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Protein

Ras association domain-containing protein 9

Gene

Rassf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating vesicuar trafficking in cells.By similarity

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 9
Alternative name(s):
PAM COOH-terminal interactor protein 1
Short name:
P-CIP1
Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
Gene namesi
Name:Rassf9
Synonyms:Pamci, Pcip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384307. Rassf9.

Subcellular locationi

Endosome
Note: Accumulates on perinuclear endosomes.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endosome Source: UniProtKB
  3. extracellular vesicular exosome Source: MGI
  4. trans-Golgi network transport vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Ras association domain-containing protein 9PRO_0000299453Add
BLAST

Proteomic databases

PRIDEiQ8K342.

Expressioni

Gene expression databases

BgeeiQ8K342.
GenevestigatoriQ8K342.

Interactioni

Subunit structurei

Interacts with PAM.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K342.
SMRiQ8K342. Positions 28-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11995Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili195 – 29197Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG237393.
GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiQ8K342.
KOiK09856.
OMAiEKCEAKF.
OrthoDBiEOG7MSMNT.
PhylomeDBiQ8K342.
TreeFamiTF326923.

Family and domain databases

InterProiIPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFGRNLLK TRHKNRSPTK DMDPEEKEIV VWVCQDEKIV CGLTKRTTSI
60 70 80 90 100
DVIQALLEEH EATFGEKRFL LGKASDYCIV EKWRGSERAL PPLTRILKLW
110 120 130 140 150
KAWGDEQPNM QFVLVKTDAF LPVPLWRTAE TKLVQNNEKP WELSPANYMK
160 170 180 190 200
TLPPDKQKRI VRKTFRKLAK IRQDTSSHDR DNMECLVHLI ISQDHTIHQQ
210 220 230 240 250
VQRMKELDME IEKCEAKIHL DRVGNDGANY VHEAYLMPRL SDEEQKLDIQ
260 270 280 290 300
AEINQTLEDL NDSEGMAQLE EQLQYYRALI DKLSAEIERE VKGAGIDGIE
310 320 330 340 350
DMEGAAACEL ENSDLESVKC DLETSMKAGL TIHSHLSGIQ REIKYSDSLL
360 370 380 390 400
QMKAREYELL AKEFSSLHIS NKDGCQGKEN RGKEAEAPSS NGETPPLTQR
410 420 430
VFNIYTNDTD SDTGISSNHS QDSETTLGDV LLLAT
Length:435
Mass (Da):49,582
Last modified:October 1, 2002 - v1
Checksum:i4F36702F273DEE49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti370 – 3701S → N in BAC28302 (PubMed:16141072).Curated
Sequence conflicti409 – 4091T → A in BAC28302 (PubMed:16141072).Curated
Sequence conflicti429 – 4291D → N in BAC28302 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033464 mRNA. Translation: BAC28302.1.
AK041688 mRNA. Translation: BAC31033.1.
BC028805 mRNA. Translation: AAH28805.1.
CCDSiCCDS36048.1.
RefSeqiNP_666352.1. NM_146240.4.
UniGeneiMm.282672.

Genome annotation databases

EnsembliENSMUST00000055355; ENSMUSP00000054767; ENSMUSG00000044921.
GeneIDi237504.
KEGGimmu:237504.
UCSCiuc007gyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033464 mRNA. Translation: BAC28302.1.
AK041688 mRNA. Translation: BAC31033.1.
BC028805 mRNA. Translation: AAH28805.1.
CCDSiCCDS36048.1.
RefSeqiNP_666352.1. NM_146240.4.
UniGeneiMm.282672.

3D structure databases

ProteinModelPortaliQ8K342.
SMRiQ8K342. Positions 28-117.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8K342.

Protocols and materials databases

DNASUi237504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055355; ENSMUSP00000054767; ENSMUSG00000044921.
GeneIDi237504.
KEGGimmu:237504.
UCSCiuc007gyf.1. mouse.

Organism-specific databases

CTDi9182.
MGIiMGI:2384307. Rassf9.

Phylogenomic databases

eggNOGiNOG237393.
GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiQ8K342.
KOiK09856.
OMAiEKCEAKF.
OrthoDBiEOG7MSMNT.
PhylomeDBiQ8K342.
TreeFamiTF326923.

Miscellaneous databases

NextBioi383390.
PROiQ8K342.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K342.
GenevestigatoriQ8K342.

Family and domain databases

InterProiIPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRASF9_MOUSE
AccessioniPrimary (citable) accession number: Q8K342
Secondary accession number(s): Q8BZV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.