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Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei222ATPPROSITE-ProRule annotationBy similarity1
Active sitei323Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 209ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

  • apoptotic nuclear changes Source: MGI
  • cell differentiation Source: UniProtKB
  • lipid storage Source: MGI
  • negative regulation of chorionic trophoblast cell proliferation Source: MGI
  • negative regulation of insulin secretion Source: MGI
  • negative regulation of trophoblast cell migration Source: MGI
  • nodal signaling pathway Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • regulation of apoptotic process Source: UniProtKB
  • response to dietary excess Source: MGI
  • response to glucose Source: MGI
  • response to insulin Source: MGI
  • trophectodermal cell proliferation Source: MGI

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1502540. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1C (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IC
Short name:
ACTR-IC
Activin receptor-like kinase 7
Short name:
ALK-7
Gene namesi
Name:Acvr1cImported
Synonyms:Alk7By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2661081. Acvr1c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 113ExtracellularSequence analysisAdd BLAST87
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 493CytoplasmicSequence analysisAdd BLAST359

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004262926 – 493Activin receptor type-1CAdd BLAST468

Proteomic databases

MaxQBiQ8K348.
PaxDbiQ8K348.
PRIDEiQ8K348.

PTM databases

PhosphoSitePlusiQ8K348.

Expressioni

Tissue specificityi

Expressed in interdigital regions in developing limb buds.1 Publication

Gene expression databases

BgeeiENSMUSG00000026834.
CleanExiMM_ACVR1C.
ExpressionAtlasiQ8K348. baseline and differential.
GenevisibleiQ8K348. MM.

Interactioni

Subunit structurei

Binds the type 2 receptor protein ACVR2A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234631. 1 interactor.
IntActiQ8K348. 1 interactor.
MINTiMINT-2842395.
STRINGi10090.ENSMUSP00000028178.

Structurei

3D structure databases

ProteinModelPortaliQ8K348.
SMRiQ8K348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 194GSPROSITE-ProRule annotationAdd BLAST30
Domaini195 – 485Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ8K348.
KOiK13568.
OMAiAPKLGPM.
OrthoDBiEOG091G0BIU.
TreeFamiTF314724.

Family and domain databases

InterProiView protein in InterPro
IPR003605. GS_dom.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
SMARTiView protein in SMART
SM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPARGSALS LALLLVALAA DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP
110 120 130 140 150
TASPNAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEALAEYSL VNAGKTLKDL IYDATASGSG SGLPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNL SIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGV VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Length:493
Mass (Da):54,700
Last modified:July 27, 2011 - v3
Checksum:iCB9BE5E368CA2D2F
GO

Sequence cautioni

The sequence AK142396 differs from that shown. Reason: Frameshift at position 236.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142396 mRNA. No translation available.
AL772179 Genomic DNA. Translation: CAM13260.1.
CH466519 Genomic DNA. Translation: EDL26940.1.
BC028780 mRNA. Translation: AAH28780.1.
CCDSiCCDS50586.1.
RefSeqiNP_001104500.1. NM_001111030.1.
UniGeneiMm.77751.

Genome annotation databases

EnsembliENSMUST00000028178; ENSMUSP00000028178; ENSMUSG00000026834.
GeneIDi269275.
KEGGimmu:269275.
UCSCiuc008jsp.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiACV1C_MOUSE
AccessioniPrimary (citable) accession number: Q8K348
Secondary accession number(s): A2AJR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families