSiCCDS15240.1.
RefSeqiNP_080136.2. NM_025860.3.
UniGeneiMm.44219.

3D structure databases

ProteinModelPortaliQ8K363.
SMRiQ8K363. Positions 159-604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211826. 3 interactions.
IntActiQ8K363. 1 interaction.
MINTiMINT-4092945.
STRINGi10090.ENSMUSP00000001724.

PTM databases

iPTMnetiQ8K363.
PhosphoSiteiQ8K363.

Proteomic databases

EPDiQ8K363.
MaxQBiQ8K363.
PaxDbiQ8K363.
PRIDEiQ8K363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001724; ENSMUSP00000001724; ENSMUSG00000001674.
GeneIDi66942.
KEGGimmu:66942.
UCSCiuc007cjw.2. mouse.

Organism-specific databases

CTDi8886.
MGIiMGI:1914192. Ddx18.

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00680000100037.
HOGENOMiHOG000268799.
HOVERGENiHBG105702.
InParanoidiQ8K363.
KOiK13179.
OMAiIQHKTIR.
OrthoDBiEOG091G06N7.
PhylomeDBiQ8K363.
TreeFamiTF300471.

Miscellaneous databases

PROiQ8K363.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001674.
CleanExiMM_DDX18.
ExpressionAtlasiQ8K363. baseline and differential.
GenevisibleiQ8K363. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX18_MOUSE
AccessioniPrimary (citable) accession number: Q8K363
Secondary accession number(s): Q3MIB0, Q8BVZ2, Q9D2E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.