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Protein

SAM and SH3 domain-containing protein 3

Gene

Sash3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a signaling adapter protein in lymphocytes.1 Publication

GO - Biological processi

  • homeostasis of number of cells within a tissue Source: MGI
  • positive regulation of adaptive immune response Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell differentiation Source: MGI
  • positive regulation of immunoglobulin production Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of interleukin-10 production Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • positive regulation of interleukin-4 production Source: MGI
  • positive regulation of lymphocyte activation Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of T cell cytokine production Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of tumor necrosis factor production Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Alternative name(s):
SH3 protein expressed in lymphocytes
Gene namesi
Name:Sash3
Synonyms:Sly
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1921381. Sash3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719631 – 380SAM and SH3 domain-containing protein 3Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei42PhosphoserineCombined sources1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei112PhosphothreonineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K352.
MaxQBiQ8K352.
PaxDbiQ8K352.
PeptideAtlasiQ8K352.
PRIDEiQ8K352.

PTM databases

iPTMnetiQ8K352.
PhosphoSitePlusiQ8K352.

Expressioni

Tissue specificityi

Preferentially expressed in lymphoid tissues. Expressed in bone marrow, thymus, spleen, lymph nodes and Peyer patches of gut. In the spleen and lymph nodes, expressed in both T- and B-cells. In the thymus, in the medulla and cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000031101.
CleanExiMM_SASH3.
GenevisibleiQ8K352. MM.

Interactioni

Protein-protein interaction databases

BioGridi216514. 1 interactor.
MINTiMINT-1341823.
STRINGi10090.ENSMUSP00000033427.

Structurei

3D structure databases

ProteinModelPortaliQ8K352.
SMRiQ8K352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 232SH3Add BLAST57
Domaini252 – 316SAMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410INAS. Eukaryota.
ENOG410YC4U. LUCA.
GeneTreeiENSGT00390000014672.
HOGENOMiHOG000049202.
HOVERGENiHBG000461.
InParanoidiQ8K352.
OMAiEMGDTLE.
OrthoDBiEOG091G0BS1.
PhylomeDBiQ8K352.
TreeFamiTF350709.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS DKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDDSGVL TPEDSGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM
110 120 130 140 150
GDTLEEGSAS PTSPDCSLDS PGPEKMALAF TEQEEREPPS LSRQTSTGSE
160 170 180 190 200
LCSPGPGSGS FLEESPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD
210 220 230 240 250
VIQIVEKPPV GTWLGLLNGK LGSFKFIYVD VLPEEAVGPV RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG
360 370 380
CFEGSESGRD EAELAGTEEQ LQGLSLSGAP
Length:380
Mass (Da):41,609
Last modified:October 24, 2003 - v2
Checksum:i8A3F19F0D79F66EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318T → TA in AAH28773 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306422 mRNA. Translation: CAC67499.1.
AK004734 mRNA. Translation: BAB23516.1.
AK156202 mRNA. Translation: BAE33623.1.
AK171017 mRNA. Translation: BAE42187.1.
BC028773 mRNA. Translation: AAH28773.1.
CCDSiCCDS40959.1.
RefSeqiNP_001300678.1. NM_001313749.1.
NP_083049.1. NM_028773.4.
UniGeneiMm.276131.

Genome annotation databases

EnsembliENSMUST00000033427; ENSMUSP00000033427; ENSMUSG00000031101.
GeneIDi74131.
KEGGimmu:74131.
UCSCiuc009tbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306422 mRNA. Translation: CAC67499.1.
AK004734 mRNA. Translation: BAB23516.1.
AK156202 mRNA. Translation: BAE33623.1.
AK171017 mRNA. Translation: BAE42187.1.
BC028773 mRNA. Translation: AAH28773.1.
CCDSiCCDS40959.1.
RefSeqiNP_001300678.1. NM_001313749.1.
NP_083049.1. NM_028773.4.
UniGeneiMm.276131.

3D structure databases

ProteinModelPortaliQ8K352.
SMRiQ8K352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216514. 1 interactor.
MINTiMINT-1341823.
STRINGi10090.ENSMUSP00000033427.

PTM databases

iPTMnetiQ8K352.
PhosphoSitePlusiQ8K352.

Proteomic databases

EPDiQ8K352.
MaxQBiQ8K352.
PaxDbiQ8K352.
PeptideAtlasiQ8K352.
PRIDEiQ8K352.

Protocols and materials databases

DNASUi74131.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033427; ENSMUSP00000033427; ENSMUSG00000031101.
GeneIDi74131.
KEGGimmu:74131.
UCSCiuc009tbw.1. mouse.

Organism-specific databases

CTDi54440.
MGIiMGI:1921381. Sash3.

Phylogenomic databases

eggNOGiENOG410INAS. Eukaryota.
ENOG410YC4U. LUCA.
GeneTreeiENSGT00390000014672.
HOGENOMiHOG000049202.
HOVERGENiHBG000461.
InParanoidiQ8K352.
OMAiEMGDTLE.
OrthoDBiEOG091G0BS1.
PhylomeDBiQ8K352.
TreeFamiTF350709.

Miscellaneous databases

PROiQ8K352.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031101.
CleanExiMM_SASH3.
GenevisibleiQ8K352. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSASH3_MOUSE
AccessioniPrimary (citable) accession number: Q8K352
Secondary accession number(s): Q3TBX0, Q9DBV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.