Reviewed,
UniProtKB/Swiss-Prot Q8K348 (ACV1C_MOUSE)
Last modified
June 16, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Activin receptor type-1C EC=2.7.11.30 Alternative name(s): ACTR-IC Activin receptor-like kinase 7 Short name=ALK-7 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 493 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese. |
| Subunit structure | Binds the type 2 receptor protein ACVR2A By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane protein By similarity. |
| Tissue specificity | Expressed in interdigital regions in developing limb buds. Ref.1 |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
| Sequence caution | The sequence AL772179 differs from that shown. Reason: Frameshift at position 236. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 493 | 468 | Activin receptor type-1C | PRO_0000042629 | |||||
Regions | |||||||||
| Topological domain | 27 – 113 | 87 | Extracellular Potential | ||||||
| Transmembrane | 114 – 134 | 21 | Potential | ||||||
| Topological domain | 135 – 493 | 359 | Cytoplasmic Potential | ||||||
| Domain | 165 – 194 | 30 | GS | ||||||
| Domain | 195 – 485 | 291 | Protein kinase | ||||||
| Nucleotide binding | 201 – 209 | 9 | ATP By similarity UniProtKB Q04771 | ||||||
Sites | |||||||||
| Active site | 323 | 1 | Proton acceptor By similarity UniProtKB Q04771 | ||||||
| Binding site | 222 | 1 | ATP By similarity UniProtKB Q04771 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse." Joernvall H., Reissmann E., Andersson O., Mehrkash M., Ibanez C.F. Mol. Cell. Biol. 24:9383-9389(2004) [PubMed: 15485907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal lung. |
| [3] | The mouse genome sequencing consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-363. Strain: C57BL/6J. Tissue: Mammary gland. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK142396 mRNA. No translation available. AL772179 Genomic DNA. No translation available. BC028780 mRNA. Translation: AAH28780.1. | |
| IPI | IPI00720121. |
| UniGene | Mm.77751 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| SMR | Q8K348. Positions 161-489. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8K348. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000026834. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:2661081. Acvr1c. |
Phylogenomic databases | |
| HOGENOM | Q8K348. |
| HOVERGEN | Q8K348. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.30. 244. |
Gene expression databases | |
| ArrayExpress | Q8K348. |
| Bgee | Q8K348. |
| CleanEx | MM_ACVR1C. |
| GermOnline | ENSMUSG00000026834. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ACV1C_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K348 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


