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Q8K348

- ACV1C_MOUSE

UniProt

Q8K348 - ACV1C_MOUSE

Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei222 – 2221ATPBy similarityPROSITE-ProRule annotation
    Active sitei323 – 3231Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2099ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin receptor activity, type I Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. growth factor binding Source: UniProt
    4. metal ion binding Source: UniProtKB-KW
    5. receptor signaling protein serine/threonine kinase activity Source: InterPro
    6. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic nuclear changes Source: Ensembl
    2. cell differentiation Source: UniProtKB
    3. lipid storage Source: MGI
    4. negative regulation of chorionic trophoblast cell proliferation Source: Ensembl
    5. negative regulation of insulin secretion Source: MGI
    6. negative regulation of trophoblast cell migration Source: Ensembl
    7. nodal signaling pathway Source: Ensembl
    8. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    9. regulation of apoptotic process Source: UniProtKB
    10. response to dietary excess Source: MGI
    11. response to glucose Source: MGI
    12. response to insulin Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_216258. Signaling by Activin.
    REACT_220645. Signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-1C (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IC
    Short name:
    ACTR-IC
    Activin receptor-like kinase 7
    Short name:
    ALK-7
    Gene namesi
    Name:Acvr1cImported
    Synonyms:Alk7By similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2661081. Acvr1c.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. activin receptor complex Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 493468Activin receptor type-1CPRO_0000042629Add
    BLAST

    Proteomic databases

    PRIDEiQ8K348.

    PTM databases

    PhosphoSiteiQ8K348.

    Expressioni

    Tissue specificityi

    Expressed in interdigital regions in developing limb buds.1 Publication

    Gene expression databases

    BgeeiQ8K348.
    CleanExiMM_ACVR1C.
    GenevestigatoriQ8K348.

    Interactioni

    Subunit structurei

    Binds the type 2 receptor protein ACVR2A.By similarity

    Protein-protein interaction databases

    BioGridi234631. 1 interaction.
    IntActiQ8K348. 1 interaction.
    MINTiMINT-2842395.
    STRINGi10090.ENSMUSP00000028178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K348.
    SMRiQ8K348. Positions 25-97, 145-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 11387ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 19430GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110337.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiA2AJR4.
    KOiK13568.
    OMAiWACQGRQ.
    OrthoDBiEOG7Q8CN3.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPARGSALS LALLLVALAA DLAAGLKCVC LLCDSSNFTC QTEGACWASV    50
    MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP 100
    TASPNAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN 150
    VEEALAEYSL VNAGKTLKDL IYDATASGSG SGLPLLVQRT IARTIVLQEI 200
    VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL 250
    GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA 300
    SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS 350
    IMNTIDIPQN PKVGTKRYMA PEMLDDTMNL SIFESFKRAD IYSVGLVYWE 400
    IARRCSVGGV VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS 450
    CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA 493
    Length:493
    Mass (Da):54,700
    Last modified:July 27, 2011 - v3
    Checksum:iCB9BE5E368CA2D2F
    GO

    Sequence cautioni

    The sequence AK142396 differs from that shown. Reason: Frameshift at position 236.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142396 mRNA. No translation available.
    AL772179 Genomic DNA. Translation: CAM13260.1.
    CH466519 Genomic DNA. Translation: EDL26940.1.
    BC028780 mRNA. Translation: AAH28780.1.
    CCDSiCCDS50586.1.
    RefSeqiNP_001104500.1. NM_001111030.1.
    UniGeneiMm.77751.

    Genome annotation databases

    EnsembliENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834.
    GeneIDi269275.
    KEGGimmu:269275.
    UCSCiuc008jsp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142396 mRNA. No translation available.
    AL772179 Genomic DNA. Translation: CAM13260.1 .
    CH466519 Genomic DNA. Translation: EDL26940.1 .
    BC028780 mRNA. Translation: AAH28780.1 .
    CCDSi CCDS50586.1.
    RefSeqi NP_001104500.1. NM_001111030.1.
    UniGenei Mm.77751.

    3D structure databases

    ProteinModelPortali Q8K348.
    SMRi Q8K348. Positions 25-97, 145-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234631. 1 interaction.
    IntActi Q8K348. 1 interaction.
    MINTi MINT-2842395.
    STRINGi 10090.ENSMUSP00000028178.

    PTM databases

    PhosphoSitei Q8K348.

    Proteomic databases

    PRIDEi Q8K348.

    Protocols and materials databases

    DNASUi 269275.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028178 ; ENSMUSP00000028178 ; ENSMUSG00000026834 .
    GeneIDi 269275.
    KEGGi mmu:269275.
    UCSCi uc008jsp.2. mouse.

    Organism-specific databases

    CTDi 130399.
    MGIi MGI:2661081. Acvr1c.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110337.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi A2AJR4.
    KOi K13568.
    OMAi WACQGRQ.
    OrthoDBi EOG7Q8CN3.
    TreeFami TF314724.

    Enzyme and pathway databases

    Reactomei REACT_216258. Signaling by Activin.
    REACT_220645. Signaling by NODAL.

    Miscellaneous databases

    NextBioi 392768.
    PROi Q8K348.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K348.
    CleanExi MM_ACVR1C.
    Genevestigatori Q8K348.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse."
      Joernvall H., Reissmann E., Andersson O., Mehrkash M., Ibanez C.F.
      Mol. Cell. Biol. 24:9383-9389(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-363.
      Strain: C57BL/6JImported.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiACV1C_MOUSE
    AccessioniPrimary (citable) accession number: Q8K348
    Secondary accession number(s): A2AJR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3