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Q8K348

- ACV1C_MOUSE

UniProt

Q8K348 - ACV1C_MOUSE

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Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221ATPBy similarityPROSITE-ProRule annotation
Active sitei323 – 3231Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin receptor activity, type I Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. growth factor binding Source: UniProt
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein serine/threonine kinase activity Source: InterPro
  6. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic nuclear changes Source: Ensembl
  2. cell differentiation Source: UniProtKB
  3. lipid storage Source: MGI
  4. negative regulation of chorionic trophoblast cell proliferation Source: Ensembl
  5. negative regulation of insulin secretion Source: MGI
  6. negative regulation of trophoblast cell migration Source: Ensembl
  7. nodal signaling pathway Source: Ensembl
  8. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  9. regulation of apoptotic process Source: UniProtKB
  10. response to dietary excess Source: MGI
  11. response to glucose Source: MGI
  12. response to insulin Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216258. Signaling by Activin.
REACT_220645. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1C (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IC
Short name:
ACTR-IC
Activin receptor-like kinase 7
Short name:
ALK-7
Gene namesi
Name:Acvr1cImported
Synonyms:Alk7By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2661081. Acvr1c.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 11387ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. activin receptor complex Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 493468Activin receptor type-1CPRO_0000042629Add
BLAST

Proteomic databases

PRIDEiQ8K348.

PTM databases

PhosphoSiteiQ8K348.

Expressioni

Tissue specificityi

Expressed in interdigital regions in developing limb buds.1 Publication

Gene expression databases

BgeeiQ8K348.
CleanExiMM_ACVR1C.
ExpressionAtlasiQ8K348. baseline and differential.
GenevestigatoriQ8K348.

Interactioni

Subunit structurei

Binds the type 2 receptor protein ACVR2A.By similarity

Protein-protein interaction databases

BioGridi234631. 1 interaction.
IntActiQ8K348. 1 interaction.
MINTiMINT-2842395.
STRINGi10090.ENSMUSP00000028178.

Structurei

3D structure databases

ProteinModelPortaliQ8K348.
SMRiQ8K348. Positions 25-97, 145-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 19430GSPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ8K348.
KOiK13568.
OMAiWACQGRQ.
OrthoDBiEOG7Q8CN3.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K348-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPARGSALS LALLLVALAA DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP
110 120 130 140 150
TASPNAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEALAEYSL VNAGKTLKDL IYDATASGSG SGLPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNL SIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGV VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Length:493
Mass (Da):54,700
Last modified:July 27, 2011 - v3
Checksum:iCB9BE5E368CA2D2F
GO

Sequence cautioni

The sequence AK142396 differs from that shown. Reason: Frameshift at position 236. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142396 mRNA. No translation available.
AL772179 Genomic DNA. Translation: CAM13260.1.
CH466519 Genomic DNA. Translation: EDL26940.1.
BC028780 mRNA. Translation: AAH28780.1.
CCDSiCCDS50586.1.
RefSeqiNP_001104500.1. NM_001111030.1.
UniGeneiMm.77751.

Genome annotation databases

EnsembliENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834.
GeneIDi269275.
KEGGimmu:269275.
UCSCiuc008jsp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142396 mRNA. No translation available.
AL772179 Genomic DNA. Translation: CAM13260.1 .
CH466519 Genomic DNA. Translation: EDL26940.1 .
BC028780 mRNA. Translation: AAH28780.1 .
CCDSi CCDS50586.1.
RefSeqi NP_001104500.1. NM_001111030.1.
UniGenei Mm.77751.

3D structure databases

ProteinModelPortali Q8K348.
SMRi Q8K348. Positions 25-97, 145-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234631. 1 interaction.
IntActi Q8K348. 1 interaction.
MINTi MINT-2842395.
STRINGi 10090.ENSMUSP00000028178.

PTM databases

PhosphoSitei Q8K348.

Proteomic databases

PRIDEi Q8K348.

Protocols and materials databases

DNASUi 269275.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028178 ; ENSMUSP00000028178 ; ENSMUSG00000026834 .
GeneIDi 269275.
KEGGi mmu:269275.
UCSCi uc008jsp.2. mouse.

Organism-specific databases

CTDi 130399.
MGIi MGI:2661081. Acvr1c.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi Q8K348.
KOi K13568.
OMAi WACQGRQ.
OrthoDBi EOG7Q8CN3.
TreeFami TF314724.

Enzyme and pathway databases

Reactomei REACT_216258. Signaling by Activin.
REACT_220645. Signaling by NODAL.

Miscellaneous databases

NextBioi 392768.
PROi Q8K348.
SOURCEi Search...

Gene expression databases

Bgeei Q8K348.
CleanExi MM_ACVR1C.
ExpressionAtlasi Q8K348. baseline and differential.
Genevestigatori Q8K348.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse."
    Joernvall H., Reissmann E., Andersson O., Mehrkash M., Ibanez C.F.
    Mol. Cell. Biol. 24:9383-9389(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-363.
    Strain: C57BL/6JImported.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiACV1C_MOUSE
AccessioniPrimary (citable) accession number: Q8K348
Secondary accession number(s): A2AJR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3