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Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221ATPPROSITE-ProRule annotationBy similarity
Active sitei323 – 3231Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

  1. activin binding Source: MGI
  2. activin receptor activity, type I Source: UniProtKB
  3. ATP binding Source: UniProtKB-KW
  4. growth factor binding Source: UniProtKB
  5. metal ion binding Source: UniProtKB-KW
  6. nodal binding Source: MGI
  7. receptor signaling protein serine/threonine kinase activity Source: InterPro
  8. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic nuclear changes Source: MGI
  2. cell differentiation Source: UniProtKB
  3. lipid storage Source: MGI
  4. negative regulation of chorionic trophoblast cell proliferation Source: MGI
  5. negative regulation of insulin secretion Source: MGI
  6. negative regulation of trophoblast cell migration Source: MGI
  7. nodal signaling pathway Source: MGI
  8. positive regulation of apoptotic process Source: MGI
  9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  10. regulation of apoptotic process Source: UniProtKB
  11. response to dietary excess Source: MGI
  12. response to glucose Source: MGI
  13. response to insulin Source: MGI
  14. trophectodermal cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_331083. Signaling by NODAL.
REACT_347120. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1C (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IC
Short name:
ACTR-IC
Activin receptor-like kinase 7
Short name:
ALK-7
Gene namesi
Name:Acvr1cImported
Synonyms:Alk7By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2661081. Acvr1c.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 11387ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. activin receptor complex Source: UniProtKB
  2. cell surface Source: MGI
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 493468Activin receptor type-1CPRO_0000042629Add
BLAST

Proteomic databases

PRIDEiQ8K348.

PTM databases

PhosphoSiteiQ8K348.

Expressioni

Tissue specificityi

Expressed in interdigital regions in developing limb buds.1 Publication

Gene expression databases

BgeeiQ8K348.
CleanExiMM_ACVR1C.
ExpressionAtlasiQ8K348. baseline and differential.
GenevestigatoriQ8K348.

Interactioni

Subunit structurei

Binds the type 2 receptor protein ACVR2A.By similarity

Protein-protein interaction databases

BioGridi234631. 1 interaction.
IntActiQ8K348. 1 interaction.
MINTiMINT-2842395.
STRINGi10090.ENSMUSP00000028178.

Structurei

3D structure databases

ProteinModelPortaliQ8K348.
SMRiQ8K348. Positions 25-97, 145-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 19430GSPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ8K348.
KOiK13568.
OMAiAPKLGPM.
OrthoDBiEOG7Q8CN3.
TreeFamiTF314724.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPARGSALS LALLLVALAA DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP
110 120 130 140 150
TASPNAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEALAEYSL VNAGKTLKDL IYDATASGSG SGLPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNL SIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGV VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Length:493
Mass (Da):54,700
Last modified:July 27, 2011 - v3
Checksum:iCB9BE5E368CA2D2F
GO

Sequence cautioni

The sequence AK142396 differs from that shown. Reason: Frameshift at position 236. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142396 mRNA. No translation available.
AL772179 Genomic DNA. Translation: CAM13260.1.
CH466519 Genomic DNA. Translation: EDL26940.1.
BC028780 mRNA. Translation: AAH28780.1.
CCDSiCCDS50586.1.
RefSeqiNP_001104500.1. NM_001111030.1.
UniGeneiMm.77751.

Genome annotation databases

EnsembliENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834.
GeneIDi269275.
KEGGimmu:269275.
UCSCiuc008jsp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142396 mRNA. No translation available.
AL772179 Genomic DNA. Translation: CAM13260.1.
CH466519 Genomic DNA. Translation: EDL26940.1.
BC028780 mRNA. Translation: AAH28780.1.
CCDSiCCDS50586.1.
RefSeqiNP_001104500.1. NM_001111030.1.
UniGeneiMm.77751.

3D structure databases

ProteinModelPortaliQ8K348.
SMRiQ8K348. Positions 25-97, 145-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234631. 1 interaction.
IntActiQ8K348. 1 interaction.
MINTiMINT-2842395.
STRINGi10090.ENSMUSP00000028178.

PTM databases

PhosphoSiteiQ8K348.

Proteomic databases

PRIDEiQ8K348.

Protocols and materials databases

DNASUi269275.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834.
GeneIDi269275.
KEGGimmu:269275.
UCSCiuc008jsp.2. mouse.

Organism-specific databases

CTDi130399.
MGIiMGI:2661081. Acvr1c.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ8K348.
KOiK13568.
OMAiAPKLGPM.
OrthoDBiEOG7Q8CN3.
TreeFamiTF314724.

Enzyme and pathway databases

ReactomeiREACT_331083. Signaling by NODAL.
REACT_347120. Signaling by Activin.

Miscellaneous databases

NextBioi392768.
PROiQ8K348.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K348.
CleanExiMM_ACVR1C.
ExpressionAtlasiQ8K348. baseline and differential.
GenevestigatoriQ8K348.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse."
    Joernvall H., Reissmann E., Andersson O., Mehrkash M., Ibanez C.F.
    Mol. Cell. Biol. 24:9383-9389(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-363.
    Strain: C57BL/6JImported.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiACV1C_MOUSE
AccessioniPrimary (citable) accession number: Q8K348
Secondary accession number(s): A2AJR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.