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Protein

Carbonyl reductase [NADPH] 3

Gene

Cbr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90NADP; via carbonyl oxygenBy similarity1
Binding sitei140SubstrateBy similarity1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 34NADPBy similarityAdd BLAST25
Nucleotide bindingi38 – 42NADPBy similarity5
Nucleotide bindingi63 – 64NADPBy similarity2
Nucleotide bindingi194 – 198NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-211945. Phase I - Functionalization of compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonyl reductase [NADPH] 3 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase 3
Gene namesi
Name:Cbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1309992. Cbr3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004158062 – 277Carbonyl reductase [NADPH] 3Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei30PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8K354.
PaxDbiQ8K354.
PeptideAtlasiQ8K354.
PRIDEiQ8K354.

PTM databases

iPTMnetiQ8K354.
PhosphoSitePlusiQ8K354.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022947.
GenevisibleiQ8K354. MM.

Interactioni

Protein-protein interaction databases

BioGridi225103. 1 interactor.
IntActiQ8K354. 2 interactors.
MINTiMINT-4117620.
STRINGi10090.ENSMUSP00000047712.

Structurei

3D structure databases

ProteinModelPortaliQ8K354.
SMRiQ8K354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00510000046499.
HOVERGENiHBG001909.
InParanoidiQ8K354.
KOiK00084.
OMAiCETLTEG.
OrthoDBiEOG091G0V7L.
PhylomeDBiQ8K354.
TreeFamiTF329359.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCSRVALV TGANKGIGFA ITRDLCRKFS GDVVLTARDE ARGRAAVQQL
60 70 80 90 100
QAEGLSPRFH QLDIDDPQSI RALRDFLRKE YGGLNVLVNN AGIAFRMDDP
110 120 130 140 150
TPFDIQAEVT LKTNFFATRN VCTELLPIMK PHGRVVNISS LQGLKALENC
160 170 180 190 200
REDLQEKFRC DTLTEVDLVD LMKKFVEDTK NEVHEREGWP DSAYGVSKLG
210 220 230 240 250
VTVLTRILAR QLDEKRKADR ILLNACCPGW VKTDMARDQG SRTVEEGAET
260 270
PVYLALLPPD ATEPHGQLVR DKVVQTW
Length:277
Mass (Da):30,953
Last modified:October 1, 2002 - v1
Checksum:iEC6009AB9C83FACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028150 mRNA. Translation: BAC25778.1.
AC154449 Genomic DNA. No translation available.
CH466602 Genomic DNA. Translation: EDL03763.1.
BC028763 mRNA. Translation: AAH28763.1.
BC087735 mRNA. Translation: AAH87735.1.
BC096658 mRNA. Translation: AAH96658.1.
CCDSiCCDS28342.1.
RefSeqiNP_766635.1. NM_173047.3.
UniGeneiMm.4512.

Genome annotation databases

EnsembliENSMUST00000039620; ENSMUSP00000047712; ENSMUSG00000022947.
GeneIDi109857.
KEGGimmu:109857.
UCSCiuc007zzs.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCBR3_MOUSE
AccessioniPrimary (citable) accession number: Q8K354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families