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Protein

Carbonyl reductase [NADPH] 3

Gene

Cbr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901NADP; via carbonyl oxygenBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Active sitei194 – 1941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3425NADPBy similarityAdd
BLAST
Nucleotide bindingi38 – 425NADPBy similarity
Nucleotide bindingi63 – 642NADPBy similarity
Nucleotide bindingi194 – 1985NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonyl reductase [NADPH] 3 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase 3
Gene namesi
Name:Cbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1309992. Cbr3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 277276Carbonyl reductase [NADPH] 3PRO_0000415806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei162 – 1621PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K354.
MaxQBiQ8K354.
PaxDbiQ8K354.
PRIDEiQ8K354.

PTM databases

iPTMnetiQ8K354.
PhosphoSiteiQ8K354.

Expressioni

Gene expression databases

BgeeiQ8K354.
GenevisibleiQ8K354. MM.

Interactioni

Protein-protein interaction databases

BioGridi225103. 1 interaction.
IntActiQ8K354. 2 interactions.
MINTiMINT-4117620.
STRINGi10090.ENSMUSP00000047712.

Structurei

3D structure databases

ProteinModelPortaliQ8K354.
SMRiQ8K354. Positions 5-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00510000046499.
HOVERGENiHBG001909.
InParanoidiQ8K354.
KOiK00084.
OMAiLENCRED.
OrthoDBiEOG7PGDR4.
PhylomeDBiQ8K354.
TreeFamiTF329359.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCSRVALV TGANKGIGFA ITRDLCRKFS GDVVLTARDE ARGRAAVQQL
60 70 80 90 100
QAEGLSPRFH QLDIDDPQSI RALRDFLRKE YGGLNVLVNN AGIAFRMDDP
110 120 130 140 150
TPFDIQAEVT LKTNFFATRN VCTELLPIMK PHGRVVNISS LQGLKALENC
160 170 180 190 200
REDLQEKFRC DTLTEVDLVD LMKKFVEDTK NEVHEREGWP DSAYGVSKLG
210 220 230 240 250
VTVLTRILAR QLDEKRKADR ILLNACCPGW VKTDMARDQG SRTVEEGAET
260 270
PVYLALLPPD ATEPHGQLVR DKVVQTW
Length:277
Mass (Da):30,953
Last modified:October 1, 2002 - v1
Checksum:iEC6009AB9C83FACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028150 mRNA. Translation: BAC25778.1.
AC154449 Genomic DNA. No translation available.
CH466602 Genomic DNA. Translation: EDL03763.1.
BC028763 mRNA. Translation: AAH28763.1.
BC087735 mRNA. Translation: AAH87735.1.
BC096658 mRNA. Translation: AAH96658.1.
CCDSiCCDS28342.1.
RefSeqiNP_766635.1. NM_173047.3.
UniGeneiMm.4512.

Genome annotation databases

EnsembliENSMUST00000039620; ENSMUSP00000047712; ENSMUSG00000022947.
GeneIDi109857.
KEGGimmu:109857.
UCSCiuc007zzs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028150 mRNA. Translation: BAC25778.1.
AC154449 Genomic DNA. No translation available.
CH466602 Genomic DNA. Translation: EDL03763.1.
BC028763 mRNA. Translation: AAH28763.1.
BC087735 mRNA. Translation: AAH87735.1.
BC096658 mRNA. Translation: AAH96658.1.
CCDSiCCDS28342.1.
RefSeqiNP_766635.1. NM_173047.3.
UniGeneiMm.4512.

3D structure databases

ProteinModelPortaliQ8K354.
SMRiQ8K354. Positions 5-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225103. 1 interaction.
IntActiQ8K354. 2 interactions.
MINTiMINT-4117620.
STRINGi10090.ENSMUSP00000047712.

PTM databases

iPTMnetiQ8K354.
PhosphoSiteiQ8K354.

Proteomic databases

EPDiQ8K354.
MaxQBiQ8K354.
PaxDbiQ8K354.
PRIDEiQ8K354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039620; ENSMUSP00000047712; ENSMUSG00000022947.
GeneIDi109857.
KEGGimmu:109857.
UCSCiuc007zzs.2. mouse.

Organism-specific databases

CTDi874.
MGIiMGI:1309992. Cbr3.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00510000046499.
HOVERGENiHBG001909.
InParanoidiQ8K354.
KOiK00084.
OMAiLENCRED.
OrthoDBiEOG7PGDR4.
PhylomeDBiQ8K354.
TreeFamiTF329359.

Miscellaneous databases

PROiQ8K354.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K354.
GenevisibleiQ8K354. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, Czech II and FVB/N-3.
    Tissue: Lung, Mammary gland and Mammary tumor.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCBR3_MOUSE
AccessioniPrimary (citable) accession number: Q8K354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.