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Protein

SAM and SH3 domain-containing protein 3

Gene

Sash3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a signaling adapter protein in lymphocytes.1 Publication

GO - Biological processi

  • homeostasis of number of cells within a tissue Source: MGI
  • positive regulation of adaptive immune response Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell differentiation Source: MGI
  • positive regulation of immunoglobulin production Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • positive regulation of interleukin-4 production Source: MGI
  • positive regulation of lymphocyte activation Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of T cell cytokine production Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Alternative name(s):
SH3 protein expressed in lymphocytes
Gene namesi
Name:Sash3
Synonyms:Sly
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1921381 Sash3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719631 – 380SAM and SH3 domain-containing protein 3Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei42PhosphoserineCombined sources1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei112PhosphothreonineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K352
MaxQBiQ8K352
PaxDbiQ8K352
PeptideAtlasiQ8K352
PRIDEiQ8K352

PTM databases

iPTMnetiQ8K352
PhosphoSitePlusiQ8K352

Expressioni

Tissue specificityi

Preferentially expressed in lymphoid tissues. Expressed in bone marrow, thymus, spleen, lymph nodes and Peyer patches of gut. In the spleen and lymph nodes, expressed in both T- and B-cells. In the thymus, in the medulla and cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000031101
CleanExiMM_SASH3
GenevisibleiQ8K352 MM

Interactioni

Protein-protein interaction databases

BioGridi216514, 1 interactor
MINTiQ8K352
STRINGi10090.ENSMUSP00000033427

Structurei

3D structure databases

ProteinModelPortaliQ8K352
SMRiQ8K352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 234SH3PROSITE-ProRule annotationAdd BLAST62
Domaini252 – 316SAMPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410INAS Eukaryota
ENOG410YC4U LUCA
GeneTreeiENSGT00390000014672
HOGENOMiHOG000049202
HOVERGENiHBG000461
InParanoidiQ8K352
OMAiEMGDTLE
OrthoDBiEOG091G0BS1
PhylomeDBiQ8K352
TreeFamiTF350709

Family and domain databases

CDDicd11968 SH3_SASH3, 1 hit
InterProiView protein in InterPro
IPR021090 rSAM/SH3_domain-containing
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR035722 SASH3
IPR035721 SASH3_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12301:SF5 PTHR12301:SF5, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF07653 SH3_2, 1 hit
PF12485 SLY, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS DKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDDSGVL TPEDSGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM
110 120 130 140 150
GDTLEEGSAS PTSPDCSLDS PGPEKMALAF TEQEEREPPS LSRQTSTGSE
160 170 180 190 200
LCSPGPGSGS FLEESPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD
210 220 230 240 250
VIQIVEKPPV GTWLGLLNGK LGSFKFIYVD VLPEEAVGPV RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG
360 370 380
CFEGSESGRD EAELAGTEEQ LQGLSLSGAP
Length:380
Mass (Da):41,609
Last modified:October 24, 2003 - v2
Checksum:i8A3F19F0D79F66EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318T → TA in AAH28773 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306422 mRNA Translation: CAC67499.1
AK004734 mRNA Translation: BAB23516.1
AK156202 mRNA Translation: BAE33623.1
AK171017 mRNA Translation: BAE42187.1
BC028773 mRNA Translation: AAH28773.1
CCDSiCCDS40959.1
RefSeqiNP_001300678.1, NM_001313749.1
NP_083049.1, NM_028773.4
UniGeneiMm.276131

Genome annotation databases

EnsembliENSMUST00000033427; ENSMUSP00000033427; ENSMUSG00000031101
GeneIDi74131
KEGGimmu:74131
UCSCiuc009tbw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSASH3_MOUSE
AccessioniPrimary (citable) accession number: Q8K352
Secondary accession number(s): Q3TBX0, Q9DBV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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